Protein: NOP4
Nucleolar protein 4 (Nucleolar protein NOP77)

Gene: NOP4
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: P37838

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0042273 - ribosomal large subunit biogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

742075

NOP12
Nucleolar protein 12

6

19

Small-scale

0.951

High

742044

NOP15
Ribosome biogenesis protein 15

4

19

High-throughput

0.892

High

742042

NOP13
Nucleolar protein 13

4

19

Small-scale

0.891

High

742003

NOP4
Nucleolar protein 4

3

16

Small-scale

0.880

High

648366

NSR1
Nuclear localization sequence-binding protein

2

17

High-throughput

0.767

High

742016

NOC2
Nucleolar complex protein 2

8

1

Small-scale

0.753

High

742058

HAS1
ATP-dependent RNA helicase HAS1

9

13

Small-scale

0.753

High

742005

MAK5
ATP-dependent RNA helicase MAK5

7

13

Small-scale

0.751

High

742010

CIC1
Proteasome-interacting protein CIC1

8

3

Small-scale

0.751

High

742095

RRP12
Ribosomal RNA-processing protein 12

7

1

Small-scale

0.749

High

742089

MAK21
Ribosome biogenesis protein MAK21

7

3

High-throughput

0.748

High

742055

NOG1
Nucleolar GTP-binding protein 1

8

5

Small-scale

0.747

High

376750

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

19

Small-scale

0.737

High

699671

DRS1
ATP-dependent RNA helicase DRS1

6

13

Small-scale

0.737

High

731797

EBP2
rRNA-processing protein EBP2

6

1

Small-scale

0.736

High

742019

NUG1
Nuclear GTP-binding protein NUG1

6

3

Small-scale

0.731

High

742025

NOP2
25S rRNA

6

2

Small-scale

0.729

High

742037

PESC
Pescadillo homolog

6

1

Small-scale

0.729

High

742066

RRP5
rRNA biogenesis protein RRP5

6

6

Small-scale

0.726

High

742011

SSF1
Ribosome biogenesis protein SSF1

6

2

Small-scale

0.722

High

733803

RPF2
Ribosome biogenesis protein RPF2

5

2

Small-scale

0.706

High

383089

RL25
Large ribosomal subunit protein uL23

2

5

High-throughput

0.705

High

638729

SPB4
ATP-dependent rRNA helicase SPB4

5

11

Small-scale

0.705

High

742092

DBP10
ATP-dependent RNA helicase DBP10

4

10

Small-scale

0.704

High

742020

NSA2
Ribosome biogenesis protein NSA2

4

1

Small-scale

0.692

High

485509

SSBP1
Single-stranded nucleic acid-binding protein

1

17

High-throughput

0.691

High

550011

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.691

High

675973

XPO1
Exportin-1

1

6

High-throughput

0.691

High

688520

KNS1
Dual specificity protein kinase KNS1

1

11

High-throughput

0.691

High

742024

RLP7
Ribosome biogenesis protein RLP7

4

6

High-throughput

0.691

High

742026

UTP10
U3 small nucleolar RNA-associated protein 10

4

1

High-throughput

0.691

High

742064

ERB1
Ribosome biogenesis protein ERB1

4

6

High-throughput

0.691

High

742076

BRX1
Ribosome biogenesis protein BRX1

4

8

Small-scale

0.691

High

710870

URB1
Nucleolar pre-ribosomal-associated protein 1

4

1

Small-scale

0.678

High

742033

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

4

Small-scale

0.672

High

732208

RRP14
Ribosomal RNA-processing protein 14

4

0

Small-scale

0.667

High

704324

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

2

High-throughput

0.667

High

490950

HSP71
Heat shock protein SSA1

4

3

High-throughput

0.666

High

715918

UTP20
U3 small nucleolar RNA-associated protein 20

3

1

High-throughput

0.662

High

742043

NAT10
RNA cytidine acetyltransferase

3

1

High-throughput

0.662

High

742070

DBP9
ATP-dependent RNA helicase DBP9

3

8

High-throughput

0.662

High

742086

YTM1
Ribosome biogenesis protein YTM1

3

13

High-throughput

0.662

High

742093

NOP56
Nucleolar protein 56

3

3

High-throughput

0.662

High

742062

PUF6
Pumilio homology domain family member 6

3

8

Small-scale

0.657

High

742018

NOP16
Nucleolar protein 16

4

0

Small-scale

0.651

High

742027

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

0

High-throughput

0.642

High

742085

MDN1
Midasin

2

1

High-throughput

0.621

High

742035

CGR1
rRNA-processing protein CGR1

3

0

Small-scale

0.619

High

742081

TMA16
Translation machinery-associated protein 16

3

0

Small-scale

0.619

High

742049

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

8

High-throughput

0.618

High

406983

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.618

High

655837

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

1

High-throughput

0.588

High

604540

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.586

High

715425

RRP1
Ribosomal RNA-processing protein 1

2

4

Small-scale

0.584

High

742040

NOG2
Nucleolar GTP-binding protein 2

2

3

High-throughput

0.584

High

742087

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.584

High

742088

RRP6
Exosome complex exonuclease RRP6

2

1

High-throughput

0.584

High

742094

NOP58
Nucleolar protein 58

2

3

High-throughput

0.584

High

742007

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

392104

H2A1
Histone H2A.1

1

10

High-throughput

0.536

High

498885

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.536

High

605009

XRN1
5'-3' exoribonuclease 1

1

5

High-throughput

0.536

High

640913

RL5
Large ribosomal subunit protein uL18

1

4

High-throughput

0.536

High

645005

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.536

High

742039

BRE5
UBP3-associated protein BRE5

1

11

High-throughput

0.536

High

742050

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

742090

RL7B
Large ribosomal subunit protein uL30B

1

6

High-throughput

0.536

High

524263

CAF20
Cap-associated protein CAF20

2

1

High-throughput

0.533

High

477234

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

19

High-throughput

0.501

High

405000

RL6B
Large ribosomal subunit protein eL6B

1

3

High-throughput

0.489

High

534955

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.489

High

667156

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.489

High

742006

ARPC1
Actin-related protein 2/3 complex subunit 1

1

10

High-throughput

0.489

High

742009

OSH3
Oxysterol-binding protein homolog 3

1

1

High-throughput

0.489

High

742048

AP1M1
AP-1 complex subunit mu-1-I

1

1

High-throughput

0.489

High

742071

MAG2
E3 ubiquitin-protein ligase MAG2

1

1

High-throughput

0.489

High

141281

