Protein: SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)

Gene: SHPS1, SIRPA
Organism: Homo sapiens
Interactions: 87
UniProt ID: P78324

Gene Ontology (top 5):
GO:0001933 - negative regulation of protein phosphorylation
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion
GO:0009986 - cell surface
GO:0010468 - regulation of gene expression

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

941686

CD47
Leukocyte surface antigen CD47

3

3

Small-scale

0.870

High

941708

SIRPG
Signal-regulatory protein gamma

3

17

High-throughput

0.855

High

350059

RASK
GTPase KRas

3

20

High-throughput

0.827

High

122308

SIRB1
Signal-regulatory protein beta-1

2

17

High-throughput

0.789

High

246302

NOL3
Nucleolar protein 3

2

0

High-throughput

0.751

High

435609

IGF1R
Insulin-like growth factor 1 receptor

1

9

Small-scale

0.724

High

681784

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.724

High

941690

ILK
Integrin-linked protein kinase

1

1

Small-scale

0.724

High

941684

PTN11
Tyrosine-protein phosphatase non-receptor type 11

5

8

Small-scale

0.721

High

788961

MATK
Megakaryocyte-associated tyrosine-protein kinase

3

5

Small-scale

0.693

High

941709

CLC4A
C-type lectin domain family 4 member A

1

5

High-throughput

0.691

High

640431

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

Small-scale

0.687

High

941706

NOX4
NADPH oxidase 4

1

0

Small-scale

0.687

High

517994

CO6A2

1

6

Small-scale

0.647

High

521524

ACTN1
Alpha-actinin-1

1

4

Small-scale

0.647

High

941681

CDK16
Cyclin-dependent kinase 16

1

4

Small-scale

0.647

High

941687

NEXN
Nexilin

1

18

Small-scale

0.647

High

348609

RASN
GTPase NRas

1

20

High-throughput

0.618

High

349238

RASH
GTPase HRas

1

19

High-throughput

0.618

High

521859

CADH1
Cadherin-1

1

3

High-throughput

0.618

High

793267

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.618

High

915597

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

941688

ANK3
Ankyrin-3

1

3

High-throughput

0.618

High

941705

TRIM2
Tripartite motif-containing protein 2

3

7

High-throughput

0.599

High

665857

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

8

Small-scale

0.594

High

536783

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.589

High

941694

K1H1
Keratin, type I cuticular Ha1

2

11

High-throughput

0.584

High

941689

DDX10
Probable ATP-dependent RNA helicase DDX10

1

2

Small-scale

0.579

High

941703

NEK1
Serine/threonine-protein kinase Nek1

1

7

Small-scale

0.579

High

438068

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.561

High

443457

VIME
Vimentin

1

5

Small-scale

0.561

High

501965

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.561

High

538193

ENPL
Endoplasmin

1

1

Small-scale

0.561

High

577011

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

4

Small-scale

0.561

High

653551

CALR
Calreticulin

1

5

Small-scale

0.561

High

751573

GRP75
Stress-70 protein, mitochondrial

1

9

Small-scale

0.561

High

770789

TCPZ
T-complex protein 1 subunit zeta

1

1

Small-scale

0.561

High

786306

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.561

High

813374

CAPZB
F-actin-capping protein subunit beta

1

1

Small-scale

0.561

High

941685

SOS1
Son of sevenless homolog 1

1

3

Small-scale

0.561

High

941699

KTN1
Kinectin

1

4

Small-scale

0.561

High

941697

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

365184

FRIH
Ferritin heavy chain

1

0

Small-scale

0.537

High

532499

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.537

High

924463

GRB2
Growth factor receptor-bound protein 2

1

8

High-throughput

0.536

High

941704

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.536

High

941695

CCD57
Coiled-coil domain-containing protein 57

2

3

High-throughput

0.533

High

430131

PROF1
Profilin-1

1

1

Small-scale

0.501

High

503877

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.501

High

531345

K1C10
Keratin, type I cytoskeletal 10

1

8

Small-scale

0.501

High

574646

ARF4
ADP-ribosylation factor 4

1

6

Small-scale

0.501

High

598058

FLNA
Filamin-A

1

8

Small-scale

0.501

High

714180

HSP74
Heat shock 70 kDa protein 4

1

3

Small-scale

0.501

High

729065

K22E
Keratin, type II cytoskeletal 2 epidermal

1

5

Small-scale

0.501

High

887801

CD81
CD81 antigen

1

11

Small-scale

0.501

High

893648

PSA6
Proteasome subunit alpha type-6

1

1

Small-scale

0.501

High

941691

SAFB2
Scaffold attachment factor B2

1

6

Small-scale

0.501

High

941701

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

1

Small-scale

0.501

High

155836

SH21B
SH2 domain-containing protein 1B

1

13

High-throughput

0.489

High

580011

K1C15
Keratin, type I cytoskeletal 15

1

8

High-throughput

0.481

High

734591

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

High-throughput

0.481

High

273417

PPM1B
Protein phosphatase 1B

1

0

Small-scale

0.480

High

594241

MX1
Interferon-induced GTP-binding protein Mx1

1

0

Small-scale

0.480

High

906987

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.480

High

907270

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.480

High

941682

NUCB1
Nucleobindin-1

1

0

Small-scale

0.480

High

941702

FUBP1
Far upstream element-binding protein 1

1

0

Small-scale

0.480

High

238396

JAK2
Tyrosine-protein kinase JAK2

1

10

Small-scale

0.479

High

666065

SHC1
SHC-transforming protein 1

1

9

Small-scale

0.479

High

941683

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

High-throughput

0.458

High

242697

IF2P
Eukaryotic translation initiation factor 5B

1

1

Small-scale

0.457

High

719334

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

8

Small-scale

0.457

High

941692

ELOA1
Elongin-A

1

3

Small-scale

0.457

High

941693

ARHG6
Rho guanine nucleotide exchange factor 6

1

2

Small-scale

0.457

High

280561

KRT34
Keratin, type I cuticular Ha4

1

9

High-throughput

0.439

High

941696

K1C40
Keratin, type I cytoskeletal 40

1

9

High-throughput

0.439

High

940770

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

791477

HD
Huntingtin

1

4

High-throughput

0.407

High

941698

SPT6H
Transcription elongation factor SPT6

1

0

Small-scale

0.292

High

941707

F1142
Protein FAM114A2

1

0

High-throughput

0.279

Low

156666

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

Small-scale

0.261

Low

168126

TBX3
T-box transcription factor TBX3

1

0

Small-scale

0.261

Low

371084

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

Small-scale

0.261

Low

738611

GNL1
Guanine nucleotide-binding protein-like 1

1

0

Small-scale

0.261

Low

941700

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

Small-scale

0.261

Low

252985

HSF2B
Heat shock factor 2-binding protein

1

0

High-throughput

0.251

Low

928582

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024