Protein: SYMC
Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)

Gene: SYMC, MES1
Organism: Saccharomyces cerevisiae S288C
Interactions: 91
UniProt ID: P00958

Gene Ontology (top 5):
GO:0004825 - methionine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006424 - glutamyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

343839

ARC1
tRNA-aminoacylation cofactor ARC1

12

11

Small-scale

0.760

High

343838

SYEC
Glutamate--tRNA ligase, cytoplasmic

5

9

Small-scale

0.712

High

343774

SYMC
Methionine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.665

High

343806

SYLC
Leucine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.618

High

343797

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.611

High

343843

TAF6
Transcription initiation factor TFIID subunit 6

2

1

High-throughput

0.588

High

343837

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

343776

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.571

High

343799

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.571

High

343804

SIS1
Protein SIS1

2

6

High-throughput

0.571

High

343834

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

343795

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.536

High

343850

IMA1
Importin subunit alpha

1

0

High-throughput

0.513

High

343803

DBF2
Cell cycle protein kinase DBF2

1

6

High-throughput

0.501

High

343808

KCC1
Calcium/calmodulin-dependent protein kinase I

1

2

High-throughput

0.501

High

343832

KC13
Casein kinase I homolog 3

1

3

High-throughput

0.501

High

343809

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.493

High

343853

STE20
Serine/threonine-protein kinase STE20

1

5

Small-scale

0.481

High

141018

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

343778

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

343779

SYTC
Threonine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

343780

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

13

High-throughput

0.479

High

343781

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

343782

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

343783

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

343784

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

343787

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

343789

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.479

High

343791

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

343793

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

343800

SYKC
Lysine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.479

High

343811

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

343812

HS104
Heat shock protein 104

1

6

High-throughput

0.479

High

343813

ZUO1
Zuotin

1

7

High-throughput

0.479

High

343816

RSSA1
Small ribosomal subunit protein uS2A

1

6

High-throughput

0.479

High

343817

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

343819

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.479

High

343821

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

343822

GBLP
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.479

High

343823

SYG
Glycine--tRNA ligase 1, mitochondrial

1

13

High-throughput

0.479

High

343825

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

343826

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

343827

YHI0
Putative proline--tRNA ligase YHR020W

1

11

High-throughput

0.479

High

343830

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

343831

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

343842

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

343846

SYC
Cysteine--tRNA ligase

1

9

High-throughput

0.479

High

343848

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

343851

ESP1
Separin

1

1

High-throughput

0.479

High

343852

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

343859

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

343862

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

343775

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

343786

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

343792

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

343807

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

343820

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

Small-scale

0.458

High

343828

ATU2
Copper-transporting ATPase

1

0

High-throughput

0.458

High

343854

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

343855

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

343858

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

343849

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.457

High

343785

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

343790

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.445

High

343796

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

343801

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

343805

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

343814

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

343815

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

343829

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.445

High

343836

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.445

High

343847

JJJ1
J protein JJJ1

1

4

High-throughput

0.445

High

343810

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

343824

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

343833

SIT1
Siderophore iron transporter 1

1

1

High-throughput

0.437

High

343835

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

343857

ENB1
Siderophore iron transporter ENB1

1

1

High-throughput

0.437

High

343788

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

343794

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.426

High

343844

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

High-throughput

0.426

High

343798

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.407

High

343840

HLJ1
Protein HLJ1

1

4

High-throughput

0.407

High

343856

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.279

Low

343861

HIF1
HAT1-interacting factor 1

1

0

High-throughput

0.269

Low

343818

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

343777

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.249

Low

343802

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.249

Low

343841

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.249

Low

343845

FRE4
Ferric reductase transmembrane component 4

1

0

High-throughput

0.249

Low

343860

TRMB
tRNA

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024