Protein: MGMT
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)

Gene: MGMT
Organism: Homo sapiens
Interactions: 86
UniProt ID: P16455

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003908 - methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006266 - DNA ligation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560369

KPCA
Protein kinase C alpha type

2

1

Small-scale

0.602

High

517037

PCNA
Proliferating cell nuclear antigen

2

0

Small-scale

0.598

High

560378

CDK2
Cyclin-dependent kinase 2

2

1

Small-scale

0.584

High

368932

ESR1
Estrogen receptor

1

1

Small-scale

0.573

High

560383

CDN1A
Cyclin-dependent kinase inhibitor 1

2

0

Small-scale

0.559

High

560389

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.515

High

560370

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

Small-scale

0.501

High

560373

CSK22
Casein kinase II subunit alpha'

1

2

Small-scale

0.501

High

560397

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

226445

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

282269

CDKL5
Cyclin-dependent kinase-like 5

1

2

Small-scale

0.479

High

376151

ANXA1
Annexin A1

1

1

Small-scale

0.479

High

414718

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.479

High

427431

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

431506

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.479

High

432540

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

Small-scale

0.479

High

437866

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.479

High

518080

ADT1
ADP/ATP translocase 1

1

1

Small-scale

0.479

High

518239

ADT3
ADP/ATP translocase 3

1

1

Small-scale

0.479

High

560372

NUCL
Nucleolin

1

1

Small-scale

0.479

High

560377

KPCL
Protein kinase C eta type

1

1

Small-scale

0.479

High

560379

MCM3
DNA replication licensing factor MCM3

1

1

Small-scale

0.479

High

560387

MCM2
DNA replication licensing factor MCM2

1

1

Small-scale

0.479

High

560390

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

560395

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

560399

H33
Histone H3.3

1

2

High-throughput

0.479

High

560403

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

560408

CDK10
Cyclin-dependent kinase 10

1

2

Small-scale

0.479

High

560409

H31T
Histone H3.1t

1

2

Small-scale

0.479

High

560411

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

560412

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

560414

TBA1C
Tubulin alpha-1C chain

1

1

Small-scale

0.479

High

560417

DDX24
ATP-dependent RNA helicase DDX24

1

1

Small-scale

0.479

High

560419

PABP3
Polyadenylate-binding protein 3

1

1

Small-scale

0.479

High

560421

CDK12
Cyclin-dependent kinase 12

1

2

Small-scale

0.479

High

560416

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.460

High

122145

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.458

High

176546

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

176938

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

0

Small-scale

0.458

High

196952

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

0

Small-scale

0.458

High

282517

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

Small-scale

0.458

High

301358

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

Small-scale

0.458

High

470254

H2A1
Histone H2A type 1

1

0

Small-scale

0.458

High

471548

H2BFM
Histone H2B type F-M

1

0

Small-scale

0.458

High

474913

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

508321

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

523501

XRCC6
X-ray repair cross-complementing protein 6

1

0

Small-scale

0.458

High

537790

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

538466

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

560371

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

560374

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.458

High

560375

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

Small-scale

0.458

High

560380

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.458

High

560381

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

0

Small-scale

0.458

High

560382

PHB1
Prohibitin 1

1

0

Small-scale

0.458

High

560384

MSH2
DNA mismatch repair protein Msh2

1

0

Small-scale

0.458

High

560386

TTPA
Alpha-tocopherol transfer protein

1

0

Small-scale

0.458

High

560388

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

560391

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.458

High

560392

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

560393

H4
Histone H4

1

0

Small-scale

0.458

High

560394

1433Z
14-3-3 protein zeta/delta

1

0

Small-scale

0.458

High

560396

TBB4B
Tubulin beta-4B chain

1

0

Small-scale

0.458

High

560398

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

560400

SET
Protein SET

1

0

Small-scale

0.458

High

560402

SSRP1
FACT complex subunit SSRP1

1

0

Small-scale

0.458

High

560404

MYO7A
Unconventional myosin-VIIa

1

0

Small-scale

0.458

High

560405

ORC1
Origin recognition complex subunit 1

1

0

Small-scale

0.458

High

560406

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

Small-scale

0.458

High

560407

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

560413

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

560415

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

0

Small-scale

0.458

High

560422

DTL
Denticleless protein homolog

1

0

Small-scale

0.458

High

560423

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

560425

PSME2
Proteasome activator complex subunit 2

1

0

Small-scale

0.458

High

560401

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.437

High

560410

FBX27
F-box only protein 27

1

1

Small-scale

0.437

High

560424

FBX2
F-box only protein 2

1

1

Small-scale

0.437

High

158072

WNT9B
Protein Wnt-9b

1

0

Small-scale

0.249

Low

400225

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.249

Low

443310

VIME
Vimentin

1

0

Small-scale

0.249

Low

560376

EF1B
Elongation factor 1-beta

1

0

Small-scale

0.249

Low

560385

SRP09
Signal recognition particle 9 kDa protein

1

0

Small-scale

0.249

Low

560418

IL25
Interleukin-25

1

0

Small-scale

0.249

Low

560420

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

330840

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024