Protein: SIN3
Transcriptional regulatory protein SIN3

Gene: SIN3
Organism: Saccharomyces cerevisiae S288C
Interactions: 161
UniProt ID: P22579

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

609082

SAP30
Transcriptional regulatory protein SAP30

9

0

Small-scale

0.918

High

609058

RPD3
Histone deacetylase RPD3

23

20

Small-scale

0.766

High

609142

RCO1
Transcriptional regulatory protein RCO1

13

20

Small-scale

0.758

High

609114

PHO23
Transcriptional regulatory protein PHO23

11

5

Small-scale

0.754

High

609154

CTI6
Histone deacetylase complex subunit CTI6

11

4

Small-scale

0.754

High

609163

EAF3
Chromatin modification-related protein EAF3

10

5

Small-scale

0.752

High

609099

SDS3
Transcriptional regulatory protein SDS3

12

0

Small-scale

0.724

High

609135

UME1
Transcriptional regulatory protein UME1

12

0

Small-scale

0.723

High

609081

RXT2
Transcriptional regulatory protein RXT2

10

0

Small-scale

0.718

High

602468

OPI1
Transcriptional repressor OPI1

7

0

Small-scale

0.714

High

609147

RXT3
Transcriptional regulatory protein RXT3

7

0

Small-scale

0.709

High

490372

HSP71
Heat shock protein SSA1

5

3

High-throughput

0.695

High

609087

UME6
Transcriptional regulatory protein UME6

5

0

Small-scale

0.688

High

609053

DEP1
Transcriptional regulatory protein DEP1

6

0

Small-scale

0.686

High

609072

ASH1
Transcriptional regulatory protein ASH1

6

0

Small-scale

0.686

High

609125

H3
Histone H3

4

5

Small-scale

0.676

High

609097

FKH1
Fork head protein homolog 1

3

5

Small-scale

0.669

High

392300

H2A2
Histone H2A.2

3

1

High-throughput

0.657

High

609080

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

3

15

High-throughput

0.657

High

609105

RSC8
Chromatin structure-remodeling complex protein RSC8

3

4

High-throughput

0.657

High

356259

H4
Histone H4

3

2

High-throughput

0.650

High

510295

SSB1
Ribosome-associated molecular chaperone SSB1

3

3

High-throughput

0.650

High

609037

SIN3
Transcriptional regulatory protein SIN3

3

3

Small-scale

0.641

High

609133

IMA1
Importin subunit alpha

3

0

High-throughput

0.629

High

609049

FUN19
SWIRM domain-containing protein FUN19

3

0

High-throughput

0.622

High

549957

CSK21
Casein kinase II subunit alpha

2

3

High-throughput

0.621

High

561844

TUP1
General transcriptional corepressor TUP1

2

4

High-throughput

0.621

High

584656

CSK22
Casein kinase II subunit alpha'

