Protein: LSG1
Large subunit GTPase 1 (EC 3.6.1.-)

Gene: LSG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 177
UniProt ID: P53145

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000054 - ribosomal subunit export from nucleus
GO:0003729 - mRNA binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

481189

RL1A
Large ribosomal subunit protein uL1A

4

3

Small-scale

0.867

High

481953

RL12B
Large ribosomal subunit protein uL11B

3

1

High-throughput

0.817

High

756371

NMD3
60S ribosomal export protein NMD3

19

1

Small-scale

0.765

High

859651

IF6
Eukaryotic translation initiation factor 6

13

5

Small-scale

0.761

High

535056

RL3
Large ribosomal subunit protein uL3

12

3

Small-scale

0.757

High

748893

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

10

2

Small-scale

0.755

High

407197

RS3
Small ribosomal subunit protein uS3

2

4

High-throughput

0.754

High

859627

ARX1
Probable metalloprotease ARX1

9

5

Small-scale

0.752

High

399560

RLA0
Large ribosomal subunit protein uL10

8

6

Small-scale

0.745

High

641010

RL5
Large ribosomal subunit protein uL18

7

5

Small-scale

0.739

High

766667

NUG1
Nuclear GTP-binding protein NUG1

2

2

Small-scale

0.737

High

784177

RL10
Large ribosomal subunit protein uL16

6

5

Small-scale

0.724

High

859620

PVH1
Tyrosine-protein phosphatase YVH1

10

0

Small-scale

0.720

High

859656

MEX67
mRNA export factor MEX67

8

0

Small-scale

0.714

High

482900

RL35A
Large ribosomal subunit protein uL29A

5

2

Small-scale

0.702

High

481377

RL2A
Large ribosomal subunit protein uL2A

4

5

High-throughput

0.676

High

859637

REH1
Cytoplasmic 60S subunit biogenesis factor REH1

4

5

Small-scale

0.669

High

859610

SDA1
Protein SDA1

3

2

High-throughput

0.662

High

810574

ALB1
Ribosome biogenesis protein ALB1

3

2

Small-scale

0.656

High

564330

RL8A
Large ribosomal subunit protein eL8A

3

6

Small-scale

0.650

High

703081

MRT4
Ribosome assembly factor MRT4

3

6

Small-scale

0.650

High

859649

YRA1
RNA annealing protein YRA1

3

2

Small-scale

0.650

High

631987

RS2
Small ribosomal subunit protein uS5

3

5

Small-scale

0.640

High

645081

RL16A
Large ribosomal subunit protein uL13A

3

6

High-throughput

0.640

High

859624

NOG1
Nucleolar GTP-binding protein 1

3

9

Small-scale

0.640

High

859639

RLP24
Ribosome biogenesis protein RLP24

3

5

Small-scale

0.633

High

829636

RL4B
Large ribosomal subunit protein uL4B

3

9

Small-scale

0.624

High

859607

LSG1
Large subunit GTPase 1

1

3

High-throughput

0.618

High

406149

RL36A
Large ribosomal subunit protein eL36A

2

3

High-throughput

0.611

High

471417

RL11A
Large ribosomal subunit protein uL5A

2

7

High-throughput

0.611

High

667232

RL8B
Large ribosomal subunit protein eL8B

2

6

High-throughput

0.611

High

450481

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

2

0

High-throughput

0.595

High

383254

RL25
Large ribosomal subunit protein uL23

2

3

High-throughput

0.584

High

405233

RL17A
Large ribosomal subunit protein uL22A

2

4

High-throughput

0.584

High

405730

RL26A
Large ribosomal subunit protein uL24A

2

6

High-throughput

0.584

High

406376

RL15A
Large ribosomal subunit protein eL15A

2

2

High-throughput

0.584

High

471801

RL27A
Large ribosomal subunit protein eL27A

2

3

High-throughput

0.584

High

479143

RL43B
Large ribosomal subunit protein eL43B

2

4

High-throughput

0.584

High

630876

NLE1
Ribosome assembly protein 4

2

7

Small-scale

0.584

High

645244

RL16B
Large ribosomal subunit protein uL13B

2

6

High-throughput

0.584

High

645552

RS7A
Small ribosomal subunit protein eS7A

2

2

High-throughput

0.584

High

743285

RL32
Large ribosomal subunit protein eL32

2

1

High-throughput

0.584

High

810878

MTR4
ATP-dependent RNA helicase DOB1

2

7

Small-scale

0.584

High

824781

RL38
Large ribosomal subunit protein eL38

2

2

High-throughput

0.584

High

859648

NOP53
Ribosome biogenesis protein NOP53

2

3

High-throughput

0.584

High

368250

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.575

High

477640

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

2

1

High-throughput

0.571

High

479267

RL44B
Large ribosomal subunit protein eL42B

2

2

Small-scale

0.571

High

499004

RL4A
Large ribosomal subunit protein uL4A

2

9

Small-scale

0.571

High

750136

IF5
Eukaryotic translation initiation factor 5

2

0

High-throughput

0.563

High

859632

CYK2
Cytokinesis protein 2

1

1

High-throughput

0.541

High

676227

XPO1
Exportin-1

1

5

High-throughput

0.536

High

859384

