Protein: H2A1
Histone H2A.1

Gene: H2A1, HTA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 241
UniProt ID: P04911

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

355289

H2B1
Histone H2B.1

18

20

Small-scale

0.984

High

392059

NAP1
Nucleosome assembly protein

15

15

Small-scale

0.983

High

392159

IMB5
Importin subunit beta-5

12

9

Small-scale

0.980

High

392084

SPT16
FACT complex subunit SPT16

13

9

Small-scale

0.979

High

392180

H3
Histone H3

12

20

Small-scale

0.973

High

356147

H4
Histone H4

11

13

Small-scale

0.971

High

392198

POB3
FACT complex subunit POB3

7

11

Small-scale

0.963

High

355722

H2B2
Histone H2B.2

7

20

Small-scale

0.951

High

392232

H2AZ
Histone H2A.Z

6

15

Small-scale

0.950

High

392099

CENPA
Histone H3-like centromeric protein CSE4

6

20

Small-scale

0.925

High

392008

H2A2
Histone H2A.2

5

15

Small-scale

0.903

High

392201

SWR1
Helicase SWR1

4

20

Small-scale

0.882

High

392161

INO80
Chromatin-remodeling ATPase INO80

4

20

Small-scale

0.878

High

392054

RPC2
DNA-directed RNA polymerase III subunit RPC2

3

3

High-throughput

0.847

High

392076

FUN30
ATP-dependent helicase FUN30

3

20

Small-scale

0.840

High

392205

IMB1
Importin subunit beta-1

3

5

Small-scale

0.840

High

392007

H2A1
Histone H2A.1

2

15

Small-scale

0.825

High

392178

ORC1
Origin recognition complex subunit 1

2

8

Small-scale

0.799

High

392130

IMB4
Importin subunit beta-4

2

8

Small-scale

0.778

High

392073

MCM2
DNA replication licensing factor MCM2

2

20

Small-scale

0.754

High

392190

VPS72
Vacuolar protein sorting-associated protein 72

2

1

Small-scale

0.754

High

392015

SIR3
Regulatory protein SIR3

3

7

Small-scale

0.751

High

392220

ESA1
Histone acetyltransferase ESA1

6

13

Small-scale

0.726

High

392208

YL455
PWWP domain-containing protein YLR455W

1

5

Small-scale

0.691

High

392212

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

20

High-throughput

0.691

High

392181

ARP4
Actin-related protein 4

3

9

Small-scale

0.672

High

392079

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

3

6

Small-scale

0.662

High

392107

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

3

1

Small-scale

0.656

High

392223

PSH1
RING finger protein PSH1

3

7

Small-scale

0.656

High

392078

IMB3
Importin subunit beta-3

3

7

Small-scale

0.651

High

392046

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

4

Small-scale

0.647

High

392052

SNF2
Transcription regulatory protein SNF2

1

20

Small-scale

0.647

High

392087

CHD1
Chromo domain-containing protein 1

1

20

Small-scale

0.647

High

392106

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

20

Small-scale

0.647

High

392172

VPS75
Vacuolar protein sorting-associated protein 75

1

16

Small-scale

0.647

High

392193

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

Small-scale

0.647

High

392224

SCM3
Protein SCM3

1

1

Small-scale

0.647

High

392189

GCN5
Histone acetyltransferase GCN5

3

20

Small-scale

0.633

High

392225

HIF1
HAT1-interacting factor 1

2

1

Small-scale

0.625

High

392061

RNA14
mRNA 3'-end-processing protein RNA14

2

6

High-throughput

0.621

High

392133

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

2

1

Small-scale

0.621

High

392167

RT102
Regulator of Ty1 transposition protein 102

2

1

Small-scale

0.619

High

392211

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.618

High

392019

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

High-throughput

0.618

High

392077

BTAF1
TATA-binding protein-associated factor MOT1

1

20

High-throughput

0.618

High

392157

TAF6
Transcription initiation factor TFIID subunit 6

1

1

Small-scale

0.618

High

392038

RAD9
DNA repair protein RAD9

2

1

Small-scale

0.613

High

392114

CENPU
Inner kinetochore subunit AME1

3

0

Small-scale

0.613

High

375555

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

6

High-throughput

0.611

High

392080

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

High-throughput

0.611

High

392227

ARP7
Actin-related protein 7

2

9

High-throughput

0.611

High

392110

IMB2
Importin subunit beta-2

2

6

Small-scale

0.602

High

392215

BRE1
E3 ubiquitin-protein ligase BRE1

2

18

Small-scale

0.602

High

392093

NCBP1
Nuclear cap-binding protein complex subunit 1

2

0

High-throughput

0.595

High

392051

RCC1
Guanine nucleotide exchange factor SRM1

2

5

Small-scale

0.595

High

392067

RFA2
Replication factor A protein 2

2

4

Small-scale

0.595

High

392176

ARP5
Actin-related protein 5

2

8

Small-scale

