Protein: P63
Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)

Gene: P63, TP63
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q9H3D4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175926

P73
Tumor protein p73

7

14

Small-scale

0.960

High

387501

P53
Cellular tumor antigen p53

6

14

Small-scale

0.931

High

1329999

P63
Tumor protein 63

4

14

Small-scale

0.902

High

1294857

ITCH
E3 ubiquitin-protein ligase Itchy homolog

6

15

Small-scale

0.738

High

999088

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.705

High

1318045

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

5

Small-scale

0.691

High

1296375

ASPP1
Apoptosis-stimulating of p53 protein 1

1

16

Small-scale

0.681

High

962970

MDM2
E3 ubiquitin-protein ligase Mdm2

4

10

Small-scale

0.680

High

808926

YAP1
Transcriptional coactivator YAP1

3

20

Small-scale

0.658

High

1038056

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

3

3

Small-scale

0.653

High

1306013

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

2

9

Small-scale

0.649

High

1043752

ASPP2
Apoptosis-stimulating of p53 protein 2

1

17

Small-scale

0.647

High

1260093

IASPP
RelA-associated inhibitor

1

14

Small-scale

0.647

High

1330008

DAXX
Death domain-associated protein 6

2

4

Small-scale

0.633

High

331338

CHK2
Serine/threonine-protein kinase Chk2

2

6

High-throughput

0.628

High

952873

FOXK1
Forkhead box protein K1

2

13

High-throughput

0.628

High

964255

FOXK2
Forkhead box protein K2

2

12

High-throughput

0.628

High

1285188

SH3K1
SH3 domain-containing kinase-binding protein 1

2

1

High-throughput

0.628

High

929657

RACK1
Small ribosomal subunit protein RACK1

2

6

Small-scale

0.627

High

930389

UBC9
SUMO-conjugating enzyme UBC9

2

8

Small-scale

0.625

High

1327910

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

15

Small-scale

0.624

High

587708

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

11

Small-scale

0.618

High

883387

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

1

High-throughput

0.606

High

1291022

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

2

3

High-throughput

0.606

High

1271496

KAT2B
Histone acetyltransferase KAT2B

2

15

Small-scale

0.602

High

262093

PEX14
Peroxisomal membrane protein PEX14

2

0

High-throughput

0.602

High

1329772

HIPK2
Homeodomain-interacting protein kinase 2

2

15

Small-scale

0.594

High

1330016

FBW1A
F-box/WD repeat-containing protein 1A

1

6

Small-scale

0.589

High

758336

CDN1A
Cyclin-dependent kinase inhibitor 1

2

4

Small-scale

0.584

High

818462

SOX2
Transcription factor SOX-2

2

10

Small-scale

0.584

High

1078660

SMAD2
Mothers against decapentaplegic homolog 2

2

4

Small-scale

0.584

High

1290756

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1017437

CDC20
Cell division cycle protein 20 homolog

1

7

Small-scale

0.578

High

1330014

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.578

High

1039493

TDG
G/T mismatch-specific thymine DNA glycosylase

1

2

Small-scale

0.573

High

579227

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

6

Small-scale

0.561

High

668976

PML
Protein PML

1

17

Small-scale

0.561

High

790877

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

13

Small-scale

0.561

High

1299472

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

3

Small-scale

0.561

High

236068

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

Small-scale

0.554

High

727035

FUS
RNA-binding protein FUS

1

10

Small-scale

0.554

High

904132

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

