Protein: CASP3
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]

Gene: CASP3
Organism: Homo sapiens
Interactions: 138
UniProt ID: P42574

Gene Ontology (top 5):
GO:0001554 - luteolysis
GO:0001666 - response to hypoxia
GO:0001782 - B cell homeostasis
GO:0001818 - negative regulation of cytokine production
GO:0002020 - protease binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788182

XIAP
E3 ubiquitin-protein ligase XIAP

35

20

Small-scale

0.994

High

788170

CASP9
Caspase-9

9

17

Small-scale

0.973

High

788202

CASP8
Caspase-8

8

17

Small-scale

0.965

High

788194

BIRC2
Baculoviral IAP repeat-containing protein 2

5

20

Small-scale

0.924

High

788230

BIRC6
Baculoviral IAP repeat-containing protein 6

4

20

Small-scale

0.909

High

177658

BIRC5
Baculoviral IAP repeat-containing protein 5

3

20

Small-scale

0.853

High

788171

CASP6
Caspase-6

2

18

Small-scale

0.841

High

788221

BIRC7
Baculoviral IAP repeat-containing protein 7

3

20

Small-scale

0.834

High

788193

BIRC3
Baculoviral IAP repeat-containing protein 3

2

20

Small-scale

0.789

High

181591

CFLAR
CASP8 and FADD-like apoptosis regulator

2

17

Small-scale

0.783

High

788156

CASP2
Caspase-2

2

17

Small-scale

0.778

High

788219

CASPA
Caspase-10

2

17

Small-scale

0.778

High

486153

GRAB
Granzyme B

11

11

Small-scale

0.757

High

455183

PARP1
Poly [ADP-ribose] polymerase 1

9

9

Small-scale

0.756

High

788183

MDM2
E3 ubiquitin-protein ligase Mdm2

4

1

Small-scale

0.688

High

358982

CRYAB
Alpha-crystallin B chain

3

10

Small-scale

0.664

High

788203

TEBP
Prostaglandin E synthase 3

3

3

Small-scale

0.663

High

758141

CDN1A
Cyclin-dependent kinase inhibitor 1

4

0

Small-scale

0.657

High

496496

TAU
Microtubule-associated protein tau

3

7

Small-scale

0.655

High

667433

CASP1
Caspase-1

1

17

Small-scale

0.647

High

788169

CASP7
Caspase-7

1

18

Small-scale

0.647

High

788155

CASP3
Caspase-3

1

17

Small-scale

0.646

High

788172

BID
BH3-interacting domain death agonist

2

4

Small-scale

0.633

High

788223

PANX1
Pannexin-1

2

2

Small-scale

0.617

High

495485

THIO
Thioredoxin

1

1

Small-scale

0.615

High

394276

A4
Amyloid-beta precursor protein

2

4

Small-scale

0.611

High

363970

FETA
Alpha-fetoprotein

2

0

Small-scale

0.607

High

124289

DFFA
DNA fragmentation factor subunit alpha

2

3

Small-scale

0.602

High

414203

RB
Retinoblastoma-associated protein

2

5

Small-scale

0.602

High

536569

HCLS1
Hematopoietic lineage cell-specific protein

2

5

Small-scale

0.602

High

788165

GDIR1
Rho GDP-dissociation inhibitor 1

2

8

Small-scale

0.602

High

788180

PRKDC
DNA-dependent protein kinase catalytic subunit

2

2

Small-scale

0.602

High

788186

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

6

Small-scale

0.602

High

788188

TRAF3
TNF receptor-associated factor 3

2

20

Small-scale

0.602

High

236620

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

2

2

Small-scale

0.595

High

499595

CH60
60 kDa heat shock protein, mitochondrial

2

2

Small-scale

0.584

High

788209

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.580

High

788207

MK14
Mitogen-activated protein kinase 14

1

11

Small-scale

0.578

High

788215

ATG4D
Cysteine protease ATG4D

1

1

Small-scale

0.569

High

152857

APAF
Apoptotic protease-activating factor 1

2

5

Small-scale

0.563

High

788178

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

Small-scale

0.561

High

788158

DCC
Netrin receptor DCC

1

1

Small-scale

0.552

High

554415

GATA1
Erythroid transcription factor

1

0

Small-scale

0.545

High

256852

SOCS5
Suppressor of cytokine signaling 5

1

3

High-throughput

0.541

High

788174

1433G
14-3-3 protein gamma

1

4

High-throughput

0.541

High

788166

GDIR2
Rho GDP-dissociation inhibitor 2

1

8

Small-scale

0.536

High

649058

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

Small-scale

0.536

High

681714

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.536

High

682146

AKT2
RAC-beta serine/threonine-protein kinase

1

5

Small-scale

0.536

High

788161

PA24A
Cytosolic phospholipase A2

1

7

Small-scale

0.536

High

788236

AKT3
RAC-gamma serine/threonine-protein kinase

1

4

Small-scale

0.536

High

182109

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

6

High-throughput

0.536

High

728531

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.518

High

788177

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

Small-scale

0.515

High

788228

WNK3
Serine/threonine-protein kinase WNK3

1

4

Small-scale

0.515

High

788235

FBW1B
F-box/WD repeat-containing protein 11

1

4

Small-scale

0.515

High

788237

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.515

High

788157

HD
Huntingtin

1

4

High-throughput

0.515

High

788168

ATX3
Ataxin-3

1

2

High-throughput

0.515

High

788198

DCTN1
Dynactin subunit 1

1

4

High-throughput

0.515

High

788229

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

240708

USO1
General vesicular transport factor p115

1

1

Small-scale

0.501

High

267134

GEMI
Geminin

1

1

Small-scale

0.501

High

321312

IL33
Interleukin-33

1

2

Small-scale

0.501

High

338078

EGFR
Epidermal growth factor receptor

