Protein: XRN2
5'-3' exoribonuclease 2 (EC 3.1.13.-) (Ribonucleic acid-trafficking protein 1) (p116)

Gene: XRN2, RAT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 181
UniProt ID: Q02792

Gene Ontology (top 5):
GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 - nuclear-transcribed mRNA catabolic process
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0004534 - 5'-3' RNA exonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

858817

DXO
Decapping nuclease RAI1

13

4

Small-scale

0.760

High

558215

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

2

Small-scale

0.676

High

733672

LAS1
Protein LAS1

4

2

Small-scale

0.676

High

965471

NOP3
Serine/arginine

4

12

Small-scale

0.676

High

754646

SSZ1
Ribosome-associated complex subunit SSZ1

3

2

High-throughput

0.650

High

972633

RT103
Regulator of Ty1 transposition protein 103

3

1

Small-scale

0.650

High

972620

XRN2
5'-3' exoribonuclease 2

1

3

Small-scale

0.647

High

383311

RL25
Large ribosomal subunit protein uL23

3

1

High-throughput

0.640

High

481405

RL2A
Large ribosomal subunit protein uL2A

3

2

High-throughput

0.640

High

972642

GRC3
Polynucleotide 5'-hydroxyl-kinase GRC3

3

2

Small-scale

0.640

High

605131

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.618

High

972653

YRA1
RNA annealing protein YRA1

2

5

High-throughput

0.601

High

376906

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

2

Small-scale

0.584

High

405789

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.584

High

407261

RS3
Small ribosomal subunit protein uS3

2

1

High-throughput

0.584

High

632044

RS2
Small ribosomal subunit protein uS5

2

2

High-throughput

0.584

High

645609

RS7A
Small ribosomal subunit protein eS7A

2

2

High-throughput

0.584

High

967713

RS15
Small ribosomal subunit protein uS19

2

1

High-throughput

0.584

High

630527

RRP7
Ribosomal RNA-processing protein 7

2

0

High-throughput

0.559

High

769252

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

492196

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.536

High

472359

RL31A
Large ribosomal subunit protein eL31A

2

2

High-throughput

0.533

High

480270

RS6A
Small ribosomal subunit protein eS6A

2

2

High-throughput

0.533

High

480837

RS8A
Small ribosomal subunit protein eS8A

2

1

High-throughput

0.533

High

706445

RS3A1
Small ribosomal subunit protein eS1A

2

1

High-throughput

0.533

High

820128

RS12
Small ribosomal subunit protein eS12

2

1

High-throughput

0.533

High

777318

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.515

High

972637

YSP2
Membrane-anchored lipid-binding protein YSP2

1

0

High-throughput

0.493

High

141484

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

356671

H4
Histone H4

1

2

High-throughput

0.479

High

404682

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.479

High

407577

RS9B
Small ribosomal subunit protein uS4B

1

3

High-throughput

0.479

High

408444

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

413670

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

416061

DED1
ATP-dependent RNA helicase DED1

1

2

High-throughput

0.479

High

426112

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

450500

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.479

High

481212

RL1A
Large ribosomal subunit protein uL1A

1

5

High-throughput

0.479

High

481817

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

482416

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

485579

SSBP1
Single-stranded nucleic acid-binding protein

1

6

High-throughput

0.479

High

499049

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.479

High

501404

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.479

High

523304

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

High-throughput

0.479

High

534830

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.479

High

535095

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

544282

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

548437

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

7

High-throughput

0.479

High

593557

DBP3
ATP-dependent RNA helicase DBP3

1

3

High-throughput

0.479

High

593686

DBP4
ATP-dependent RNA helicase HCA4

1

6

High-throughput

0.479

High

594357

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.479

High

597885

PWP1
Periodic tryptophan protein 1

1

6

High-throughput

0.479

High

606115

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.479

High

624162

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

633985

GBP2
Serine/arginine

1

6

High-throughput

0.479

High

634182

SRO9
RNA-binding protein SRO9

1

1

High-throughput

0.479

High

634741

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

635915

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

4

High-throughput

0.479

High

645266

RL16B
Large ribosomal subunit protein uL13B

1

3

High-throughput

0.479

High

648420

NSR1
Nuclear localization sequence-binding protein

1

6

High-throughput

0.479

High

663094

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

667264

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.479

High

688390

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

694198

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

6

High-throughput

0.479

High

696242

STH1
Nuclear protein STH1/NPS1

1

3

High-throughput

0.479

High

697347

ECM32
Putative ATP-dependent RNA helicase ECM32

1

6

High-throughput

0.479

High

699716

DRS1
ATP-dependent RNA helicase DRS1

1

4

High-throughput

0.479

High

700090

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

3

High-throughput

0.479

High

703102

MRT4
Ribosome assembly factor MRT4

1

1

High-throughput

0.479

High

716200

SKI2
Antiviral helicase SKI2

1

5

High-throughput

0.479

High

730080

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

733229

SA190
SIT4-associating protein SAP190

1

1

High-throughput

0.479

High

733910

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.479

High

742054

NOP4
Nucleolar protein 4

1

5

High-throughput

0.479

High

742952

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

745551

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.479

High

748684

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

752391

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

4

High-throughput

0.479

High

752623

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

753699

RL14B
Large ribosomal subunit protein eL14B

1

1

High-throughput

0.479

High

754175

CIC1
Proteasome-interacting protein CIC1

1

1

High-throughput

0.479

High

758092

BFR1
Nuclear segregation protein BFR1

1

1

High-throughput

0.479

High

759433

STM1
Suppressor protein STM1

1

1

High-throughput

0.479

High

763893

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

