Protein: LSM2
U6 snRNA-associated Sm-like protein LSm2 (Small nuclear ribonucleoprotein D homolog SNP3)

Gene: LSM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 185
UniProt ID: P38203

Gene Ontology (top 5):
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

746307

LSM1
Sm-like protein LSm1

14

20

Small-scale

0.983

High

746331

LSM3
U6 snRNA-associated Sm-like protein LSm3

12

20

Small-scale

0.980

High

635852

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

11

5

Small-scale

0.979

High

746309

LSM8
U6 snRNA-associated Sm-like protein LSm8

9

20

Small-scale

0.974

High

746327

LSM7
U6 snRNA-associated Sm-like protein LSm7

7

20

Small-scale

0.967

High

746297

LSM5
U6 snRNA-associated Sm-like protein LSm5

7

7

Small-scale

0.965

High

746296

LSM4
U6 snRNA-associated Sm-like protein LSm4

6

14

Small-scale

0.955

High

746349

LSM6
U6 snRNA-associated Sm-like protein LSm6

6

19

Small-scale

0.945

High

746315

PRP24
U4/U6 snRNA-associated-splicing factor PRP24

5

4

Small-scale

0.925

High

746348

SMD2
Small nuclear ribonucleoprotein Sm D2

5

10

Small-scale

0.922

High

704657

PRP8
Pre-mRNA-splicing factor 8

4

7

Small-scale

0.892

High

731722

SN114
Pre-mRNA-splicing factor SNU114

3

11

High-throughput

0.855

High

746294

RSMB
Small nuclear ribonucleoprotein-associated protein B

3

15

High-throughput

0.847

High

746339

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

2

7

High-throughput

0.789

High

746337

SMD1
Small nuclear ribonucleoprotein Sm D1

2

7

High-throughput

0.776

High

367987

EF1A
Elongation factor 1-alpha

2

1

Small-scale

0.767

High

746305

SMD3
Small nuclear ribonucleoprotein Sm D3

2

16

Small-scale

0.754

High

697202

BRR2
Pre-mRNA-splicing helicase BRR2

7

20

Small-scale

0.737

High

746288

DHH1
ATP-dependent RNA helicase DHH1

5

9

High-throughput

0.718

High

605016

XRN1
5'-3' exoribonuclease 1

5

2

High-throughput

0.716

High

589075

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

3

17

High-throughput

0.662

High

746314

PRP31
Pre-mRNA-processing factor 31

3

8

High-throughput

0.662

High

746371

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

4

Small-scale

0.656

High

612515

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.622

High

746366

RUXE
Small nuclear ribonucleoprotein E

1

10

Small-scale

0.621

High

746298

RUXG
Small nuclear ribonucleoprotein G

1

20

High-throughput

0.618

High

746330

RUXF
Small nuclear ribonucleoprotein F

1

19

High-throughput

0.618

High

636132

NOT1
General negative regulator of transcription subunit 1

2

1

High-throughput

0.613

High

586396

PRP6
Pre-mRNA-splicing factor 6

2

15

High-throughput

0.611

High

746334

PRP38
Pre-mRNA-splicing factor 38

2

1

High-throughput

0.611

High

746374

DCP1
mRNA-decapping enzyme subunit 1

2

1

Small-scale

0.600

High

690913

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

2

High-throughput

0.587

High

746310

MTR3
Exosome complex component MTR3

2

0

High-throughput

0.577

High

694021

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

8

High-throughput

0.541

High

376759

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

High-throughput

0.536

High

746356

BUD20
Bud site selection protein 20

1

1

High-throughput

0.536

High

409986

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.518

High

423456

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.513

High

145721

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.508

High

500609

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.508

High

624214

DBP1
ATP-dependent RNA helicase DBP1

1

6

High-throughput

0.508

High

699548

BEM3
GTPase-activating protein BEM3

1

3

High-throughput

0.508

High

746286

SSN3
Meiotic mRNA stability protein kinase SSN3

1

2

High-throughput

0.508

High

746290

SWD1
COMPASS component SWD1

1

20

High-throughput

0.508

High

746292

EDC3
Enhancer of mRNA-decapping protein 3

1

2

High-throughput

0.508

High

746321

DCP2
m7GpppN-mRNA hydrolase

1

1

High-throughput

0.508

High

746340

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.508

High

746357

ULS1
ATP-dependent helicase ULS1

1

3

High-throughput

0.508

High

746368

GYP5
GTPase-activating protein GYP5

1

2

High-throughput

0.508

High

746372

AIR2
Protein AIR2

1

1

High-throughput

0.508

High

746304

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.500

High

519868

WHI2
Growth regulation protein

1

0

High-throughput

0.486

High

597576

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.486

High

599968

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.486

High

699574

HFA1
Acetyl-CoA carboxylase, mitochondrial

1

0

High-throughput

0.486

High

710652

SEF1
Putative transcription factor SEF1

1

0

High-throughput

0.486

High

746301

CSM2
Chromosome segregation in meiosis protein 2

