Protein: M3K7
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)

Gene: M3K7, Map3k7
Organism: Mus musculus
Interactions: 67
UniProt ID: Q62073

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0001223 - transcription coactivator binding
GO:0001525 - angiogenesis
GO:0001649 - osteoblast differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1143249

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

15

Small-scale

0.834

High

1143251

TGFR2
TGF-beta receptor type-2

3

20

Small-scale

0.827

High

291465

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

7

Small-scale

0.768

High

936234

TRAF6
TNF receptor-associated factor 6

10

17

Small-scale

0.750

High

1143268

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

7

5

Small-scale

0.739

High

1143263

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

6

8

Small-scale

0.719

High

1143278

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

7

Small-scale

0.691

High

1123042

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

4

4

Small-scale

0.683

High

140030

BIRC3
Baculoviral IAP repeat-containing protein 3

1

8

Small-scale

0.665

High

515233

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

Small-scale

0.665

High

814031

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

19

Small-scale

0.665

High

1142138

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

7

Small-scale

0.665

High

1143250

BIRC2
Baculoviral IAP repeat-containing protein 2

1

5

Small-scale

0.665

High

1143252

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.665

High

1143274

TLR4
Toll-like receptor 4

1

16

Small-scale

0.665

High

1143280

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

Small-scale

0.665

High

1143275

HIPK2
Homeodomain-interacting protein kinase 2

1

13

Small-scale

0.646

High

936609

SMAD1
Mothers against decapentaplegic homolog 1

2

7

Small-scale

0.624

High

815733

KSYK
Tyrosine-protein kinase SYK

1

19

Small-scale

0.618

High

886053

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

13

Small-scale

0.618

High

936341

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

20

Small-scale

0.618

High

1125555

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

7

Small-scale

0.618

High

1142161

KSR1
Kinase suppressor of Ras 1

1

17

Small-scale

0.618

High

1143254

TGFR1
TGF-beta receptor type-1

1

15

Small-scale

0.618

High

1143258

VRK2
Serine/threonine-protein kinase VRK2

1

5

Small-scale

0.618

High

1143259

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

7

Small-scale

0.618

High

1143269

TLR3
Toll-like receptor 3

1

19

Small-scale

0.618

High

1143277

GSK3B
Glycogen synthase kinase-3 beta

1

13

Small-scale

0.618

High

476829

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

2

6

Small-scale

0.602

High

291805

NEMO
NF-kappa-B essential modulator

2

5

Small-scale

0.601

High

761816

TRAF2
TNF receptor-associated factor 2

2

19

Small-scale

0.601

High

1143279

BCL10
B-cell lymphoma/leukemia 10

2

1

Small-scale

0.601

High

562601

IL7RA
Interleukin-7 receptor subunit alpha

1

0

Small-scale

0.586

High

626866

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

5

Small-scale

0.584

High

956496

SMAD5
Mothers against decapentaplegic homolog 5

2

7

Small-scale

0.584

High

1141193

SKIL
Ski-like protein

1

1

Small-scale

0.573

High

887163

SASH1
SAM and SH3 domain-containing protein 1

1

1

Small-scale

0.553

High

1143264

CAR11
Caspase recruitment domain-containing protein 11

1

5

Small-scale

0.534

High

607557

MYD88
Myeloid differentiation primary response protein MyD88

1

4

Small-scale

0.515

High

896583

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

Small-scale

0.515

High

1103183

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

3

Small-scale

0.515

High

548984

TR30A
Tripartite motif-containing protein 30A

1

4

Small-scale

0.479

High

620963

GRIA2
Glutamate receptor 2

1

2

High-throughput

0.479

High

648959

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

Small-scale

0.479

High

681671

NOTC4
Neurogenic locus notch homolog protein 4

1

1

Small-scale

0.479

High

956544

SMAD4
Mothers against decapentaplegic homolog 4

1

7

Small-scale

0.479

High

957143

DAB2
Disabled homolog 2

1

1

Small-scale

0.479

High

1141210

PPP5
Serine/threonine-protein phosphatase 5

1

3

High-throughput

0.479

High

1143253

SMAD2
Mothers against decapentaplegic homolog 2

1

7

Small-scale

0.479

High

1143255

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1143256

TIPRL
TIP41-like protein

1

1

Small-scale

0.479

High

1143260

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

3

Small-scale

0.479

High

1143261

SMAD3
Mothers against decapentaplegic homolog 3

1

7

Small-scale

0.479

High

1143262

MT21E
Protein-lysine methyltransferase METTL21E

1

1

High-throughput

0.479

High

1143265

CIKS
E3 ubiquitin ligase TRAF3IP2

1

1

Small-scale

0.479

High

1143267

MIB2
E3 ubiquitin-protein ligase MIB2

1

4

Small-scale

0.479

High

1143270

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

4

Small-scale

0.479

High

1143272

DAZP2
DAZ-associated protein 2

1

1

Small-scale

0.479

High

1143273

SMAD9
Mothers against decapentaplegic homolog 9

1

7

Small-scale

0.479

High

1143257

TCAM2
TIR domain-containing adapter molecule 2

1

0

Small-scale

0.458

High

432432

HS90A
Heat shock protein HSP 90-alpha

1

14

Small-scale

0.445

High

1142130

CDC37
Hsp90 co-chaperone Cdc37

1

6

Small-scale

0.445

High

1109879

Q3SXA6
TNFAIP3-interacting protein 3

1

2

Small-scale

0.437

High

1143266

TRI29
Tripartite motif-containing protein 29

1

9

Small-scale

0.437

High

1143271

TBE
Tubulin epsilon chain

1

5

Small-scale

0.437

High

1143276

TM115
Transmembrane protein 115

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024