Protein: TUP1
General transcriptional corepressor TUP1 (Flocculation suppressor protein) (Glucose repression regulatory protein TUP1) (Repressor AER2)

Gene: TUP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 118
UniProt ID: P16649

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000433 - carbon catabolite repression of transcription from RNA polymerase II promoter by glucose
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

542095

CYC8
General transcriptional corepressor CYC8

21

16

Small-scale

0.991

High

561841

TUP1
General transcriptional corepressor TUP1

4

18

Small-scale

0.865

High

561867

DOA1
Protein DOA1

1

18

High-throughput

0.665

High

561899

SKO1
CRE-binding bZIP protein SKO1

3

0

Small-scale

0.634

High

510160

SSB1
Ribosome-associated molecular chaperone SSB1

3

17

High-throughput

0.633

High

493119

HSP72
Heat shock protein SSA2

3

17

High-throughput

0.624

High

561844

SIN3
Transcriptional regulatory protein SIN3

2

4

High-throughput

0.621

High

561889

RFX1
RFX-like DNA-binding protein RFX1

2

2

Small-scale

0.617

High

561855

RPD3
Histone deacetylase RPD3

2

20

Small-scale

0.612

High

514229

NHP6B
Non-histone chromosomal protein 6B

2

20

Small-scale

0.609

High

561920

CTI6
Histone deacetylase complex subunit CTI6

2

7

Small-scale

0.602

High

561881

MED3
Mediator of RNA polymerase II transcription subunit 3

2

0

Small-scale

0.598

High

561873

MET30
F-box protein MET30

1

18

High-throughput

0.590

High

561874

SSN3
Meiotic mRNA stability protein kinase SSN3

2

12

Small-scale

0.586

High

561888

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

Small-scale

0.581

High

381591

GAL80
Galactose/lactose metabolism regulatory protein GAL80

2

0

Small-scale

0.577

High

490241

HSP71
Heat shock protein SSA1

2

16

High-throughput

0.571

High

356226

H4
Histone H4

1

11

Small-scale

0.561

High

561895

HDA1
Histone deacetylase HDA1

1

20

Small-scale

0.561

High

561897

H3
Histone H3

1

15

Small-scale

0.561

High

561866

DYHC
Dynein heavy chain, cytoplasmic

1

7

High-throughput

0.555

High

561884

SET4
SET domain-containing protein 4

1

7

Small-scale

0.553

High

561879

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.552

High

561885

NSE4
Non-structural maintenance of chromosome element 4

2

0

High-throughput

0.541

High

561849

CDC48
Cell division control protein 48

1

6

High-throughput

0.515

High

561925

HOS1
Histone deacetylase HOS1

1

18

Small-scale

0.515

High

140427

CET1
mRNA-capping enzyme subunit beta

1

2

Small-scale

0.512

High

483018

HMAL2
Silenced mating-type protein ALPHA2

1

0

Small-scale

0.504

High

477110

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

14

Small-scale

0.501

High

561847

ROX1
Repressor ROX1

1

18

Small-scale

0.501

High

561850

DAL80
Nitrogen regulatory protein DAL80

1

12

Small-scale

0.501

High

561863

YOX1
Homeobox protein YOX1

1

5

Small-scale

0.501

High

561882

FKH1
Fork head protein homolog 1

1

10

Small-scale

0.501

High

554541

HSP26
Heat shock protein 26

1

3

High-throughput

0.500

High

561917

DHSO2
Sorbitol dehydrogenase 2

1

1

High-throughput

0.494

High

521168

EI2BD
Translation initiation factor eIF2B subunit delta

1

3

High-throughput

0.489

High

551341

ABP1
Actin-binding protein

1

6

High-throughput

0.489

High

561878

HSP7E
Heat shock protein SSC3, mitochondrial

1

19

High-throughput

0.489

High

561904

CLU
Clustered mitochondria protein 1

1

2

High-throughput

0.489

High

561909

SPH1
Protein SPH1

1

1

High-throughput

0.489

High

561859

KPR1
Ribose-phosphate pyrophosphokinase 1

1

1

Small-scale

0.481

High

409943

NOT3
General negative regulator of transcription subunit 3

1

1

High-throughput

0.481

High

561843

KIN3
Serine/threonine-protein kinase KIN3

1

6

High-throughput

0.481

High

561862

NUF2
Kinetochore protein NUF2

1

8

High-throughput

0.481

High

561891

PFD6
Prefoldin subunit 6

1

7

High-throughput

0.481

High

561893

AF9
Protein AF-9 homolog

1

11

High-throughput

0.481

High

561898

CTR9
RNA polymerase-associated protein CTR9

1

14

High-throughput

0.481

High

561911

MED10
Mediator of RNA polymerase II transcription subunit 10

1

2

Small-scale

0.481

High

561846

URE2
Transcriptional regulator URE2

1

0

Small-scale

0.480

High

561872

UME6
Transcriptional regulatory protein UME6

1

0

Small-scale

0.480

High

561896

MOT3
Transcriptional activator/repressor MOT3

1

0

Small-scale

0.480

High

561919

RDR1
Protein RDR1

1

0

Small-scale

0.480

High

561932

WHI5
G1-specific transcriptional repressor WHI5

1

0

Small-scale

0.480

High

423655

ADR1
Regulatory protein ADR1

1

5

High-throughput

0.479

High

557853

