Protein: STE20
Serine/threonine-protein kinase STE20 (EC 2.7.11.1)

Gene: STE20
Organism: Saccharomyces cerevisiae S288C
Interactions: 231
UniProt ID: Q03497

Gene Ontology (top 5):
GO:0000011 - vacuole inheritance
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000131 - incipient cellular bud site
GO:0000282 - cellular bud site selection
GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

580329

CDC42
Cell division control protein 42

21

20

Small-scale

0.988

High

593409

CG12
G1/S-specific cyclin CLN2

5

11

Small-scale

0.906

High

618343

STE11
Serine/threonine-protein kinase STE11

3

18

Small-scale

0.845

High

976576

STE20
Serine/threonine-protein kinase STE20

3

17

Small-scale

0.835

High

865844

CBK1
Serine/threonine-protein kinase CBK1

2

19

Small-scale

0.793

High

743184

BOB1
Protein BOB1

2

8

High-throughput

0.781

High

339815

CDK1
Cyclin-dependent kinase 1

2

9

Small-scale

0.768

High

666281

BEM1
Bud emergence protein 1

15

20

Small-scale

0.763

High

544319

HSC82
ATP-dependent molecular chaperone HSC82

2

20

High-throughput

0.754

High

859574

MLC1
Myosin light chain 1

2

1

Small-scale

0.754

High

976610

NBP2
NAP1-binding protein 2

7

3

Small-scale

0.750

High

628406

SIS1
Protein SIS1

2

9

High-throughput

0.737

High

765861

BOI2
Protein BOI2

1

12

High-throughput

0.656

High

606121

RAD53
Serine/threonine-protein kinase RAD53

1

17

Small-scale

0.647

High

615176

BUR1
Serine/threonine-protein kinase BUR1

1

15

Small-scale

0.647

High

624662

CG21
G2/mitotic-specific cyclin-1

1

6

High-throughput

0.647

High

648424

NSR1
Nuclear localization sequence-binding protein

1

3

High-throughput

0.647

High

698924

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

8

High-throughput

0.647

High

746536

IMB2
Importin subunit beta-2

1

6

Small-scale

0.647

High

753477

RIM4
Meiotic activator RIM4

1

5

High-throughput

0.647

High

783863

AZF1
Transcription factor AZF1

1

5

High-throughput

0.647

High

798379

CSK2B
Casein kinase II subunit beta

1

7

High-throughput

0.647

High

866760

CRZ1
Transcriptional regulator CRZ1

1

9

High-throughput

0.647

High

961911

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

14

Small-scale

0.647

High

509444

CDC24
Cell division control protein 24

3

11

Small-scale

0.645

High

579443

GBB
Guanine nucleotide-binding protein subunit beta

2

9

Small-scale

0.634

High

539272

YAK1
Dual specificity protein kinase YAK1

1

16

Small-scale

0.621

High

715599

PP2C1
Protein phosphatase 2C homolog 1

1

8

High-throughput

0.621

High

865747

NOP13
Nucleolar protein 13

1

8

Small-scale

0.621

High

593370

CG11
G1/S-specific cyclin CLN1

1

12

Small-scale

0.618

High

624716

CG22
G2/mitotic-specific cyclin-2

1

6

Small-scale

0.618

High

649924

CDC15
Cell division control protein 15

1

15

Small-scale

0.618

High

673217

CGS5
S-phase entry cyclin-5

1

6

Small-scale

0.618

High

751231

NCB5R
NADH-cytochrome b5 reductase 1

2

2

Small-scale

0.614

High

865790

MDG1
Signal transduction protein MDG1

1

0

High-throughput

0.614

High

713000

BMH2
Protein BMH2

2

15

Small-scale

0.611

High

730591

MYO3
Myosin-3

2

20

Small-scale

0.602

High

976603

BMS1
Ribosome biogenesis protein BMS1

2

1

Small-scale

0.602

High

512520

SSB1
Ribosome-associated molecular chaperone SSB1

2

19

High-throughput

0.601

High

797936

RSC8
Chromatin structure-remodeling complex protein RSC8

2

4

Small-scale

0.594

High

767914

SHO1
High osmolarity signaling protein SHO1

2

0

Small-scale

0.588

High

407281

RS3
Small ribosomal subunit protein uS3

2

4

Small-scale

0.584

High

561489

NCPR
NADPH--cytochrome P450 reductase

2

2

Small-scale

0.576

High

747655

HSL7
Protein arginine N-methyltransferase HSL7

1

2

Small-scale

0.552

High

858461

SUT1
Sterol uptake protein 1

1

2

Small-scale

0.552

High

976584

MYO5
Myosin-5

1

20

High-throughput

0.552

High

769319

SSB2
Ribosome-associated molecular chaperone SSB2

2

19

High-throughput

0.552

High

690257

CDC3
Cell division control protein 3

2

3

Small-scale

0.550

High

692897

SPT16
FACT complex subunit SPT16

2

5

Small-scale

0.550

High

863679

ARE2
Sterol O-acyltransferase 2

2

3

Small-scale

0.543

High

976600

BUD7
Bud site selection protein 7

2

0

High-throughput

0.541

High

676326

XPO1
Exportin-1

1

10

High-throughput

0.536

High

635241

HSP30
30 kDa heat shock protein

1

0

High-throughput

0.518

High

665025

BMH1
Protein BMH1

1

15

Small-scale

0.515

High

976587

ERB1
Ribosome biogenesis protein ERB1

1

15

High-throughput

0.515

High

419570

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.513

High

976423

EBS1
Nonsense-mediated mRNA decay factor EBS1

1

0

High-throughput

0.513

High

355616

H2B1
Histone H2B.1

1

17

Small-scale

0.501

