Protein: SRP54
Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein homolog)

Gene: SRP54
Organism: Saccharomyces cerevisiae S288C
Interactions: 201
UniProt ID: P20424

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005525 - GTP binding
GO:0005783 - endoplasmic reticulum
GO:0005786 - signal recognition particle, endoplasmic reticulum targeting

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

592846

SEC65
Signal recognition particle subunit SEC65

5

3

Small-scale

0.918

High

592892

SRP68
Signal recognition particle subunit SRP68

3

2

High-throughput

0.855

High

592893

SRP72
Signal recognition particle subunit SRP72

5

3

Small-scale

0.706

High

592902

SRP14
Signal recognition particle subunit SRP14

5

0

High-throughput

0.682

High

592849

SRP21
Signal recognition particle subunit SRP21

4

0

High-throughput

0.664

High

141146

RS9A
Small ribosomal subunit protein uS4A

3

1

Small-scale

0.624

High

592909

BEM2
GTPase-activating protein BEM2/IPL2

2

0

High-throughput

0.595

High

592840

SRO9
RNA-binding protein SRO9

2

3

High-throughput

0.588

High

592857

SRPR
Signal recognition particle receptor subunit alpha homolog

1

10

High-throughput

0.575

High

592853

GSP1
GTP-binding nuclear protein GSP1/CNR1

2

6

High-throughput

0.571

High

592856

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.571

High

592974

SCC2
Sister chromatid cohesion protein 2

2

1

High-throughput

0.571

High

592861

LHP1
La protein homolog

2

2

High-throughput

0.567

High

493173

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

592877

CAF4
CCR4-associated factor 4

1

1

High-throughput

0.536

High

592963

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

592977

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.513

High

592833

SEC22
Protein transport protein SEC22

1

1

Small-scale

0.501

High

592832

PUR6
Phosphoribosylaminoimidazole carboxylase

1

1

High-throughput

0.494

High

592847

XPO1
Exportin-1

1

2

High-throughput

0.489

High

592992

YTM1
Ribosome biogenesis protein YTM1

1

1

High-throughput

0.489

High

592908

RV167
Reduced viability upon starvation protein 167

1

0

Small-scale

0.486

High

592865

SEC66
Translocation protein SEC66

1

0

Small-scale

0.480

High

503045

ARF1
ADP-ribosylation factor 1

1

1

High-throughput

0.479

High

592836

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

592838

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

592848

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

592870

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

592878

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

592906

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

592933

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

592962

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.479

High

405422

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

406773

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

407717

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

480473

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

534879

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

592843

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.458

High

592862

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

592867

UBX1
UBX domain-containing protein 1

1

0

Small-scale

0.458

High

592944

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

592964

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

592969

PEX29
Peroxisomal membrane protein PEX29

1

0

Small-scale

0.458

High

592983

PEX30
Peroxisomal membrane protein PEX30

1

0

Small-scale

0.458

High

592990

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

579957

DAP2
Dipeptidyl aminopeptidase B

1

1

Small-scale

0.457

High

342658

ENO1
Enolase 1

1

1

High-throughput

0.445

High

342852

ENO2
Enolase 2

1

1

High-throughput

0.445

High

360732

TBB
Tubulin beta chain

1

1

High-throughput

0.445

High

367728

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

413297

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.445

High

424337

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

454172

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.445

High

472011

RL31A
Large ribosomal subunit protein eL31A

1

2

Small-scale

0.445

High

481112

RL1A
Large ribosomal subunit protein uL1A

1

2

High-throughput

0.445

High

592850

MSS1
tRNA modification GTPase MSS1, mitochondrial

1

1

High-throughput

0.445

High

592851

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

592854

GSP2
GTP-binding nuclear protein GSP2/CNR2

1

4

High-throughput

0.445

High

592871

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.445

High

592894

RS27B
Small ribosomal subunit protein eS27B

1

1

High-throughput

0.445

High

592904

RS14B
Small ribosomal subunit protein uS11B

1

3

High-throughput

0.445

High

592916

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

592936

NMD5
Nonsense-mediated mRNA decay protein 5

1

1

High-throughput

0.445

High

592945

RL4B
Large ribosomal subunit protein uL4B

1

2

Small-scale

0.445

High

592960

ERG5
C-22 sterol desaturase ERG5

1

1

High-throughput

0.445

High

592966

YP113
Putative 2-hydroxyacid dehydrogenase YPL113C

1

1

High-throughput

0.445

High

592845