2

3

High-throughput

0.621

High

609132

ABF2
ARS-binding factor 2, mitochondrial

2

7

High-throughput

0.621

High

609098

XBP1
Transcriptional repressor XBP1

3

0

Small-scale

0.613

High

609077

STB6
Protein STB6

2

1

Small-scale

0.594

High

425298

PHO4
Phosphate system positive regulatory protein PHO4

2

0

Small-scale

0.592

High

609108

STB2
Protein STB2

2

1

Small-scale

0.590

High

609149

CDC45
Cell division control protein 45

2

0

High-throughput

0.576

High

355785

H2B2
Histone H2B.2

2

2

High-throughput

0.571

High

609051

BMH1
Protein BMH1

2

1

High-throughput

0.571

High

609101

HAC1
Transcriptional activator HAC1

2

0

Small-scale

0.569

High

609103

STB1
Protein STB1

2

0

Small-scale

0.565

High

609167

MTR10
mRNA transport regulator MTR10

2

0

High-throughput

0.563

High

493229

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.552

High

609059

HSP7F
Heat shock protein homolog SSE1

2

4

High-throughput

0.552

High

609102

FKH2
Fork head protein homolog 2

1

5

High-throughput

0.536

High

609137

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

609122

HDA1
Histone deacetylase HDA1

1

19

Small-scale

0.527

High

609159

HOS1
Histone deacetylase HOS1

1

20

Small-scale

0.527

High

609091

IFH1
Protein IFH1

1

1

High-throughput

0.515

High

609140

HMO1
High mobility group protein 1

1

5

High-throughput

0.515

High

609083

STB5
Protein STB5

1

2

Small-scale

0.508

High

609094

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

High-throughput

0.508

High

609040

ROX1
Repressor ROX1

1

7

Small-scale

0.501

High

609070

YOX1
Homeobox protein YOX1

1

1

Small-scale

0.501

High

609141

YHP1
Homeobox protein YHP1

1

1

Small-scale

0.501

High

609088

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

609157

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.493

High

609112

STB4
Probable transcriptional regulatory protein STB4

1

0

Small-scale

0.486

High

609128

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.486

High

609162

STB3
Protein STB3

1

0

Small-scale

0.486

High

609045

DAL80
Nitrogen regulatory protein DAL80

1

0

Small-scale

0.480

High

609047

INO2
Protein INO2

1

0

Small-scale

0.480

High

609123

MOT3
Transcriptional activator/repressor MOT3

1

0

Small-scale

0.480

High

609153

RDR1
Protein RDR1

1

0

Small-scale

0.480

High

609161

WHI5
G1-specific transcriptional repressor WHI5

1

0

Small-scale

0.480

High

355355

H2B1
Histone H2B.1

1

2

High-throughput

0.479

High

609063

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

609078

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

609121

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

609155

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

609165

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.479

High

557882

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

593376

CG12
G1/S-specific cyclin CLN2

1

0

Small-scale

0.458

High

609050

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

609056

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

609074

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

609075

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

609113

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

609144

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

609150

SGO1
Shugoshin

1

0

High-throughput

0.458

High

609156

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

609158

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

609166

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

365814

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

472620

YP14B
Transposon Ty1-PR3 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

609038

MCM3
DNA replication licensing factor MCM3

1

1

High-throughput

0.445

High

609043

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

609052

MCM5
Minichromosome maintenance protein 5

1

1

High-throughput

0.445

High

609055

BTAF1
TATA-binding protein-associated factor MOT1

1

17

High-throughput

0.445

High

609060

STH1
Nuclear protein STH1/NPS1

1

16

High-throughput

0.445

High

609061

CHD1
Chromo domain-containing protein 1

1

12

High-throughput

0.445

High

609066

TFC4
Transcription factor tau 131 kDa subunit

1

1

High-throughput

0.445

High

609068

IXR1
Intrastrand cross-link recognition protein

1

3

High-throughput

0.445

High

609073

SPT7
Transcriptional activator SPT7

1

12

High-throughput

0.445

High

609079

TAF5
Transcription initiation factor TFIID subunit 5

1

2

High-throughput

0.445

High

609090

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

609095

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

609124

ACT
Actin

1

1

High-throughput

0.445

High

609126

ARP4
Actin-related protein 4

1

3

High-throughput

0.445

High

609127

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.445

High

609130

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

8

High-throughput

0.445

High

609131

ADA2
Transcriptional adapter 2

1

4

High-throughput

0.445

High

609134

HOS3
Histone deacetylase HOS3

1

20

High-throughput

0.445

High

609138

TAF12
Transcription initiation factor TFIID subunit 12

1

2

High-throughput

0.445

High

609139

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

609143

ARP9
Actin-like protein ARP9

1

3

High-throughput

0.445

High

609152

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

16

High-throughput

0.445

High

609164

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.445

High

609120

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

609064

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

609039

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.426

High

609044

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.426

High

609048

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

609057

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.426

High

609062

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.426

High

609085

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.426

High

609086

SPT8
Transcription factor SPT8

1

0

High-throughput

0.426

High

609093

DOT6
Transcriptional regulatory protein DOT6

1

0

High-throughput

0.426

High

609096

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.426

High

609107

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.426

High

609109

NET1
Nucleolar protein NET1

1

0

High-throughput

0.426

High

609111

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

609115

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.426

High

609116

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.426

High

609118

H1
Histone H1

1

0

High-throughput

0.426

High

609136

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.426

High

609146

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.426

High

609148

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

424350

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.407

High

609041

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.407

High

609054

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

609067

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

609100

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

609119

JJJ1
J protein JJJ1

1

1

High-throughput

0.407

High

609104

IOC3
ISWI one complex protein 3

2

0

High-throughput

0.324

High

609106

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.324

High

609089

TCPD
T-complex protein 1 subunit delta

2

0

High-throughput

0.307

High

609071

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

609145

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.269

Low

609117

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

141162

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

357890

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

382958

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

405438

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

407733

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

413313

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

470871

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

472024

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

479930

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

480492

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

482090

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

609042

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

609046

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

609065

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

609069

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

609076

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

609084

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

609092

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

609110

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

609129

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

609151

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

360747

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

609160

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024