Protein: MCM6
DNA replication licensing factor MCM6 (EC 3.6.4.12) (Minichromosome maintenance protein 6)

Gene: MCM6
Organism: Saccharomyces cerevisiae S288C
Interactions: 131
UniProt ID: P53091

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

675537

MCM4
DNA replication licensing factor MCM4

20

20

Small-scale

0.986

High

859026

CDC45
Cell division control protein 45

15

18

Small-scale

0.981

High

667606

MCM2
DNA replication licensing factor MCM2

13

20

Small-scale

0.980

High

859011

SLD5
DNA replication complex GINS protein SLD5

13

16

Small-scale

0.975

High

811831

CDT1
Cell division cycle protein CDT1

9

3

Small-scale

0.972

High

622176

MCM3
DNA replication licensing factor MCM3

8

20

Small-scale

0.962

High

667872

MCM5
Minichromosome maintenance protein 5

8

19

Small-scale

0.956

High

744781

MCM7
DNA replication licensing factor MCM7

7

20

Small-scale

0.950

High

859034

PSF1
DNA replication complex GINS protein PSF1

4

11

Small-scale

0.885

High

859029

PSF3
DNA replication complex GINS protein PSF3

3

9

Small-scale

0.840

High

772606

PSF2
DNA replication complex GINS protein PSF2

2

11

Small-scale

0.778

High

688655

MCM10
Minichromosome maintenance protein 10

9

14

Small-scale

0.758

High

412576

CDC7
Cell division control protein 7

7

20

Small-scale

0.744

High

858993

SLD3
DNA replication regulator SLD3

5

3

Small-scale

0.710

High

859006

CTF4
DNA polymerase alpha-binding protein

4

8

Small-scale

0.676

High

858997

TOF1
Topoisomerase 1-associated factor 1

3

9

Small-scale

0.656

High

687544

DBF4
DDK kinase regulatory subunit DBF4

2

3

Small-scale

0.625

High

566629

VATA
V-type proton ATPase catalytic subunit A

2

5

High-throughput

0.588

High

859014

RPN9
26S proteasome regulatory subunit RPN9

2

1

High-throughput

0.588

High

634888

MRC1
Mediator of replication checkpoint protein 1

2

3

Small-scale

0.584

High

692848

SPT16
FACT complex subunit SPT16

2

5

Small-scale

0.584

High

859018

CSM3
Chromosome segregation in meiosis protein 3

2

3

Small-scale

0.584

High

842055

ORC5
Origin recognition complex subunit 5

1

6

Small-scale

0.575

High

859000

ORC4
Origin recognition complex subunit 4

1

20

Small-scale

0.575

High

340215

KPYK1
Pyruvate kinase 1

2

5

High-throughput

0.571

High

494485

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.571

High

512048

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.571

High

716293

SPT10
Protein SPT10

2

3

High-throughput

0.571

High

785114

MPG1
Mannose-1-phosphate guanyltransferase

2

2

High-throughput

0.571

High

859003

H3
Histone H3

2

20

High-throughput

0.571

High

420573

SPT2
Protein SPT2

2

0

Small-scale

0.570

High

631984

RS2
Small ribosomal subunit protein uS5

2

0

Small-scale

0.559

High

356602

H4
Histone H4

2

8

High-throughput

0.552

High

697969

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.541

High

743165

BOB1
Protein BOB1

1

7

High-throughput

0.541

High

755645

BZZ1
Protein BZZ1

1

2

High-throughput

0.541

High

764097

RV167
Reduced viability upon starvation protein 167

1

4

High-throughput

0.541

High

797820

LSB3
LAS seventeen-binding protein 3

1

3

High-throughput

0.541

High

859016

MYO5
Myosin-5

1

9

High-throughput

0.541

High

859020

CYK2
Cytokinesis protein 2

1

3

High-throughput

0.541

High

859022

PIN3
[PSI+] inducibility protein 3

1

6

High-throughput

0.541

High

676220

XPO1
Exportin-1

1

3

High-throughput

0.536

High

715362

SPT7
Transcriptional activator SPT7

1

8

High-throughput

0.536

High

859010

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.536

High

625947

PSB2
Proteasome subunit beta type-2

1

3

High-throughput

0.515

High

859032

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

602364

DPOE
DNA polymerase epsilon catalytic subunit A

1

10

Small-scale

0.501

High

693726

IME2
Meiosis induction protein kinase IME2/SME1

1

16

Small-scale

0.501

High

711172

SLD2
DNA replication regulator SLD2

1

3

Small-scale

0.501

High

858999

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.501

High

566203

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.486

High

634692

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.486

High

416234

SIR2
NAD-dependent histone deacetylase SIR2

1

14

Small-scale

0.481

High

774058

NDC80
Kinetochore protein NDC80

1

13

Small-scale

0.481

High

859024

NOC3
Nucleolar complex-associated protein 3

1

1

Small-scale

0.481

High

333857

ADH1
Alcohol dehydrogenase 1

1

3

High-throughput

0.479

High

340717

PGK
Phosphoglycerate kinase

1

3

High-throughput

0.479

High

402990

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

6

Small-scale

0.479

High

407192

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

411045

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

485777

IF4A
ATP-dependent RNA helicase eIF4A

1

9

High-throughput

0.479

High

544103

HSC82
ATP-dependent molecular chaperone HSC82

1

12

High-throughput

0.479

High

561025

EF3A
Elongation factor 3A

1