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

High-throughput

0.536

High

859611

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.536

High

859631

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.536

High

768023

NSA2
Ribosome biogenesis protein NSA2

2

4

Small-scale

0.533

High

859608

CGR1
rRNA-processing protein CGR1

2

2

High-throughput

0.521

High

859628

HMO1
High mobility group protein 1

1

5

High-throughput

0.515

High

389726

CDC25
Cell division control protein 25

1

1

High-throughput

0.501

High

562738

FUS3
Mitogen-activated protein kinase FUS3

1

1

High-throughput

0.501

High

747192

FES1
Hsp70 nucleotide exchange factor FES1

1

0

High-throughput

0.493

High

514639

FUS1
Nuclear fusion protein FUS1

1

0

High-throughput

0.480

High

551381

ABP1
Actin-binding protein

1

0

High-throughput

0.480

High

859630

MYO5
Myosin-5

1

0

High-throughput

0.480

High

141435

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

145758

RL36B
Large ribosomal subunit protein eL36B

1

3

High-throughput

0.479

High

357702

RL28
Large ribosomal subunit protein uL15

1

2

High-throughput

0.479

High

358166

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.479

High

387921

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

404643

RL7A
Large ribosomal subunit protein uL30A

1

8

High-throughput

0.479

High

404879

RL9A
Large ribosomal subunit protein uL6A

1

3

High-throughput

0.479

High

405038

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.479

High

406030

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.479

High

406579

RL22A
Large ribosomal subunit protein eL22A

1

5

High-throughput

0.479

High

408021

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

426056

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

471161

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

471916

RL27B
Large ribosomal subunit protein eL27B

1

3

High-throughput

0.479

High

859614

RL34A
Large ribosomal subunit protein eL34A

1

4

High-throughput

0.479

High

472300

RL31A
Large ribosomal subunit protein eL31A

1

6

High-throughput

0.479

High

472515

RL31B
Large ribosomal subunit protein eL31B

1

6

High-throughput

0.479

High

478933

RL20B
Large ribosomal subunit protein eL20B

1

3

High-throughput

0.479

High

480215

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

480784

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

481675

RL18B
Large ribosomal subunit protein eL18B

1

4

High-throughput

0.479

High

482363

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

482755

RL19B
Large ribosomal subunit protein eL19

1

5

High-throughput

0.479

High

534805

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

544116

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

597865

PWP1
Periodic tryptophan protein 1

1

14

Small-scale

0.479

High

621492

RL24B
Large ribosomal subunit protein eL24B

1

5

High-throughput

0.479

High

624135

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

628288

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

700527

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.479

High

706385

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

730024

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

731833

EBP2
rRNA-processing protein EBP2

1

1

Small-scale

0.479

High

732754

RL14A
Large ribosomal subunit protein eL14A

1

4

High-throughput

0.479

High

742901

GBLP
Small ribosomal subunit protein RACK1

1

15

High-throughput

0.479

High

748163

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

752565

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

753683

RL14B
Large ribosomal subunit protein eL14B

1

4

High-throughput

0.479

High

761990

DHH1
ATP-dependent RNA helicase DHH1

1

7

High-throughput

0.479

High

762399

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

763576

ECM1
Shuttling pre-60S factor ECM1

1

1

High-throughput

0.479

High

767065

ARB1
ABC transporter ATP-binding protein ARB1

1

2

Small-scale

0.479

High

770415

RL13B
Large ribosomal subunit protein eL13B

1

4

High-throughput

0.479

High

775066

RL34B
Large ribosomal subunit protein eL34B

1

4

High-throughput

0.479

High

776463

RLP7
Ribosome biogenesis protein RLP7

1

8

High-throughput

0.479

High

780487

RL33B
Large ribosomal subunit protein eL33B

1

2

High-throughput

0.479

High

797487

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

810265

RL17B
Large ribosomal subunit protein uL22B

1

4

High-throughput

0.479

High

820071

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

