Protein: SPCS3
Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)

Gene: SPCS3
Organism: Homo sapiens
Interactions: 119
UniProt ID: P61009

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

894896

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

2

High-throughput

0.628

High

654223

CALX
Calnexin

2

1

High-throughput

0.611

High

123556

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

170827

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.536

High

310581

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.536

High

335395

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.536

High

501900

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

762948

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

894842

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

2

High-throughput

0.536

High

894860

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.536

High

894909

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

369286

ESR1
Estrogen receptor

2

2

High-throughput

0.521

High

894844

HTRA3
Serine protease HTRA3

1

0

High-throughput

0.513

High

894848

OS9
Protein OS-9

1

0

High-throughput

0.513

High

894851

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.513

High

894852

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

894854

LAMA3
Laminin subunit alpha-3

1

0

High-throughput

0.513

High

894857

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

894886

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

894895

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.513

High

894898

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.513

High

894901

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.513

High

894914

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.513

High

894918

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.513

High

791439

HD
Huntingtin

1

0

High-throughput

0.493

High

894837

RAP2B
Ras-related protein Rap-2b

1

1

High-throughput

0.489

High

894846

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.489

High

894870

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

1

High-throughput

0.489

High

894877

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.489

High

894878

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.489

High

894913

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.489

High

894916

RAP2C
Ras-related protein Rap-2c

1

1

High-throughput

0.489

High

436231

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

545296

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

573645

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

893848

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

894838

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

894841

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

894845

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

894880

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

894890

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

894891

CALR3
Calreticulin-3

1

1

High-throughput

0.479

High

894899

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

894911

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

167881

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

227026

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

531777

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.458

High

890050

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

894850

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

894859

MKS3
Meckelin

1

0

High-throughput

0.458

High

894865

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

894887

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

894903

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

894893

MIA2
Melanoma inhibitory activity protein 2

1

1

High-throughput

0.445

High

120372

RHOD
Rho-related GTP-binding protein RhoD

1

7

High-throughput

0.437

High

377214

GCR
Glucocorticoid receptor

1

2

High-throughput

0.437

High

894843

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

894858

TECT1
Tectonic-1

1

2

High-throughput

0.437

High

894863

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

894875

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

894879

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.437

High

894884

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

894889

TECT2
Tectonic-2

1

2

High-throughput

0.437

High

894900

RHOF
Rho-related GTP-binding protein RhoF

1

7

High-throughput

0.437

High

894861

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

868404

ATX1
Ataxin-1

2

0

High-throughput

0.324

High

207037

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.279

Low

238482

CST8
Cystatin-8

1

0

High-throughput

0.279

Low

260227

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.279

Low

382590

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.279

Low

513556

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.279

Low

714804

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.279

Low

894839

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.279

Low

894840

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.279

Low

894849

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.279

Low

894853

LRC41
Leucine-rich repeat-containing protein 41

1

0

High-throughput

0.279

Low

894862

DNLZ
DNL-type zinc finger protein

1

0

High-throughput

0.279

Low

894864

CSPG4
Chondroitin sulfate proteoglycan 4

1

0

High-throughput

0.279

Low

894866

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

0

High-throughput

0.279

Low

894869

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.279

Low

894872

LRP11
Low-density lipoprotein receptor-related protein 11

1

0

High-throughput

0.279

Low

894873

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.279

Low

894876

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

894881

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.279

Low

894883

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.279

Low

894888

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

894892

SFXN2
Sideroflexin-2

1

0

High-throughput

0.279

Low

894894

NEUR1
Sialidase-1

1

0

High-throughput

0.279

Low

894897

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.279

Low

894904

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

894905

RAB6B
Ras-related protein Rab-6B

1

0

High-throughput

0.279

Low

894906

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

894912

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

894885

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.269

Low

205233

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

214169

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

346376

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

373974

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

506949

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.249

Low

552383

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

650830

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720115

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

832289

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

894847

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

894855

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

894856

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.249

Low

894867

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

894868

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

894871

LBN
Limbin

1

0

High-throughput

0.249

Low

894874

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

894882

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

894902

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

894907

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

894908

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

894910

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

894915

SF3B6
Splicing factor 3B subunit 6

1

0

High-throughput

0.249

Low

894917

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

496693

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

789227

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024