Protein: ROK1
ATP-dependent RNA helicase ROK1 (EC 3.6.4.13) (Rescuer of KEM1 protein 1)

Gene: ROK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 120
UniProt ID: P45818

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635597

PWP2
Periodic tryptophan protein 2

3

12

High-throughput

0.855

High

799858

SGD1
Suppressor of glycerol defect protein 1

2

6

Small-scale

0.768

High

799848

DHR1
Probable ATP-dependent RNA helicase DHR1

2

12

High-throughput

0.754

High

799856

UTP21
U3 small nucleolar RNA-associated protein 21

2

8

Small-scale

0.754

High

748641

ENP1
Essential nuclear protein 1

6

4

Small-scale

0.719

High

799834

UTP22
U3 small nucleolar RNA-associated protein 22

5

0

High-throughput

0.692

High

799851

RRP5
rRNA biogenesis protein RRP5

4

8

Small-scale

0.689

High

634664

KRR1
KRR1 small subunit processome component

3

3

High-throughput

0.640

High

792475

UTP10
U3 small nucleolar RNA-associated protein 10

3

3

High-throughput

0.640

High

799844

UTP6
U3 small nucleolar RNA-associated protein 6

3

0

High-throughput

0.628

High

593661

DBP4
ATP-dependent RNA helicase HCA4

1

13

High-throughput

0.618

High

733574

RL1D1
Ribosome biogenesis protein UTP30

1

1

High-throughput

0.618

High

799826

MTR4
ATP-dependent RNA helicase DOB1

1

13

High-throughput

0.618

High

799853

HRQ1
ATP-dependent helicase HRQ1

1

17

Small-scale

0.618

High

799849

UTP15
U3 small nucleolar RNA-associated protein 15

2

10

High-throughput

0.611

High

799876

FAL1
ATP-dependent RNA helicase FAL1

1

17

Small-scale

0.590

High

799877

SAS10
Something about silencing protein 10

2

0

High-throughput

0.588

High

630217

RRP43
Exosome complex component RRP43

2

2

High-throughput

0.584

High

799850

UTP14
U3 small nucleolar RNA-associated protein 14

2

1

High-throughput

0.584

High

799863

NOC4
Nucleolar complex protein 4

2

5

High-throughput

0.584

High

799865

UTP4
U3 small nucleolar RNA-associated protein 4

2

11

Small-scale

0.584

High

799883

NOP58
Nucleolar protein 58

2

5

High-throughput

0.584

High

799828

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

0

Small-scale

0.559

High

511773

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.552

High

498978

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.536

High

613717

RS3A2
Small ribosomal subunit protein eS1B

1

5

High-throughput

0.536

High

664490

HRR25
Casein kinase I homolog HRR25

1

3

Small-scale

0.536

High

799857

MRD1
Multiple RNA-binding domain-containing protein 1

1

6

Small-scale

0.536

High

471124

RS22A
Small ribosomal subunit protein uS8A

2

4

High-throughput

0.533

High

701487

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.517

High

799880

UTP23
rRNA-processing protein UTP23

1

3

Small-scale

0.501

High

635130

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.493

High

479492

RS24A
Small ribosomal subunit protein eS24A

1

2

High-throughput

0.489

High

715347

SPT7
Transcriptional activator SPT7

1

13

High-throughput

0.489

High

141398

RS9A
Small ribosomal subunit protein uS4A

1

5

High-throughput

0.479

High

407984

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

413580

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

426015

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.479

High

480171

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

480742

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

482320

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.479

High

543965

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

549425

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

594053

MAK11
Protein MAK11

1

17

Small-scale

0.479

High

631948

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.479

High

688303

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

700074

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

5

High-throughput

0.479

High

700483

RSSA1
Small ribosomal subunit protein uS2A

1

7

High-throughput

0.479

High

705337

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

706343

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.479

High

707105

DCA13
Protein SOF1

1

11

High-throughput

0.479

High

758443

RRP8
25S rRNA

1

1

High-throughput

0.479

High

767376

UTP7
U3 small nucleolar RNA-associated protein 7

1

8

High-throughput

0.479

High

799827

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

799832

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.479

High

799835

RRP46
Exosome complex component RRP46

1

1

High-throughput

0.479

High

799841

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.479

High

799843

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

799845

UTP17
NET1-associated nuclear protein 1

1

8

High-throughput

0.479

High

799846

TOM1
E3 ubiquitin-protein ligase TOM1

1

12

High-throughput

0.479

High

799847

UTP5
U3 small nucleolar RNA-associated protein 5

1

10

High-throughput

0.479

High

799852

FCF1
rRNA-processing protein FCF1

1

3

High-throughput

0.479

High

799855

UTP13
U3 small nucleolar RNA-associated protein 13

1

16

High-throughput

0.479

High

799862

RRP9
Ribosomal RNA-processing protein 9

1

17

High-throughput

0.479

High

799868

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

1

High-throughput

0.479

High

799869

RRP44
Exosome complex exonuclease DIS3

1

5

High-throughput

0.479

High

799873

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

799874

BMS1
Ribosome biogenesis protein BMS1

1

3

High-throughput

0.479

High

799878

RIO1
Serine/threonine-protein kinase RIO1

1

9

High-throughput

0.479

High

799879

UTP12
U3 small nucleolar RNA-associated protein 12

1

12

High-throughput

0.479

High

799881

NOP56
Nucleolar protein 56

1

5

High-throughput

0.479

High

630505

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

711046

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

715939

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

756748

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

768085

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

772640

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

774254

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

774720

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

775367

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

799829

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

799836

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

799837

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.458

High

799838

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.458

High

799839

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

799854

RRP45
Exosome complex component RRP45

1

0

High-throughput

0.458

High

799860

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

799861

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

799864

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

799867

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

799872

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

799875

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

799882

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

799884

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

799885

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

799886

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

491620

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

754501

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

768760

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

358130

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.437

High

478919

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

524359

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

628205

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

650322

SPT5
Transcription elongation factor SPT5

1

4

High-throughput

0.437

High

662580

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

698854

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.437

High

742860

GBLP
Small ribosomal subunit protein RACK1

1

14

High-throughput

0.437

High

762325

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.437

High

775199

ULP2
Ubiquitin-like-specific protease 2

1

4

High-throughput

0.437

High

799830

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.437

High

799840

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.437

High

799842

NUM1
Nuclear migration protein NUM1

1

7

High-throughput

0.437

High

799859

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

799866

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

799871

SGO1
Shugoshin

1

3

High-throughput

0.437

High

799870

RBX1
RING-box protein HRT1

1

2

High-throughput

0.417

High

799833

ARI1
NADPH-dependent aldehyde reductase ARI1

1

0

High-throughput

0.269

Low

753073

OSH3
Oxysterol-binding protein homolog 3

1

0

Small-scale

0.264

Low

743107

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.249

Low

799831

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024