Protein: PLK4
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)

Gene: PLK4
Organism: Homo sapiens
Interactions: 142
UniProt ID: O00444

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0001741 - XY body
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

128939

PLK4
Serine/threonine-protein kinase PLK4

4

18

Small-scale

0.918

High

128982

DJB13
DnaJ homolog subfamily B member 13

2

6

High-throughput

0.783

High

128953

CE152
Centrosomal protein of 152 kDa

8

14

Small-scale

0.757

High

128984

ARP2
Actin-related protein 2

1

2

Small-scale

0.724

High

128941

ZBT39
Zinc finger and BTB domain-containing protein 39

2

1

High-throughput

0.700

High

129034

TET5B
Terminal nucleotidyltransferase 5B

2

3

High-throughput

0.700

High

129014

TET5C
Terminal nucleotidyltransferase 5C

1

3

High-throughput

0.698

High

128952

PPM1B
Protein phosphatase 1B

1

18

High-throughput

0.691

High

128968

IF4B
Eukaryotic translation initiation factor 4B

1

7

High-throughput

0.691

High

129004

STK38
Serine/threonine-protein kinase 38

1

12

High-throughput

0.691

High

129005

SF3B3
Splicing factor 3B subunit 3

1

7

High-throughput

0.691

High

129006

SF3B4
Splicing factor 3B subunit 4

1

8

High-throughput

0.691

High

129070

ST38L
Serine/threonine-protein kinase 38-like

1

13

High-throughput

0.691

High

129045

DUS23
Dual specificity protein phosphatase 23

1

14

High-throughput

0.665

High

129069

FBW1A
F-box/WD repeat-containing protein 1A

3

10

Small-scale

0.658

High

129030

CE192
Centrosomal protein of 192 kDa

2

5

Small-scale

0.649

High

129007

STIL
SCL-interrupting locus protein

3

0

Small-scale

0.649

High

128972

1433S
14-3-3 protein sigma

2

20

High-throughput

0.637

High

128994

RBM10
RNA-binding protein 10

1

9

High-throughput

0.618

High

129043

CAB45
45 kDa calcium-binding protein

1

13

High-throughput

0.618

High

128973

TTK
Dual specificity protein kinase TTK

1

17

High-throughput

0.618

High

128980

PLK1
Serine/threonine-protein kinase PLK1

1

17

High-throughput

0.618

High

128983

ARP3
Actin-related protein 3

1

2

Small-scale

0.618

High

128990

ACTS
Actin, alpha skeletal muscle

1

2

Small-scale

0.618

High

129002

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

5

Small-scale

0.618

High

129009

ACTBL
Beta-actin-like protein 2

1

2

Small-scale

0.618

High

129013

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

13

Small-scale

0.618

High

129018

MPRIP
Myosin phosphatase Rho-interacting protein

1

17

Small-scale

0.618

High

129024

MIB1
E3 ubiquitin-protein ligase MIB1

1

12

Small-scale

0.618

High

129029

NEK7
Serine/threonine-protein kinase Nek7

1

16

Small-scale

0.618

High

129003

ELOA1
Elongin-A

3

4

High-throughput

0.616

High

128986

1433E
14-3-3 protein epsilon

2

12

High-throughput

0.611

High

129039

SPAG5
Sperm-associated antigen 5

2

19

High-throughput

0.606

High

129049

OSBL3
Oxysterol-binding protein-related protein 3

2

4

High-throughput

0.606

High

129061

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.606

High

128970

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

128971

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

128985

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

129051

ECT2
Protein ECT2

1

12

Small-scale

0.598

High

129053

CENPJ
Centromere protein J

2

16

Small-scale

0.595

High

129052

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.589

High

128996

1433F
14-3-3 protein eta

2

20

High-throughput

0.588

High

129012

CE350
Centrosome-associated protein 350

2

13

Small-scale

0.584

High

129016

CEP85
Centrosomal protein of 85 kDa

2

19

Small-scale

0.584

High

129017

SAS6
Spindle assembly abnormal protein 6 homolog

2

13

Small-scale

0.584

High

129026

NEDD1
Protein NEDD1

2

3

Small-scale

0.584

High

129028

ALMS1
Centrosome-associated protein ALMS1

2

7

Small-scale

0.584

High

129035

ENTR1
Endosome-associated-trafficking regulator 1

2

3

Small-scale

0.584

High

129036

CEP63
Centrosomal protein of 63 kDa

2

12

Small-scale

0.584

High

129054

Q9HCK3
KIAA1569 protein

2

5

Small-scale

0.584

High

128957

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

128995

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

1

High-throughput

0.574

High

129056

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

Small-scale

0.561

High

129047

TRI54
Tripartite motif-containing protein 54

2

7

High-throughput

0.553

High

128963

POTEI
POTE ankyrin domain family member I

1

3

Small-scale

0.553

High

128998

NEXN
Nexilin

1

6

Small-scale

0.553

High

129057

RFOX1
RNA binding protein fox-1 homolog 1

1

10

High-throughput

0.553

High

129058

AIRIM
AFG2-interacting ribosome maturation factor

1

0

High-throughput

0.549

High

128940

TX1B3
Tax1-binding protein 3

1

4

High-throughput

0.541

High

128948

ATP9A
Probable phospholipid-transporting ATPase IIA

1

2

High-throughput

0.536

High

128949

SF3B1
Splicing factor 3B subunit 1

1

6

High-throughput

0.536

High

128976

TCPZ
T-complex protein 1 subunit zeta

1

5

High-throughput

0.536

High

128977

MAP1B
Microtubule-associated protein 1B

1

10

High-throughput

0.536

High

128988

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

128992

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.536

High

129048

SKI8
Superkiller complex protein 8

1

7

High-throughput

0.536

High

128975

ARRC
Arrestin-C

1

1

High-throughput

0.523

High

128961

PDIA1
Protein disulfide-isomerase

1

4

High-throughput

0.515

High

128945

RFOX2
RNA binding protein fox-1 homolog 2

1

8

