Protein: PFKA2
ATP-dependent 6-phosphofructokinase subunit beta (EC 2.7.1.11) (ATP-dependent 6-phosphofructokinase) (ATP-PFK) (Phosphofructokinase 2) (Phosphohexokinase)

Gene: PFKA2, PFK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 190
UniProt ID: P16862

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

562174

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

11

13

Small-scale

0.976

High

367702

EF1A
Elongation factor 1-alpha

2

1

High-throughput

0.618

High

498428

METK1
S-adenosylmethionine synthase 1

2

1

High-throughput

0.618

High

339417

CDK1
Cyclin-dependent kinase 1

2

3

High-throughput

0.594

High

562328

SIS1
Protein SIS1

3

2

High-throughput

0.593

High

562311

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

13

High-throughput

0.590

High

562404

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

562427

GCN5
Histone acetyltransferase GCN5

2

2

High-throughput

0.574

High

510164

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.571

High

470840

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.558

High

562448

RS10A
Small ribosomal subunit protein eS10A

2

1

High-throughput

0.558

High

485631

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.536

High

562315

FKBP
FK506-binding protein 1

1

1

High-throughput

0.536

High

562316

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

High-throughput

0.536

High

562322

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

2

High-throughput

0.536

High

562330

KIN82
Serine/threonine-protein kinase KIN82

1

3

High-throughput

0.536

High

562354

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.536

High

562357

SPT7
Transcriptional activator SPT7

1

3

High-throughput

0.536

High

562389

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.536

High

562418

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

562423

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

562417

COPA
Coatomer subunit alpha

2

3

High-throughput

0.533

High

562408

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

1

High-throughput

0.508

High

412641

KAPA
cAMP-dependent protein kinase type 1

1

5

High-throughput

0.501

High

419792

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.501

High

562312

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.501

High

562318

MCK1
Protein kinase MCK1

1

3

High-throughput

0.501

High

562350

SWE1
Mitosis inhibitor protein kinase SWE1

1

8

High-throughput

0.501

High

562371

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

8

High-throughput

0.501

High

562374

KSP1
Serine/threonine-protein kinase KSP1

1

7

High-throughput

0.501

High

562390

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

High-throughput

0.501

High

562444

PSK2
Serine/threonine-protein kinase PSK2

1

6

High-throughput

0.501

High

562452

RTK1
Probable serine/threonine-protein kinase RTK1

1

10

High-throughput

0.501

High

341908

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.500

High

409594

KAPC
cAMP-dependent protein kinase type 3

1

5

High-throughput

0.500

High

412515

CDC7
Cell division control protein 7

1

6

High-throughput

0.500

High

526183

KIN2
Serine/threonine-protein kinase KIN2

1

4

High-throughput

0.500

High

539295

KSS1
Mitogen-activated protein kinase KSS1

1

12

High-throughput

0.500

High

548501

GCN2
eIF-2-alpha kinase GCN2

1

2

High-throughput

0.500

High

562314

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.500

High

562320

DBF2
Cell cycle protein kinase DBF2

1

9

High-throughput

0.500

High

562323

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

5

High-throughput

0.500

High

562324

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

5

High-throughput

0.500

High

562325

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.500

High

562326

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

1

High-throughput

0.500

High

562329

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.500

High

562331

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.500

High

562335

CDC15
Cell division control protein 15

1

3

High-throughput

0.500

High

562337

HRR25
Casein kinase I homolog HRR25

1

3

High-throughput

0.500

High

562341

PSK1
Serine/threonine-protein kinase PSK1

1

4

High-throughput

0.500

High

562343

DBF20
Serine/threonine-protein kinase DBF20

1

9

High-throughput

0.500

High

562344

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

4

High-throughput

0.500

High

562345

ARP2
Actin-related protein 2

1

2

High-throughput

0.500

High

562358

MDJ1
DnaJ homolog 1, mitochondrial

1

2

High-throughput

0.500

High

562362

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.500

High

562365

CHK1
Serine/threonine-protein kinase CHK1

1

2

High-throughput

0.500

High

562372

RCK1
Serine/threonine-protein kinase RCK1

1

4

High-throughput

0.500

High

562373

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.500

High

562376

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.500

High

562395

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.500

High

562422

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

12

High-throughput

0.500

High

562434

SML1
Ribonucleotide reductase inhibitor protein SML1

1

1

High-throughput

0.500

High

562445

RBX1
RING-box protein HRT1

1

2

High-throughput

0.500

High

562400

EGH1
Ergosteryl-beta-glucosidase

1

0

High-throughput

0.493

High

562313

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.489

High

562334

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.480

High

562405

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.480

High

424328

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.479

High

562353

PRS6B
26S proteasome regulatory subunit 6B homolog

1

0

High-throughput

0.479

High

562388

RBG1
Ribosome-interacting GTPase 1

1

0

High-throughput

0.479

High

562396

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.479

High

562407

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.479

High

562415

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.479

High

562424

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.479

High

562428

CCE1
Cruciform cutting endonuclease 1, mitochondrial

1

0

High-throughput

0.479

High

562433

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.479

High

562439

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.479

High

562454

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.479

High

141132

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

340003

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.479

High

343349

TPIS
Triosephosphate isomerase

1

1

High-throughput

0.479

High

343524

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

365741

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

375258

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

413282

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

543133

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

562319

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

562333