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

343529

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.426

High

357632

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.426

High

400190

PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase

1

0

High-throughput

0.426

High

406202

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.426

High

425593

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

High-throughput

0.426

High

525215

GAL3
Protein GAL3

1

0

High-throughput

0.426

High

580886

IRA2
Inhibitory regulator protein IRA2

1

0

High-throughput

0.426

High

592837

SED4
Putative guanine nucleotide-exchange factor SED4

1

0

High-throughput

0.426

High

592841

PGPS1
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

1

0

High-throughput

0.426

High

592844

SEC20
Protein transport protein SEC20

1

0

High-throughput

0.426

High

592858

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.426

High

592859

TKT2
Transketolase 2

1

0

High-throughput

0.426

High

592863

MSN4
Zinc finger protein MSN4

1

0

High-throughput

0.426

High

592891

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.426

High

592901

ALP1
Basic amino-acid permease

1

0

High-throughput

0.426

High

592911

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.426

High

592925

LCB2
Serine palmitoyltransferase 2

1

0

High-throughput

0.426

High

592927

CIN1
Chromosome instability protein 1

1

0

High-throughput

0.426

High

592930

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.426

High

592932

AGX1
Alanine--glyoxylate aminotransferase 1

1

0

High-throughput

0.426

High

592934

ROG3
Protein ROG3

1

0

High-throughput

0.426

High

592959

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.426

High

592967

GIP3
GLC7-interacting protein 3

1

0

High-throughput

0.426

High

592968

YD476
Uncharacterized protein YDR476C

1

0

High-throughput

0.426

High

592975

LCMT1
Leucine carboxyl methyltransferase 1

1

0

High-throughput

0.426

High

592982

SGPL
Sphingosine-1-phosphate lyase

1

0

High-throughput

0.426

High

592987

THI3
Thiamine metabolism regulatory protein THI3

1

0

High-throughput

0.426

High

593000

YO093
Uncharacterized protein YOR093C

1

0

High-throughput

0.426

High

592835

PTP1
Tyrosine-protein phosphatase 1

1

2

High-throughput

0.407

High

592879

CDC27
Anaphase-promoting complex subunit CDC27

1

2

High-throughput

0.407

High

592882

MAL33
Maltose fermentation regulatory protein MAL33

1

1

High-throughput

0.407

High

592895

YHE9
Uncharacterized protein YHL049C

1

1

High-throughput

0.407

High

592899

CRG1
Probable S-adenosylmethionine-dependent methyltransferase CRG1

1

1

High-throughput

0.407

High

592903

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.407

High

592907

SWD1
COMPASS component SWD1

1

1

High-throughput

0.407

High

592910

YEI6
Uncharacterized protein YEL076C

1

1

High-throughput

0.407

High

592926

HUL4
Probable E3 ubiquitin-protein ligase HUL4

1

1

High-throughput

0.407

High

592935

CHA4
Activatory protein CHA4

1

3

High-throughput

0.407

High

592953

MAL13
Maltose fermentation regulatory protein MAL13

1

1

High-throughput

0.407

High

592955

COPA
Coatomer subunit alpha

1

1

High-throughput

0.407

High

592999

YB11A
Transposon Ty1-BL Gag polyprotein

1

1

High-throughput

0.407

High

592898

NACA
Nascent polypeptide-associated complex subunit alpha

3

0

Small-scale

0.337

High

375267

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

592834

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

592921

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

592923

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

592956

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

592984

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

592986

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

368718

GCN4
General control transcription factor GCN4

1

0

High-throughput

0.232

Low

443969

CISY2
Citrate synthase, peroxisomal

1

0

High-throughput

0.232

Low

474321

U5072
UPF0507 protein YML002W

1

0

High-throughput

0.232

Low

555800

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

592839

MXR2
Peptide methionine sulfoxide reductase 2

1

0

High-throughput

0.232

Low

592842

CTO1
Cold tolerance protein 1

1

0

High-throughput

0.232

Low

592852

TIM12
Mitochondrial import inner membrane translocase subunit TIM12

1

0

High-throughput

0.232

Low

592855

RGT1
Glucose transport transcription regulator RGT1

1

0

High-throughput

0.232

Low

592860

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.232

Low

592864

PAD1
Flavin prenyltransferase PAD1, mitochondrial

1

0

High-throughput

0.232

Low

592866

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.232

Low

592868

MDJ1
DnaJ homolog 1, mitochondrial

1

0

High-throughput

0.232

Low

592869

NU120
Nucleoporin NUP120

1

0

High-throughput

0.232

Low

592872

CBT1
Cytochrome b termination protein 1

1

0

High-throughput

0.232

Low

592873

PMU1
Probable phosphoglycerate mutase PMU1

1

0

High-throughput

0.232

Low

592874

YKH0
Uncharacterized protein YKL070W

1

0

High-throughput

0.232

Low

592875

PHD1
Putative transcription factor PHD1

1

0

High-throughput

0.232

Low

592876

TTI1