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

405572

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

407865

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

408334

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

9

High-throughput

0.479

High

413456

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

480055

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.479

High

501209

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

594033

MAK11
Protein MAK11

1

14

High-throughput

0.479

High

597825

PWP1
Periodic tryptophan protein 1

1

12

High-throughput

0.479

High

627936

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

631822

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

634396

SPB1
27S pre-rRNA

1

4

High-throughput

0.479

High

634565

KRR1
KRR1 small subunit processome component

1

4

High-throughput

0.479

High

645391

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

661977

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

664779

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

675727

RENT1
ATP-dependent helicase NAM7

1

12

Small-scale

0.479

High

698773

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

4

High-throughput

0.479

High

703036

MRT4
Ribosome assembly factor MRT4

1

2

High-throughput

0.479

High

728222

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

731563

EAP1
Protein EAP1

1

1

High-throughput

0.479

High

742004

GBLP
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.479

High

742008

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

742014

RIX1
Pre-rRNA-processing protein RIX1

1

1

Small-scale

0.479

High

742017

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

14

Small-scale

0.479

High

742022

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

742023

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

742032

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

742036

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.479

High

742038

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

742041

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.479

High

742046

ORC1
Origin recognition complex subunit 1

1

4

High-throughput

0.479

High

742054

XRN2
5'-3' exoribonuclease 2

1

5

High-throughput

0.479

High

742057

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.479

High

742061

DHR1
Probable ATP-dependent RNA helicase DHR1

1

6

High-throughput

0.479

High

742063

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.479

High

742065

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.479

High

742067

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

742068

FKBP4
FK506-binding protein 4

1

1

High-throughput

0.479

High

742069

JIP5
WD repeat-containing protein JIP5

1

5

High-throughput

0.479

High

742072

NOC4
Nucleolar complex protein 4

1

3

High-throughput

0.479

High

742074

RLP24
Ribosome biogenesis protein RLP24

1

2

High-throughput

0.479

High

742077

REXO4
RNA exonuclease 4

1

5

High-throughput

0.479

High

742079

SGO1
Shugoshin

1

1

High-throughput

0.479

High

742080

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.479

High

742083

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.479

High

742084

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

419471

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

630187

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

635112

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

688202

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

742013

RPF1
Ribosome production factor 1

1

0

High-throughput

0.458

High

742028

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

742029

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

742034

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

742045

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

742056

ESP1
Separin

1

0

High-throughput

0.458

High

742060

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

742078

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

366145

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

399422

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

510990

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

742021

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

742031

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.445

High

742047

SEN1
Helicase SEN1

1

13

Small-scale

0.445

High

358017

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

425902

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

471006

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

472148

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

480621

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

481322

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.437

High

481623

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.437

High

482218

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

520819

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.437

High

560338

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

2

High-throughput

0.437

High

700360

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

701390

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

706220

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

729860

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

742015

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

742030

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

742051

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

742082

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

612226

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

742052

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.417

High

742059

BUL2
Ubiquitin ligase-binding protein BUL2

2

0

Small-scale

0.318

High

471767

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

705074

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

742012

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

742053

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

742073

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

704204

RIB7
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

1

0

High-throughput

0.232

Low

742091

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024