5

High-throughput

0.479

High

562413

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

4

High-throughput

0.479

High

607309

RFA1
Replication factor A protein 1

1

8

High-throughput

0.479

High

615289

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.479

High

622882

DPB2
DNA polymerase epsilon subunit B

1

3

Small-scale

0.479

High

644926

RS5
Small ribosomal subunit protein uS7

1

3

High-throughput

0.479

High

662805

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

680870

HS104
Heat shock protein 104

1

5

High-throughput

0.479

High

698879

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

727629

LRG1
Rho-GTPase-activating protein LRG1

1

10

High-throughput

0.479

High

728283

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

730020

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

730861

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.479

High

756205

RT107
Regulator of Ty1 transposition protein 107

1

3

Small-scale

0.479

High

858696

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

858994

CDH1
APC/C activator protein CDH1

1

12

Small-scale

0.479

High

858996

HST2
NAD-dependent protein deacetylase HST2

1

14

High-throughput

0.479

High

859002

ACT
Actin

1

7

High-throughput

0.479

High

859005

SEN1
Helicase SEN1

1

1

Small-scale

0.479

High

859007

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

859015

SIZ1
E3 SUMO-protein ligase SIZ1

1

2

High-throughput

0.479

High

859017

POB3
FACT complex subunit POB3

1

10

Small-scale

0.479

High

859021

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

859023

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

859027

DIA2
Protein DIA2

1

3

Small-scale

0.479

High

859030

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

859031

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

High-throughput

0.479

High

859033

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

859036

CMR1
DNA damage-binding protein CMR1

1

9

High-throughput

0.479

High

368751

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.460

High

409911

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.460

High

817339

ASK10
Activator of SKN7 protein 10

1

0

Small-scale

0.460

High

859001

DAK1
Dihydroxyacetone kinase 1

1

0

High-throughput

0.458

High

859012

SKY1
Serine/threonine-protein kinase SKY1

1

16

High-throughput

0.457

High

355554

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

368242

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

419363

HAP2
Transcriptional activator HAP2

1

2

High-throughput

0.445

High

454409

TBA1
Tubulin alpha-1 chain

1

7

High-throughput

0.445

High

515073

MCM1
Pheromone receptor transcription factor

1

1

High-throughput

0.445

High

556177

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.445

High

605242

AFT1
Iron-regulated transcriptional activator AFT1

1

1

High-throughput

0.445

High

628878

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

629005

SCJ1
DnaJ-related protein SCJ1

1

4

High-throughput

0.445

High

689914

ASF1
Histone chaperone ASF1

1

12

High-throughput

0.445

High

733272

SET3
SET domain-containing protein 3

1

6

High-throughput

0.445

High

858992

HOS2
Probable histone deacetylase HOS2

1

4

High-throughput

0.445

High

859013

GIS1
Transcriptional activator/repressor GIS1

1

9

High-throughput

0.445

High

859025

RSC58
Chromatin structure-remodeling complex protein RSC58

1

1

High-throughput

0.445

High

859035

RLF2
Chromatin assembly factor 1 subunit p90

1

5

High-throughput

0.445

High

859037

H2AZ
Histone H2A.Z

1

20

High-throughput

0.445

High

767589

NU157
Nucleoporin NUP157

1

1

Small-scale

0.439

High

859009

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.438

High

342974

ENO2
Enolase 2

1

5

High-throughput

0.437

High

343655

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.437

High

358163

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

405727

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

858998

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.437

High

859004

NUM1
Nuclear migration protein NUM1

1

18

High-throughput

0.437

High

859028

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

609115

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

691916

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.426

High

757443

SPT8
Transcription factor SPT8

1

0

High-throughput

0.426

High

805215

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.426

High

810075

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

858995

PESC
Pescadillo homolog

1

0

Small-scale

0.426

High

859019

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.426

High

859008

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

16

High-throughput

0.407

High

767898

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.282

High

140788

FOB1
DNA replication fork-blocking protein FOB1

1

0

Small-scale

0.251

Low


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Last updated: 15 Jul 2024