0.595

High

392191

RUVB1
RuvB-like protein 1

2

9

Small-scale

0.595

High

392135

ATAD2
ATPase histone chaperone YTA7

2

4

Small-scale

0.594

High

392030

NHP6A
Non-histone chromosomal protein 6A

2

20

Small-scale

0.594

High

392057

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

2

4

High-throughput

0.588

High

392115

SWC5
SWR1-complex protein 5

2

5

Small-scale

0.585

High

392075

MCM4
DNA replication licensing factor MCM4

2

20

Small-scale

0.584

High

392163

SWC4
SWR1-complex protein 4

2

1

Small-scale

0.584

High

392226

ARP8
Actin-like protein ARP8

2

8

Small-scale

0.584

High

392143

EPL1
Enhancer of polycomb-like protein 1

2

1

Small-scale

0.571

High

392184

ADA2
Transcriptional adapter 2

2

7

Small-scale

0.571

High

392132

IES2
Ino eighty subunit 2

2

0

Small-scale

0.569

High

392192

CTK1
CTD kinase subunit alpha

1

8

Small-scale

0.561

High

392041

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.536

High

392082

HIR2
Protein HIR2

1

8

High-throughput

0.536

High

392094

SAS3
Histone acetyltransferase SAS3

1

11

Small-scale

0.536

High

392104

NOP4
Nucleolar protein 4

1

10

High-throughput

0.536

High

392124

FHL1
Pre-rRNA-processing protein FHL1

1

3

High-throughput

0.536

High

392164

PESC
Pescadillo homolog

1

1

High-throughput

0.536

High

392182

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

19

High-throughput

0.536

High

392213

RSC3
Chromatin structure-remodeling complex protein RSC3

1

2

High-throughput

0.536

High

392219

DNLI4
DNA ligase 4

1

4

High-throughput

0.536

High

392031

NHP6B
Non-histone chromosomal protein 6B

1

20

Small-scale

0.527

High

392122

RT107
Regulator of Ty1 transposition protein 107

1

8

Small-scale

0.516

High

392217

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

392044

FUS3
Mitogen-activated protein kinase FUS3

1

3

High-throughput

0.501

High

392045

CBF1
Centromere-binding protein 1

1

3

Small-scale

0.501

High

392050

REB1
DNA-binding protein REB1

1

2

Small-scale

0.501

High

392086

SWI3
SWI/SNF complex subunit SWI3

1

12

Small-scale

0.501

High

392095

TAF14
Transcription initiation factor TFIID subunit 14

1

3

Small-scale

0.501

High

392112

HSL7
Protein arginine N-methyltransferase HSL7

1

3

Small-scale

0.501

High

392129

IES5
Ino eighty subunit 5

1

1

Small-scale

0.501

High

392153

JHD2
Histone demethylase JHD2

1

1

Small-scale

0.501

High

392169

SNF12
Transcription regulatory protein SNF12

1

3

Small-scale

0.501

High

392173

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

20

Small-scale

0.501

High

392177

HDA1
Histone deacetylase HDA1

1

12

Small-scale

0.501

High

392179

ACT
Actin

1

5

Small-scale

0.501

High

392228

RUVB2
RuvB-like protein 2

1

9

Small-scale

0.501

High

392026

SSBP1
Single-stranded nucleic acid-binding protein

1

9

High-throughput

0.500

High

392043

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.500

High

392053

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.500

High

392103

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.489

High

392141

KRI1
Protein KRI1

1

5

High-throughput

0.489

High

392170

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.489

High

392204

UTP13
U3 small nucleolar RNA-associated protein 13

1

11

High-throughput

0.489

High

381509

GAL4
Regulatory protein GAL4

1

2

Small-scale

0.481

High

392121

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.480

High

140751

FOB1
DNA replication fork-blocking protein FOB1

1

1

Small-scale

0.479

High

375187

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

High-throughput

0.479

High

388068

TOP1
DNA topoisomerase 1

1

4

Small-scale

0.479

High

392010

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

392012

KAPA
cAMP-dependent protein kinase type 1

1

7

Small-scale

0.479

High

392014

SIR2
NAD-dependent histone deacetylase SIR2

1

10

Small-scale

0.479

High

392016

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

1

High-throughput

0.479

High

392018

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.479

High

392033

RAP1
DNA-binding protein RAP1

1

1

High-throughput

0.479

High

392037

TBP
TATA-box-binding protein

1

1

High-throughput

0.479

High

392042

DPOG
DNA polymerase gamma

1

1

High-throughput

0.479

High

392048

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.479

High

392049

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

392055

RFA1
Replication factor A protein 1

1

4

Small-scale

0.479

High

392058