765042

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

770444

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.479

High

816535

RS7B
Small ribosomal subunit protein eS7B

1

2

High-throughput

0.479

High

837281

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

4

High-throughput

0.479

High

837335

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

4

High-throughput

0.479

High

859412

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

Small-scale

0.479

High

860354

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

860722

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.479

High

861281

PBP1
PAB1-binding protein 1

1

2

High-throughput

0.479

High

863693

PAP2
Poly(A) RNA polymerase protein 2

1

2

High-throughput

0.479

High

865744

NOP13
Nucleolar protein 13

1

4

High-throughput

0.479

High

866251

NOP15
Ribosome biogenesis protein 15

1

4

High-throughput

0.479

High

902010

H3
Histone H3

1

2

High-throughput

0.479

High

959994

SEN1
Helicase SEN1

1

7

High-throughput

0.479

High

965022

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.479

High

972623

HAS1
ATP-dependent RNA helicase HAS1

1

7

High-throughput

0.479

High

972625

HMO1
High mobility group protein 1

1

3

High-throughput

0.479

High

972627

RRP17
Ribosomal RNA-processing protein 17

1

1

High-throughput

0.479

High

972629

PUF6
Pumilio homology domain family member 6

1

1

High-throughput

0.479

High

972631

ERB1
Ribosome biogenesis protein ERB1

1

3

High-throughput

0.479

High

972632

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.479

High

972634

MRD1
Multiple RNA-binding domain-containing protein 1

1

5

High-throughput

0.479

High

972636

DBP9
ATP-dependent RNA helicase DBP9

1

5

High-throughput

0.479

High

972638

TSR1
Ribosome biogenesis protein TSR1

1

1

High-throughput

0.479

High

972640

SUB2
ATP-dependent RNA helicase SUB2

1

3

Small-scale

0.479

High

972641

NOP6
Nucleolar protein 6

1

1

High-throughput

0.479

High

972643

NOC3
Nucleolar complex-associated protein 3

1

2

High-throughput

0.479

High

972645

NOP12
Nucleolar protein 12

1

6

High-throughput

0.479

High

972646

BRX1
Ribosome biogenesis protein BRX1

1

3

High-throughput

0.479

High

972647

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

972648

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.479

High

972649

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

972650

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

972655

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.479

High

972657

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.479

High

972658

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.479

High

420159

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.458

High

425247

PHO2
Regulatory protein PHO2

1

0

High-throughput

0.458

High

479807

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

621510

RL24B
Large ribosomal subunit protein eL24B

1

0

High-throughput

0.458

High

634438

SPB1
27S pre-rRNA

1

0

High-throughput

0.458

High

635151

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

650371

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

657762

YJU2
Splicing factor YJU2

1

0

Small-scale

0.458

High

715970

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

734860

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

756062

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

756177

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

High-throughput

0.458

High

758456

RRP8
25S rRNA

1

0

High-throughput

0.458

High

764231

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.458

High

765976

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.458

High

768038

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.458

High

778842

NOP2
25S rRNA

1

0

High-throughput

0.458

High

811339

NOP9
Nucleolar protein 9

1

0

High-throughput

0.458

High

859623

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.458

High

862732

H1
Histone H1

1

0

High-throughput

0.458

High

865562

SQS1
Protein SQS1

1

0

High-throughput

0.458

High

872753

RL15B
Large ribosomal subunit protein eL15B

1

0

High-throughput

0.458

High

970343

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.458

High

972621

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.458

High

972624

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.458

High

972626

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

972628

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.458

High

972635

IMB1
Importin subunit beta-1

1

0

High-throughput

0.458

High

972644

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

972651

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

972652

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

972654

PSH1
RING finger protein PSH1

1

0

High-throughput

0.458

High

972659

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

972660

IGO2
mRNA stability protein IGO2

1

0

High-throughput

0.458

High

366768

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

494768

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

512431

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

633504

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

695354

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

705562

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

358221

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

408078

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

471213

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

635315

SYP1
Suppressor of yeast profilin deletion

1

1

High-throughput

0.437

High

700586

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

762493

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

791265

KRI1
Protein KRI1

1

1

High-throughput

0.437

High

866034

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.437

High

972639

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

972656

CLF1
Pre-mRNA-splicing factor CLF1

1

4

Small-scale

0.437

High

761060

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.407

High

710073

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.279

Low

471823

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

478966

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

598643

ISY1
Pre-mRNA-splicing factor ISY1

1

0

Small-scale

0.249

Low

696823

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.249

Low

780495

RL33B
Large ribosomal subunit protein eL33B

1

0

High-throughput

0.249

Low

784207

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

972622

SVL3
Styryl dye vacuolar localization protein 3

1

0

High-throughput

0.249

Low

972630

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024