Protein: DAPLE
Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)

Gene: DAPLE, CCDC88C
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q9P219

Gene Ontology (top 5):
GO:0001932 - regulation of protein phosphorylation
GO:0001965 - G-protein alpha-subunit binding
GO:0003383 - apical constriction
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005109 - frizzled binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444802

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

8

Small-scale

0.664

High

1218467

WDFY1
WD repeat and FYVE domain-containing protein 1

2

10

High-throughput

0.628

High

709090

MCM7
DNA replication licensing factor MCM7

3

18

High-throughput

0.609

High

277218

AL1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

2

2

High-throughput

0.574

High

592545

RAB5A
Ras-related protein Rab-5A

2

7

High-throughput

0.571

High

254200

FZD7
Frizzled-7

1

2

Small-scale

0.561

High

280085

MPDZ
Multiple PDZ domain protein

1

20

Small-scale

0.561

High

265437

KTNA1
Katanin p60 ATPase-containing subunit A1

1

7

High-throughput

0.536

High

851713

NEK4
Serine/threonine-protein kinase Nek4

1

17

High-throughput

0.536

High

1328676

RNAS7
Ribonuclease 7

1

1

High-throughput

0.536

High

916036

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.533

High

800838

MK08
Mitogen-activated protein kinase 8

1

15

High-throughput

0.508

High

150759

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.501

High

233085

FZD6
Frizzled-6

1

2

Small-scale

0.501

High

395962

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

1229578

SYCE1
Synaptonemal complex central element protein 1

1

3

High-throughput

0.489

High

1316994

LOXE3
Hydroperoxide isomerase ALOXE3

1

2

High-throughput

0.489

High

1349277

ITSN2
Intersectin-2

1

15

High-throughput

0.481

High

1350004

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

324657

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

325919

LATS1
Serine/threonine-protein kinase LATS1

1

20

High-throughput

0.479

High

331895

NSD2
Histone-lysine N-methyltransferase NSD2

1

14

Small-scale

0.479

High

434048

LYN
Tyrosine-protein kinase Lyn

1

10

High-throughput

0.479

High

610084

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

13

High-throughput

0.479

High

647340

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

683774

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

684368

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

716792

CTNA1
Catenin alpha-1

1

4

High-throughput

0.479

High

717387

CTNB1
Catenin beta-1

1

13

High-throughput

0.479

High

876522

AFAD
Afadin

1

20

High-throughput

0.479

High

900999

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

905200

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

910111

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.479

High

915524

ACTA
Actin, aortic smooth muscle

1

17

High-throughput

0.479

High

927605

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

982568

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1036960

SQSTM
Sequestosome-1

1

9

Small-scale

0.479

High

1051492

DCTN1
Dynactin subunit 1

1

20

High-throughput

0.479

High

1051699

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

10

High-throughput

0.479

High

1145962

CP135
Centrosomal protein of 135 kDa

1

18

High-throughput

0.479

High

1256910

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1290898

TRI11
E3 ubiquitin-protein ligase TRIM11

1

6

Small-scale

0.479

High

1291723

BICD1
Protein bicaudal D homolog 1

1

19

High-throughput

0.479

High

1306715

TCPH
T-complex protein 1 subunit eta

1

11

High-throughput

0.479

High

1307026

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1336100

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

10

High-throughput

0.479

High

1344953

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.479

High

1350002

ZRAN1
Ubiquitin thioesterase ZRANB1

1

17

High-throughput

0.479

High

1350003

NINL
Ninein-like protein

1

20

High-throughput

0.479

High

1284260

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

121034

APBB1
Amyloid beta precursor protein binding family B member 1

1

4

High-throughput

0.445

High

241653

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.437

High

470595

H2A1
Histone H2A type 1

1

20

High-throughput

0.437

High

643922

SYVC
Valine--tRNA ligase

1

4

High-throughput

0.437

High

909256

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.437

High

1022227

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.437

High

1151391

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.437

High

1274461

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.437

High

1300969

CIC
Protein capicua homolog

1

14

High-throughput

0.437

High

384010

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

9

High-throughput

0.407

High

609584

FGFR3
Fibroblast growth factor receptor 3

1

16

High-throughput

0.407

High

1310711

SIKE1
Suppressor of IKBKE 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024