Protein: SMAD6
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)

Gene: SMAD6
Organism: Homo sapiens
Interactions: 55
UniProt ID: O43541

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0001657 - ureteric bud development
GO:0003148 - outflow tract septum morphogenesis
GO:0003180 - aortic valve morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

206964

SMAD1
Mothers against decapentaplegic homolog 1

4

19

Small-scale

0.900

High

167312

SMAD7
Mothers against decapentaplegic homolog 7

2

19

Small-scale

0.800

High

206956

SMAD4
Mothers against decapentaplegic homolog 4

2

19

Small-scale

0.754

High

206977

SMUF1
E3 ubiquitin-protein ligase SMURF1

6

20

Small-scale

0.719

High

206932

SMAD6
Mothers against decapentaplegic homolog 6

1

19

Small-scale

0.653

High

206976

SMUF2
E3 ubiquitin-protein ligase SMURF2

3

20

Small-scale

0.650

High

206975

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

3

20

Small-scale

0.640

High

206963

SMAD2
Mothers against decapentaplegic homolog 2

1

19

Small-scale

0.618

High

206972

SMAD5
Mothers against decapentaplegic homolog 5

1

20

Small-scale

0.618

High

201132

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

8

Small-scale

0.612

High

206948

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

13

Small-scale

0.586

High

122278

BMR1B
Bone morphogenetic protein receptor type-1B

2

20

Small-scale

0.584

High

206941

TGFR1
TGF-beta receptor type-1

2

20

Small-scale

0.584

High

206953

ACVR1
Activin receptor type-1

2

20

Small-scale

0.584

High

206955

CTBP1
C-terminal-binding protein 1

2

2

Small-scale

0.584

High

206970

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.584

High

206934

STABP
STAM-binding protein

1

3

Small-scale

0.573

High

206938

HXC8
Homeobox protein Hox-C8

1

12

Small-scale

0.573

High

206968

PIAS4
E3 SUMO-protein ligase PIAS4

1

16

Small-scale

0.552

High

206957

CUL2
Cullin-2

1

7

High-throughput

0.536

High

206969

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

2

Small-scale

0.529

High

206962

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

4

Small-scale

0.515

High

206974

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

Small-scale

0.515

High

206933

KS6A5
Ribosomal protein S6 kinase alpha-5

1

10

High-throughput

0.508

High

206965

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.508

High

125023

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.479

High

206937

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

Small-scale

0.479

High

206939

BMR1A
Bone morphogenetic protein receptor type-1A

1

20

Small-scale

0.479

High

206940

ACV1B
Activin receptor type-1B

1

20

Small-scale

0.479

High

206942

ZEB1
Zinc finger E-box-binding homeobox 1

1

20

Small-scale

0.479

High

206943

ACTY
Beta-centractin

1

2

Small-scale

0.479

High

206944

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

Small-scale

0.479

High

206945

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.479

High

206946

NASP
Nuclear autoantigenic sperm protein

1

1

Small-scale

0.479

High

206947

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

16

Small-scale

0.479

High

206949

IMA1
Importin subunit alpha-1

1

1

Small-scale

0.479

High

206950

CTBP2
C-terminal-binding protein 2

1

2

Small-scale

0.479

High

206954

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

1

Small-scale

0.479

High

206958

AVR2B
Activin receptor type-2B

1

20

Small-scale

0.479

High

206959

BMPR2
Bone morphogenetic protein receptor type-2

1

20

Small-scale

0.479

High

206960

RUNX2
Runt-related transcription factor 2

1

16

Small-scale

0.479

High

206961

T22D1
TSC22 domain family protein 1

1

10

Small-scale

0.479

High

206966

RN111
E3 ubiquitin-protein ligase Arkadia

1

9

Small-scale

0.479

High

206967

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

10

Small-scale

0.479

High

206971

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

Small-scale

0.479

High

206973

MYD88
Myeloid differentiation primary response protein MyD88

1

4

Small-scale

0.479

High

206979

STRAP
Serine-threonine kinase receptor-associated protein

1

8

Small-scale

0.479

High

206980

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

13

Small-scale

0.479

High

206981

PIAS3
E3 SUMO-protein ligase PIAS3

1

16

Small-scale

0.479

High

206952

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

Small-scale

0.457

High

206936

ACM5
Muscarinic acetylcholine receptor M5

1

0

High-throughput

0.282

High

206935

PIGR
Polymeric immunoglobulin receptor

1

0

Small-scale

0.249

Low

206951

LYSC
Lysozyme C

1

0

Small-scale

0.249

Low

206978

BPIA1
BPI fold-containing family A member 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024