Protein: MYD88
Myeloid differentiation primary response protein MyD88

Gene: MYD88
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q99836

Gene Ontology (top 5):
GO:0002238 - response to molecule of fungal origin
GO:0002269 - leukocyte activation involved in inflammatory response
GO:0002283 - neutrophil activation involved in immune response
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0005121 - Toll binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1306773

MYD88
Myeloid differentiation primary response protein MyD88

19

20

Small-scale

0.989

High

848461

IRAK1
Interleukin-1 receptor-associated kinase 1

22

20

Small-scale

0.988

High

886018

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

14

6

Small-scale

0.984

High

197912

IRAK2
Interleukin-1 receptor-associated kinase-like 2

4

20

Small-scale

0.896

High

1026645

FADD
FAS-associated death domain protein

3

7

Small-scale

0.829

High

1164538

SARM1
NAD(+) hydrolase SARM1

2

2

Small-scale

0.800

High

1306796

IRAK3
Interleukin-1 receptor-associated kinase 3

2

20

Small-scale

0.776

High

1306787

IRAK4
Interleukin-1 receptor-associated kinase 4

21

10

Small-scale

0.767

High

120173

TLR4
Toll-like receptor 4

15

19

Small-scale

0.761

High

214354

SPOP
Speckle-type POZ protein

8

3

Small-scale

0.756

High

540400

IL1R1
Interleukin-1 receptor type 1

11

13

Small-scale

0.752

High

237513

TLR2
Toll-like receptor 2

7

16

Small-scale

0.743

High

1306794

TRAF6
TNF receptor-associated factor 6

7

19

Small-scale

0.739

High

1273344

IRF7
Interferon regulatory factor 7

4

20

Small-scale

0.701

High

237435

TLR5
Toll-like receptor 5

5

19

Small-scale

0.701

High

1306783

TLR9
Toll-like receptor 9

3

20

Small-scale

0.650

High

1306790

HDAC6
Histone deacetylase 6

3

1

Small-scale

0.650

High

1306780

IL1AP
Interleukin-1 receptor accessory protein

3

20

Small-scale

0.640

High

1216692

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

7

Small-scale

0.631

High

1039469

IRF5
Interferon regulatory factor 5

2

20

Small-scale

0.624

High

436640

TNR16
Tumor necrosis factor receptor superfamily member 16

1

1

Small-scale

0.618

High

1204726

TCAM2
TIR domain-containing adapter molecule 2

1

12

Small-scale

0.618

High

1153191

SPOPL
Speckle-type POZ protein-like

2

3

High-throughput

0.606

High

156712

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

1

Small-scale

0.604

High

1071068

IRF4
Interferon regulatory factor 4

2

20

Small-scale

0.601

High

596923

MAL
Myelin and lymphocyte protein

2

1

Small-scale

0.586

High

796639

KSYK
Tyrosine-protein kinase SYK

2

18

Small-scale

0.584

High

1064073

TNIP1
TNFAIP3-interacting protein 1

2

2

Small-scale

0.584

High

1151862

SIGIR
Single Ig IL-1-related receptor

2

15

Small-scale

0.584

High

532327

ZNF35
Zinc finger protein 35

2

0

High-throughput

0.580

High

941359

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

1293229

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

925562

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

Small-scale

0.578

High

1306788

TLR7
Toll-like receptor 7

2

20

Small-scale

0.576

High

950264

SMAD3
Mothers against decapentaplegic homolog 3

1

4

High-throughput

0.573

High

495600

THIO
Thioredoxin

1

0

High-throughput

0.561

High

1237824

RN152
E3 ubiquitin-protein ligase RNF152

1

2

Small-scale

0.561

High

1306792

STAP2
Signal-transducing adaptor protein 2

1

0

Small-scale

0.554

High

1306786

CISH
Cytokine-inducible SH2-containing protein

1

18

Small-scale

0.552

High

1273826

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.549

High

1067903

RAGE
Advanced glycosylation end product-specific receptor

1

4

Small-scale

0.536

High

1306795

LRRF2
Leucine-rich repeat flightless-interacting protein 2

2

4

Small-scale

0.533

High

571765

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

0

High-throughput

0.518

High

962939

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.518

High

989376

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.518

High

1306785

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.518

High

501085

IRF1
Interferon regulatory factor 1

1

20

Small-scale

0.515

High

965959

ILRL1
Interleukin-1 receptor-like 1

1

13

Small-scale

0.515

High

986390

BTK
Tyrosine-protein kinase BTK

1

15

Small-scale

0.515

High

1291021

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

2

Small-scale