1

6

Small-scale

0.501

High

413852

GELS
Gelsolin

1

2

Small-scale

0.501

High

434153

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

3

Small-scale

0.501

High

434996

SP1
Transcription factor Sp1

1

2

Small-scale

0.501

High

441928

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

Small-scale

0.501

High

443381

VIME
Vimentin

1

5

Small-scale

0.501

High

473774

PA24B
Cytosolic phospholipase A2 beta

1

7

Small-scale

0.501

High

489380

BCL2
Apoptosis regulator Bcl-2

1

8

Small-scale

0.501

High

521784

CADH1
Cadherin-1

1

2

Small-scale

0.501

High

595521

GRAH
Granzyme H

1

11

Small-scale

0.501

High

596512

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

1

Small-scale

0.501

High

673846

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

2

Small-scale

0.501

High

786266

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.501

High

788159

MK08
Mitogen-activated protein kinase 8

1

11

Small-scale

0.501

High

788160

MK09
Mitogen-activated protein kinase 9

1

9

Small-scale

0.501

High

788162

TNF10
Tumor necrosis factor ligand superfamily member 10

1

13

Small-scale

0.501

High

788163

GRAM
Granzyme M

1

10

Small-scale

0.501

High

788164

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

2

Small-scale

0.501

High

788167

BLM
RecQ-like DNA helicase BLM

1

5

Small-scale

0.501

High

788181

NUCB2
Nucleobindin-2

1

5

Small-scale

0.501

High

788185

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.501

High

788187

SRBP2
Sterol regulatory element-binding protein 2

1

4

Small-scale

0.501

High

788189

PAK2
Serine/threonine-protein kinase PAK 2

1

6

Small-scale

0.501

High

788192

ROCK1
Rho-associated protein kinase 1

1

4

Small-scale

0.501

High

788195

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

Small-scale

0.501

High

788197

IL18
Interleukin-18

1

3

Small-scale

0.501

High

788199

SRC8
Src substrate cortactin

1

5

Small-scale

0.501

High

788200

BECN1
Beclin-1

1

1

Small-scale

0.501

High

788201

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

Small-scale

0.501

High

788206

PKN1
Serine/threonine-protein kinase N1

1

4

Small-scale

0.501

High

788208

GRAP1
GRIP1-associated protein 1

1

1

Small-scale

0.501

High

788211

A16L1
Autophagy-related protein 16-1

1

3

Small-scale

0.501

High

788213

CSN6
COP9 signalosome complex subunit 6

1

5

Small-scale

0.501

High

788218

HDAC7
Histone deacetylase 7

1

6

Small-scale

0.501

High

788224

RING2
E3 ubiquitin-protein ligase RING2

1

4

Small-scale

0.501

High

788234

DBNL
Drebrin-like protein

1

2

Small-scale

0.501

High

215598

AKAP8
A-kinase anchor protein 8

1

0

Small-scale

0.493

High

416945

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.493

High

489572

OSTP
Osteopontin

1

1

Small-scale

0.490

High

788226

ERP44
Endoplasmic reticulum resident protein 44

1

3

High-throughput

0.489

High

409424

CALB1
Calbindin

1

0

Small-scale

0.480

High

788217

PARG
Poly(ADP-ribose) glycohydrolase

1

0

Small-scale

0.480

High

226757

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

386254

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

388281

HSPB1
Heat shock protein beta-1

1

10

Small-scale

0.479

High

417180

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

625198

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

719878

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

778960

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

788175

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

788184

RON
Macrophage-stimulating protein receptor

1

1

High-throughput

0.479

High

788190

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.479

High

788191

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

788212

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

788231

RBX2
RING-box protein 2

1

4

Small-scale

0.479

High

788233

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

788222

THA11
THAP domain-containing protein 11

1

0

Small-scale

0.460

High

650574

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

788196

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

788204

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

788216

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

788220

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

788232

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

0

Small-scale

0.458

High

788214

MAVS
Mitochondrial antiviral-signaling protein

1

4

Small-scale

0.457

High

788176

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.457

High

528721

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

788210

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

788227

LS14B
Protein LSM14 homolog B

2

0

High-throughput

0.328

High

788179

S35A1
CMP-sialic acid transporter

1

0

High-throughput

0.279

Low

788205

KCA10
Potassium voltage-gated channel subfamily A member 10

1

0

High-throughput

0.279

Low

658016

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.261

Low

788225

GORS1
Golgi reassembly-stacking protein 1

1

0

Small-scale

0.261

Low

788173

CH10
10 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024