High-throughput

0.514

High

128981

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.513

High

129055

PLPL8
Calcium-independent phospholipase A2-gamma

1

0

High-throughput

0.513

High

129074

SPIN1
Spindlin-1

1

0

High-throughput

0.513

High

129015

CP135
Centrosomal protein of 135 kDa

1

14

Small-scale

0.500

High

129010

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

19

High-throughput

0.494

High

128959

H2A1B
Histone H2A type 1-B/E

1

7

High-throughput

0.489

High

128966

H12
Histone H1.2

1

2

High-throughput

0.489

High

128979

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.489

High

128991

TBA1B
Tubulin alpha-1B chain

1

11

High-throughput

0.489

High

128993

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.489

High

129068

SORC3
VPS10 domain-containing receptor SorCS3

1

1

High-throughput

0.489

High

129000

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.486

High

116730

KIF2A
Kinesin-like protein KIF2A

1

11

High-throughput

0.479

High

128942

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

5

Small-scale

0.479

High

128943

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

Small-scale

0.479

High

128946

TXNL1
Thioredoxin-like protein 1

1

6

Small-scale

0.479

High

128947

WDR1
WD repeat-containing protein 1

1

8

Small-scale

0.479

High

128950

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

7

High-throughput

0.479

High

128951

OFD1
Centriole and centriolar satellite protein OFD1

1

18

High-throughput

0.479

High

128954

PCNT
Pericentrin

1

16

High-throughput

0.479

High

128956

CEP43
Centrosomal protein 43

1

1

Small-scale

0.479

High

128958

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

2

Small-scale

0.479

High

128960

GELS
Gelsolin

1

2

Small-scale

0.479

High

128967

CXA1
Gap junction alpha-1 protein

1

1

Small-scale

0.479

High

128969

APC
Adenomatous polyposis coli protein

1

12

Small-scale

0.479

High

128974

SPRE
Sepiapterin reductase

1

1

High-throughput

0.479

High

128987

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

10

High-throughput

0.479

High

128989

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

10

High-throughput

0.479

High

128999

TWF1
Twinfilin-1

1

1

Small-scale

0.479

High

129001

FLII
Protein flightless-1 homolog

1

4

Small-scale

0.479

High

129011

FRPD1
FERM and PDZ domain-containing protein 1

1

1

Small-scale

0.479

High

129020

CE128
Centrosomal protein of 128 kDa

1

17

High-throughput

0.479

High

129031

HS105
Heat shock protein 105 kDa

1

9

High-throughput

0.479

High

129032

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

5

Small-scale

0.479

High

129040

CK5P2
CDK5 regulatory subunit-associated protein 2

1

18

High-throughput

0.479

High

129042

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

129044

CP250
Centrosome-associated protein CEP250

1

12

High-throughput

0.479

High

129064

FBW1B
F-box/WD repeat-containing protein 11

1

11

High-throughput

0.479

High

129066

SYNP2
Synaptopodin-2

1

3

High-throughput

0.479

High

129067

CP131
Centrosomal protein of 131 kDa

1

13

High-throughput

0.479

High

129071

NDK7
Nucleoside diphosphate kinase homolog 7

1

3

Small-scale

0.479

High

129072

MAGD1
Melanoma-associated antigen D1

1

4

High-throughput

0.479

High

128944

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.458

High

128978

CAZA2
F-actin-capping protein subunit alpha-2

1

0

Small-scale

0.458

High

128997

CCD15
Coiled-coil domain-containing protein 15

1

0

High-throughput

0.458

High

129008

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.458

High

129019

FA83H
Protein FAM83H

1

0

High-throughput

0.458

High

129025

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

129033

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.458

High

129065

SPAT2
Spermatogenesis-associated protein 2

1

0

Small-scale

0.458

High

129075

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

16

High-throughput

0.457

High

108820

H0Y9Y3
Synaptopodin 2

1

8

High-throughput

0.445

High

433

A0A087WUI6
Progesterone immunomodulatory binding factor 1

1

0

High-throughput

0.438

High

129027

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.438

High

128955

EYA4
Eyes absent homolog 4

1

3

High-throughput

0.437

High

128962

H2AZ
Histone H2A.Z

1

11

Small-scale

0.437

High

129021

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

1

6

High-throughput

0.437

High

129023

GA2L3
GAS2-like protein 3

1

4

Small-scale

0.437

High

129037

DOCK7
Dedicator of cytokinesis protein 7

1

3

High-throughput

0.437

High

129038

H2A1A
Histone H2A type 1-A

1

7

Small-scale

0.437

High

129041

AIF1L
Allograft inflammatory factor 1-like

1

9

Small-scale

0.437

High

129059

TMOD2
Tropomodulin-2

1

2

Small-scale

0.437

High

129060

CING
Cingulin

1

10

Small-scale

0.437

High

129073

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

13

Small-scale

0.437

High

128964

AMY1B
Alpha-amylase 1B

1

3

High-throughput

0.407

High

128965

ACE
Angiotensin-converting enzyme

1

0

High-throughput

0.279

Low

63704

CC85C
Coiled-coil domain-containing protein 85C

1

0

Small-scale

0.249

Low

129022

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

Small-scale

0.249

Low

129046

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.249

Low

129050

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

Small-scale

0.249

Low

129062

GBG12

1

0

Small-scale

0.249

Low

129063

SH3L2
SH3 domain-binding glutamic acid-rich-like protein 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024