Protein: RECQ5
ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)

Gene: RECQ5, RECQL5
Organism: Homo sapiens
Interactions: 108
UniProt ID: O94762

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000724 - double-strand break repair via homologous recombination
GO:0000993 - RNA polymerase II complex binding
GO:0003677 - DNA binding
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

295494

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

4

Small-scale

0.886

High

295499

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

3

Small-scale

0.886

High

295496

RPB1
DNA-directed RNA polymerase II subunit RPB1

8

9

Small-scale

0.753

High

295516

RPB7
DNA-directed RNA polymerase II subunit RPB7

6

2

Small-scale

0.736

High

295495

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

1

Small-scale

0.699

High

295564

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

4

8

High-throughput

0.699

High

295539

DDX42
ATP-dependent RNA helicase DDX42

1

17

High-throughput

0.698

High

295476

RECQ5
ATP-dependent DNA helicase Q5

1

18

Small-scale

0.692

High

295567

ASB6
Ankyrin repeat and SOCS box protein 6

1

5

High-throughput

0.691

High

181370

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

0

Small-scale

0.674

High

285144

DXO
Decapping and exoribonuclease protein

3

1

High-throughput

0.667

High

295525

RAD51
DNA repair protein RAD51 homolog 1

3

14

Small-scale

0.660

High

125059

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

13

Small-scale

0.656

High

295502

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

3

Small-scale

0.656

High

295490

PCNA
Proliferating cell nuclear antigen

2

5

Small-scale

0.639

High

295497

RBTN2
Rhombotin-2

2

4

High-throughput

0.628

High

294215

RECQ4
ATP-dependent DNA helicase Q4

1

17

Small-scale

0.618

High

295482

TOP3B
DNA topoisomerase 3-beta-1

1

10

Small-scale

0.618

High

295517

H4
Histone H4

1

9

High-throughput

0.618

High

295529

TOP3A
DNA topoisomerase 3-alpha

1

10

Small-scale

0.618

High

295553

DDX23
Probable ATP-dependent RNA helicase DDX23

1

17

High-throughput

0.618

High

295519

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

1

High-throughput

0.611

High

295515

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.602

High

295488

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

0

High-throughput

0.585

High

295512

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

246518

MCE1
mRNA-capping enzyme

2

3

High-throughput

0.584

High

295503

BRCA1
Breast cancer type 1 susceptibility protein

2

16

High-throughput

0.584

High

295521

H31
Histone H3.1

2

17

High-throughput

0.584

High

295485

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

295552

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

High-throughput

0.571

High

246142

NBN
Nibrin

1

4

Small-scale

0.561

High

295509

MRE11
Double-strand break repair protein MRE11

1

3

Small-scale

0.561

High

295546

RAD50
DNA repair protein RAD50

1

10

Small-scale

0.561

High

200919

MTSS1
Protein MTSS 1

1

8

High-throughput

0.541

High

295492

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.541

High

295498

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

295504

CUX1
Homeobox protein cut-like 1

1

10

High-throughput

0.541

High

295513

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.541

High

295571

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

3

High-throughput

0.541

High

295550

MUS81
Crossover junction endonuclease MUS81

1

0

Small-scale

0.537

High

295491

FOSL2
Fos-related antigen 2

1

3

High-throughput

0.536

High

295522

SRPK2
SRSF protein kinase 2

1

15

High-throughput

0.536

High

295547

CUL5
Cullin-5

1

20

High-throughput

0.536

High

295551

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

8

High-throughput

0.536

High

295557

PAR6B
Partitioning defective 6 homolog beta

1

1

High-throughput

0.536

High

295559

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

13

High-throughput

0.536

High

295528

CENPR
Centromere protein R

1

0

High-throughput

0.518

High

295558

PITH1
PITH domain-containing protein 1

1

0

High-throughput

0.513

High

295483

TIMP1
Metalloproteinase inhibitor 1

1

1

High-throughput

0.494

High

295569

FBLN5
Fibulin-5

1

3

High-throughput

0.489

High

123811

SPT5H
Transcription elongation factor SPT5

1

12

High-throughput

0.479

High

133265

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

295477

UBR5
E3 ubiquitin-protein ligase UBR5

1

14

Small-scale

0.479

High

295478

SCAF4
SR-related and CTD-associated factor 4

1

5

High-throughput

0.479

High

295480

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

9

Small-scale

0.479

High

295484

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

295486

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

295489

TOP1
DNA topoisomerase 1

1

6

Small-scale

0.479

High

295493

NUCL
Nucleolin

1

12

Small-scale

0.479

High

295500

MCM7
DNA replication licensing factor MCM7

1

13

Small-scale

0.479

High

295501

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

295505

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

295506

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.479

High

295508

RBP2
E3 SUMO-protein ligase RanBP2

1

9

Small-scale

0.479

High

295511

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

295518

H2B1C
Histone H2B type 1-C/E/F/G/I

1

13

High-throughput

0.479

High

295520

RL31
Large ribosomal subunit protein eL31

1

7

High-throughput

0.479

High

295523

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

Small-scale

0.479

High

295524

H33
Histone H3.3

1

17

High-throughput

0.479

High

295526

TP53B
TP53-binding protein 1

1

12

High-throughput

0.479

High

295527

TIF1B
Transcription intermediary factor 1-beta

1

17

Small-scale

0.479

High

295531

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

High-throughput

0.479

High

295532

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

295533

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

13

High-throughput

0.479

High

295537

SPT6H
Transcription elongation factor SPT6

1

1

High-throughput

0.479

High

295540

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

295541

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

295542

SLX4
Structure-specific endonuclease subunit SLX4

1

15

High-throughput

0.479

High

295543

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

295545

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

295548

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

19

High-throughput

0.479

High

295554

KLF16
Krueppel-like factor 16

1

7

High-throughput

0.479

High

295555

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.479

High

295556

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

17

High-throughput

0.479

High

295560

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

295561

SFR19
Splicing factor, arginine/serine-rich 19

1

15

High-throughput

0.479

High

295562

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.479

High

295565

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

295566

NLE1
Notchless protein homolog 1

1

14

High-throughput

0.479

High

295568

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

295570

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

295572

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

295538

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

0

High-throughput

0.460

High

295514

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

295530

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.458

High

295535

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

295549

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

295563

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

295507

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

2

High-throughput

0.457

High

295510

NCBP2
Nuclear cap-binding protein subunit 2

1

20

High-throughput

0.445

High

295481

STABP
STAM-binding protein

1

0

High-throughput

0.438

High

129625

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

2

High-throughput

0.437

High

295536

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

295479

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.426

High

295487

MYZAP
Myocardial zonula adherens protein

1

7

High-throughput

0.407

High

295534

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

295544

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024