Protein: EHMT1
Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)

Gene: EHMT1
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9H9B1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001222 - transcription corepressor binding
GO:0002039 - p53 binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1296421

EHMT2
Histone-lysine N-methyltransferase EHMT2

7

16

Small-scale

0.963

High

935251

H31
Histone H3.1

6

20

Small-scale

0.931

High

1304468

MPP8
M-phase phosphoprotein 8

3

15

Small-scale

0.870

High

203794

SUV91
Histone-lysine N-methyltransferase SUV39H1

3

14

Small-scale

0.861

High

1331975

SUV92
Histone-lysine N-methyltransferase SUV39H2

3

14

High-throughput

0.861

High

952633

H33
Histone H3.3

3

20

Small-scale

0.847

High

470164

H2AZ
Histone H2A.Z

2

10

High-throughput

0.811

High

1282965

H2B1A
Histone H2B type 1-A

2

9

High-throughput

0.789

High

387535

P53
Cellular tumor antigen p53

2

5

Small-scale

0.778

High

978897

TF65
Transcription factor p65

1

4

Small-scale

0.770

High

1065725

SETB1
Histone-lysine N-methyltransferase SETDB1

2

14

Small-scale

0.767

High

917944

H4
Histone H4

2

3

High-throughput

0.754

High

1032620

CTBP1
C-terminal-binding protein 1

5

4

Small-scale

0.712

High

1038721

HDAC1
Histone deacetylase 1

4

15

High-throughput

0.704

High

1318673

TRI15
E3 ubiquitin-protein ligase TRIM15

1

5

High-throughput

0.698

High

470560

H2A1
Histone H2A type 1

1

7

High-throughput

0.691

High

586990

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

934484

CSK21
Casein kinase II subunit alpha

1

6

High-throughput

0.691

High

1087410

H2B2E
Histone H2B type 2-E

1

9

High-throughput

0.691

High

949889

CBX1
Chromobox protein homolog 1

3

20

High-throughput

0.675

High

1295381

ZN462
Zinc finger protein 462

3

4

High-throughput

0.675

High

1027268

CBX3
Chromobox protein homolog 3

3

20

High-throughput

0.667

High

1200814

ZBT46
Zinc finger and BTB domain-containing protein 46

3

7

High-throughput

0.667

High

1231970

MIER2
Mesoderm induction early response protein 2

3

14

High-throughput

0.667

High

1086320

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

1334130

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

16

Small-scale

0.647

High

800530

CBX5
Chromobox protein homolog 5

2

20

Small-scale

0.628

High

1270450

HDAC2
Histone deacetylase 2

2

16

High-throughput

0.628

High

1334145

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

5

High-throughput

0.628

High

214374

SPOP
Speckle-type POZ protein

2

2

Small-scale

0.620

High

268290

EED
Polycomb protein EED

1

12

High-throughput

0.618

High

781230

ETV3
ETS translocation variant 3

1

10

High-throughput

0.618

High

785408

ELK3
ETS domain-containing protein Elk-3

1

11

High-throughput

0.618

High

822681

LHX1
LIM/homeobox protein Lhx1

1

12

High-throughput

0.618

High

826359

CDK8
Cyclin-dependent kinase 8

1

7

High-throughput

0.618

High

828381

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

839827

LHX2
LIM/homeobox protein Lhx2

1

14

High-throughput

0.618

High

918699

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.618

High

1024598

CAF1B
Chromatin assembly factor 1 subunit B

1

5

High-throughput

0.618

High

1077603

ELF2
ETS-related transcription factor Elf-2

1

9

High-throughput

0.618

High

1080355

EZH2
Histone-lysine N-methyltransferase EZH2

1

17

High-throughput

0.618

High

1244501

NUP43
Nucleoporin Nup43

1

14

High-throughput

0.618

High

1281184

LHX4
LIM/homeobox protein Lhx4

1

12

High-throughput

0.618

High

1304702

FEV
Protein FEV

1

8

High-throughput

0.618

High

1334137

LHX3
LIM/homeobox protein Lhx3

1

12

High-throughput

0.618

High

1334140

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

1

Small-scale

0.618

High

1334143

ELF5
ETS-related transcription factor Elf-5

1

9

High-throughput

0.618

High

1334146

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.618

High

321838

WIZ
Protein Wiz

2

10

High-throughput

0.611

High

1331886

ZN644
Zinc finger protein 644

2

11

High-throughput

0.611

High

841326

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.586

High

1259394

XAGE3
X antigen family member 3

2

10

High-throughput

0.574

High

1292803

XAGE2
X antigen family member 2

2

10

High-throughput

0.574

High

370465

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

830795

ARL4D
ADP-ribosylation factor-like protein 4D

1

8

High-throughput

0.553

High

868748

ATX1
Ataxin-1

1

2

High-throughput

0.541

High

900075

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.541

High

158621

RGS12
Regulator of G-protein signaling 12

1

5

High-throughput

0.536

High

781451

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.536

High

1029326

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.536

High

1061253

NUMA1
Nuclear mitotic apparatus protein 1

1

10

High-throughput

0.536

High

1236506

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.536

High

1334131

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

1

High-throughput

0.536

High

1334134

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

13

High-throughput

0.536

High

267193

GEMI
Geminin

1

0

High-throughput

0.513

High

1257334

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

579489

DNLI1
DNA ligase 1

1

5

Small-scale

0.501

High

902757

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

1334149

DNM3A
DNA

1

8

Small-scale

0.501

High

1306495

NKX31
Homeobox protein Nkx-3.1

1

20

Small-scale

0.500

High

1235458

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

8

High-throughput

0.494

High

834544

TIG1
Retinoic acid receptor responder protein 1

1

1

High-throughput

0.489

High

1118290

GAG2E
G antigen 2E

1

7

High-throughput

0.489

High

1334139

