Protein: IRAK4
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)

Gene: IRAK4
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q9NWZ3

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002224 - toll-like receptor signaling pathway
GO:0002446 - neutrophil mediated immunity
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

848494

IRAK1
Interleukin-1 receptor-associated kinase 1

13

19

Small-scale

0.985

High

1347563

IRAK4
Interleukin-1 receptor-associated kinase 4

3

18

Small-scale

0.845

High

197919

IRAK2
Interleukin-1 receptor-associated kinase-like 2

2

20

Small-scale

0.811

High

120179

TLR4
Toll-like receptor 4

2

20

Small-scale

0.789

High

1306787

MYD88
Myeloid differentiation primary response protein MyD88

21

10

Small-scale

0.767

High

1291025

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

9

2

Small-scale

0.757

High

237439

TLR5
Toll-like receptor 5

2

20

Small-scale

0.754

High

1334833

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

2

Small-scale

0.660

High

965963

ILRL1
Interleukin-1 receptor-like 1

3

2

Small-scale

0.657

High

886022

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

1

Small-scale

0.640

High

647321

1433T
14-3-3 protein theta

1

2

Small-scale

0.618

High

1347566

IRAK3
Interleukin-1 receptor-associated kinase 3

1

20

High-throughput

0.618

High

299132

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.586

High

537672

NCF1
Neutrophil cytosol factor 1

1

0

Small-scale

0.586

High

1297533

ZN597
Zinc finger protein 597

2

0

High-throughput

0.580

High

1318699

TRIM7
E3 ubiquitin-protein ligase TRIM7

2

0

High-throughput

0.580

High

1347564

I36RA
Interleukin-36 receptor antagonist protein

2

0

High-throughput

0.580

High

1347565

TRAF6
TNF receptor-associated factor 6

2

0

Small-scale

0.576

High

1067905

RAGE
Advanced glycosylation end product-specific receptor

1

1

Small-scale

0.536

High

649166

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.518

High

156721

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

1

Small-scale

0.515

High

540403

IL1R1
Interleukin-1 receptor type 1

1

2

Small-scale

0.515

High

153812

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.513

High

376118

CYTB
Cystatin-B

1

0

High-throughput

0.513

High

668048

SPB3
Serpin B3

1

0

High-throughput

0.513

High

849030

SSDH
Succinate-semialdehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

855748

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

489311

H14
Histone H1.4

1

5

Small-scale

0.501

High

559267

H15
Histone H1.5

1

5

Small-scale

0.501

High

559515

H13
Histone H1.3

1

5

Small-scale

0.501

High

559977

H12
Histone H1.2

1

5

Small-scale

0.501

High

608651

H1T
Histone H1t

1

5

Small-scale

0.501

High

971379

H11
Histone H1.1

1

5

Small-scale

0.501

High

362109

MBP
Myelin basic protein

1

0

Small-scale

0.480

High

1038231

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.480

High

1347567

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.480

High

950468

HPCA
Neuron-specific calcium-binding protein hippocalcin

1

1

High-throughput

0.479

High

1231624

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

2

Small-scale

0.479

High

913433

TBPL1
TATA box-binding protein-like 1

1

0

High-throughput

0.473

High

1217289

UN5CL
UNC5C-like protein

1

0

Small-scale

0.458

High

740701

HPCL1
Hippocalcin-like protein 1

1

1

High-throughput

0.437

High

815037

LEG7
Galectin-7

1

0

High-throughput

0.426

High

484337

VSIG8
V-set and immunoglobulin domain-containing protein 8

2

0

High-throughput

0.305

High

1237825

RN152
E3 ubiquitin-protein ligase RNF152

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024