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.479

High

392060

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

392068

RFA3
Replication factor A protein 3

1

1

High-throughput

0.479

High

392070

SPT5
Transcription elongation factor SPT5

1

6

Small-scale

0.479

High

392071

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

392072

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

392074

RIF1
Telomere length regulator protein RIF1

1

1

High-throughput

0.479

High

392088

KU70
ATP-dependent DNA helicase II subunit 1

1

9

High-throughput

0.479

High

392089

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

2

High-throughput

0.479

High

392090

PPZ2
Serine/threonine-protein phosphatase PP-Z2

1

6

High-throughput

0.479

High

392096

CENPC
Inner kinetochore subunit MIF2

1

1

Small-scale

0.479

High

392097

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.479

High

392102

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

1

High-throughput

0.479

High

392105

GBLP
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.479

High

392108

HEK2
Heterogeneous nuclear rnp K-like protein 2

1

5

High-throughput

0.479

High

392109

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

1

High-throughput

0.479

High

392113

EXO5
Exonuclease V, mitochondrial

1

1

High-throughput

0.479

High

392117

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

392119

TRA1
Transcription-associated protein 1

1

10

Small-scale

0.479

High

392120

DMA1
E3 ubiquitin-protein ligase DMA1

1

1

Small-scale

0.479

High

392126

RSP5
E3 ubiquitin-protein ligase RSP5

1

7

High-throughput

0.479

High

392140

REF2
RNA end formation protein 2

1

1

High-throughput

0.479

High

392144

IES1
Ino eighty subunit 1

1

1

Small-scale

0.479

High

392147

CTK2
CTD kinase subunit beta

1

1

Small-scale

0.479

High

392149

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.479

High

392150

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

1

High-throughput

0.479

High

392151

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

392158

RTF1
RNA polymerase-associated protein RTF1

1

1

Small-scale

0.479

High

392160

VID30
Vacuolar import and degradation protein 30

1

7

High-throughput

0.479

High

392174

DMA2
E3 ubiquitin-protein ligase DMA2

1

1

Small-scale

0.479

High

392175

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

392185

ABF2
ARS-binding factor 2, mitochondrial

1

20

High-throughput

0.479

High

392187

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

1

High-throughput

0.479

High

392188

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

392195

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.479

High

392196

KU80
ATP-dependent DNA helicase II subunit 2

1

9

High-throughput

0.479

High

392200

TRI1
Protein TRI1

1

4

High-throughput

0.479

High

392202

HRQ1
ATP-dependent helicase HRQ1

1

6

Small-scale

0.479

High

392203

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

1

High-throughput

0.479

High

392214

BDF2
Bromodomain-containing factor 2

1

20

High-throughput

0.479

High

392216

SUB2
ATP-dependent RNA helicase SUB2

1

4

High-throughput

0.479

High

392221

NEW1
[NU+] prion formation protein 1

1

4

High-throughput

0.479

High

392229

CMR1
DNA damage-binding protein CMR1

1

12

High-throughput

0.479

High

392233

SUS1
Transcription and mRNA export factor SUS1

1

1

Small-scale

0.479

High

392168

DCP2
m7GpppN-mRNA hydrolase

1

0

Small-scale

0.458

High

392206

NEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

392207

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

392209

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

392218

THP1
Nuclear mRNA export protein THP1

1

0

Small-scale

0.458

High

392234

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.458

High

392040

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

Small-scale

0.457

High

392145

IOC3
ISWI one complex protein 3

1

1

Small-scale

0.457

High

392027

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

392028

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

392029

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

392085

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

392118

YNG2
Chromatin modification-related protein YNG2

1

13

Small-scale

0.445

High

392128

EAF5
Chromatin modification-related protein EAF5

1

1

Small-scale

0.445

High

392131

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

392152

EAF6
Chromatin modification-related protein EAF6

1

1

Small-scale

0.445

High

392210

ESF1
Pre-rRNA-processing protein ESF1

