Protein: RPA1
DNA-directed RNA polymerase I subunit RPA190 (EC 2.7.7.6) (DNA-directed RNA polymerase I 190 kDa polypeptide) (A190) (DNA-directed RNA polymerase I largest subunit)

Gene: RPA1, RPA190
Organism: Saccharomyces cerevisiae S288C
Interactions: 154
UniProt ID: P10964

Gene Ontology (top 5):
GO:0001054 - RNA polymerase I activity
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005736 - RNA polymerase I complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

501319

RPA2
DNA-directed RNA polymerase I subunit RPA135

16

20

Small-scale

0.985

High

501315

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

12

14

Small-scale

0.980

High

501380

RPA43
DNA-directed RNA polymerase I subunit RPA43

12

1

Small-scale

0.977

High

429597

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

10

18

Small-scale

0.976

High

501316

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

9

10

Small-scale

0.972

High

501399

RPA49
DNA-directed RNA polymerase I subunit RPA49

9

3

Small-scale

0.968

High

501339

RPA12
DNA-directed RNA polymerase I subunit RPA12

8

20

Small-scale

0.963

High

501317

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

6

10

Small-scale

0.943

High

501329

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

5

11

Small-scale

0.919

High

501355

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

5

2

Small-scale

0.908

High

501328

SPT5
Transcription elongation factor SPT5

4

3

Small-scale

0.886

High

501374

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

9

Small-scale

0.881

High

501386

RPA14
DNA-directed RNA polymerase I subunit RPA14

5

0

Small-scale

0.865

High

501304

RPA1
DNA-directed RNA polymerase I subunit RPA190

2

11

Small-scale

0.759

High

501312

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

18

Small-scale

0.754

High

501320

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

6

11

Small-scale

0.730

High

501381

RPA34
DNA-directed RNA polymerase I subunit RPA34

7

0

Small-scale

0.706

High

501382

NET1
Nucleolar protein NET1

4

1

Small-scale

0.691

High

501415

RIX7
Ribosome biogenesis ATPase RIX7

3

4

High-throughput

0.657

High

501305

SSB1
Ribosome-associated molecular chaperone SSB1

3

7

High-throughput

0.650

High

501409

RRP5
rRNA biogenesis protein RRP5

3

4

Small-scale

0.624

High

501314

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

8

Small-scale

0.618

High

501331

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.618

High

501335

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.618

High

490132

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.611

High

493021

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.601

High

501354

DOA1
Protein DOA1

2

7

High-throughput

0.588

High

141108

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.586

High

416184

SIR2
NAD-dependent histone deacetylase SIR2

2

5

Small-scale

0.584

High

501357

GBLP
Small ribosomal subunit protein RACK1

2

8

Small-scale

0.584

High

501379

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

501398

CDC14
Tyrosine-protein phosphatase CDC14

2

5

Small-scale

0.584

High

501394

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

5

High-throughput

0.561

High

501372

SSB2
Ribosome-associated molecular chaperone SSB2

2

7

High-throughput

0.552

High

501310

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

501313

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.536

High

501324

SGF29
SAGA-associated factor 29

1

1

High-throughput

0.536

High

501351

SPT7
Transcriptional activator SPT7

1

16

High-throughput

0.536

High

501358

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.536

High

501389

FMP48
Probable serine/threonine-protein kinase FMP48

1

2

High-throughput

0.536

High

501400

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

501417

RBX1
RING-box protein HRT1

1

1

High-throughput

0.536

High

501378

BUD27
Bud site selection protein 27

2

2

Small-scale

0.533

High

501330

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.518

High

405378

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.517

High

501322

SIS1
Protein SIS1

1

4

High-throughput

0.515

High

501321

CG23
G2/mitotic-specific cyclin-3

1

0

High-throughput

0.513

High

501376

YCH1
CDC25-like phosphatase YCH1

1

0

High-throughput

0.513

High

501388

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.513

High

477086

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

501325

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

501416

PSR2
Probable phosphatase PSR2

1

7

High-throughput

0.489

High

501387

PFD6
Prefoldin subunit 6

1

3

High-throughput

0.481

High

356195

H4
Histone H4

1

4

High-throughput

0.479

High

376599

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

Small-scale

0.479

High

392260

H2A2
Histone H2A.2

1

6

High-throughput

0.479

High

406709

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

408252

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

3

High-throughput

0.479

High

413254

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

479872

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

501307

DPOLA
DNA polymerase alpha catalytic subunit A

1

1

Small-scale

0.479

High

501323

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

501326

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.479

High

501327

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

501332

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

501333

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

1

Small-scale

0.479

High

501334

HS104
Heat shock protein 104

1

7

High-throughput

0.479

High

501341

STH1
Nuclear protein STH1/NPS1

1

9

Small-scale

0.479

High

501342

PP12
Serine/threonine-protein phosphatase PP1-2

1

7

Small-scale

0.479

High

501343

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

501347

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

501352

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

501363

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

501366

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

501373

ATAD2
ATPase histone chaperone YTA7

1

7

High-throughput

0.479

High

501375

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

501392

THO2
THO complex subunit 2

1

2

Small-scale

0.479

High

501395

H3
Histone H3

1

6

High-throughput

0.479

High

501397

SEN1
Helicase SEN1

1

5

Small-scale

0.479

High

501403

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.479

High

501404

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

501406

ESP1
Separin

1

1

High-throughput

0.479

High

501407

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.479

High

501408

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

501411

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

501412

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

10

Small-scale

0.479

High

501414

IWR1
RNA polymerase II nuclear localization protein IWR1

1

2

High-throughput

0.479

High

501418

SGO1
Shugoshin

1

1

High-throughput

0.479

High

501421

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

501425

SMT3
Ubiquitin-like protein SMT3

1

2

High-throughput

0.479

High

501427

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

501346

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

501361

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

407673

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

501337

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

501348

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

501356

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

501360

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

501377

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

501384

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

501391

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

501393

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

501405

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

501410

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

Small-scale

0.458

High

501419

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

501422

PSH1
RING finger protein PSH1

1

0

High-throughput

0.458

High

501423

MAK21
Ribosome biogenesis protein MAK21

1

0

High-throughput

0.458

High

501424

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

343508

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.457

High

365667

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

501309

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.445

High

501364

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

501367

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

Small-scale

0.445

High

501368

SPT8
Transcription factor SPT8

1

1

High-throughput

0.445

High

501369

CAJ1
Protein CAJ1

1

3

High-throughput

0.445

High

446093

MYO1
Myosin-1

1

1

Small-scale

0.437

High

470807

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

482030

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

482654

RL19B
Large ribosomal subunit protein eL19

1

2

High-throughput

0.437

High

501306

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

501340

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.437

High

501344

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

501345

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

501350

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

501362

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

501370

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

501383

GPN1
GPN-loop GTPase 1

1

9

Small-scale

0.437

High

501396

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

501401

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

501413

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

501420

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

454138

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

501318

REB1
DNA-binding protein REB1

1

0

Small-scale

0.426

High

501353

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.426

High

501402

UBC7
Ubiquitin-conjugating enzyme E2 7

1

5

High-throughput

0.417

High

389832

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.407

High

501308

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.407

High

501311

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.407

High

501338

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.407

High

501349

HSP78
Heat shock protein 78, mitochondrial

1

9

High-throughput

0.407

High

501371

PFD2
Prefoldin subunit 2

1

3

High-throughput

0.407

High

501426

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

378262

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

501336

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.251

Low

357831

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

382902

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

425708

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

471972

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

480430

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

501365

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

501385

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

501390

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

501359

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024