Protein: COPA
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (Retrieval from endoplasmic reticulum protein 1) (Secretory protein 22) (Suppressor of osmo-sensitivity 1)

Gene: COPA, COP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 224
UniProt ID: P53622

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005198 - structural molecule activity
GO:0006886 - intracellular protein transport
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

774850

COPE
Coatomer subunit epsilon

13

1

Small-scale

0.985

High

784397

COPB2
Coatomer subunit beta'

12

16

Small-scale

0.978

High

784341

COPB
Coatomer subunit beta

10

6

Small-scale

0.974

High

685556

COPG
Coatomer subunit gamma

9

10

Small-scale

0.970

High

863617

COPA
Coatomer subunit alpha

3

15

Small-scale

0.829

High

798106

COPD
Coatomer subunit delta

9

4

Small-scale

0.752

High

863052

COPZ
Coatomer subunit zeta

5

5

High-throughput

0.714

High

751991

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

5

5

Small-scale

0.703

High

744660

TAF5
Transcription initiation factor TFIID subunit 5

1

17

High-throughput

0.691

High

863660

DUF1
DUB-associated factor 1

1

18

High-throughput

0.691

High

797034

EMP47
Protein EMP47

3

1

Small-scale

0.656

High

863636

ERV41
ER-derived vesicles protein ERV41

3

7

High-throughput

0.656

High

863618

DSL1
Protein transport protein DSL1

3

1

Small-scale

0.640

High

863629

GCN5
Histone acetyltransferase GCN5

1

14

High-throughput

0.618

High

707444

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

4

2

Small-scale

0.618

High

743400

AP2A
AP-2 complex subunit alpha

1

6

High-throughput

0.618

High

863643

VPS74
Vacuolar protein sorting-associated protein 74

2

7

Small-scale

0.602

High

503120

ARF1
ADP-ribosylation factor 1

2

12

Small-scale

0.584

High

611789

BET1
Protein transport protein BET1

2

4

Small-scale

0.584

High

763781

ERV46
ER-derived vesicles protein ERV46

2

7

High-throughput

0.584

High

863622

ACT
Actin

1

6

High-throughput

0.578

High

863621

TMEDA
Endoplasmic reticulum vesicle protein 25

2

13

Small-scale

0.571

High

735348

RM10
Large ribosomal subunit protein uL15m

2

1

High-throughput

0.567

High

358183

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.553

High

564339

RL8A
Large ribosomal subunit protein eL8A

1

5

High-throughput

0.553

High

634258

GID7
Glucose-induced degradation protein 7

1

17

High-throughput

0.553

High

716305

SPT10
Protein SPT10

1

1

High-throughput

0.553

High

742918

GBLP
Small ribosomal subunit protein RACK1

1

19

High-throughput

0.553

High

820088

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.553

High

863657

SEC39
Protein transport protein SEC39

1

1

Small-scale

0.552

High

477393

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

11

Small-scale

0.550

High

366669

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.543

High

863632

RUVB1
RuvB-like protein 1

2

5

High-throughput

0.543

High

340723

PGK
Phosphoglycerate kinase

2

1

High-throughput

0.537

High

628316

SIS1
Protein SIS1

2

9

High-throughput

0.537

High

562417

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

2

3

High-throughput

0.533

High

655046

CIN8
Kinesin-like protein CIN8

2

9

High-throughput

0.533

High

752581

RS20
Small ribosomal subunit protein uS10

2

1

High-throughput

0.533

High

797501

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.533

High

512192

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.521

High

680897

HS104
Heat shock protein 104

2

4

High-throughput

0.521

High

706983

MSN2
Zinc finger protein MSN2

2

2

High-throughput

0.521

High

772308

ATAD2
ATPase histone chaperone YTA7

2

6

High-throughput

0.521

High

817590

SEC16
COPII coat assembly protein SEC16

1

0

Small-scale

0.519

High

772387

VPS27
Vacuolar protein sorting-associated protein 27

1

6

Small-scale

0.515

High

837445

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

High-throughput

0.514

High

863638

TAF9
Transcription initiation factor TFIID subunit 9

1

2

High-throughput

0.514

High

809668

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.513

High

491987

HSP71
Heat shock protein SSA1

2

13

High-throughput

0.504

High

769053

SSB2
Ribosome-associated molecular chaperone SSB2

2

13

High-throughput

0.504

High

761462

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

1

Small-scale

0.501

High

810028

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

1

Small-scale

0.501

High

859929

MST27
Multicopy suppressor of SEC21 protein 27

1

1

Small-scale

0.501

High

636696

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

343299

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.489

High

423697

ADR1
Regulatory protein ADR1

1

3

High-throughput

0.489

High

448511

PRTB
Cerevisin

1

2

High-throughput

0.489

High

636163

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.489

High

701914

SWE1
Mitosis inhibitor protein kinase SWE1

1

7

High-throughput

0.489

High

710516

PP2C3
Protein phosphatase 2C homolog 3

1

2

High-throughput

0.489

High

743820

ATPG
ATP synthase subunit gamma, mitochondrial

1

2

High-throughput

0.489

High

774654

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

8

High-throughput

0.489

High

863634

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.489

High

863646

PRP11
Pre-mRNA-splicing factor PRP11

1

1

High-throughput

0.489

High

605865

SEC22
Protein transport protein SEC22

1

2

Small-scale

0.479

High

634079

RER1
Protein RER1

1

3

Small-scale

0.479

High

689110

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.479

High

697972

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

5

Small-scale

0.479

High

698450

EMP24
Endosomal protein P24B

1

11

Small-scale

0.479

High

701011

