Protein: DBP8
ATP-dependent RNA helicase DBP8 (EC 3.6.4.13) (DEAD box protein 8)

Gene: DBP8
Organism: Saccharomyces cerevisiae S288C
Interactions: 156
UniProt ID: P38719

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635572

PWP2
Periodic tryptophan protein 2

3

14

High-throughput

0.855

High

753176

DHR1
Probable ATP-dependent RNA helicase DHR1

2

11

High-throughput

0.754

High

730694

DHR2
Probable ATP-dependent RNA helicase DHR2

1

6

High-throughput

0.752

High

753161

ESF2
Pre-rRNA-processing protein ESF2

4

3

Small-scale

0.707

High

485721

IF4A
ATP-dependent RNA helicase eIF4A

1

15

High-throughput

0.691

High

748595

ENP1
Essential nuclear protein 1

3

5

Small-scale

0.640

High

753134

RPN1
26S proteasome regulatory subunit RPN1

2

1

High-throughput

0.628

High

593632

DBP4
ATP-dependent RNA helicase HCA4

1

18

High-throughput

0.618

High

638742

SPB4
ATP-dependent rRNA helicase SPB4

1

18

High-throughput

0.618

High

753181

UTP21
U3 small nucleolar RNA-associated protein 21

1

12

High-throughput

0.618

High

753196

SAS10
Something about silencing protein 10

2

1

High-throughput

0.614

High

407025

RS3
Small ribosomal subunit protein uS3

2

6

High-throughput

0.611

High

599174

RIR1
Ribonucleoside-diphosphate reductase large chain 1

2

0

High-throughput

0.602

High

480651

RS8A
Small ribosomal subunit protein eS8A

2

5

High-throughput

0.584

High

634585

KRR1
KRR1 small subunit processome component

2

4

High-throughput

0.584

High

753141

IMB4
Importin subunit beta-4

2

5

High-throughput

0.584

High

753150

UTP10
U3 small nucleolar RNA-associated protein 10

2

4

High-throughput

0.584

High

753153

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

2

Small-scale

0.584

High

753166

ACT
Actin

2

5

High-throughput

0.584

High

383123

RL25
Large ribosomal subunit protein uL23

2

4

High-throughput

0.571

High

753167

H3
Histone H3

2

11

High-throughput

0.571

High

358046

RS17A
Small ribosomal subunit protein eS17A

2

5

High-throughput

0.558

High

471035

RS22A
Small ribosomal subunit protein uS8A

2

6

High-throughput

0.558

High

753159

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.558

High

491108

HSP71
Heat shock protein SSA1

2

12

High-throughput

0.552

High

511184

SSB1
Ribosome-associated molecular chaperone SSB1

2

12

High-throughput

0.552

High

366236

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.541

High

372821

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

1

High-throughput

0.536

High

399449

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

406330

RL15A
Large ribosomal subunit protein eL15A

1

2

High-throughput

0.536

High

498514

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

498912

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.536

High

534974

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.536

High

560966

EF3A
Elongation factor 3A

1

8

High-throughput

0.536

High

562229

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.536

High

564278

RL8A
Large ribosomal subunit protein eL8A

1

4

High-throughput

0.536

High

583219

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.536

High

649888

CDC15
Cell division control protein 15

1

7

High-throughput

0.536

High

676027

XPO1
Exportin-1

1

15

High-throughput

0.536

High

746567

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.536

High

753136

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.536

High

753137

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.536

High

753139

ARB1
ABC transporter ATP-binding protein ARB1

1

6

High-throughput

0.536

High

753157

ACS2
Acetyl-coenzyme A synthetase 2

1

1

High-throughput

0.536

High

753164

EF3B
Elongation factor 3B

1

8

High-throughput

0.536

High

753170

RL6A
Large ribosomal subunit protein eL6A

1

3

High-throughput

0.536

High

753193

NEW1
[NU+] prion formation protein 1

1

8

High-throughput

0.536

High

340125

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

434529

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

456693

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

657061

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

High-throughput

0.513

High

753173

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.513

High

485517

SSBP1
Single-stranded nucleic acid-binding protein

1

9

High-throughput

0.500

High

562376

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.500

High

636612

CDC48
Cell division control protein 48

1

3

High-throughput

0.500

High

664808

BMH1
Protein BMH1

1

5

High-throughput

0.500

High

753191

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

2

High-throughput

0.500

High

753194

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

2

High-throughput

0.500

High

368023

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.489

High

479465

RS24A
Small ribosomal subunit protein eS24A

1

3

High-throughput

0.489

High

596639

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

687370

EF2
Elongation factor 2

1

8

High-throughput

0.489

High

753183

THI22
Thiamine biosynthesis protein THI22

1

2

High-throughput

0.489

High

588062

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

141311

RS9A
Small ribosomal subunit protein uS4A

1

6

High-throughput

0.479

High

404568

RL7A
Large ribosomal subunit protein uL30A

1

7

High-throughput

0.479

High

405602

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

407894

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

408348

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

3

High-throughput

0.479

High

413485

RS14A
Small ribosomal subunit protein uS11A

1

5

High-throughput

0.479

High

425930

RS19A
Small ribosomal subunit protein eS19A

1

6

High-throughput

0.479

High

480083

RS6A
Small ribosomal subunit protein eS6A

1

6

High-throughput

0.479

High

481504

RS11B
Small ribosomal subunit protein uS17B

1

5

High-throughput

0.479

High

482244

RS18A
Small ribosomal subunit protein uS13A

1

5

