Protein: MRCKA
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)

Gene: MRCKA, CDC42BPA
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q5VT25

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

894116

CDC42
Cell division control protein 42 homolog

5

20

Small-scale

0.929

High

1137871

MRCKA
Serine/threonine-protein kinase MRCK alpha

2

18

Small-scale

0.841

High

904690

1433G
14-3-3 protein gamma

3

20

High-throughput

0.839

High

982116

1433F
14-3-3 protein eta

3

20

High-throughput

0.839

High

1137917

MRCKB
Serine/threonine-protein kinase MRCK beta

2

19

High-throughput

0.817

High

909658

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.789

High

927145

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.789

High

1137911

INKA2
PAK4-inhibitor INKA2

3

1

High-throughput

0.770

High

348715

RASN
GTPase NRas

2

20

High-throughput

0.754

High

350237

RASK
GTPase KRas

2

20

High-throughput

0.754

High

564564

RHOQ
Rho-related GTP-binding protein RhoQ

2

20

Small-scale

0.754

High

915741

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

198102

MTLR
Motilin receptor

1

1

High-throughput

0.691

High

626651

ARBK1
Beta-adrenergic receptor kinase 1

1

17

High-throughput

0.691

High

877483

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

20

High-throughput

0.691

High

931679

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.691

High

1137918

RBM8A
RNA-binding protein 8A

1

9

High-throughput

0.691

High

1137884

KCD17
BTB/POZ domain-containing protein KCTD17

3

5

High-throughput

0.667

High

580656

ML12A
Myosin regulatory light chain 12A

1

15

Small-scale

0.647

High

728622

PPM1A
Protein phosphatase 1A

1

4

Small-scale

0.647

High

435121

SP1
Transcription factor Sp1

1

6

High-throughput

0.646

High

120483

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

129013

PLK4
Serine/threonine-protein kinase PLK4

1

13

Small-scale

0.618

High

349389

RASH
GTPase HRas

1

20

High-throughput

0.618

High

374373

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

384981

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

411758

LCK
Tyrosine-protein kinase Lck

1

16

High-throughput

0.618

High

433818

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.618

High

545430

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

646981

1433T
14-3-3 protein theta

1

20

High-throughput

0.618

High

660856

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

4

High-throughput

0.618

High

683425

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.618

High

684102

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

841770

CDK9
Cyclin-dependent kinase 9

1

12

High-throughput

0.618

High

844984

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.618

High

852514

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

876412

AFAD
Afadin

1

20

High-throughput

0.618

High

892423

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

895123

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.618

High

900570

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

901179

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

914124

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.618

High

925344

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

940452

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.618

High

951069

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1070238

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.618

High

1076613

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1137875

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1137877

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1137889

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1137890

ARHG2
Rho guanine nucleotide exchange factor 2

1

15

High-throughput

0.618

High

1137901

DNJC7
DnaJ homolog subfamily C member 7

1

10

High-throughput

0.618

High

1137904

DNJC5
DnaJ homolog subfamily C member 5

1

8

High-throughput

0.618

High

1137905

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1137906

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1137908

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1137879

LUR1L
Leucine rich adaptor protein 1-like

3

8

High-throughput

0.609

High

912950

ARF6
ADP-ribosylation factor 6

2

7

High-throughput

0.584

High

1137886

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.578

High

519340

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

8

High-throughput

0.574

High

1137894

F167A
Protein FAM167A

2

2

High-throughput

0.574

High

369789

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

318159

DIRA3
GTP-binding protein Di-Ras3

1

9

High-throughput

0.553

High

442228

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.553

High

793347

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.553

High

1137874

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.553

High

1137895

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1137902

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.553

High

1137915

DNJ5B
DnaJ homolog subfamily C member 5B

1

11

High-throughput

0.553

High

600162

TAF1
Transcription initiation factor TFIID subunit 1

1

15

High-throughput

0.541

High

408831

K1C18
Keratin, type I cytoskeletal 18

1

3

High-throughput

0.536

High

422410

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.536

High

515874

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

806556

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.536

High

885258

EPIPL
Epiplakin

1

17

High-throughput

0.536

High

913571

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.536

High

1038450

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.536

High

1069374

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1137880

SKA3
Spindle and kinetochore-associated protein 3

1

1

High-throughput

0.536

High

1137896

LURA1
Leucine rich adaptor protein 1

1

8

High-throughput

0.536

High

1137898

KI20B
Kinesin-like protein KIF20B

1

15

High-throughput

0.536

High

1137913

GPC5B
G-protein coupled receptor family C group 5 member B

1

6

High-throughput

0.536

High

310958

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

962144

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

8

High-throughput

0.515

High

1137885

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.515

High

602850

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1137878

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1137891

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.501

High

179194

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.489

High

985673

CTSL2
CTD small phosphatase-like protein 2

1

5

High-throughput

0.489

High

178587

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

279590

FLOT1
Flotillin-1

1

5

High-throughput

0.479

High

347019

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

487504

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

507057

LAMP1
Lysosome-associated membrane glycoprotein 1

1

10

High-throughput

0.479

High

527515

LAMP2
Lysosome-associated membrane glycoprotein 2

1

10

High-throughput

0.479

High

547095

EZRI
Ezrin

1

10

High-throughput

0.479

High

567105

CXA1
Gap junction alpha-1 protein

1

7

High-throughput

0.479

High

648791

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

670066

MARCS
Myristoylated alanine-rich C-kinase substrate

1

9

High-throughput

0.479

High

818141

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.479

High

881516

ARL4C
ADP-ribosylation factor-like protein 4C

1

13

High-throughput

0.479

High

908682

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

1017665

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1084038

OCLN
Occludin

1

3

High-throughput

0.479

High

1137873

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1137888

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1137892

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.479

High

1137897

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

1137899

RUFY1
RUN and FYVE domain-containing protein 1

1

19

High-throughput

0.479

High

1137900

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.479

High

1137909

E41LA
Band 4.1-like protein 4A

1

10

High-throughput

0.479

High

1137912

ARL15
ADP-ribosylation factor-like protein 15

1

12

High-throughput

0.479

High

1137916

SEPT9
Septin-9

1

4

High-throughput

0.479

High

559754

H12
Histone H1.2

1

6

High-throughput

0.470

High

122820

MEN1
Menin

1

0

High-throughput

0.458

High

212867

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

615757

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

1137887

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

988940

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.457

High

1137910

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

302536

CE152
Centrosomal protein of 152 kDa

1

7

High-throughput

0.445

High

1137872

CP135
Centrosomal protein of 135 kDa

1

12

High-throughput

0.445

High

1137882

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.445

High

974864

CAV1
Caveolin-1

1

3

High-throughput

0.437

High

1137881

CXD3
Gap junction delta-3 protein

1

7

High-throughput

0.437

High

1137883

ARL14
ADP-ribosylation factor-like protein 14

1

9

High-throughput

0.437

High

1137893

VP33A
Vacuolar protein sorting-associated protein 33A

1

3

High-throughput

0.437

High

1137914

SEP10
Septin-10

1

2

High-throughput

0.437

High

1137907

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.279

Low

132498

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

305497

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

1137903

IN80B
INO80 complex subunit B

1

0

High-throughput

0.249

Low

1137876

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024