824744

RL37A
Large ribosomal subunit protein eL37A

1

3

High-throughput

0.479

High

846289

RL9B
Large ribosomal subunit protein uL6B

1

3

High-throughput

0.479

High

846324

RL37B
Large ribosomal subunit protein eL37B

1

3

High-throughput

0.479

High

859609

RL26B
Large ribosomal subunit protein uL24B

1

6

High-throughput

0.479

High

859612

JJJ1
J protein JJJ1

1

11

High-throughput

0.479

High

859613

RL22B
Large ribosomal subunit protein eL22B

1

5

High-throughput

0.479

High

859617

CDC14
Tyrosine-protein phosphatase CDC14

1

5

High-throughput

0.479

High

859618

NOP3
Serine/arginine

1

9

High-throughput

0.479

High

859619

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

859621

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.479

High

859622

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

859625

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

859635

NOC4
Nucleolar complex protein 4

1

9

High-throughput

0.479

High

859638

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.479

High

859640

BUD20
Bud site selection protein 20

1

2

Small-scale

0.479

High

859642

SGO1
Shugoshin

1

2

High-throughput

0.479

High

859645

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

859650

RL7B
Large ribosomal subunit protein uL30B

1

8

High-throughput

0.479

High

859652

RQC2
Ribosome quality control complex subunit 2

1

1

High-throughput

0.479

High

859653

RL21B
Large ribosomal subunit protein eL21B

1

2

High-throughput

0.479

High

859654

RL13A
Large ribosomal subunit protein eL13A

1

4

High-throughput

0.479

High

859655

RL11B
Large ribosomal subunit protein uL5B

1

7

High-throughput

0.479

High

859626

HAS1
ATP-dependent RNA helicase HAS1

1

18

High-throughput

0.470

High

859646

RRS1
Regulator of ribosome biosynthesis

1

2

High-throughput

0.470

High

357535

RLA4
Large ribosomal subunit protein P2B

1

0

High-throughput

0.458

High

399772

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.458

High

406235

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

479363

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.458

High

482987

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

859623

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

859633

RQC1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.458

High

474402

YL016
Putative truncated guanine nucleotide exchange factor SDC25

1

1

High-throughput

0.457

High

859643

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.457

High

478366

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.445

High

491897

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

512078

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.445

High

588162

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

705447

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

754565

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

755242

IPI1
Pre-rRNA-processing protein IPI1

1

2

Small-scale

0.445

High

768988

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

810077

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

606705

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.437

High

634696

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

662830

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

733140

DBP7
ATP-dependent RNA helicase DBP7

1

16

High-throughput

0.437

High

744214

MAK5
ATP-dependent RNA helicase MAK5

1

14

High-throughput

0.437

High

745780

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

792510

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

812050

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

859615

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.437

High

859629

DHR1
Probable ATP-dependent RNA helicase DHR1

1

4

High-throughput

0.437

High

859634

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

859636

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

859641

NOP12
Nucleolar protein 12

1

6

High-throughput

0.437

High

859644

TMA16
Translation machinery-associated protein 16

1

2

High-throughput

0.437

High

859647

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

421665

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

859616

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

355560

H2B1
Histone H2B.1

1

6

High-throughput

0.407

High

772906

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.407

High

710713

MTR2
mRNA transport regulator MTR2

4

0

Small-scale

0.354

High

822882

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024