Protein: MFN1
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)

Gene: MFN1
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q8IWA4

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0008053 - mitochondrial fusion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

304850

MFN2
Mitofusin-2

5

3

Small-scale

0.925

High

1218390

MFN1
Mitofusin-1

2

3

Small-scale

0.802

High

227978

PRKN
E3 ubiquitin-protein ligase parkin

7

5

Small-scale

0.744

High

1218407

MARH5
E3 ubiquitin-protein ligase MARCHF5

4

3

Small-scale

0.676

High

1190024

MAVS
Mitochondrial antiviral-signaling protein

2

3

Small-scale

0.612

High

1218398

FAF2
FAS-associated factor 2

3

1

High-throughput

0.609

High

1218406

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

0

High-throughput

0.602

High

1083802

BAK
Bcl-2 homologous antagonist/killer

2

3

Small-scale

0.584

High

1218397

S2546
Mitochondrial outer membrane protein SLC25A46

2

1

Small-scale

0.584

High

913308

PRS10
26S proteasome regulatory subunit 10B

1

5

High-throughput

0.536

High

1218401

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.513

High

851579

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.489

High

1218408

PLK2
Serine/threonine-protein kinase PLK2

1

1

High-throughput

0.489

High

230154

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

1

Small-scale

0.479

High

1066358

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1130293

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.479

High

1218393

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1218399

S2538
Mitochondrial glycine transporter

1

1

Small-scale

0.479

High

1218403

LFG4
Protein lifeguard 4

1

1

High-throughput

0.479

High

1218409

MTCH1
Mitochondrial carrier homolog 1

1

1

High-throughput

0.479

High

1218412

SAM50
Sorting and assembly machinery component 50 homolog

1

1

Small-scale

0.479

High

538576

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

1024706

TRAF3
TNF receptor-associated factor 3

1

0

Small-scale

0.458

High

1077307

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

1218394

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1218400

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

1218404

MID51
Mitochondrial dynamics protein MIEF1

1

0

Small-scale

0.458

High

385128

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

941129

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1170701

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1218391

NNRE
NAD(P)H-hydrate epimerase

1

1

Small-scale

0.437

High

1218392

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

1218402

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1218410

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

795988

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

1031003

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1052899

FLNC
Filamin-C

1

0

High-throughput

0.279

Low

1218396

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.279

Low

1218411

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1218413

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

120162

TLR4
Toll-like receptor 4

1

0

Small-scale

0.249

Low

998870

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.249

Low

1174257

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

1218395

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.249

Low

1218405

ANLN
Anillin

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024