TEL2-interacting protein 1

1

0

High-throughput

0.232

Low

592880

YMC2
Carrier protein YMC2, mitochondrial

1

0

High-throughput

0.232

Low

592881

THI2
Thiamine biosynthesis regulatory protein

1

0

High-throughput

0.232

Low

592883

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.232

Low

592884

YBI1
Uncharacterized protein YBL081W

1

0

High-throughput

0.232

Low

592885

MOH1
Protein yippee-like MOH1

1

0

High-throughput

0.232

Low

592886

UMP1
Proteasome maturation factor UMP1

1

0

High-throughput

0.232

Low

592887

CS111
F-box protein COS111

1

0

High-throughput

0.232

Low

592888

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.232

Low

592889

YB75
Uncharacterized protein YBR225W

1

0

High-throughput

0.232

Low

592890

SHG1
COMPASS component SHG1

1

0

High-throughput

0.232

Low

592896

SHU1
Suppressor of HU sensitivity involved in recombination protein 1

1

0

High-throughput

0.232

Low

592897

RRF1
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.232

Low

592900

YH10
Uncharacterized isomerase YHR210C

1

0

High-throughput

0.232

Low

592905

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

592912

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.232

Low

592913

JHD1
JmjC domain-containing histone demethylation protein 1

1

0

High-throughput

0.232

Low

592914

YEW7
Uncharacterized protein YEL137C

1

0

High-throughput

0.232

Low

592915

YE17
Uncharacterized protein YER187W

1

0

High-throughput

0.232

Low

592917

LDO45
Lipid droplet organization protein LDO45

1

0

High-throughput

0.232

Low

592918

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

592919

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.232

Low

592920

TAO3
Cell morphogenesis protein PAG1

1

0

High-throughput

0.232

Low

592922

MSL1
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.232

Low

592924

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

1

0

High-throughput

0.232

Low

592928

HAC1
Transcriptional activator HAC1

1

0

High-throughput

0.232

Low

592929

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.232

Low

592931

THI5
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5

1

0

High-throughput

0.232

Low

592937

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

592938

ZAP1
Zinc-responsive transcriptional regulator ZAP1

1

0

High-throughput

0.232

Low

592939

TAD2
tRNA-specific adenosine deaminase subunit TAD2

1

0

High-throughput

0.232

Low

592940

MHO1
MEMO1 family protein MHO1

1

0

High-throughput

0.232

Low

592941

YJ11B
Transposon Ty1-JR1 Gag-Pol polyprotein

1

0

High-throughput

0.232

Low

592942

LIH1
Putative lipase LIH1

1

0

High-throughput

0.232

Low

592943

BPL1
Biotin--protein ligase

1

0

High-throughput

0.232

Low

592946

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.232

Low

592947

RPA14
DNA-directed RNA polymerase I subunit RPA14

1

0

High-throughput

0.232

Low

592948

LGUL
Glyoxalase I

1

0

High-throughput

0.232

Low

592949

ALAM
Probable alanine aminotransferase, mitochondrial

1

0

High-throughput

0.232

Low

592950

STR3
Cystathionine beta-lyase

1

0

High-throughput

0.232

Low

592951

YG29
Uncharacterized protein YGR066C

1

0

High-throughput

0.232

Low

592952

ZPR1
Zinc finger chaperone ZPR1

1

0

High-throughput

0.232

Low

592954

COPZ
Coatomer subunit zeta

1

0

High-throughput

0.232

Low

592957

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.232

Low

592958

YNT3
Uncharacterized protein YNL193W

1

0

High-throughput

0.232

Low

592961

ACT
Actin

1

0

High-throughput

0.232

Low

592965

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.232

Low

592970

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.232

Low

592971

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

0

High-throughput

0.232

Low

592972

YD132
Uncharacterized protein YDR132C

1

0

High-throughput

0.232

Low

592973

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.232

Low

592976

SDHF3
Succinate dehydrogenase assembly factor 3, mitochondrial

1

0

High-throughput

0.232

Low

592978

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.232

Low

592979

YD124
Uncharacterized protein YDR124W

1

0

High-throughput

0.232

Low

592980

AIM32
Altered inheritance of mitochondria protein 32

1

0

High-throughput

0.232

Low

592981

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.232

Low

592985

IPK1
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.232

Low

592988

BDS1
Alkyl/aryl-sulfatase BDS1

1

0

High-throughput

0.232

Low

592989

SGO1
Shugoshin

1

0

High-throughput

0.232

Low

592991

RDR1
Protein RDR1

1

0

High-throughput

0.232

Low

592993

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.232

Low

592994

BSC1
Bypass of stop codon protein 1

1

0

High-throughput

0.232

Low

592995

YG31A
Transposon Ty3-G Gag polyprotein

1

0

High-throughput

0.232

Low

592996

MSH5
MutS protein homolog 5

1

0

High-throughput

0.232

Low

592997

REC8
Meiotic recombination protein REC8

1

0

High-throughput

0.232

Low

592998

DAD1
DASH complex subunit DAD1

1

0

High-throughput

0.232

Low

593001

SFM1
Protein arginine N-methyltransferase SFM1

1

0

High-throughput

0.232

Low

593002

POM34
Nucleoporin POM34

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024