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

562336

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

562338

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

562340

MCM4
DNA replication licensing factor MCM4

1

5

High-throughput

0.479

High

562342

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

562347

HOG1
Mitogen-activated protein kinase HOG1

1

10

High-throughput

0.479

High

562349

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

562352

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

562361

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

562364

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.479

High

562368

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

562375

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

562378

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

562385

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

562401

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.479

High

562409

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

562410

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

562413

MCM6
DNA replication licensing factor MCM6

1

4

High-throughput

0.479

High

562414

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

562420

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

562426

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

562430

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

562441

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

1

Small-scale

0.479

High

562446

SGO1
Shugoshin

1

1

High-throughput

0.479

High

562447

MCA1
Metacaspase-1

1

2

High-throughput

0.479

High

562450

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

562459

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.479

High

562461

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

446107

MYO1
Myosin-1

1

0

Small-scale

0.458

High

562359

ATG19
Autophagy-related protein 19

1

0

Small-scale

0.458

High

562398

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

562403

SET4
SET domain-containing protein 4

1

0

Small-scale

0.458

High

562421

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.458

High

562431

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

562432

GIS4
Protein GIS4

1

0

High-throughput

0.458

High

562351

PRP40
Pre-mRNA-processing protein PRP40

1

3

High-throughput

0.457

High

429616

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.457

High

562380

UTP9
U3 small nucleolar RNA-associated protein 9

1

1

High-throughput

0.457

High

562383

TEM1
Protein TEM1

1

1

High-throughput

0.457

High

562391

UTP7
U3 small nucleolar RNA-associated protein 7

1

3

High-throughput

0.457

High

562402

PFS2
Polyadenylation factor subunit 2

1

5

High-throughput

0.457

High

477864

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

490245

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

493121

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

562321

NPR1
Nitrogen permease reactivator protein

1

15

High-throughput

0.445

High

562346

APE2
Aminopeptidase 2, mitochondrial

1

2

High-throughput

0.445

High

562355

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

562366

SEA4
SEH-associated protein 4

1

1

High-throughput

0.445

High

562370

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

1

High-throughput

0.445

High

562393

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

562399

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.445

High

562456

SMT3
Ubiquitin-like protein SMT3

1

4

High-throughput

0.439

High

382928

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

405405

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

480456

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

562348

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

562356

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

562367

GID4
Vacuolar import and degradation protein 24

1

1

High-throughput

0.437

High

562381

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

562387

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

562406

NU192
Nucleoporin NUP192

1

1

High-throughput

0.437

High

562440

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

562449

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

562453

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

424988

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.426

High

498630

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.426

High

562317

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.426

High

562369

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.426

High

562379

YHI9
Uncharacterized isomerase YHI9

1

0

High-throughput

0.426

High

562384

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.426

High

562386

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.426

High

562412

NIF3
NGG1-interacting factor 3

1

0

High-throughput

0.426

High

562419

FMP41
Uncharacterized mitochondrial hydrolase FMP41

1

0

High-throughput

0.426

High

562436

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.426

High

562437

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.426

High

562327

ROX1
Repressor ROX1

1

3

High-throughput

0.407

High

562363

TAF5
Transcription initiation factor TFIID subunit 5

1

3

High-throughput

0.407

High

562397

JEM1
DnaJ-like chaperone JEM1

1

4

High-throughput

0.407

High

562411

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.407

High

562429

WDR59
Maintenance of telomere capping protein 5

1

8

High-throughput

0.407

High

562455

CENPH
Inner kinetochore subunit MCM16

1

1

High-throughput

0.407

High

526940

TBP
TATA-box-binding protein

2

0

High-throughput

0.307

High

562382

SPT8
Transcription factor SPT8

1

0

High-throughput

0.279

Low

562443

PSR2
Probable phosphatase PSR2

1

0

High-throughput

0.279

Low

562394

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

378273

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

420543

SPT2
Protein SPT2

1

0

High-throughput

0.261

Low

516840

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

562332

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

562442

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

562458

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.261

Low

562339

SEC65
Signal recognition particle subunit SEC65

1

0

High-throughput

0.249

Low

562360

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

562377

MUP3
Low-affinity methionine permease

1

0

High-throughput

0.249

Low

562392

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low

562416

COPZ
Coatomer subunit zeta

1

0

High-throughput

0.249

Low

562438

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

562457

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.249

Low

562425

ADA2
Transcriptional adapter 2

1

0

High-throughput

0.232

Low

562435

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.232

Low

562451

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.232

Low

562460

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024