Protein: RPA2
DNA-directed RNA polymerase I subunit RPA135 (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (A135) (DNA-directed RNA polymerase I polypeptide 2) (RNA polymerase I subunit 2)

Gene: RPA2, RPA135
Organism: Saccharomyces cerevisiae S288C
Interactions: 208
UniProt ID: P22138

Gene Ontology (top 5):
GO:0001054 - RNA polymerase I activity
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005736 - RNA polymerase I complex
GO:0006360 - transcription by RNA polymerase I

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

501319

RPA1
DNA-directed RNA polymerase I subunit RPA190

16

20

Small-scale

0.985

High

429629

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

9

16

Small-scale

0.974

High

604521

RPA12
DNA-directed RNA polymerase I subunit RPA12

9

13

Small-scale

0.972

High

604601

RPA49
DNA-directed RNA polymerase I subunit RPA49

9

5

Small-scale

0.966

High

604577

RPA43
DNA-directed RNA polymerase I subunit RPA43

9

1

Small-scale

0.965

High

604511

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

6

9

Small-scale

0.949

High

604566

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

6

Small-scale

0.891

High

604498

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

9

Small-scale

0.891

High

604579

RPA34
DNA-directed RNA polymerase I subunit RPA34

5

0

High-throughput

0.861

High

604510

SPT5
Transcription elongation factor SPT5

3

4

Small-scale

0.853

High

593202

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

8

High-throughput

0.776

High

604538

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

2

2

Small-scale

0.776

High

355780

H2B2
Histone H2B.2

2

4

High-throughput

0.759

High

557875

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

16

Small-scale

0.754

High

604497

RPA2
DNA-directed RNA polymerase I subunit RPA135

2

10

High-throughput

0.754

High

604499

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

10

High-throughput

0.754

High

604585

RPA14
DNA-directed RNA polymerase I subunit RPA14

2

0

High-throughput

0.736

High

593101

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

6

9

High-throughput

0.735

High

490350

HSP71
Heat shock protein SSA1

6

6

High-throughput

0.722

High

604589

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

1

High-throughput

0.705

High

604527

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

2

High-throughput

0.665

High

356250

H4
Histone H4

3

3

High-throughput

0.662

High

604616

RRP5
rRNA biogenesis protein RRP5

2

1

Small-scale

0.659

High

604646

IF6
Eukaryotic translation initiation factor 6

3

1

High-throughput

0.650

High

604600

CDC14
Tyrosine-protein phosphatase CDC14

3

4

Small-scale

0.640

High

604580

NET1
Nucleolar protein NET1

4

2

Small-scale

0.623

High

604505

RAD51
DNA repair protein RAD51

2

5

High-throughput

0.621

High

392294

H2A2
Histone H2A.2

1

3

High-throughput

0.618

High

406790

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.618

High

415885

DED1
ATP-dependent RNA helicase DED1

1

1

High-throughput

0.618

High

604509

NSR1
Nuclear localization sequence-binding protein

1

1

High-throughput

0.618

High

604512

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.618

High

604542

RDH54
DNA repair and recombination protein RDH54

1

3

High-throughput

0.618

High

604597

H3
Histone H3

1

4

High-throughput

0.618

High

604612

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

13

High-throughput

0.618

High

604619

MRD1
Multiple RNA-binding domain-containing protein 1

1

3

High-throughput

0.618

High

493210

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.611

High

510272

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.611

High

593276

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

6

High-throughput

0.611

High

604500

SAN1
Protein SAN1

2

1

Small-scale

0.611

High

604644

RUVB2
RuvB-like protein 2

2

8

High-throughput

0.611

High

604503

SIS1
Protein SIS1

2

3

High-throughput

0.601

High

604535

NDK
Nucleoside diphosphate kinase

2

0

High-throughput

0.595

High

604536

DOA1
Protein DOA1

2

4

High-throughput

0.588

High

604627

RIX7
Ribosome biogenesis ATPase RIX7

2

2

High-throughput

0.588

High

604540

NOP4
Nucleolar protein 4

1

0

High-throughput

0.586

High

604611

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.586

High

416193

SIR2
NAD-dependent histone deacetylase SIR2

2

2

Small-scale

0.584

High

604515

HS104
Heat shock protein 104

2

6

High-throughput

0.584

High

604575

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

365798

HSP82
ATP-dependent molecular chaperone HSP82

2

4

High-throughput

0.571

High

597787

PWP1
Periodic tryptophan protein 1

2

5

High-throughput

0.571

High

604599

SEN1
Helicase SEN1

2

3

Small-scale

0.571

High

604543

ATR
Serine/threonine-protein kinase MEC1

1

0

Small-scale

0.564

High

604530

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.559

High

141156

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.553

High

405434

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.553

High

593496

DBP3
ATP-dependent RNA helicase DBP3

1

2

High-throughput

0.553

High

604524

DRS1
ATP-dependent RNA helicase DRS1

1

5

High-throughput

0.553

High

604544

MAK5
ATP-dependent RNA helicase MAK5

1

6

High-throughput

0.553

High

604606

HAS1
ATP-dependent RNA helicase HAS1

1

6

High-throughput

0.553

High

604640

HSP42
Heat shock protein 42

2

2

High-throughput

0.549

High

519559

ERF1
Eukaryotic peptide chain release factor subunit 1

2

2

High-throughput

0.537

High

360738

TBB
Tubulin beta chain

1

1

High-throughput

0.536

High

498437

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

539305

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.536

High

604501

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

5

High-throughput

0.536

High

604528

SPT4
Transcription elongation factor SPT4

1

1

Small-scale

0.536

High

604558

FHP
Flavohemoprotein

1

1

High-throughput

0.536

High

479925

RS6A
Small ribosomal subunit protein eS6A

2

2

High-throughput

0.533

High

604573

BUD27
Bud site selection protein 27

2

2

Small-scale

0.533

High

604645

NOP58
Nucleolar protein 58

2

3

High-throughput

0.533

High

424343

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.513

High

425296

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

477127

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

604617

RRP45
Exosome complex component RRP45

1

0

High-throughput

0.493

High

340021

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.489

High

343271

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.489

High

389846

VDAC1
Mitochondrial outer membrane protein porin 1

1

3

High-throughput

0.489

High

540025

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

4

High-throughput

0.489

High

604517

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

6

High-throughput

0.489

High

604519

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

3

High-throughput

0.489

High

604520

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.489

High

604547

GID4
Vacuolar import and degradation protein 24

1

1

High-throughput

0.489

High

604559

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.489

High

604570

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.489

High

604594

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.489

High

604642

AHA1
Hsp90 co-chaperone AHA1

1

1

High-throughput

0.489

High

604563

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

0

High-throughput

0.486

High

408271

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

High-throughput

0.479

High

514145

NHP6A
Non-histone chromosomal protein 6A

1

5

High-throughput

0.479

High

514234

NHP6B
Non-histone chromosomal protein 6B

1

5

High-throughput

0.479

High

549954

