Protein: CBL
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)

Gene: CBL
Organism: Mus musculus
Interactions: 152
UniProt ID: P22682

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0001784 - phosphotyrosine residue binding
GO:0005509 - calcium ion binding
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

610546

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

16

20

Small-scale

0.759

High

610609

CRK
Adapter molecule crk

11

20

Small-scale

0.752

High

610598

GRB2
Growth factor receptor-bound protein 2

8

20

Small-scale

0.744

High

610584

EGFR
Epidermal growth factor receptor

8

20

Small-scale

0.741

High

610589

CBLB
E3 ubiquitin-protein ligase CBL-B

2

9

Small-scale

0.737

High

403415

SRC
Proto-oncogene tyrosine-protein kinase Src

6

20

Small-scale

0.737

High

610565

CRKL
Crk-like protein

7

20

Small-scale

0.736

High

610554

FYN
Tyrosine-protein kinase Fyn

6

20

Small-scale

0.722

High

337618

ABL1
Tyrosine-protein kinase ABL1

4

20

Small-scale

0.692

High

435877

HCK
Tyrosine-protein kinase HCK

3

20

Small-scale

0.678

High

610545

LYN
Tyrosine-protein kinase Lyn

4

20

Small-scale

0.676

High

610649

SH2B2
SH2B adapter protein 2

4

20

Small-scale

0.671

High

610656

ITSN1
Intersectin-1

3

20

Small-scale

0.650

High

404008

PGFRB
Platelet-derived growth factor receptor beta

3

20

Small-scale

0.646

High

411917

LCK
Proto-oncogene tyrosine-protein kinase LCK

3

20

Small-scale

0.640

High

610608

SRBS1
Sorbin and SH3 domain-containing protein 1

3

20

Small-scale

0.640

High

610647

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

3

2

Small-scale

0.633

High

610651

CD2AP
CD2-associated protein

3

20

Small-scale

0.629

High

610553

VGFR1
Vascular endothelial growth factor receptor 1

2

20

Small-scale

0.601

High

610628

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.586

High

536206

FGR
Tyrosine-protein kinase Fgr

2

20

Small-scale

0.584

High

610633

NCK1
SH2/SH3 adapter protein Nck1

2

20

Small-scale

0.584

High

610596

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

High-throughput

0.575

High

610620

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.575

High

610552

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

12

Small-scale

0.571

High

610571

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.571

High

610604

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

3

Small-scale

0.571

High

610630

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.571

High

610560

ZAP70
Tyrosine-protein kinase ZAP-70

2

20

Small-scale

0.563

High

610632

PAXI
Paxillin

1

11

Small-scale

0.561

High

526810

CD5
T-cell surface glycoprotein CD5

1

3

High-throughput

0.536

High

610582

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.536

High

222501

ITB3
Integrin beta-3

1

4

High-throughput

0.501

High

447065

ITB1
Integrin beta-1

1

4

High-throughput

0.501

High

610595

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.501

High

610612

RIGI
Antiviral innate immune response receptor RIG-I

1

7

Small-scale

0.500

High

610591

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.479

High

139921

O08797
SPI6

1

1

Small-scale

0.479

High

192580

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

9

Small-scale

0.479

High

250684

ATX2
Ataxin-2

1

10

Small-scale

0.479

High

403532

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.479

High

420388

TNFA
Tumor necrosis factor

1

1

Small-scale

0.479

High

434794

SPTA1
Spectrin alpha chain, erythrocytic 1

1

7

Small-scale

0.479

High

452178

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

Small-scale

0.479

High

610549

TNR5
Tumor necrosis factor receptor superfamily member 5

1

10

Small-scale

0.479

High

610561

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

11

Small-scale

0.479

High

610566

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

610579

TRAF6
TNF receptor-associated factor 6

1

15

Small-scale

0.479

High

610580

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.479

High

610586

ITK
Tyrosine-protein kinase ITK/TSK

1

20

Small-scale

0.479

High

610587

EPS8
Epidermal growth factor receptor kinase substrate 8

1

20

Small-scale

0.479

High

610588

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

610600

SLAP1
Src-like-adapter

1

20

Small-scale

0.479

High

610606

TGFR2
TGF-beta receptor type-2

1

2

Small-scale

0.479

High

610607

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.479

High

610619

DLG1
Disks large homolog 1

1

5

Small-scale

0.479

High

610625

Q8C5V7
Rap guanine nucleotide exchange factor 1

1

5

Small-scale

0.479

High

610629

SLAP2
Src-like-adapter 2

1

20

Small-scale

0.479

High

610637

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

Small-scale

0.479

High

610652

SPY2
Protein sprouty homolog 2

1

7

Small-scale

0.479

High

610653

DOK3
Docking protein 3

1

6

Small-scale

0.479

High

140057

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.445

High

140352

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.445

High

193567

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

6

High-throughput

0.445

High

193606

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.445

High

222750

LAT
Linker for activation of T-cells family member 1

1

2

High-throughput

0.445

High

292681

GRAP2
GRB2-related adaptor protein 2

1

20

High-throughput

0.445

High

420369

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

7

High-throughput

0.445

High

515642

ITB2
Integrin beta-2

1

4

High-throughput

0.445

High

540512

ANXA6
Annexin A6

1

2

High-throughput

0.445

High

554834

LEG1
Galectin-1

1

5

High-throughput

0.445

High

586552

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.445

High

610543

CBX3
Chromobox protein homolog 3

1

8

High-throughput

0.445

High

610548

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

2