0.515

High

1148536

Q69FE3
Interleukin-1 receptor-associated kinase 4

1

10

High-throughput

0.515

High

1244075

DOCK8
Dedicator of cytokinesis protein 8

1

0

Small-scale

0.513

High

1303449

CYH2
Cytohesin-2

1

0

Small-scale

0.512

High

1073330

TLR1
Toll-like receptor 1

1

17

Small-scale

0.506

High

1306793

TLR6
Toll-like receptor 6

1

20

Small-scale

0.506

High

179958

TLR3
Toll-like receptor 3

1

20

Small-scale

0.501

High

1306797

NEMO
NF-kappa-B essential modulator

1

3

Small-scale

0.501

High

199139

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

19

High-throughput

0.481

High

1306781

C1QR1
Complement component C1q receptor

1

4

High-throughput

0.481

High

206973

SMAD6
Mothers against decapentaplegic homolog 6

1

4

Small-scale

0.479

High

428389

TBB5
Tubulin beta chain

1

6

Small-scale

0.479

High

432202

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

504644

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

564165

HSP76
Heat shock 70 kDa protein 6

1

6

Small-scale

0.479

High

575559

EGR1
Early growth response protein 1

1

2

High-throughput

0.479

High

655454

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

Small-scale

0.479

High

714057

HS71L
Heat shock 70 kDa protein 1-like

1

6

Small-scale

0.479

High

781435

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.479

High

843015

TCPQ
T-complex protein 1 subunit theta

1

3

Small-scale

0.479

High

843352

TCPD
T-complex protein 1 subunit delta

1

2

Small-scale

0.479

High

933326

TBA1B
Tubulin alpha-1B chain

1

7

Small-scale

0.479

High

943432

TCPB
T-complex protein 1 subunit beta

1

2

Small-scale

0.479

High

1023224

FLII
Protein flightless-1 homolog

1

1

Small-scale

0.479

High

1024747

TRAF3
TNF receptor-associated factor 3

1

19

Small-scale

0.479

High

1027623

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.479

High

1036846

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1050256

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

6

Small-scale

0.479

High

1052835

FAK2
Protein-tyrosine kinase 2-beta

1

7

Small-scale

0.479

High

1056459

IRF3
Interferon regulatory factor 3

1

20

Small-scale

0.479

High

1076518

TRIP6
Thyroid receptor-interacting protein 6

1

1

Small-scale

0.479

High

1103957

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

3

Small-scale

0.479

High

1171414

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1172832

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

6

Small-scale

0.479

High

1175132

TBA1A
Tubulin alpha-1A chain

1

7

Small-scale

0.479

High

1242383

BANK1
B-cell scaffold protein with ankyrin repeats

1

6

Small-scale

0.479

High

1262707

ATX2L
Ataxin-2-like protein

1

2

Small-scale

0.479

High

1306640

TCPH
T-complex protein 1 subunit eta

1

2

Small-scale

0.479

High

1306774

TLR10
Toll-like receptor 10

1

20

Small-scale

0.479

High

1306776

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1306777

ILRL2
Interleukin-1 receptor-like 2

1

19

Small-scale

0.479

High

1306791

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

169924

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.460

High

182871

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

299125

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.458

High

352230

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

640604

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

Small-scale

0.458

High

909958

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

1014283

BST2
Bone marrow stromal antigen 2

1

0

Small-scale

0.458

High

1018861

SF3A3
Splicing factor 3A subunit 3

1

0

Small-scale

0.458

High

1029791

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1188777

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1306563

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

1306775

ATG5
Autophagy protein 5

1

0

Small-scale

0.458

High

1306779

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

Small-scale

0.458

High

1306782

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

1306789

UBAP1
Ubiquitin-associated protein 1

1

0

Small-scale

0.458

High

1306784

TLR8
Toll-like receptor 8

1

20

Small-scale

0.457

High

158534

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

6

Small-scale

0.445

High

1184603

ARMX6
Protein ARMCX6

1

0

High-throughput

0.279

Low

1306778

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024