Protein: EXOS3
Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)

Gene: EXOS3, EXOSC3
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q9NQT5

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1304450

MPH6
M-phase phosphoprotein 6

7

0

Small-scale

0.917

High

1342613

EXOS4
Exosome complex component RRP41

10

11

Small-scale

0.758

High

1343581

EXOS5
Exosome complex component RRP46

10

13

Small-scale

0.758

High

1046347

EXOS2
Exosome complex component RRP4

10

5

Small-scale

0.755

High

1257155

DI3L1
DIS3-like exonuclease 1

8

4

Small-scale

0.754

High

1343616

EXOS1
Exosome complex component CSL4

9

7

Small-scale

0.754

High

966490

EXOSX
Exosome complex component 10

8

1

Small-scale

0.750

High

1284981

EXOS8
Exosome complex component RRP43

7

11

Small-scale

0.749

High

986728

EXOS9
Exosome complex component RRP45

6

12

Small-scale

0.738

High

1063772

EXOS7
Exosome complex component RRP42

6

11

Small-scale

0.735

High

1130059

EXOS6
Exosome complex component MTR3

6

13

Small-scale

0.735

High

787020

MTREX
Exosome RNA helicase MTR4

4

3

High-throughput

0.699

High

1343617

HBS1L
HBS1-like protein

5

0

Small-scale

0.689

High

1343618

RBM7
RNA-binding protein 7

5

0

High-throughput

0.688

High

1157908

ZCHC8
Zinc finger CCHC domain-containing protein 8

4

0

High-throughput

0.670

High

1343615

RRP44
Exosome complex exonuclease RRP44

3

4

Small-scale

0.657

High

788069

AF9
Protein AF-9

3

0

High-throughput

0.638

High

1047041

C1D
Nuclear nucleic acid-binding protein C1D

3

0

High-throughput

0.638

High

1343619

CERT
Ceramide transfer protein

3

0

High-throughput

0.638

High

1281094

TSR2
Pre-rRNA-processing protein TSR2 homolog

2

0

High-throughput

0.580

High

347979

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

370505

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1031717

GRB10
Growth factor receptor-bound protein 10

2

0

High-throughput

0.547

High

1343605

EXOS3
Exosome complex component RRP40

2

0

Small-scale

0.547

High

1203146

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

Small-scale

0.537

High

781834

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

929677

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.536

High

1067248

WDR43
WD repeat-containing protein 43

1

3

High-throughput

0.536

High

1076115

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1218382

WDR75
WD repeat-containing protein 75

1

3

High-throughput

0.536

High

1326851

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.536

High

1343614

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1343620

OAS3
2'-5'-oligoadenylate synthase 3

1

1

High-throughput

0.536

High

237323

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.513

High

418700

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

532620

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

850983

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

857017

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.513

High

864018

CLH2
Clathrin heavy chain 2

1

0

High-throughput

0.513

High

1167991

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.513

High

1343610

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1343611

TSKS
Testis-specific serine kinase substrate

1

0

High-throughput

0.513

High

1343613

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

1302628

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.486

High

395853

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1271671

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

Small-scale

0.479

High

295291

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

1085973

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1270946

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

1287392

OPTN
Optineurin

1

1

High-throughput

0.479

High

1326335

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

1343607

DCA13
DDB1- and CUL4-associated factor 13

1

1

Small-scale

0.479

High

123026

MEN1
Menin

1

0

High-throughput

0.458

High

125734

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

149329

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

298816

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

323183

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

339020

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

553805

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

652338

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

721531

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

841895

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

855952

ZN131
Zinc finger protein 131

1

0

High-throughput

0.458

High

877910

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

909178

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

917988

H4
Histone H4

1

0

High-throughput

0.458

High

918713

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1029911

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1064751

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1066749

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1080378

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1132456

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

0

High-throughput

0.458

High

1140793

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1187801

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

Small-scale

0.458

High

1201698

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1236521

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1256417

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1267177

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1281410

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1294035

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1331373

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1343606

ANLN
Anillin

1

0

High-throughput

0.458

High

1343608

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1343609

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1343612

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

402513

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

891331

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.426

High

1057668

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1334541

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

571219

EGLN
Endoglin

1

0

High-throughput

0.279

Low

671125

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.251

Low

1053664

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1129182

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024