High

355992

H2B2
Histone H2B.2

1

17

Small-scale

0.501

High

356685

H4
Histone H4

1

4

Small-scale

0.501

High

424910

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.501

High

426465

SYSC
Serine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.501

High

546211

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

563982

SEC2
Rab guanine nucleotide exchange factor SEC2

1

2

High-throughput

0.501

High

634440

SPB1
27S pre-rRNA

1

4

Small-scale

0.501

High

667365

PTP2
Tyrosine-protein phosphatase 2

1

8

High-throughput

0.501

High

680096

ATS1
Protein KTI13

1

3

High-throughput

0.501

High

699720

DRS1
ATP-dependent RNA helicase DRS1

1

8

High-throughput

0.501

High

703727

PRS6A
26S proteasome regulatory subunit 6A

1

8

Small-scale

0.501

High

740837

SOL2
6-phosphogluconolactonase-like protein 2

1

1

High-throughput

0.501

High

747081

IST2
Increased sodium tolerance protein 2

1

1

High-throughput

0.501

High

751258

AGM1
Phosphoacetylglucosamine mutase

1

1

High-throughput

0.501

High

765772

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

10

High-throughput

0.501

High

773901

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.501

High

784651

BNI1
Protein BNI1

1

2

Small-scale

0.501

High

804902

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

4

High-throughput

0.501

High

810674

ALY2
Arrestin-related trafficking adapter 3

1

4

Small-scale

0.501

High

861558

REXO1
RNA exonuclease 1

1

2

High-throughput

0.501

High

866856

RCM1
25S rRNA

1

2

High-throughput

0.501

High

976585

ASND1
Asparagine synthetase domain-containing protein YML096W

1

1

High-throughput

0.501

High

976591

MMR1
Mitochondrial MYO2 receptor-related protein 1

1

1

Small-scale

0.501

High

976596

BDF2
Bromodomain-containing factor 2

1

9

High-throughput

0.501

High

976604

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

4

High-throughput

0.501

High

976607

SAS10
Something about silencing protein 10

1

2

High-throughput

0.501

High

976612

MSB4
GTPase-activating protein MSB4

1

5

High-throughput

0.501

High

976614

NSI1
RNA polymerase I termination factor

1

7

High-throughput

0.501

High

976615

YO098
Uncharacterized protein YOL098C

1

8

High-throughput

0.501

High

334528

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

5

High-throughput

0.500

High

334979

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

5

High-throughput

0.500

High

342769

ENO1
Enolase 1

1

2

High-throughput

0.500

High

521046

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.500

High

556264

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.500

High

692424

PRP21
Pre-mRNA-splicing factor PRP21

1

0

High-throughput

0.486

High

783902

BUD8
Bud site selection protein 8

1

0

High-throughput

0.486

High

343853

SYMC
Methionine--tRNA ligase, cytoplasmic

1

5

Small-scale

0.481

High

500617

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

4

Small-scale

0.481

High

542150

CYC8
General transcriptional corepressor CYC8

1

11

Small-scale

0.481

High

643694

SYLC
Leucine--tRNA ligase, cytoplasmic

1

4

Small-scale

0.481

High

696772

PEP7
Vacuolar segregation protein PEP7

1

3

Small-scale

0.481

High

704219

CNS1
Hsp70/Hsp90 co-chaperone CNS1

1

5

Small-scale

0.481

High

746032

ATG8
Autophagy-related protein 8

1

12

Small-scale

0.481

High

754257

RSC30
Chromatin structure-remodeling complex protein RSC30

1

1

Small-scale

0.481

High

765155

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

9

Small-scale

0.481

High

766906

YAT2
Carnitine O-acetyltransferase YAT2

1

1

Small-scale

0.481

High

792683

LSB6
Phosphatidylinositol 4-kinase LSB6

1

1

Small-scale

0.481

High

798354

MHP1
MAP-homologous protein 1

1

1

Small-scale

0.481

High

860514

TWF1
Twinfilin-1

1

2

Small-scale

0.481

High

959997

SEN1
Helicase SEN1

1

2

Small-scale

0.481

High

964813

HPC2
Histone promoter control protein 2

1

2

Small-scale

0.481

High

964867

CTF4
DNA polymerase alpha-binding protein

1

9

Small-scale

0.481

High

967542

MDM1
Structural protein MDM1

1

3

Small-scale

0.481

High

976588

ENT2
Epsin-2

1

1

High-throughput

0.481

High

976590

RGC1
Regulator of the glycerol channel 1

1

2

Small-scale

0.481

High

976592

RGA2
Rho-type GTPase-activating protein 2

1

13

High-throughput

0.481

High

976597

SDO1
Ribosome maturation protein SDO1

1

1

Small-scale

0.481

High

976605

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

1

Small-scale

0.481

High

342482

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.480

High

593182

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.480

High

622076

SSD1
Protein SSD1

1

0

High-throughput

0.480

High

634897

MRC1
Mediator of replication checkpoint protein 1

1

0

Small-scale

