Protein: NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)

Gene: NGLY1
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q96IV0

Gene Ontology (top 5):
GO:0000224 - peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

872298

RD23B
UV excision repair protein RAD23 homolog B

8

8

Small-scale

0.753

High

875224

TERA
Transitional endoplasmic reticulum ATPase

6

1

Small-scale

0.739

High

872198

RD23A
UV excision repair protein RAD23 homolog A

5

7

Small-scale

0.716

High

1062083

UBX2B
UBX domain-containing protein 2B

4

1

High-throughput

0.698

High

1294675

UBQL1
Ubiquilin-1

4

4

High-throughput

0.698

High

147628

TRAD1
TRAF-type zinc finger domain-containing protein 1

4

0

High-throughput

0.668

High

1294667

TRI54
Tripartite motif-containing protein 54

4

0

High-throughput

0.668

High

236369

B4GT4
Beta-1,4-galactosyltransferase 4

3

0

High-throughput

0.638

High

641522

PAX6
Paired box protein Pax-6

2

1

High-throughput

0.606

High

1294676

FAF1
FAS-associated factor 1

2

1

Small-scale

0.595

High

1102211

VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

2

0

High-throughput

0.580

High

1294663

HTF4
Transcription factor 12

2

0

High-throughput

0.580

High

1294664

NPAS2
Neuronal PAS domain-containing protein 2

2

0

High-throughput

0.580

High

1294674

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

2

1

High-throughput

0.574

High

338837

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.559

High

971674

PAX5
Paired box protein Pax-5

2

1

High-throughput

0.553

High

1294661

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.546

High

942872

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.545

High

621812

PRTN3
Myeloblastin

1

3

High-throughput

0.536

High

265789

CRLF1
Cytokine receptor-like factor 1

1

0

High-throughput

0.513

High

526676

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.513

High

849845

SPHM
N-sulphoglucosamine sulphohydrolase

1

0

High-throughput

0.513

High

1078983

NPTX1
Neuronal pentraxin-1

1

0

High-throughput

0.513

High

476204

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

1294677

NSF1C
NSFL1 cofactor p47

1

1

Small-scale

0.501

High

509878

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

1

High-throughput

0.489

High

685281

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

1

High-throughput

0.489

High

1203261

AMGO1
Amphoterin-induced protein 1

1

1

High-throughput

0.489

High

1263134

OIT3
Oncoprotein-induced transcript 3 protein

1

1

High-throughput

0.489

High

1294668

RTN4R
Reticulon-4 receptor

1

1

High-throughput

0.489

High

395487

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1204812

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

1294673

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

122939

MEN1
Menin

1

0

High-throughput

0.458

High

532352

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.458

High

868297

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

1135115

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1294670

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1294671

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

989057

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

177968

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

1198131

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1294672

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

575822

VINC
Vinculin

1

0

High-throughput

0.426

High

1294662

GUCD1
Protein GUCD1

4

0

High-throughput

0.364

High

1205542

TMM25
Transmembrane protein 25

3

0

High-throughput

0.347

High

1291074

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

2

0

High-throughput

0.328

High

1149591

BICRL
BRD4-interacting chromatin-remodeling complex-associated protein-like

2

0

High-throughput

0.316

High

1294665

DERL1
Derlin-1

1

0

Small-scale

0.306

High

1087971

PTPRO
Receptor-type tyrosine-protein phosphatase O

2

0

High-throughput

0.305

High

217668

EFNA2
Ephrin-A2

1

0

High-throughput

0.279

Low

323519

CER1
Cerberus

1

0

High-throughput

0.279

Low

421289

LIPF
Gastric triacylglycerol lipase

1

0

High-throughput

0.279

Low

516116

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

560531

TSHR
Thyrotropin receptor

1

0

High-throughput

0.279

Low

1059128

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.279

Low

1116846

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

1291414

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

1294666

BOC
Brother of CDO

1

0

High-throughput

0.279

Low

1294669

CST9L
Cystatin-9-like

1

0

High-throughput

0.279

Low

1294678

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

205835

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

1192647

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024