Protein: TLR4
Toll-like receptor 4 (CD antigen CD284)

Gene: TLR4
Organism: Mus musculus
Interactions: 56
UniProt ID: Q9QUK6

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001726 - ruffle
GO:0001774 - microglial cell activation
GO:0001875 - lipopolysaccharide immune receptor activity
GO:0001891 - phagocytic cup

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1351519

TLR4
Toll-like receptor 4

4

19

Small-scale

0.873

High

607581

MYD88
Myeloid differentiation primary response protein MyD88

15

20

Small-scale

0.759

High

1337438

LY96
Lymphocyte antigen 96

5

2

Small-scale

0.726

High

1193564

TCAM1
TIR domain-containing adapter molecule 1

5

9

Small-scale

0.712

High

1141536

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.691

High

1206756

TCAM2
TIR domain-containing adapter molecule 2

4

8

Small-scale

0.674

High

1143274

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

16

Small-scale

0.665

High

1265201

SIG12
Sialic acid-binding Ig-like lectin 12

1

20

Small-scale

0.665

High

936285

TRAF6
TNF receptor-associated factor 6

3

10

Small-scale

0.650

High

403461

SRC
Proto-oncogene tyrosine-protein kinase Src

1

13

Small-scale

0.618

High

500270

CD14
Monocyte differentiation antigen CD14

1

20

Small-scale

0.618

High

815745

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

1162020

Q6PJ50
Sialic acid binding Ig-like lectin E

1

20

Small-scale

0.618

High

1208640

C209B
CD209 antigen-like protein B

1

9

Small-scale

0.618

High

1265317

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.618

High

619087

IRF8
Interferon regulatory factor 8

2

13

Small-scale

0.584

High

1143895

IRAK1
Interleukin-1 receptor-associated kinase 1

2

20

Small-scale

0.584

High

1351522

BCL10
B-cell lymphoma/leukemia 10

2

0

Small-scale

0.576

High

291820

NEMO
NF-kappa-B essential modulator

1

3

Small-scale

0.515

High

1141445

TRAF3
TNF receptor-associated factor 3

1

10

Small-scale

0.515

High

1143670

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

Small-scale

0.515

High

1246919

IRAK4
Interleukin-1 receptor-associated kinase 4

1

20

Small-scale

0.515

High

1112177

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.513

High

1322365

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

5

Small-scale

0.506

High

506797

FINC
Fibronectin

1

8

Small-scale

0.501

High

291971

BECN1
Beclin-1

1

0

Small-scale

0.493

High

896596

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

Small-scale

0.493

High

1307779

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

3

Small-scale

0.481

High

193255

NEUR1
Sialidase-1

1

3

Small-scale

0.479

High

567573

SPI1
Transcription factor PU.1

1

5

Small-scale

0.479

High

782856

MMP9
Matrix metalloproteinase-9

1

3

Small-scale

0.479

High

835150

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

885393

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

2

Small-scale

0.479

High

919009

RAB1A
Ras-related protein Rab-1A

1

3

Small-scale

0.479

High

926167

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

926323

CH60
60 kDa heat shock protein, mitochondrial

1

5

Small-scale

0.479

High

927932

HMGB1
High mobility group protein B1

1

5

Small-scale

0.479

High

956487

AMPN
Aminopeptidase N

1

1

Small-scale

0.479

High

973817

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.479

High

995949

EPS8
Epidermal growth factor receptor kinase substrate 8

1

4

Small-scale

0.479

High

1111704

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.479

High

1145136

IRF4
Interferon regulatory factor 4

1

13

Small-scale

0.479

High

1194711

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.479

High

1207142

CNPY4
Protein canopy homolog 4

1

14

Small-scale

0.479

High

1225029

I17RD
Interleukin-17 receptor D

1

1

Small-scale

0.479

High

1322128

Q9DAD3
WD repeat and FYVE domain containing 1

1

2

Small-scale

0.479

High

1351521

TBK1
Serine/threonine-protein kinase TBK1

1

7

Small-scale

0.479

High

140035

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.470

High

427736

ANXA2
Annexin A2

1

0

Small-scale

0.458

High

646015

S10A8
Protein S100-A8

1

0

Small-scale

0.458

High

1112079

CBLB
E3 ubiquitin-protein ligase CBL-B

1

0

Small-scale

0.458

High

669512

FETUA
Alpha-2-HS-glycoprotein

1

1

Small-scale

0.457

High

193575

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

2

Small-scale

0.445

High

1321936

RN115
E3 ubiquitin-protein ligase RNF115

1

5

Small-scale

0.437

High

1351520

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.437

High


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Last updated: 15 Jul 2024