Protein: TCAM1
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)

Gene: TCAM1, TICAM1
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q8IUC6

Gene Ontology (top 5):
GO:0002224 - toll-like receptor signaling pathway
GO:0002281 - macrophage activation involved in immune response
GO:0002735 - positive regulation of myeloid dendritic cell cytokine production
GO:0005739 - mitochondrion
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1216090

TCAM1
TIR domain-containing adapter molecule 1

5

3

Small-scale

0.908

High

1216108

TBK1
Serine/threonine-protein kinase TBK1

14

3

Small-scale

0.759

High

1216111

TRAF6
TNF receptor-associated factor 6

9

11

Small-scale

0.756

High

1038276

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

9

5

Small-scale

0.747

High

1024705

TRAF3
TNF receptor-associated factor 3

8

10

Small-scale

0.741

High

179947

TLR3
Toll-like receptor 3

7

8

Small-scale

0.739

High

1020783

TRAF2
TNF receptor-associated factor 2

4

13

Small-scale

0.703

High

120161

TLR4
Toll-like receptor 4

4

8

Small-scale

0.683

High

1204720

TCAM2
TIR domain-containing adapter molecule 2

4

3

Small-scale

0.683

High

1056434

IRF3
Interferon regulatory factor 3

4

2

Small-scale

0.676

High

1023712

TRAF1
TNF receptor-associated factor 1

3

9

Small-scale

0.674

High

1059317

CASP8
Caspase-8

3

1

Small-scale

0.640

High

1204046

CARM1
Histone-arginine methyltransferase CARM1

3

0

High-throughput

0.634

High

1216112

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

4

Small-scale

0.618

High

1216095

TANK
TRAF family member-associated NF-kappa-B activator

2

1

Small-scale

0.611

High

1164529

SARM1
NAD(+) hydrolase SARM1

2

1

Small-scale

0.606

High

1216110

TMED7
Transmembrane emp24 domain-containing protein 7

3

2

Small-scale

0.581

High

1216102

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

3

Small-scale

0.561

High

1216105

AZI2
5-azacytidine-induced protein 2

2

0

Small-scale

0.559

High

1216109

UBQL1
Ubiquilin-1

1

0

Small-scale

0.554

High

1216094

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.536

High

1216103

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

1

High-throughput

0.536

High

599685

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.515

High

1216100

TRI56
E3 ubiquitin-protein ligase TRIM56

1

3

Small-scale

0.515

High

1216101

TRAF4
TNF receptor-associated factor 4

1

11

Small-scale

0.515

High

176467

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

422622

GPX1
Glutathione peroxidase 1

1

0

High-throughput

0.513

High

1216091

DI3L2
DIS3-like exonuclease 2

1

0

High-throughput

0.513

High

1216098

CDCA5
Sororin

1

0

High-throughput

0.513

High

1190022

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.493

High

1216092

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.488

High

1071476

ZMY11
Zinc finger MYND domain-containing protein 11

1

0

Small-scale

0.484

High

129577

TRAF5
TNF receptor-associated factor 5

1

13

Small-scale

0.479

High

158504

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

3

Small-scale

0.479

High

181625

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

Small-scale

0.479

High

201813

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

4

Small-scale

0.479

High

237430

TLR5
Toll-like receptor 5

1

8

Small-scale

0.479

High

237502

TLR2
Toll-like receptor 2

1

8

Small-scale

0.479

High

796606

KSYK
Tyrosine-protein kinase SYK

1

3

Small-scale

0.479

High

1027614

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

Small-scale

0.479

High

1050235

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

Small-scale

0.479

High

1216096

IRF7
Interferon regulatory factor 7

1

2

Small-scale

0.479

High

1216107

RN216
E3 ubiquitin-protein ligase RNF216

1

1

Small-scale

0.479

High

135031

TRI38
E3 ubiquitin-protein ligase TRIM38

1

0

Small-scale

0.458

High

162953

XPO1
Exportin-1

1

0

High-throughput

0.458

High

301415

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

Small-scale

0.458

High

548253

FOSL1
Fos-related antigen 1

1

0

Small-scale

0.458

High

787264

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

1189996

R144B
E3 ubiquitin-protein ligase RNF144B

1

0

Small-scale

0.458

High

1216093

ABCF1
ATP-binding cassette sub-family F member 1

1

0

Small-scale

0.458

High

1216097

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

1216104

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.458

High

253265

KI21B
Kinesin-like protein KIF21B

1

0

High-throughput

0.279

Low

1216106

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.279

Low

993760

SRSF4
Serine/arginine-rich splicing factor 4

1

0

High-throughput

0.251

Low

1216099

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024