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

753362

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.479

High

765342

RSP5
E3 ubiquitin-protein ligase RSP5

1

7

Small-scale

0.479

High

822890

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

863628

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

863647

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

565716

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.470

High

567594

PHO81
Phosphate system positive regulatory protein PHO81

1

3

High-throughput

0.470

High

767803

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

2

High-throughput

0.464

High

633770

VATL1
V-type proton ATPase subunit c

1

0

High-throughput

0.458

High

682244

OCH1
Initiation-specific alpha-1,6-mannosyltransferase

1

1

Small-scale

0.457

High

731641

MNN4
Protein MNN4

1

11

Small-scale

0.457

High

744749

KTR3
Probable mannosyltransferase KTR3

1

1

Small-scale

0.457

High

342753

ENO1
Enolase 1

1

3

High-throughput

0.457

High

378376

LEU3
3-isopropylmalate dehydrogenase

1

8

High-throughput

0.457

High

427278

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

4

High-throughput

0.457

High

450129

HSP73
Heat shock protein SSA3

1

13

High-throughput

0.457

High

454641

TBA3
Tubulin alpha-3 chain

1

11

High-throughput

0.457

High

498560

METK1
S-adenosylmethionine synthase 1

1

2

High-throughput

0.457

High

554707

HSP26
Heat shock protein 26

1

3

High-throughput

0.457

High

588175

HSP60
Heat shock protein 60, mitochondrial

1

16

High-throughput

0.457

High

605373

HSP74
Heat shock protein SSA4

1

13

High-throughput

0.457

High

619617

MPCP
Mitochondrial phosphate carrier protein

1

6

High-throughput

0.457

High

687440

EF2
Elongation factor 2

1

4

High-throughput

0.457

High

712971

BMH2
Protein BMH2

1

4

High-throughput

0.457

High

752947

YHI0
Putative proline--tRNA ligase YHR020W

1

3

High-throughput

0.457

High

863655

HSP42
Heat shock protein 42

1

3

High-throughput

0.457

High

478400

HSP77
Import motor subunit, mitochondrial

1

13

High-throughput

0.445

High

863645

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

8

High-throughput

0.445

High

141450

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

334511

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

5

High-throughput

0.437

High

334769

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

5

High-throughput

0.437

High

383269

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

387996

ADT1
ADP,ATP carrier protein 1

1

4

High-throughput

0.437

High

402995

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

Small-scale

0.437

High

405746

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.437

High

407215

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.437

High

408037

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.437

High

411190

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.437

High

413633

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.437

High

416039

DED1
ATP-dependent RNA helicase DED1

1

5

High-throughput

0.437

High

419931

SNF1
Carbon catabolite-derepressing protein kinase

1

4

Small-scale

0.437

High

425642

KAPR
cAMP-dependent protein kinase regulatory subunit

1

1

Small-scale

0.437

High

426073

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

471175

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472316

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

480230

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

480798

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

482380

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

632005

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.437

High

645566

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

648406

NSR1
Nuclear localization sequence-binding protein

1

2

High-throughput

0.437

High

657020

IPYR2
Inorganic pyrophosphatase, mitochondrial

1

1

High-throughput

0.437

High

657092

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

6

High-throughput

0.437

High

662911

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

667875

MCM5
Minichromosome maintenance protein 5

1

1

High-throughput

0.437

High

681329

TPS2
Trehalose-phosphatase

1

3

High-throughput

0.437

High

688612

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

High-throughput

0.437

High

690956

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

5

High-throughput

0.437

High

691095

HOG1
Mitogen-activated protein kinase HOG1

1

4

High-throughput

0.437

High

691574

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.437

High

706404

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

715829

MDJ1
DnaJ homolog 1, mitochondrial

1

12

High-throughput

0.437

High

716483

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

730042

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

730872

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.437

High

733670

LAS1
Protein LAS1

1

1

Small-scale

0.437

High

733717

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

1

High-throughput

0.437

High

747018

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

10

High-throughput

0.437

High

747830

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

6

High-throughput

0.437

High

750049

TPS3
Trehalose synthase complex regulatory subunit TPS3

1

3

High-throughput

0.437

High

750070

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

3

High-throughput

0.437

High

750139

IF5
Eukaryotic translation initiation factor 5

1

3

High-throughput

0.437

High

752077

KPR3
Ribose-phosphate pyrophosphokinase 3

1

1

High-throughput

0.437

High

753897

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.437

High

756991

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

761997

DHH1