9

Small-scale

0.554

High

1330000

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

3

High-throughput

0.553

High

1330009

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.549

High

803744

BAG6
Large proline-rich protein BAG6

1

13

High-throughput

0.541

High

980975

EMX1
Homeobox protein EMX1

1

3

High-throughput

0.541

High

202281

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

6

Small-scale

0.536

High

241365

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

3

Small-scale

0.536

High

401102

RLA0
Large ribosomal subunit protein uL10

1

1

Small-scale

0.536

High

438522

HS90B
Heat shock protein HSP 90-beta

1

4

Small-scale

0.536

High

445532

RSSA
Small ribosomal subunit protein uS2

1

1

Small-scale

0.536

High

446790

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

Small-scale

0.536

High

502551

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.536

High

531632

K2C5
Keratin, type II cytoskeletal 5

1

7

Small-scale

0.536

High

533341

PLST
Plastin-3

1

3

Small-scale

0.536

High

541146

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

7

Small-scale

0.536

High

559490

H13
Histone H1.3

1

2

Small-scale

0.536

High

653373

PYR1
Multifunctional protein CAD

1

2

Small-scale

0.536

High

671340

RL12
Large ribosomal subunit protein uL11

1

1

Small-scale

0.536

High

760309

RL3
Large ribosomal subunit protein uL3

1

1

Small-scale

0.536

High

843046

TCPQ
T-complex protein 1 subunit theta

1

6

Small-scale

0.536

High

852168

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

10

Small-scale

0.536

High

875309

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.536

High

932865

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.536

High

944704

MAP1A
Microtubule-associated protein 1A

1

6

Small-scale

0.536

High

949559

RL24
Large ribosomal subunit protein eL24

1

1

Small-scale

0.536

High

969616

CENPE
Centromere-associated protein E

1

2

Small-scale

0.536

High

994334

DHX9
ATP-dependent RNA helicase A

1

7

Small-scale

0.536

High

1027790

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

Small-scale

0.536

High

1034623

GOGA4
Golgin subfamily A member 4

1

8

Small-scale

0.536

High

1052936

FLNC
Filamin-C

1

5

Small-scale

0.536

High

1069790

NONO
Non-POU domain-containing octamer-binding protein

1

7

Small-scale

0.536

High

1073560

SAFB1
Scaffold attachment factor B1

1

6

Small-scale

0.536

High

1084618

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

Small-scale

0.536

High

1204093

CARM1
Histone-arginine methyltransferase CARM1

1

6

Small-scale

0.536

High

1237208

ZN676
Zinc finger protein 676

1

3

Small-scale

0.536

High

1309492

TBA1C
Tubulin alpha-1C chain

1

7

Small-scale

0.536

High

1330001

RENT2
Regulator of nonsense transcripts 2

1

1

Small-scale

0.536

High

1330007

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

9

Small-scale

0.536

High

1330015

SATB2
DNA-binding protein SATB2

1

2

Small-scale

0.534

High

1285579

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.518

High

557410

BGAL
Beta-galactosidase

1

0

High-throughput

0.513

High

773562

RL13A
Large ribosomal subunit protein uL13

1

0

Small-scale

0.513

High

1329003

S1PR5
Sphingosine 1-phosphate receptor 5

1

0

Small-scale

0.513

High

1330006

SACS
Sacsin

1

0

Small-scale

0.513

High

304655

SCAF4
SR-related and CTD-associated factor 4

1

8

Small-scale

0.508

High

169308

MDM4
Protein Mdm4

1

10

Small-scale

0.501

High

586981

CSK22
Casein kinase II subunit alpha'

