Protein: SENP1
Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)

Gene: SENP1
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q9P0U3

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

928213

SUMO1
Small ubiquitin-related modifier 1

9

20

Small-scale

0.978

High

801793

RAGP1
Ran GTPase-activating protein 1

7

3

Small-scale

0.966

High

902778

SUMO2
Small ubiquitin-related modifier 2

6

20

Small-scale

0.956

High

879158

SUMO3
Small ubiquitin-related modifier 3

3

20

Small-scale

0.868

High

1349826

SENP1
Sentrin-specific protease 1

1

3

Small-scale

0.724

High

360496

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

5

8

High-throughput

0.702

High

1244538

NUP43
Nucleoporin Nup43

4

10

High-throughput

0.676

High

669029

PML
Protein PML

2

7

Small-scale

0.629

High

341296

FA9
Coagulation factor IX

2

1

High-throughput

0.628

High

612121

PROZ
Vitamin K-dependent protein Z

2

2

High-throughput

0.628

High

992718

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

2

High-throughput

0.628

High

228938

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.618

High

398122

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.618

High

395956

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

1031291

SKP2
S-phase kinase-associated protein 2

2

0

High-throughput

0.602

High

1282091

ARL11
ADP-ribosylation factor-like protein 11

2

0

High-throughput

0.602

High

1349831

RUVB2
RuvB-like 2

2

2

Small-scale

0.584

High

1018726

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

Small-scale

0.573

High

1301525

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

5

Small-scale

0.561

High

1349835

MORC2
ATPase MORC2

1

1

Small-scale

0.561

High

1251655

ZN420
Zinc finger protein 420

1

0

Small-scale

0.537

High

1342308

GCM1
Chorion-specific transcription factor GCMa

1

0

Small-scale

0.537

High

197920

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

626270

APC
Adenomatous polyposis coli protein

1

1

High-throughput

0.536

High

834679

NU153
Nuclear pore complex protein Nup153

1

8

High-throughput

0.536

High

1060949

IMB1
Importin subunit beta-1

1

5

High-throughput

0.536

High

1203522

SKAP1
Src kinase-associated phosphoprotein 1

1

2

High-throughput

0.536

High

1231867

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.536

High

1246187

COP1
E3 ubiquitin-protein ligase COP1

1

9

High-throughput

0.536

High

1349836

COL10
Collectin-10

1

1

High-throughput

0.536

High

1176154

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

1

0

High-throughput

0.513

High

1236544

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.513

High

1347978

TRM1
tRNA

1

0

High-throughput

0.513

High

455953

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.501

High

507588

PIM1
Serine/threonine-protein kinase pim-1

1

1

Small-scale

0.501

High

617383

SP100
Nuclear autoantigen Sp-100

1

6

Small-scale

0.501

High

834857

RBP2
E3 SUMO-protein ligase RanBP2

1

4

Small-scale

0.501

High

923258

RL11
Large ribosomal subunit protein uL5

1

1

Small-scale

0.501

High

1206224

HIPK1
Homeodomain-interacting protein kinase 1

1

2

Small-scale

0.501

High

1300841

NACC1
Nucleus accumbens-associated protein 1

1

6

Small-scale

0.501

High

1329777

HIPK2
Homeodomain-interacting protein kinase 2

1

2

Small-scale

0.501

High

1349829

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

5

Small-scale

0.501

High

533090

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.489

High

1238124

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

1

High-throughput

0.489

High

1349827

DKK3
Dickkopf-related protein 3

1

1

High-throughput

0.489

High

1349828

FBLN5
Fibulin-5

1

5

High-throughput

0.489

High

1349834

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.481

High

881119

CAV3
Caveolin-3

1

0

Small-scale

0.480

High

896390

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

Small-scale

0.480

High

929372

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

Small-scale

0.480

High

1273935

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.480

High

164494

TRI66
Tripartite motif-containing protein 66

1

4

High-throughput

0.479

High

208796

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.479

High

271799

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.479

High

274021

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

320044

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.479

High

350630

RASK
GTPase KRas

1

2

High-throughput

0.479

High

387638

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

495630

THIO
Thioredoxin

1

2

Small-scale

0.479

High

545670

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

573954

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

575608

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

595452

LMNB1
Lamin-B1

1

8

High-throughput

0.479

High

652469

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

686086

ARRB2
Beta-arrestin-2

1

1

Small-scale

0.479

High

839196

EMD
Emerin

1

1

High-throughput

0.479

High

880836

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

884801

NU107
Nuclear pore complex protein Nup107

1

1

High-throughput

0.479

High

894530

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

900995

RHOA
Transforming protein RhoA

1

13

High-throughput

0.479

High

903566

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.479

High

925685

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

941530

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

951422

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1038763

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

1064219

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1066800

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1168719

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1188967

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1193197

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1270483

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.479

High

1288354

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

1296101

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.479

High

1300617

PHF12
PHD finger protein 12

1

3

High-throughput

0.479

High

1330869

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

1345811

RN146
E3 ubiquitin-protein ligase RNF146

1

2

Small-scale

0.479

High

1346193

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

1346959

NLE1
Notchless protein homolog 1

1

5

High-throughput

0.479

High

1349830

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

324656

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

554527

GATA1
Erythroid transcription factor

1

0

Small-scale

0.458

High

1200362

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1233472

NIN
Ninein

1

0

High-throughput

0.458

High

1239336

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

1251057

SNIP1
Smad nuclear-interacting protein 1

1

0

Small-scale

0.458

High

1286486

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1288101

OTUB2
Ubiquitin thioesterase OTUB2

1

0

Small-scale

0.458

High

1304829

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

1332708

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1349833

RBGP1
Rab GTPase-activating protein 1

1

1

Small-scale

0.457

High

883660

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

120685

RHOD
Rho-related GTP-binding protein RhoD

1

15

High-throughput

0.437

High

795319

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

852656

RND2
Rho-related GTP-binding protein RhoN

1

14

High-throughput

0.437

High

890478

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

892645

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

High-throughput

0.437

High

1283969

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1303610

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1310193

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.437

High

1313088

DERL1
Derlin-1

1

1

High-throughput

0.437

High

1330961

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.437

High

1333604

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.437

High

1335359

RHOF
Rho-related GTP-binding protein RhoF

1

14

High-throughput

0.437

High

1344455

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1056257

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

1149868

SCAR3
Scavenger receptor class A member 3

2

0

High-throughput

0.318

High

318434

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.279

Low

825103

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

1101783

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1153753

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.279

Low

1242758

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

0

High-throughput

0.279

Low

1349832

TDRKH
Tudor and KH domain-containing protein

1

0

High-throughput

0.279

Low

846535

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024