Protein: TFAP4
Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)

Gene: TFAP4
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q01664

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

966306

FBW1B
F-box/WD repeat-containing protein 11

7

1

Small-scale

0.745

High

966276

AJUBA
LIM domain-containing protein ajuba

2

0

High-throughput

0.742

High

966309

FBW1A
F-box/WD repeat-containing protein 1A

5

1

Small-scale

0.721

High

966233

TRAF1
TNF receptor-associated factor 1

3

1

High-throughput

0.675

High

964166

FOXK2
Forkhead box protein K2

3

3

High-throughput

0.675

High

966312

CABIN
Calcineurin-binding protein cabin-1

3

1

Small-scale

0.667

High

966274

EXOS8
Exosome complex component RRP43

3

0

High-throughput

0.646

High

952795

FOXK1
Forkhead box protein K1

2

2

High-throughput

0.628

High

966258

UBN2
Ubinuclein-2

2

2

High-throughput

0.628

High

966284

TRAF4
TNF receptor-associated factor 4

2

1

High-throughput

0.606

High

579138

ATF1
Cyclic AMP-dependent transcription factor ATF-1

2

0

High-throughput

0.602

High

685912

ARRB2
Beta-arrestin-2

2

0

High-throughput

0.602

High

867856

HIRA
Protein HIRA

2

0

High-throughput

0.602

High

966248

CTC1
CST complex subunit CTC1

2

0

High-throughput

0.602

High

966268

TRIB2
Tribbles homolog 2

2

0

High-throughput

0.602

High

966290

STN1
CST complex subunit STN1

2

0

High-throughput

0.602

High

181514

CLOCK
Circadian locomoter output cycles protein kaput

1

0

Small-scale

0.586

High

966246

USF2
Upstream stimulatory factor 2

1

0

Small-scale

0.586

High

928877

SKP1
S-phase kinase-associated protein 1

2

0

Small-scale

0.585

High

966227

SUH
Recombining binding protein suppressor of hairless

2

0

High-throughput

0.585

High

443166

NFIC
Nuclear factor 1 C-type

2

2

Small-scale

0.584

High

817933

SOX2
Transcription factor SOX-2

2

2

Small-scale

0.584

High

966229

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

966253

SMBT2
Scm-like with four MBT domains protein 2

2

0

High-throughput

0.580

High

966267

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

966275

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

244302

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

966279

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

0

Small-scale

0.559

High

126453

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.536

High

157030

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

877698

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.536

High

966234

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

966281

SIN3A
Paired amphipathic helix protein Sin3a

1

2

High-throughput

0.536

High

966305

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.536

High

566358

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.513

High

957823

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

177263

HDAC3
Histone deacetylase 3

1

2

Small-scale

0.500

High

568451

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.493

High

966271

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

661231

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

966242

KCTD2
BTB/POZ domain-containing protein KCTD2

1

1

High-throughput

0.489

High

966262

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.489

High

169706

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

1

Small-scale

0.479

High

175772

HMGB3
High mobility group protein B3

1

4

Small-scale

0.479

High

197694

CRX
Cone-rod homeobox protein

1

1

High-throughput

0.479

High

225728

SOX15
Transcription factor SOX-15

1

1

High-throughput

0.479

High

257767

SIN3B
Paired amphipathic helix protein Sin3b

1

2

Small-scale

0.479

High

312055

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

396720

S10A8
Protein S100-A8

1

1

Small-scale

0.479

High

435049

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

449679

HMGB1
High mobility group protein B1

1

4

Small-scale

0.479

High

490059

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

3

Small-scale

0.479

High

490097

COT1
COUP transcription factor 1

1

3

Small-scale

0.479

High

510015

ERR1
Steroid hormone receptor ERR1

1

3

Small-scale

0.479

High

569609

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

622782

COT2
COUP transcription factor 2

1

3

Small-scale

0.479

High

643329

HMGB2
High mobility group protein B2

1

4

Small-scale

0.479

High

679094

TLX1
T-cell leukemia homeobox protein 1

1

1

High-throughput

0.479

High

749387

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

831235

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

966226

SP3
Transcription factor Sp3

1

2

Small-scale

0.479

High

966230

TFCP2
Alpha-globin transcription factor CP2

1

2

Small-scale

0.479

High

966232

NFIA
Nuclear factor 1 A-type

1

3

Small-scale

0.479

High

966237

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.479

High

966243

NFIX
Nuclear factor 1 X-type

1

2

High-throughput

0.479

High

966250

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

Small-scale

0.479

High

966255

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

966257

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

1

Small-scale

0.479

High

966264

SMRC2
SWI/SNF complex subunit SMARCC2

1

1

Small-scale

0.479

High

966269

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.479

High

966270

HDAC2
Histone deacetylase 2

1

2

Small-scale

0.479

High

966273