GGE2D
G antigen 2D

1

7

High-throughput

0.489

High

123012

MEN1
Menin

1

2

High-throughput

0.479

High

135163

NFIB
Nuclear factor 1 B-type

1

5

High-throughput

0.479

High

179824

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

197829

CRX
Cone-rod homeobox protein

1

12

High-throughput

0.479

High

211969

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

213385

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

225789

SOX15
Transcription factor SOX-15

1

8

High-throughput

0.479

High

244954

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

316998

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

347918

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.479

High

377694

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

443252

NFIC
Nuclear factor 1 C-type

1

8

High-throughput

0.479

High

455884

PARP1
Poly [ADP-ribose] polymerase 1

1

14

High-throughput

0.479

High

486832

MYB
Transcriptional activator Myb

1

4

High-throughput

0.479

High

546045

MYOD1
Myoblast determination protein 1

1

8

High-throughput

0.479

High

570074

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

620425

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

631594

BRD2
Bromodomain-containing protein 2

1

11

High-throughput

0.479

High

632914

TYY1
Transcriptional repressor protein YY1

1

8

High-throughput

0.479

High

641281

DNMT1
DNA

1

16

Small-scale

0.479

High

641566

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.479

High

652995

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

658562

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

679173

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

718205

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

750477

COIL
Coilin

1

1

High-throughput

0.479

High

782659

HNF4A
Hepatocyte nuclear factor 4-alpha

1

16

High-throughput

0.479

High

818475

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

831699

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.479

High

881299

CTBP2
C-terminal-binding protein 2

1

4

Small-scale

0.479

High

884246

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

931871

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

962978

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

966291

TFAP4
Transcription factor AP-4

1

1

Small-scale

0.479

High

971757

IRF8
Interferon regulatory factor 8

1

5

High-throughput

0.479

High

971820

HEN1
Helix-loop-helix protein 1

1

4

High-throughput

0.479

High

1018269

NFIA
Nuclear factor 1 A-type

1

6

High-throughput

0.479

High

1024523

CAF1A
Chromatin assembly factor 1 subunit A

1

9

High-throughput

0.479

High

1029886

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.479

High

1036091

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1042562

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1059880

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

7

High-throughput

0.479

High

1060369

NFIX
Nuclear factor 1 X-type

1

8

High-throughput

0.479

High

1067147

BRD3
Bromodomain-containing protein 3

1

9

High-throughput

0.479

High

1125688

SGO1
Shugoshin 1

1

1

High-throughput

0.479

High

1158402

PMF1
Polyamine-modulated factor 1

1

1

High-throughput

0.479

High

1188881

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

1189302

POGZ
Pogo transposable element with ZNF domain

1

6

High-throughput

0.479

High

1222582

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.479

High

1235654

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.479

High

1254927

SP7
Transcription factor Sp7

1

18

High-throughput

0.479

High

1264191

DNJC9
DnaJ homolog subfamily C member 9

1

5

High-throughput

0.479

High

1271541

JARD2
Protein Jumonji

1

2

Small-scale

0.479

High

1273884

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

Small-scale

0.479

High

1294760

NSL1
Kinetochore-associated protein NSL1 homolog

1

1

High-throughput

0.479

High

1295406

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

13

High-throughput

0.479

High

1300945

CIC
Protein capicua homolog

1

18

High-throughput

0.479

High

1315359

KLF16
Krueppel-like factor 16

1

18

High-throughput

0.479

High

1326415

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1327287

MIS12
Protein MIS12 homolog

1

1

High-throughput

0.479

High

1330479

DSN1
Kinetochore-associated protein DSN1 homolog

1

1

High-throughput

0.479

High

1331242

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

5

High-throughput

0.479

High

1334132

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

1

5

Small-scale

0.479

High

1334135

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1334136

VSX1
Visual system homeobox 1

1

20

High-throughput

0.479

High

1334138

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

1334142

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1334147

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

1334148

CDY2
Testis-specific chromodomain protein Y 2

1

7

High-throughput

0.479

High

1334144

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

791991

HD
Huntingtin

1

2

High-throughput

0.457

High

1303758

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.445

High

1334141

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

3

Small-scale

0.445

High

323157

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.437

High

365351

PRPC
Salivary acidic proline-rich phosphoprotein 1/2

1

7

High-throughput

0.437

High

1326154

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

12

High-throughput

0.437

High

1190570

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1334133

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.279

Low

486209

IL8
Interleukin-8

1

0

Small-scale

0.249

Low

1261418

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024