High-throughput

0.445

High

610551

HMGB2
High mobility group protein B2

1

7

High-throughput

0.445

High

610555

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.445

High

610556

STAT1
Signal transducer and activator of transcription 1

1

3

High-throughput

0.445

High

610557

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

6

High-throughput

0.445

High

610558

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

610559

H11
Histone H1.1

1

3

High-throughput

0.445

High

610562

CAZA1
F-actin-capping protein subunit alpha-1

1

3

High-throughput

0.445

High

610563

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.445

High

610564

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.445

High

610568

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

High-throughput

0.445

High

610570

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.445

High

610573

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.445

High

610575

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.445

High

610576

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

610578

1433F
14-3-3 protein eta

1

20

High-throughput

0.445

High

610583

TBB5
Tubulin beta-5 chain

1

9

High-throughput

0.445

High

610585

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.445

High

610592

DDB1
DNA damage-binding protein 1

1

2

High-throughput

0.445

High

610593

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.445

High

610597

ACACA
Acetyl-CoA carboxylase 1

1

6

High-throughput

0.445

High

610601

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

16

High-throughput

0.445

High

610605

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

High-throughput

0.445

High

610610

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.445

High

610613

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.445

High

610614

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.445

High

610618

SIG10
Sialic acid-binding Ig-like lectin 10

1

4

Small-scale

0.445

High

610623

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

610624

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

6

High-throughput

0.445

High

610626

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.445

High

610634

SYK
Lysine--tRNA ligase

1

3

High-throughput

0.445

High

610638

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

610640

GRAP
GRB2-related adapter protein

1

20

High-throughput

0.445

High

610641

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

1

High-throughput

0.445

High

610643

F162A
Protein FAM162A

1

1

High-throughput

0.445

High

610648

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

6

Small-scale

0.445

High

610650

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.445

High

610654

TPSN
Tapasin

1

1

High-throughput

0.445

High

610657

ITSN2
Intersectin-2

1

20

High-throughput

0.445

High

554961

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.437

High

610544

IRF8
Interferon regulatory factor 8

1

6

High-throughput

0.437

High

610611

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

7

Small-scale

0.437

High

610615

SYNEM
Synemin

1

14

Small-scale

0.437

High

193257

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.426

High

417784

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.426

High

539496

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.426

High

610550

PSB8
Proteasome subunit beta type-8

1

0

High-throughput

0.426

High

610567

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.426

High

610574

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.426

High

610599

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.426

High

610616

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.426

High

610642

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

251049

DIAP2
Protein diaphanous homolog 2

1

1

High-throughput

0.407

High

354650

HA1D
H-2 class I histocompatibility antigen, K-D alpha chain

1

1

High-throughput

0.407

High

550486

H12
Histone H1.2

1

3

High-throughput

0.407

High

566266

PTBP1
Polypyrimidine tract-binding protein 1

1

2

High-throughput

0.407

High

610547

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

1

High-throughput

0.407

High

610569

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.407

High

610572

PRS10
26S proteasome regulatory subunit 10B

1

4

High-throughput

0.407

High

610577

TBB4B
Tubulin beta-4B chain

1

9

High-throughput

0.407

High

610590

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

3

High-throughput

0.407

High

610594

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.407

High

610603

SERA
D-3-phosphoglycerate dehydrogenase

1

5

High-throughput

0.407

High

610631

VIGLN
Vigilin

1

3

High-throughput

0.407

High

610635

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.407

High

610636

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.407

High

610639

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.407

High

610645

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

2

High-throughput

0.407

High

610655

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

8

High-throughput

0.407

High

371560

CFAD
Complement factor D

1

0

High-throughput

0.249

Low

335886

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.232

Low

610581

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.232

Low

610602

VDAC3
Voltage-dependent anion-selective channel protein 3

1

0

High-throughput

0.232

Low

610617

MOGS
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.232

Low

610621

THMS1
Protein THEMIS

1

0

Small-scale

0.232

Low

610622

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

0

High-throughput

0.232

Low

610627

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.232

Low

610644

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.232

Low

610646

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024