1

9

Small-scale

0.501

High

808269

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

15

High-throughput

0.501

High

931858

CSK2B
Casein kinase II subunit beta

1

2

Small-scale

0.501

High

934472

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.501

High

1054199

BECN1
Beclin-1

1

1

Small-scale

0.500

High

344566

A2MG
Alpha-2-macroglobulin

1

1

Small-scale

0.489

High

637056

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.489

High

821689

K2C6C
Keratin, type II cytoskeletal 6C

1

7

Small-scale

0.489

High

867127

SC24C
Protein transport protein Sec24C

1

4

Small-scale

0.489

High

364805

HEMO
Hemopexin

1

1

High-throughput

0.481

High

624510

CCNC
Cyclin-C

1

9

High-throughput

0.481

High

1184977

CSN6
COP9 signalosome complex subunit 6

1

3

High-throughput

0.481

High

131083

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

157832

IRF6
Interferon regulatory factor 6

1

4

Small-scale

0.479

High

158543

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

9

Small-scale

0.479

High

167616

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

10

Small-scale

0.479

High

258190

DNJB6
DnaJ homolog subfamily B member 6

1

6

High-throughput

0.479

High

305197

UBE4B
Ubiquitin conjugation factor E4 B

1

7

Small-scale

0.479

High

398093

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

509123

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.479

High

551273

ITF2
Transcription factor 4

1

1

Small-scale

0.479

High

570065

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.479

High

617775

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.479

High

624367

MYL9
Myosin regulatory light polypeptide 9

1

5

High-throughput

0.479

High

632400

TNR6
Tumor necrosis factor receptor superfamily member 6

1

5

Small-scale

0.479

High

684322

1433S
14-3-3 protein sigma

1

7

Small-scale

0.479

High

714407

HSP74
Heat shock 70 kDa protein 4

1

11

Small-scale

0.479

High

749852

BRCA1
Breast cancer type 1 susceptibility protein

1

12

Small-scale

0.479

High

777076

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

Small-scale

0.479

High

794568

ETV4
ETS translocation variant 4

1

5

Small-scale

0.479

High

874689

BI1
Bax inhibitor 1

1

1

Small-scale

0.479

High

928196

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.479

High

941957

PITX1
Pituitary homeobox 1

1

4

Small-scale

0.479

High

944129

JAG1
Protein jagged-1

1

4

Small-scale

0.479

High

978893

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

984532

KPCD
Protein kinase C delta type

1

4

Small-scale

0.479

High

1022982

CDC16
Cell division cycle protein 16 homolog

1

4

Small-scale

0.479

High

1048224

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

9

Small-scale

0.479

High

1079152

STK11
Serine/threonine-protein kinase STK11

1

2

Small-scale

0.479

High

1085673

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

Small-scale

0.479

High

1101599

MTHSD
Methenyltetrahydrofolate synthase domain-containing protein

1

3

High-throughput

0.479

High

1139211

DAB2P
Disabled homolog 2-interacting protein

1

4

High-throughput

0.479

High

1173402

STXB4
Syntaxin-binding protein 4

1

3

Small-scale

0.479

High

1188128

TPC11
Trafficking protein particle complex subunit 11

1

3

High-throughput

0.479

High

1190000

R144B
E3 ubiquitin-protein ligase RNF144B

1

6

Small-scale

0.479

High

1190349

TRM11
tRNA

1

3

High-throughput

0.479

High

1200237

N4BP2
NEDD4-binding protein 2

1

1

High-throughput

0.479

High

1224794

ASPM
Abnormal spindle-like microcephaly-associated protein

1

10

High-throughput

0.479

High

1255159

CABL1
CDK5 and ABL1 enzyme substrate 1

1

3

Small-scale

0.479

High

1266882

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

Small-scale

0.479

High

1270437

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.479

High

1272981

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

6

High-throughput

0.479

High

1281386

FBXW7
F-box/WD repeat-containing protein 7

1

6

Small-scale

0.479

High

1283221

MYL11
Myosin regulatory light chain 11

1

5

Small-scale

0.479

High

1294946

PIWL1
Piwi-like protein 1

1

10

High-throughput

0.479

High

1301515

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

8

Small-scale

0.479

High

1302556

CRBN
Protein cereblon

1

2

Small-scale

0.479

High

1313163

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

High-throughput

0.479

High

1318077

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

3

High-throughput

0.479

High

1327650

BRD8
Bromodomain-containing protein 8

1

20

High-throughput

0.479

High

1327682

RNF38
E3 ubiquitin-protein ligase RNF38

1

7

High-throughput

0.479

High

1328967

CDT1
DNA replication factor Cdt1

1

2

High-throughput

0.479

High

1330002

JPH1
Junctophilin-1

1

2

High-throughput

0.479

High

1330003

KCTD5
BTB/POZ domain-containing protein KCTD5

1

2

Small-scale

0.479

High

1330004

WWOX
WW domain-containing oxidoreductase

1

5

Small-scale

0.479

High

1330005

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

7

High-throughput

0.479

High

1330010

ANC2
Anaphase-promoting complex subunit 2

1

7

Small-scale

0.479

High

1330011

AGO2
Protein argonaute-2

1

10

High-throughput

0.479

High

1330012

AGO1
Protein argonaute-1

1

10

High-throughput

0.479

High

1330019

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

717343

CTNB1
Catenin beta-1

1

3

Small-scale

0.457

High

1021729

GNDS
Ral guanine nucleotide dissociation stimulator

1

2

Small-scale

0.457

High

121018

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

580691

ML12A
Myosin regulatory light chain 12A

1

5

Small-scale

0.445

High

826062

FAS
Fatty acid synthase

1

4

Small-scale

0.445

High

1300669

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

6

High-throughput

0.445

High

341238

HPT
Haptoglobin

1

2

High-throughput

0.439

High

330135

DRC4
Dynein regulatory complex subunit 4

1

2

High-throughput

0.437

High

515155

ADHX
Alcohol dehydrogenase class-3

1

3

High-throughput

0.437

High

1021888

NPRL3
GATOR1 complex protein NPRL3

1

3

High-throughput

0.437

High

1137446

CBPC2
Cytosolic carboxypeptidase 2

1

4

High-throughput

0.437

High

1330013

COHA1
Collagen alpha-1(XVII) chain

1

1

Small-scale

0.437

High

1330020

CEP83
Centrosomal protein of 83 kDa

1

9

High-throughput

0.437

High

271636

ERAL1
GTPase Era, mitochondrial

1

3

Small-scale

0.417

High

901899

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

Small-scale

0.417

High

1330018

RP3A
Rabphilin-3A

2

0

High-throughput

0.328

High

363460

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.251

Low

814306

GLR
Glucagon receptor

1

0

High-throughput

0.251

Low

1056183

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

0

High-throughput

0.251

Low

1330017

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024