1

0

High-throughput

0.486

High

746317

YGT5
Putative 2-hydroxyacid dehydrogenase YGL185C

1

0

High-throughput

0.486

High

746324

PDR17
Phosphatidylinositol transfer protein PDR17

1

0

High-throughput

0.486

High

746351

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.486

High

746359

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

0

High-throughput

0.486

High

746363

TPT1
tRNA 2'-phosphotransferase

1

0

High-throughput

0.486

High

746364

YL126
Putative glutamine amidotransferase YLR126C

1

0

High-throughput

0.486

High

710006

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

Small-scale

0.481

High

360851

TBB
Tubulin beta chain

1

0

High-throughput

0.479

High

389272

HXKA
Hexokinase-1

1

0

High-throughput

0.479

High

454296

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.479

High

746308

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.479

High

746332

ACT
Actin

1

0

High-throughput

0.479

High

405581

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

424857

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.479

High

543620

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

631833

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

634572

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

645401

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

662030

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

675728

RENT1
ATP-dependent helicase NAM7

1

2

Small-scale

0.479

High

691991

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

3

High-throughput

0.479

High

696865

RML2
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.479

High

735271

RM07
Large ribosomal subunit protein uL5m

1

2

High-throughput

0.479

High

746306

SCD6
Protein SCD6

1

3

Small-scale

0.479

High

746329

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

746341

RM34
Large ribosomal subunit protein bL34m

1

1

High-throughput

0.479

High

746342

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.479

High

746350

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

6

Small-scale

0.479

High

746352

MHR1
Large ribosomal subunit protein mL67

1

1

High-throughput

0.479

High

746354

DIB1
Spliceosomal protein DIB1

1

4

High-throughput

0.479

High

746355

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

746361

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

746362

YRA1
RNA annealing protein YRA1

1

5

Small-scale

0.479

High

746365

CLF1
Pre-mRNA-splicing factor CLF1

1

20

Small-scale

0.479

High

746367

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.479

High

471488

RS28B
Small ribosomal subunit protein eS28B

1

3

High-throughput

0.464

High

746370

DCN1
Defective in cullin neddylation protein 1

1

2

High-throughput

0.464

High

593058

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.460

High

141290

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383100

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

406999

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

425911

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

700856

SMY2
Protein SMY2

1

0

Small-scale

0.458

High

746284

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

746312

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

746335

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

746358

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

746360

NMD4
Nonsense-mediated decay protein 4

1

0

Small-scale

0.458

High

746285

YHS2
MIP18 family protein YHR122W

1

2

High-throughput

0.457

High

342001

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.457

High

423834

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

491005

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

511061

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

640919

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.445

High

692287

PRP19
Pre-mRNA-processing factor 19

1

17

Small-scale

0.445

High

694561

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

705097

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

746287

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

746291

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

746293

NUG1
Nuclear GTP-binding protein NUG1

1

1

High-throughput

0.445

High

746313

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.445

High

746323

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.445

High

746343

ERB1
Ribosome biogenesis protein ERB1

1

9

High-throughput

0.445

High

746346

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

7

High-throughput

0.445

High

746375

RS28A
Small ribosomal subunit protein eS28A

1

3

High-throughput

0.439

High

520518

RM02
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.437

High

534483

RM31
Large ribosomal subunit protein mL60

1

1

High-throughput

