Protein: SPB1
27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase (EC 2.1.1.167) (2'-O-ribose RNA methyltransferase SPB1) (AdoMet-dependent rRNA methyltransferase SPB1) (S-adenosyl-L-methionine-dependent methyltransferase) (Suppressor of PAB1 protein 1)

Gene: SPB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 128
UniProt ID: P25582

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0008650 - rRNA (uridine-2'-O-)-methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

634465

YTM1
Ribosome biogenesis protein YTM1

3

10

High-throughput

0.827

High

634377

SPB1
27S pre-rRNA

2

8

High-throughput

0.767

High

634395

RPF2
Ribosome biogenesis protein RPF2

7

1

High-throughput

0.745

High

634447

ERB1
Ribosome biogenesis protein ERB1

2

8

High-throughput

0.737

High

634453

RLP24
Ribosome biogenesis protein RLP24

2

2

High-throughput

0.737

High

634466

NOP53
Ribosome biogenesis protein NOP53

6

3

Small-scale

0.730

High

634428

PESC
Pescadillo homolog

6

1

Small-scale

0.730

High

634413

NUG1
Nuclear GTP-binding protein NUG1

6

6

Small-scale

0.728

High

634378

SPB4
ATP-dependent rRNA helicase SPB4

5

10

High-throughput

0.709

High

634411

NOC2
Nucleolar complex protein 2

5

1

Small-scale

0.704

High

634427

NSA1
Ribosome biogenesis protein NSA1

5

1

Small-scale

0.702

High

634470

DBP10
ATP-dependent RNA helicase DBP10

4

6

High-throughput

0.692

High

634431

NOP15
Ribosome biogenesis protein 15

4

7

High-throughput

0.691

High

634420

LOC1
60S ribosomal subunit assembly/export protein LOC1

5

0

High-throughput

0.688

High

634452

NOC3
Nucleolar complex-associated protein 3

4

3

High-throughput

0.676

High

634385

PP12
Serine/threonine-protein phosphatase PP1-2

3

1

High-throughput

0.667

High

634444

RRP17
Ribosomal RNA-processing protein 17

3

1

High-throughput

0.656

High

634407

RPF1
Ribosome production factor 1

3

1

High-throughput

0.646

High

634409

FKBP3
Peptidyl-prolyl cis-trans isomerase

3

2

High-throughput

0.646

High

634448

FKBP4
FK506-binding protein 4

3

2

High-throughput

0.646

High

634455

NOP12
Nucleolar protein 12

3

6

High-throughput

0.646

High

634404

CIC1
Proteasome-interacting protein CIC1

3

2

High-throughput

0.640

High

634418

NOP2
25S rRNA

3

5

Small-scale

0.640

High

634439

NOG1
Nucleolar GTP-binding protein 1

3

5

Small-scale

0.640

High

634441

HAS1
ATP-dependent RNA helicase HAS1

3

11

High-throughput

0.640

High

382974

RL25
Large ribosomal subunit protein uL23

3

3

Small-scale

0.633

High

634393

EBP2
rRNA-processing protein EBP2

3

0

High-throughput

0.618

High

634394

RRP14
Ribosomal RNA-processing protein 14

3

0

High-throughput

0.618

High

594015

MAK11
Protein MAK11

1

8

High-throughput

0.618

High

630845

NLE1
Ribosome assembly protein 4

1

6

High-throughput

0.618

High

634397

GBLP
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.618

High

634445

RRB1
Ribosome assembly protein RRB1

1

6

High-throughput

0.618

High

634430

NOP13
Nucleolar protein 13

2

3

High-throughput

0.611

High

634471

NOP58
Nucleolar protein 58

2

4

Small-scale

0.601

High

634468

MAK21
Ribosome biogenesis protein MAK21

2

4

High-throughput

0.594

High

392315

H2A2
Histone H2A.2

2

5

High-throughput

0.584

High

634405

SSF1
Ribosome biogenesis protein SSF1

2

1

High-throughput

0.584

High

634408

RIX1
Pre-rRNA-processing protein RIX1

2

1

Small-scale

0.584

High

634417

RLP7
Ribosome biogenesis protein RLP7

2

4

High-throughput

0.584

High

634429

NOG2
Nucleolar GTP-binding protein 2

2

6

High-throughput

0.584

High

634442

ARX1
Probable metalloprotease ARX1

2

2

High-throughput

0.584

High

634472

IF6
Eukaryotic translation initiation factor 6

2

1

Small-scale

0.584

High

498810

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.575

High

634422

URB2
Nucleolar pre-ribosomal-associated protein 2

2

0

High-throughput

0.569

High

634426

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

High-throughput

0.536

High

549337

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

Small-scale

0.534

High

534896

RL3
Large ribosomal subunit protein uL3

2

3

High-throughput

0.533

High

615119

BUR1
Serine/threonine-protein kinase BUR1

1

3

High-throughput

0.515

High

634458

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

614890

KC12
Casein kinase I homolog 2

1

1

High-throughput

0.508

High

376652

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

Small-scale

0.501

High

634423

CLA4
Serine/threonine-protein kinase CLA4

1

4

Small-scale

0.501

High

634440

STE20
Serine/threonine-protein kinase STE20

1

4

Small-scale

0.501

High

634459

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.501

High

141181

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

355366

H2B1
Histone H2B.1

1

6

High-throughput

0.479

High

355800

