Protein: GLYM
Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

Gene: GLYM, SHM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 148
UniProt ID: P37292

Gene Ontology (top 5):
GO:0004372 - glycine hydroxymethyltransferase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0006565 - L-serine catabolic process
GO:0006730 - one-carbon metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

478115

HSP77
Import motor subunit, mitochondrial

2

2

High-throughput

0.584

High

741268

RQC1
Ribosome quality control complex subunit 1

2

1

Small-scale

0.584

High

741226

NACA
Nascent polypeptide-associated complex subunit alpha

2

0

High-throughput

0.547

High

741257

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

405569

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.533

High

425899

RS19A
Small ribosomal subunit protein eS19A

2

1

High-throughput

0.533

High

472146

RL31A
Large ribosomal subunit protein eL31A

2

1

High-throughput

0.533

High

645002

RL16A
Large ribosomal subunit protein uL13A

2

1

High-throughput

0.533

High

366143

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.479

High

404552

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.479

High

405169

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.479

High

410359

SC160
Protein SCP160

1

1

High-throughput

0.479

High

588040

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.479

High

624069

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

631821

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

680631

HS104
Heat shock protein 104

1

3

Small-scale

0.479

High

692500

ZUO1
Zuotin

1

4

High-throughput

0.479

High

732132

CAB3
Coenzyme A biosynthesis protein 3

1

1

High-throughput

0.479

High

741225

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.479

High

741230

IF2P
Eukaryotic translation initiation factor 5B

1

3

High-throughput

0.479

High

741236

TM108
Protein TMA108

1

1

High-throughput

0.479

High

741248

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.479

High

741252

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

741253

JJJ1
J protein JJJ1

1

1

High-throughput

0.479

High

741254

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

741260

ABF2
ARS-binding factor 2, mitochondrial

1

1

High-throughput

0.479

High

741263

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

741266

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

741276

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

741277

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.479

High

141279

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

357659

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

373235

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

387896

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

399420

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

406216

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

407863

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

450421

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

482216

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

519511

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

534738

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

534953

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

627602

NAP1
Nucleosome assembly protein

1

0

Small-scale

0.458

High

640912

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

699862

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

729857

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

732428

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.458

High

732881

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

741221

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

741223

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

741227

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

741229

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.458

High

741241

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

741245

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

741247

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

741258

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

741261

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

0

High-throughput

0.458

High

741267

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

741272

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

741273

SGO1
Shugoshin

1

0

High-throughput

0.458

High

741278

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.458

High

490943

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

493725

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

510981

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

694517

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

741233

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

741269

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

7

High-throughput

0.445

High

145717

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.437

High

357487

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.437

High

382735

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.437

High

399744

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.437

High

399867

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.437

High

404826

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.437

High

404999

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.437

High

405979

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.437

High

406123

RL36A
Large ribosomal subunit protein eL36A

1

1

High-throughput

0.437

High

406509

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.437

High

413453

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

426282

RS19B
Small ribosomal subunit protein eS19B

1

1

High-throughput

0.437

High

471387

RL11A
Large ribosomal subunit protein uL5A

1

1

High-throughput

0.437

High

472498

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.437

High

496037

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.437

High

498883

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.437

High

532778

ACOX
Acyl-coenzyme A oxidase

1

1

High-throughput

0.437

High

564267

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.437

High

621462

RL24B
Large ribosomal subunit protein eL24B

1

1

High-throughput

0.437

High

627934

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

645193

RL16B
Large ribosomal subunit protein uL13B

1

1

High-throughput

0.437

High

645388

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

661970

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

663848

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

667155

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.437

High

700357

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

731384

SIS2
Phosphopantothenoylcysteine decarboxylase subunit SIS2

1

1

High-throughput

0.437

High

732697

RL14A
Large ribosomal subunit protein eL14A

1

1

High-throughput

0.437

High

741222

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

741224

RL14B
Large ribosomal subunit protein eL14B

1

1

High-throughput

0.437

High

741228

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

741234

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.437

High

741237

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.437

High

741240

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.437

High

741242

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.437

High

741243

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.437

High

741244

RS7B
Small ribosomal subunit protein eS7B

1

1

High-throughput

0.437

High

741246

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.437

High

741249

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.437

High

741250

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.437

High

741251

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.437

High

741255

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.437

High

741256

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.437

High

741259

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.437

High

741262

RL21A
Large ribosomal subunit protein eL21A

1

1

High-throughput

0.437

High

741270

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

741271

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

741275

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

741279

RL21B
Large ribosomal subunit protein eL21B

1

1

High-throughput

0.437

High

741280

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.437

High

741281

RL11B
Large ribosomal subunit protein uL5B

1

1

High-throughput

0.437

High

741264

GCN5
Histone acetyltransferase GCN5

1

1

High-throughput

0.407

High

481321

RL2A
Large ribosomal subunit protein uL2A

3

0

High-throughput

0.334

High

358014

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.305

High

383086

RL25
Large ribosomal subunit protein uL23

2

0

High-throughput

0.305

High

480053

RS6A
Small ribosomal subunit protein eS6A

2

0

High-throughput

0.305

High

706217

RS3A1
Small ribosomal subunit protein eS1A

2

0

High-throughput

0.305

High

355455

H2B1
Histone H2B.1

1

0

High-throughput

0.249

Low

406321

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.249

Low

471004

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

471890

RL27B
Large ribosomal subunit protein eL27B

1

0

High-throughput

0.249

Low

478872

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

479091

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.249

Low

480619

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

481142

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.249

Low

481622

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

481897

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

482700

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

482856

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

482975

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.249

Low

606620

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

634564

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

689867

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.249

Low

692754

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

741231

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.249

Low

741232

THO1
Protein THO1

1

0

High-throughput

0.249

Low

741235

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.249

Low

741238

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

741239

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.249

Low

741274

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

741265

YMB8
Uncharacterized vacuolar membrane protein YML018C

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024