ATP-dependent RNA helicase DHH1

1

9

High-throughput

0.437

High

762427

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

765017

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.437

High

773964

MLP2
Protein MLP2

1

11

High-throughput

0.437

High

774311

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

7

High-throughput

0.437

High

776471

RLP7
Ribosome biogenesis protein RLP7

1

5

High-throughput

0.437

High

778524

PHB1
Prohibitin-1

1

6

High-throughput

0.437

High

785135

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.437

High

792524

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.437

High

797114

LAM5
Membrane-anchored lipid-binding protein LAM5

1

2

High-throughput

0.437

High

807612

RS10B
Small ribosomal subunit protein eS10B

1

4

High-throughput

0.437

High

858727

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.437

High

858898

VID30
Vacuolar import and degradation protein 30

1

5

High-throughput

0.437

High

860236

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.437

High

863620

APJ1
J domain-containing protein APJ1

1

12

High-throughput

0.437

High

863624

NUM1
Nuclear migration protein NUM1

1

8

High-throughput

0.437

High

863625

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

3

High-throughput

0.437

High

863626

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

863627

ESP1
Separin

1

1

High-throughput

0.437

High

863630

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

1

High-throughput

0.437

High

863633

BUD22
Bud site selection protein 22

1

1

High-throughput

0.437

High

863635

MYO5
Myosin-5

1

3

High-throughput

0.437

High

863639

FAR8
Factor arrest protein 8

1

1

High-throughput

0.437

High

863641

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

863648

SGO1
Shugoshin

1

1

High-throughput

0.437

High

863649

ESA1
Histone acetyltransferase ESA1

1

4

Small-scale

0.437

High

863650

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

863653

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

2

Small-scale

0.437

High

863656

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.437

High

863658

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.437

High

863659

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.437

High

863642

KEI1
Inositol phosphorylceramide synthase regulatory subunit KEI1

1

0

Small-scale

0.426

High

392519

H2A2
Histone H2A.2

1

4

High-throughput

0.407

High

494582

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.407

High

561254

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.407

High

592955

SRP54
Signal recognition particle subunit SRP54

1

1

High-throughput

0.407

High

633441

MAS5
Mitochondrial protein import protein MAS5

1

12

High-throughput

0.407

High

695208

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.407

High

705484

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

731129

LHS1
Heat shock protein 70 homolog LHS1

1

15

High-throughput

0.407

High

757447

SPT8
Transcription factor SPT8

1

1

High-throughput

0.407

High

760660

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.407

High

760917

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.407

High

772570

JEM1
DnaJ-like chaperone JEM1

1

8

High-throughput

0.407

High

812321

DPH4
Diphthamide biosynthesis protein 4

1

6

High-throughput

0.407

High

857265

ACS2
Acetyl-coenzyme A synthetase 2

1

5

High-throughput

0.407

High

863619

JJJ1
J protein JJJ1

1

6

High-throughput

0.407

High

863640

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

17

High-throughput

0.407

High

859297

RRT6
Regulator of rDNA transcription protein 6

1

1

Small-scale

0.373

High

597588

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.279

Low

711174

SLD2
DNA replication regulator SLD2

1

0

High-throughput

0.279

Low

764834

SLN1
Osmosensing histidine protein kinase SLN1

1

0

High-throughput

0.279

Low

859710

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

863652

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.279

Low

754887

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.269

Low

863644

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.269

Low

863651

PCL8
PHO85 cyclin-8

1

0

High-throughput

0.269

Low

425037

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.261

Low

772725

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

400196

PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase

1

0

High-throughput

0.249

Low

440219

MET3
Sulfate adenylyltransferase

1

0

High-throughput

0.249

Low

496076

RLA3
Large ribosomal subunit protein P1B

1

0

High-throughput

0.249

Low

653072

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.249

Low

688093

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.249

Low

688350

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

693444

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

High-throughput

0.249

Low

732325

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

747419

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

748498

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.249

Low

765198

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.249

Low

797211

BUD27
Bud site selection protein 27

1

0

High-throughput

0.249

Low

812486

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.249

Low

819506

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.249

Low

863623

CACM
Putative mitochondrial carnitine O-acetyltransferase

1

0

High-throughput

0.249

Low

863631

SRC1
Inner nuclear membrane protein SRC1

1

0

High-throughput

0.249

Low

863637

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.249

Low

863654

YVC1
Calcium channel YVC1

1

0

High-throughput

0.249

Low

863661

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024