High-throughput

0.479

High

527000

TBP
TATA-box-binding protein

1

2

High-throughput

0.479

High

631855

RS2
Small ribosomal subunit protein uS5

1

8

High-throughput

0.479

High

645422

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

662132

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

688222

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

700389

RSSA1
Small ribosomal subunit protein uS2A

1

10

High-throughput

0.479

High

706252

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.479

High

707082

DCA13
Protein SOF1

1

14

High-throughput

0.479

High

729891

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

742774

GBLP
Small ribosomal subunit protein RACK1

1

17

High-throughput

0.479

High

753140

UTP7
U3 small nucleolar RNA-associated protein 7

1

12

High-throughput

0.479

High

753145

DSN1
Kinetochore-associated protein DSN1

1

4

High-throughput

0.479

High

753154

NOL10
Ribosome biogenesis protein ENP2

1

2

High-throughput

0.479

High

753162

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

753163

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

3

High-throughput

0.479

High

753169

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.479

High

753171

UTP6
U3 small nucleolar RNA-associated protein 6

1

1

High-throughput

0.479

High

753172

UTP17
NET1-associated nuclear protein 1

1

9

High-throughput

0.479

High

753174

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

753175

UTP5
U3 small nucleolar RNA-associated protein 5

1

13

High-throughput

0.479

High

753177

UTP15
U3 small nucleolar RNA-associated protein 15

1

13

High-throughput

0.479

High

753178

UTP14
U3 small nucleolar RNA-associated protein 14

1

4

High-throughput

0.479

High

753179

RRP5
rRNA biogenesis protein RRP5

1

11

High-throughput

0.479

High

753180

UTP13
U3 small nucleolar RNA-associated protein 13

1

20

High-throughput

0.479

High

753182

ESF1
Pre-rRNA-processing protein ESF1

1

3

High-throughput

0.479

High

753184

NOC4
Nucleolar complex protein 4

1

8

High-throughput

0.479

High

753185

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

753186

UTP4
U3 small nucleolar RNA-associated protein 4

1

15

High-throughput

0.479

High

753190

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

1

High-throughput

0.479

High

753192

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.479

High

753197

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

753199

UTP12
U3 small nucleolar RNA-associated protein 12

1

15

High-throughput

0.479

High

753200

CMR1
DNA damage-binding protein CMR1

1

12

High-throughput

0.479

High

753202

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

753187

IMH1
Golgin IMH1

1

12

High-throughput

0.470

High

711032

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

753135

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

753143

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

753144

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

753160

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

753201

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

378341

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

355472

H2B1
Histone H2B.1

1

9

High-throughput

0.445

High

424500

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

478163

HSP77
Import motor subunit, mitochondrial

1

11

High-throughput

0.445

High

493877

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

640931

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.445

High

753142

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

753149

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.445

High

753151

GCN20
Protein GCN20

1

5

High-throughput

0.445

High

753152

RSSA2
Small ribosomal subunit protein uS2B

1

10

High-throughput

0.445

High

753195

MDN1
Midasin

1

5

High-throughput

0.445

High

753198

RL7B
Large ribosomal subunit protein uL30B

1

7

High-throughput

0.445

High

472171

RL31A
Large ribosomal subunit protein eL31A

1

7

High-throughput

0.437

High

478885

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

752429

RS20
Small ribosomal subunit protein uS10

1

7

High-throughput

0.437

High

753138

LAA1
AP-1 accessory protein LAA1

1

5

High-throughput

0.437

High

753155

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.437

High

753158

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.437

High

753168

NUM1
Nuclear migration protein NUM1

1

11

High-throughput

0.437

High

753188

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

410989

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.426

High

454311

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

556026

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

752894

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.426

High

421630

FAS1
Fatty acid synthase subunit beta

1

1

High-throughput

0.407

High

540087

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.407

High

707848

GCN1
eIF-2-alpha kinase activator GCN1

1

10

High-throughput

0.407

High

753146

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.407

High

753148

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

732351

YKH5
Uncharacterized protein YKL075C

1

0

High-throughput

0.282

High

343119

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.279

Low

730972

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

739486

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.279

Low

753147

COPB
Coatomer subunit beta

1

0

High-throughput

0.279

Low

753189

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.279

Low

558620

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.261

Low

753165

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.261

Low

423959

CBP1
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.249

Low

735393

RM11
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.249

Low

360868

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

753156

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024