0.437

High

589379

RM33
Large ribosomal subunit protein uL30m

1

1

High-throughput

0.437

High

607415

RM08
Large ribosomal subunit protein bL17m

1

1

High-throughput

0.437

High

607484

RM20
Large ribosomal subunit protein mL58

1

1

High-throughput

0.437

High

615607

RM25
Large ribosomal subunit protein mL59

1

1

High-throughput

0.437

High

629854

RM32
Large ribosomal subunit protein bL32m

1

1

High-throughput

0.437

High

635367

IMG1
Large ribosomal subunit protein bL19m

1

1

High-throughput

0.437

High

635778

IMG2
Large ribosomal subunit protein mL49

1

1

High-throughput

0.437

High

679556

RM09
Large ribosomal subunit protein uL3m

1

1

High-throughput

0.437

High

689492

RM41
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.437

High

689583

RM49
Large ribosomal subunit protein mL61

1

1

High-throughput

0.437

High

700275

RM06
Large ribosomal subunit protein uL6m

1

2

High-throughput

0.437

High

700367

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

729795

RM38
Large ribosomal subunit protein uL14m

1

1

High-throughput

0.437

High

735136

RM03
Large ribosomal subunit protein mL44

1

1

High-throughput

0.437

High

735202

RM04
Large ribosomal subunit protein uL29m

1

1

High-throughput

0.437

High

735325

RM10
Large ribosomal subunit protein uL15m

1

1

High-throughput

0.437

High

735391

RM11
Large ribosomal subunit protein uL10m

1

1

High-throughput

0.437

High

735440

RM15
Large ribosomal subunit protein mL57

1

1

High-throughput

0.437

High

735505

RM24
Large ribosomal subunit protein bL28m

1

1

High-throughput

0.437

High

735556

RM27
Large ribosomal subunit protein mL41

1

1

High-throughput

0.437

High

735594

RM28
Large ribosomal subunit protein mL40

1

1

High-throughput

0.437

High

735651

RM17
Large ribosomal subunit protein mL46

1

1

High-throughput

0.437

High

735719

RM36
Large ribosomal subunit protein bL31m

1

1

High-throughput

0.437

High

735762

RM37
Large ribosomal subunit protein mL54

1

1

High-throughput

0.437

High

735790

RM39
Large ribosomal subunit protein bL33m

1

1

High-throughput

0.437

High

735819

RM40
Large ribosomal subunit protein uL24m

1

1

High-throughput

0.437

High

743341

RM16
Large ribosomal subunit protein uL16m

1

1

High-throughput

0.437

High

746289

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

746303

RN49
Large ribosomal subunit protein bL21m

1

1

High-throughput

0.437

High

746316

RL4P
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.437

High

746318

MNP1
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.437

High

746319

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

746322

RM50
Large ribosomal subunit protein bL9m

1

1

High-throughput

0.437

High

746325

RM19
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.437

High

746326

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.437

High

746328

RN35
Large ribosomal subunit protein bL35m

1

1

High-throughput

0.437

High

746336

RM13
Large ribosomal subunit protein mL50

1

1

High-throughput

0.437

High

746338

ATP25
ATPase synthesis protein 25, mitochondrial

1

1

High-throughput

0.437

High

746347

RM51
Large ribosomal subunit protein mL43

1

1

High-throughput

0.437

High

746353

RM35
Large ribosomal subunit protein mL38

1

1

High-throughput

0.437

High

746373

RM23
Large ribosomal subunit protein uL13m

1

1

High-throughput

0.437

High

746311

HLJ1
Protein HLJ1

1

1

High-throughput

0.407

High

746369

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.279

Low

685512

COPG
Coatomer subunit gamma

1

0

High-throughput

0.265

Low

687598

YPS1
Aspartic proteinase 3

1

0

High-throughput

0.265

Low

696688

PT127
Putative mitochondrial translation system component PET127

1

0

High-throughput

0.265

Low

746300

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.265

Low

746302

ATC7
Phospholipid-transporting ATPase NEO1

1

0

High-throughput

0.265

Low

746320

PEX8
Peroxisomal biogenesis factor 8

1

0

High-throughput

0.265

Low

746333

SEC5
Exocyst complex component SEC5

1

0

High-throughput

0.265

Low

746344

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.265

Low

746345

BCH1
Protein BCH1

1

0

High-throughput

0.265

Low

378335

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

381700

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

549666

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

619567

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

630797

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

746299

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

474388

YO163
Putative uncharacterized transporter YOL163W

1

0

High-throughput

0.251

Low

358029

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

746295

MRX1
MIOREX complex component 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024