Protein: RN168
E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)

Gene: RN168, RNF168
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q8IYW5

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003682 - chromatin binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476036

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

8

4

Small-scale

0.968

High

896490

UBE2N
Ubiquitin-conjugating enzyme E2 N

7

7

Small-scale

0.962

High

895843

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

7

Small-scale

0.916

High

849367

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

7

Small-scale

0.845

High

919783

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

7

Small-scale

0.845

High

475096

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

4

Small-scale

0.768

High

391788

H2A1B
Histone H2A type 1-B/E

8

12

Small-scale

0.747

High

1087045

H2A2C
Histone H2A type 2-C

5

12

Small-scale

0.720

High

891414

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

4

High-throughput

0.698

High

1036725

SQSTM
Sequestosome-1

3

4

Small-scale

0.667

High

470084

H2AZ
Histone H2A.Z

3

14

Small-scale

0.655

High

555539

H2AX
Histone H2AX

3

13

Small-scale

0.651

High

851840

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

7

Small-scale

0.647

High

932548

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

7

High-throughput

0.647

High

1223724

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

7

Small-scale

0.647

High

1223728

KMT5A
N-lysine methyltransferase KMT5A

2

1

Small-scale

0.634

High

994246

DHX9
ATP-dependent RNA helicase A

2

3

Small-scale

0.624

High

1223734

RNF11
RING finger protein 11

2

1

High-throughput

0.620

High

559820

H12
Histone H1.2

2

5

Small-scale

0.608

High

1223726

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

3

High-throughput

0.606

High

1223714

RN168
E3 ubiquitin-protein ligase RNF168

2

5

Small-scale

0.602

High

232310

KDM1A
Lysine-specific histone demethylase 1A

2

0

Small-scale

0.598

High

707684

H2B1B
Histone H2B type 1-B

2

14

Small-scale

0.595

High

1087252

H2B2E
Histone H2B type 2-E

2

14

Small-scale

0.595

High

1151353

H2A2A
Histone H2A type 2-A

2

12

Small-scale

0.595

High

1019020

TP53B
TP53-binding protein 1

2

7

Small-scale

0.584

High

526423

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

2

0

High-throughput

0.580

High

509053

TOP2A
DNA topoisomerase 2-alpha

1

1

Small-scale

0.561

High

599688

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

Small-scale

0.561

High

902662

SUMO2
Small ubiquitin-related modifier 2

1

4

Small-scale

0.561

High

1223722

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.561

High

1223725

RN126
E3 ubiquitin-protein ligase RNF126

1

1

Small-scale

0.561

High

579356

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

Small-scale

0.537

High

1205473

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.537

High

1223719

DGCR8
Microprocessor complex subunit DGCR8

1

0

Small-scale

0.537

High

304242

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

Small-scale

0.536

High

1056594

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

2

Small-scale

0.536

High

1170066

SRCAP
Helicase SRCAP

1

3

High-throughput

0.536

High

1223727

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

2

High-throughput

0.536

High

1223735

NUB1
NEDD8 ultimate buster 1

1

1

High-throughput

0.536

High

1223736

TACC3
Transforming acidic coiled-coil-containing protein 3

1

3

High-throughput

0.536

High

1051358

DCTN1
Dynactin subunit 1

1

3

High-throughput

0.515

High

121813

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.513

High

589892

TBP
TATA-box-binding protein

1

0

High-throughput

0.513

High

1161782

CC174
Coiled-coil domain-containing protein 174

1

0

High-throughput

0.513

High

1076342

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

Small-scale

0.505

High

260933

H2AY
Core histone macro-H2A.1

1

13

Small-scale

0.501

High

455640

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.501

High

470451

H2A1
Histone H2A type 1

1

12

Small-scale

0.501

High

1185204

H2A3
Histone H2A type 3

1

12

Small-scale

0.501

High

742387

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

1039503

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

High-throughput

0.486

High

1139396

ECM29
Proteasome adapter and scaffold protein ECM29

1

3

Small-scale

0.481

High

256976

KDM4A
Lysine-specific demethylase 4A

1

0

Small-scale

0.480

High

426689

H10
Histone H1.0

1

0

Small-scale

0.480

High

195485

DHX15
ATP-dependent RNA helicase DHX15

1

3

Small-scale

0.479

High

229436

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

1

Small-scale

0.479

High

244653

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

319913

HERC2
E3 ubiquitin-protein ligase HERC2

1

2

Small-scale

0.479

High

436396

RHOC
Rho-related GTP-binding protein RhoC

1

4

Small-scale

0.479

High

575496

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

582383

NUCL
Nucleolin

1

4

Small-scale

0.479

High

749666

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

801241

KI67
Proliferation marker protein Ki-67

1

8

Small-scale

0.479

High

852987

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

Small-scale

0.479

High

879135

SUMO3
Small ubiquitin-related modifier 3

1

4

Small-scale

0.479

High

917574

H4
Histone H4

1

3

High-throughput

0.479

High

928133

SUMO1
Small ubiquitin-related modifier 1

1

4

Small-scale

0.479

High

934968

H31
Histone H3.1

1

8

High-throughput

0.479

High

941141

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

990883

ZO1
Tight junction protein ZO-1

1

2

Small-scale

0.479

High

1031387

PABP4
Polyadenylate-binding protein 4

1

4

Small-scale

0.479

High

1057972

RRP5
Protein RRP5 homolog

1

1

Small-scale

0.479

High

1058242

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

1063943

TNIP1
TNFAIP3-interacting protein 1

1

4

High-throughput

0.479

High

1223717

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

1223721

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

1223729

DDX21
Nucleolar RNA helicase 2

1

1

Small-scale

0.479

High

1223731

RAI14
Ankycorbin

1

3

Small-scale

0.479

High

1223732

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1223733

LIMA1
LIM domain and actin-binding protein 1

1

4

Small-scale

0.479

High

531900

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.470

High

1223723

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.460

High

201814

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

0

Small-scale

0.458

High

330262

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.458

High

534125

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.458

High

786387

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

847846

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

870849

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

Small-scale

0.458

High

993330

FOXM1
Forkhead box protein M1

1

0

Small-scale

0.458

High

1068800

PCM1
Pericentriolar material 1 protein

1

0

Small-scale

0.458

High

1193123

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1223715

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

1223720

H1X
Histone H1.10

1

0

Small-scale

0.458

High

1223716

RN169
E3 ubiquitin-protein ligase RNF169

1

1

Small-scale

0.445

High

1084997

DREB
Drebrin

1

5

Small-scale

0.437

High

1223718

DEN10
DENN domain-containing protein 10

1

0

High-throughput

0.279

Low

281744

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1223730

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.249

Low

1079756

EREP1
Endosomal transmembrane epsin interactor 1

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024