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.479

High

604502

CG23
G2/mitotic-specific cyclin-3

1

1

High-throughput

0.479

High

604508

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

604513

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

604514

PTP2
Tyrosine-protein phosphatase 2

1

1

High-throughput

0.479

High

604516

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

604523

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

604529

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

604533

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

604541

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

604545

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.479

High

604548

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.479

High

604551

ECM29
Proteasome component ECM29

1

3

High-throughput

0.479

High

604552

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

604553

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

604562

SNU13
13 kDa ribonucleoprotein-associated protein

1

1

High-throughput

0.479

High

604565

ATAD2
ATPase histone chaperone YTA7

1

5

High-throughput

0.479

High

604567

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

604568

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

604569

NOP2
25S rRNA

1

1

High-throughput

0.479

High

604586

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

604588

MSN5
Protein MSN5

1

3

Small-scale

0.479

High

604590

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.479

High

604596

RL15B
Large ribosomal subunit protein eL15B

1

3

High-throughput

0.479

High

604605

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

604607

VHS1
Serine/threonine-protein kinase VHS1

1

1

High-throughput

0.479

High

604609

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.479

High

604610

HMO1
High mobility group protein 1

1

7

High-throughput

0.479

High

604615

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.479

High

604618

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

1

Small-scale

0.479

High

604620

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

604621

FKBP4
FK506-binding protein 4

1

4

High-throughput

0.479

High

604622

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

604625

IWR1
RNA polymerase II nuclear localization protein IWR1

1

1

High-throughput

0.479

High

604631

SGO1
Shugoshin

1

2

High-throughput

0.479

High

604636

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

5

High-throughput

0.479

High

604637

SAS10
Something about silencing protein 10

1

1

High-throughput

0.479

High

604638

MAK21
Ribosome biogenesis protein MAK21

1

1

High-throughput

0.479

High

604639

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

604643

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

604613

SPC24
Kinetochore protein SPC24

1

0

Small-scale

0.460

High

140763

FOB1
DNA replication fork-blocking protein FOB1

1

0

High-throughput

0.458

High

604539

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

604546

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

604578

TRM61
tRNA

1

0

High-throughput

0.458

High

604591

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

604592

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

604593

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

604604

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

604608

FIN1
Filament protein FIN1

1

0

Small-scale

0.458

High

604628

NOC3
Nucleolar complex-associated protein 3

1

0

High-throughput

0.458

High

604634

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.458

High

604635

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

604648

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

531658

DHAS
Aspartate-semialdehyde dehydrogenase

1

2

High-throughput

0.445

High

561213

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.445

High

604522

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

604555

CAJ1
Protein CAJ1

1

4

High-throughput

0.445

High

604564

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

604587

PFD6
Prefoldin subunit 6

1

4

High-throughput

0.445

High

357886

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

382954

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

406289

RL15A
Large ribosomal subunit protein eL15A

1

3

High-throughput

0.437

High

407730

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

413308

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

425770

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

470865

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472021

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

480486

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

482086

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

524168

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

549328

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.437

High

604504

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.437

High

604518

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

1

High-throughput

0.437

High

604525

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

604526

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

604532

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

604549

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

604554

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

4

High-throughput

0.437

High

604557

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

604560

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.437

High

604571

KRI1
Protein KRI1

1

1

High-throughput

0.437

High

604572

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

604581

GPN1
GPN-loop GTPase 1

1

13

Small-scale

0.437

High

604583

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

604584

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

604595

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.437

High

604598

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.437

High

604602

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

604603

TOF2
Topoisomerase 1-associated factor 2

1

2

High-throughput

0.437

High

604624

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

604629

PSR2
Probable phosphatase PSR2

1

4

High-throughput

0.437

High

604632

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

424993

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.426

High

604556

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.426

High

604574

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.426

High

399331

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

427177

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.407

High

604531

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.407

High

604550

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.407

High

604561

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.407

High

604534

AP1B1
AP-1 complex subunit beta-1

2

0

High-throughput

0.313

High

604576

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

481591

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

604506

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

604507

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

604537

EBP2
rRNA-processing protein EBP2

1

0

High-throughput

0.249

Low

604582

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.249

Low

604614

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.249

Low

604623

BFR2
Protein BFR2

1

0

High-throughput

0.249

Low

604626

NOP6
Nucleolar protein 6

1

0

High-throughput

0.249

Low

604630

BRX1
Ribosome biogenesis protein BRX1

1

0

High-throughput

0.249

Low

604633

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.249

Low

604647

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

High-throughput

0.249

Low

604641

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024