H2B2
Histone H2B.2

1

6

High-throughput

0.479

High

404508

RL7A
Large ribosomal subunit protein uL30A

1

4

High-throughput

0.479

High

406822

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

407755

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

479949

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

501191

MAK16
Protein MAK16

1

2

High-throughput

0.479

High

627736

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

631700

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

634379

RL5
Large ribosomal subunit protein uL18

1

2

Small-scale

0.479

High

634381

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

634382

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

634384

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

634386

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

4

High-throughput

0.479

High

634387

DRS1
ATP-dependent RNA helicase DRS1

1

10

High-throughput

0.479

High

634389

MRT4
Ribosome assembly factor MRT4

1

2

High-throughput

0.479

High

634392

RRP1
Ribosomal RNA-processing protein 1

1

3

High-throughput

0.479

High

634396

NOP4
Nucleolar protein 4

1

4

High-throughput

0.479

High

634399

MAK5
ATP-dependent RNA helicase MAK5

1

10

High-throughput

0.479

High

634401

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

634402

ENP1
Essential nuclear protein 1

1

2

High-throughput

0.479

High

634406

IPI1
Pre-rRNA-processing protein IPI1

1

1

High-throughput

0.479

High

634414

NSA2
Ribosome biogenesis protein NSA2

1

2

High-throughput

0.479

High

634415

BMT5
25S rRNA

1

1

High-throughput

0.479

High

634416

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.479

High

634421

ALB1
Ribosome biogenesis protein ALB1

1

1

High-throughput

0.479

High

634433

RCM1
25S rRNA

1

5

High-throughput

0.479

High

634436

NOP3
Serine/arginine

1

11

High-throughput

0.479

High

634443

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

634446

PUF6
Pumilio homology domain family member 6

1

1

High-throughput

0.479

High

634449

JIP5
WD repeat-containing protein JIP5

1

8

High-throughput

0.479

High

634451

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

634454

BUD20
Bud site selection protein 20

1

1

High-throughput

0.479

High

634456

BRX1
Ribosome biogenesis protein BRX1

1

6

High-throughput

0.479

High

634462

RRS1
Regulator of ribosome biosynthesis

1

2

High-throughput

0.479

High

634463

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

634464

MDN1
Midasin

1

8

High-throughput

0.479

High

634469

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.479

High

408285

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

413331

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

566139

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

634383

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

634391

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.458

High

634412

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

634419

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

634425

RL37A
Large ribosomal subunit protein eL37A

1

0

High-throughput

0.458

High

634432

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

634438

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

634450

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

634457

SGO1
Shugoshin

1

0

High-throughput

0.458

High

634467

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

357907

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

405458

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.437

High

425794

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

470889

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

472041

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

480509

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

634380

RL16A
Large ribosomal subunit protein uL13A

1

3

High-throughput

0.437

High

634388

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

634390

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

634398

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.437

High

634410

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

634435

NUM1
Nuclear migration protein NUM1

1

7

High-throughput

0.437

High

634437

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

634461

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

634434

RL34A
Large ribosomal subunit protein eL34A

1

0

High-throughput

0.426

High

534701

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.407

High

634460

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.279

Low

482107

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

634400

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

634403

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

634424

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024