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

561842

MED14
Mediator of RNA polymerase II transcription subunit 14

1

2

Small-scale

0.479

High

561851

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

561853

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

561854

HOG1
Mitogen-activated protein kinase HOG1

1

5

High-throughput

0.479

High

561864

DEF1
RNA polymerase II degradation factor 1

1

7

High-throughput

0.479

High

561871

SKN7
Transcription factor SKN7

1

6

Small-scale

0.479

High

561883

YAP4
AP-1-like transcription factor YAP4

1

2

Small-scale

0.479

High

561887

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

5

Small-scale

0.479

High

561902

NRG1
Transcriptional regulator NRG1

1

19

Small-scale

0.479

High

561903

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

561905

YAP6
AP-1-like transcription factor YAP6

1

2

Small-scale

0.479

High

561906

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

High-throughput

0.479

High

561910

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

561922

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

561924

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

561927

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.479

High

561930

HMS1
Probable transcription factor HMS1

1

8

High-throughput

0.479

High

561900

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

561914

CDC73
Cell division control protein 73

1

0

Small-scale

0.460

High

561852

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.458

High

561856

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.458

High

561868

PHD1
Putative transcription factor PHD1

1

0

Small-scale

0.458

High

561901

ESP1
Separin

1

0

High-throughput

0.458

High

561913

HDA3
HDA1 complex subunit 3

1

0

Small-scale

0.458

High

561918

YAP7
AP-1-like transcription factor YAP7

1

0

Small-scale

0.458

High

561923

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

Small-scale

0.458

High

342647

ENO1
Enolase 1

1

3

High-throughput

0.457

High

378272

LEU3
3-isopropylmalate dehydrogenase

1

5

High-throughput

0.457

High

561921

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

1

High-throughput

0.457

High

365738

HSP82
ATP-dependent molecular chaperone HSP82

1

13

High-throughput

0.445

High

561857

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

446106

MYO1
Myosin-1

1

7

High-throughput

0.439

High

561845

SPA2
Protein SPA2

1

11

High-throughput

0.439

High

561848

STP22
Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease

1

1

High-throughput

0.439

High

561865

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.439

High

561870

KOG1
Target of rapamycin complex 1 subunit KOG1

1

19

High-throughput

0.439

High

561875

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.439

High

561877

SNF7
Vacuolar-sorting protein SNF7

1

6

High-throughput

0.439

High

561880

TBP6
Probable 26S proteasome subunit YTA6

1

11

High-throughput

0.439

High

561890

KEL2
Kelch repeat-containing protein 2

1

7

High-throughput

0.439

High

561926

IQG1
Ras GTPase-activating-like protein IQG1

1

7

High-throughput

0.439

High

561928

GYP5
GTPase-activating protein GYP5

1

2

High-throughput

0.439

High

561931

ERP3
Protein ERP3

1

2

High-throughput

0.439

High

561933

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

High-throughput

0.438

High

561860

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

561869

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

2

High-throughput

0.437

High

367699

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.407

High

477862

HSP77
Import motor subunit, mitochondrial

1

19

High-throughput

0.407

High

561861

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

561886

SSY5
SPS-sensor serine protease component SSY5

1

0

High-throughput

0.279

Low

145899

YO304
Uncharacterized protein YOR304C-A

1

0

High-throughput

0.251

Low

561858

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.251

Low

561876

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

561892

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

561908

HOB2
Protein YPR117W

1

0

High-throughput

0.251

Low

561912

MMR1
Mitochondrial MYO2 receptor-related protein 1

1

0

High-throughput

0.251

Low

561915

YET3
Endoplasmic reticulum transmembrane protein 3

1

0

High-throughput

0.251

Low

561929

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.251

Low

410519

CATT
Catalase T

1

0

High-throughput

0.249

Low

561894

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

561907

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

561916

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024