1

2

High-throughput

0.445

High

141031

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.437

High

357757

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

382827

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

392009

RL26A
Large ribosomal subunit protein uL24A

1

7

High-throughput

0.437

High

392011

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

392013

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

392017

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

392020

MYO1
Myosin-1

1

2

Small-scale

0.437

High

392022

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

392024

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

392025

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

392035

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

392036

DPOLA
DNA polymerase alpha catalytic subunit A

1

1

Small-scale

0.437

High

392047

SEC18
Vesicular-fusion protein SEC18

1

4

High-throughput

0.437

High

392062

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.437

High

392063

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.437

High

392064

KRR1
KRR1 small subunit processome component

1

6

High-throughput

0.437

High

392065

CSM1
Monopolin complex subunit CSM1

1

1

Small-scale

0.437

High

392066

SPB4
ATP-dependent rRNA helicase SPB4

1

9

High-throughput

0.437

High

392069

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

392081

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

1

High-throughput

0.437

High

392083

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.437

High

392092

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

392101

EBP2
rRNA-processing protein EBP2

1

3

High-throughput

0.437

High

392116

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

392134

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.437

High

392136

NTA1
Protein N-terminal amidase

1

1

High-throughput

0.437

High

392137

MLP2
Protein MLP2

1

17

High-throughput

0.437

High

392138

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

392139

FKS2
1,3-beta-glucan synthase component GSC2

1

1

High-throughput

0.437

High

392146

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.437

High

392148

CTK3
CTD kinase subunit gamma

1

1

Small-scale

0.437

High

392154

SEC16
COPII coat assembly protein SEC16

1

1

High-throughput

0.437

High

392156

ASE1
Anaphase spindle elongation protein

1

17

High-throughput

0.437

High

392171

GIS2
Zinc finger protein GIS2

1

4

High-throughput

0.437

High

392183

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

392186

GIP3
GLC7-interacting protein 3

1

1

High-throughput

0.437

High

392194

DHR1
Probable ATP-dependent RNA helicase DHR1

1

10

High-throughput

0.437

High

392197

UTP14
U3 small nucleolar RNA-associated protein 14

1

3

High-throughput

0.437

High

392199

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.437

High

392230

RQC2
Ribosome quality control complex subunit 2

1

1

High-throughput

0.437

High

392231

GLT1
Glutamate synthase [NADH]

1

2

High-throughput

0.437

High

392032

MCM1
Pheromone receptor transcription factor

1

0

High-throughput

0.426

High

392056

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

392023

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.407

High

392039

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.407

High

392091

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

392100

LHS1
Heat shock protein 70 homolog LHS1

1

10

High-throughput

0.407

High

392123

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.407

High

392127

HSP7E
Heat shock protein SSC3, mitochondrial

1

10

High-throughput

0.407

High

392142

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.407

High

392162

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

High-throughput

0.407

High

392222

ENV7
Serine/threonine-protein kinase ENV7

1

0

Small-scale

0.261

Low

381668

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

392021

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

392034

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.249

Low

392098

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

392111

GID4
Vacuolar import and degradation protein 24

1

0

High-throughput

0.249

Low

392125

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

392155

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

392165

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.249

Low

392166

CENPQ
Inner kinetochore subunit OKP1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024