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

1

Small-scale

0.479

High

966278

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

Small-scale

0.479

High

966280

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

966283

MTA3
Metastasis-associated protein MTA3

1

2

Small-scale

0.479

High

966285

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.479

High

966286

SP130
Histone deacetylase complex subunit SAP130

1

2

Small-scale

0.479

High

966291

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

1

Small-scale

0.479

High

966299

TF2L1
Transcription factor CP2-like protein 1

1

2

Small-scale

0.479

High

966300

UBIP1
Upstream-binding protein 1

1

2

Small-scale

0.479

High

966307

YETS2
YEATS domain-containing protein 2

1

2

Small-scale

0.479

High

966308

TTF2
Transcription termination factor 2

1

1

Small-scale

0.479

High

283301

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

1

0

High-throughput

0.460

High

122673

MEN1
Menin

1

0

High-throughput

0.458

High

146199

ARI1A
AT-rich interactive domain-containing protein 1A

1

0

Small-scale

0.458

High

163596

BTAF1
TATA-binding protein-associated factor 172

1

0

Small-scale

0.458

High

321757

WIZ
Protein Wiz

1

0

Small-scale

0.458

High

386551

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

517204

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

641375

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.458

High

652820

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.458

High

658483

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

750226

COIL
Coilin

1

0

High-throughput

0.458

High

830925

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.458

High

874264

GEM
GTP-binding protein GEM

1

0

Small-scale

0.458

High

878120

PKNX1
Homeobox protein PKNOX1

1

0

Small-scale

0.458

High

880339

DPOE2
DNA polymerase epsilon subunit 2

1

0

Small-scale

0.458

High

917131

H4
Histone H4

1

0

High-throughput

0.458

High

919045

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

942139

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

966231

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

966235

CTBP1
C-terminal-binding protein 1

1

0

Small-scale

0.458

High

966236

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

Small-scale

0.458

High

966238

CUL1
Cullin-1

1

0

Small-scale

0.458

High

966239

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.458

High

966241

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

Small-scale

0.458

High

966244

ELOB
Elongin-B

1

0

High-throughput

0.458

High

966245

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.458

High

966247

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

966254

ARID2
AT-rich interactive domain-containing protein 2

1

0

Small-scale

0.458

High

966256

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

966260

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

Small-scale

0.458

High

966263

IN80E
INO80 complex subunit E

1

0

Small-scale

0.458

High

966265

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

966272

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

966277

ZN462
Zinc finger protein 462

1

0

Small-scale

0.458

High

966282

VRK1
Serine/threonine-protein kinase VRK1

1

0

Small-scale

0.458

High

966287

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

Small-scale

0.458

High

966288

ZHX3
Zinc fingers and homeoboxes protein 3

1

0

Small-scale

0.458

High

966289

ZN335
Zinc finger protein 335

1

0

Small-scale

0.458

High

966293

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

Small-scale

0.458

High

966294

BRD7
Bromodomain-containing protein 7

1

0

Small-scale

0.458

High

966296

CHRC1
Chromatin accessibility complex protein 1

1

0

Small-scale

0.458

High

966297

HPF1
Histone PARylation factor 1

1

0

Small-scale

0.458

High

966298

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.458

High

966301

THYN1
Thymocyte nuclear protein 1

1

0

Small-scale

0.458

High

966303

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.458

High

966304

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.458

High

966311

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.458

High

966295

PRDM5
PR domain zinc finger protein 5

1

0

High-throughput

0.438

High

966228

GOGA2
Golgin subfamily A member 2

3

0

High-throughput

0.352

High

966310

NEUR2
Sialidase-2

3

0

High-throughput

0.347

High

215845

ANGL7
Angiopoietin-related protein 7

2

0

High-throughput

0.328

High

257259

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

0

High-throughput

0.328

High

966251

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

2

0

High-throughput

0.328

High

640235

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

0

High-throughput

0.316

High

966249

VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

2

0

High-throughput

0.316

High

966266

S2543
Solute carrier family 25 member 43

1

0

High-throughput

0.279

Low

966292

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

High-throughput

0.279

Low

966302

ARP3B
Actin-related protein 3B

1

0

High-throughput

0.279

Low

966240

CKAP5
Cytoskeleton-associated protein 5

1

0

Small-scale

0.249

Low

966252

MTCL3
Microtubule cross-linking factor 3

1

0

Small-scale

0.249

Low

966259

NAV3
Neuron navigator 3

1

0

Small-scale

0.249

Low

966261

NGEF
Ephexin-1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024