0.480

High

635527

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

Small-scale

0.480

High

693447

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

High-throughput

0.480

High

697813

RRN6
RNA polymerase I-specific transcription initiation factor RRN6

1

0

High-throughput

0.480

High

741431

PAM1
Protein PAM1

1

0

High-throughput

0.480

High

746901

YBS1
Uncharacterized protein YBR071W

1

0

High-throughput

0.480

High

747229

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.480

High

747623

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.480

High

756007

YHT1
PH domain-containing protein YHR131C

1

0

High-throughput

0.480

High

767222

THO1
Protein THO1

1

0

High-throughput

0.480

High

777416

YAP4
AP-1-like transcription factor YAP4

1

0

High-throughput

0.480

High

783888

BUD6
Bud site selection protein 6

1

0

Small-scale

0.480

High

862706

DCP2
m7GpppN-mRNA hydrolase

1

0

Small-scale

0.480

High

864786

DUS1
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]

1

0

High-throughput

0.480

High

976593

UBX5
UBX domain-containing protein 5

1

0

High-throughput

0.480

High

976598

MPC54
Meiotic plaque component protein 54

1

0

High-throughput

0.480

High

976602

YIG1
Protein YIG1

1

0

High-throughput

0.480

High

976613

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.480

High

976617

ECM3
Protein ECM3

1

0

High-throughput

0.480

High

404369

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

141501

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

340740

PGK
Phosphoglycerate kinase

1

1

Small-scale

0.479

High

408095

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

413685

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

632063

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

663153

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

663908

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.479

High

730094

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

730902

CENPA
Histone H3-like centromeric protein CSE4

1

5

High-throughput

0.479

High

742969

GBLP
Small ribosomal subunit protein RACK1

1

11

Small-scale

0.479

High

752644

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

755664

BZZ1
Protein BZZ1

1

8

Small-scale

0.479

High

820145

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

967730

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

975804

TOM1
E3 ubiquitin-protein ligase TOM1

1

17

High-throughput

0.479

High

976609

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

976611

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

333893

ADH1
Alcohol dehydrogenase 1

1

0

Small-scale

0.460

High

345215

IPA3
Protease A inhibitor 3

1

0

Small-scale

0.460

High

440222

MET3
Sulfate adenylyltransferase

1

0

Small-scale

0.460

High

579866

DDR48
Stress protein DDR48

1

0

Small-scale

0.460

High

608482

SAN1
Protein SAN1

1

0

Small-scale

0.460

High

635690

YIH1
Protein IMPACT homolog

1

0

Small-scale

0.460

High

659366

TRK2
Low-affinity potassium transport protein

1

0

Small-scale

0.460

High

693938

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.460

High

699139

SEC6
Exocyst complex component SEC6

1

0

Small-scale

0.460

High

746439

POP8
Ribonucleases P/MRP protein subunit POP8

1

0

Small-scale

0.460

High

759199

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.460

High

763620

FLC2
Flavin carrier protein 2

1

0

Small-scale

0.460

High

775607

AIM21
Altered inheritance of mitochondria protein 21

1

0

Small-scale

0.460

High

784878

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.460

High

815476

TEA1
TY1 enhancer activator

1

0

Small-scale

0.460

High

976577

YMH9
Uncharacterized protein YML079W

1

0

Small-scale

0.460

High

976579

YD239
Uncharacterized protein YDR239C

1

0

Small-scale

0.460

High

976582

BUD22
Bud site selection protein 22

1

0

Small-scale

0.460

High

976583

RBA50
RNA polymerase II-associated protein RBA50

1

0

Small-scale

0.460

High

976606

CHS5
Chitin biosynthesis protein CHS5

1

0

Small-scale

0.460

High

976616

LSO2
Protein LSO2

1

0

Small-scale

0.460

High

811214

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

697799

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

2

High-throughput

0.457

High

747565

AIM3
Altered inheritance of mitochondria protein 3

1

6

High-throughput

0.457

High

748977

UBX7
UBX domain-containing protein 7

1

3

High-throughput

0.457

High

750723

GRPE
GrpE protein homolog, mitochondrial

1

1

High-throughput

0.457

High

751996

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

13

High-throughput

0.457

High

763989

HPH2
Protein HPH2

1

1

High-throughput

0.457

High

767406

UTP7
U3 small nucleolar RNA-associated protein 7

1

2

Small-scale

0.457

High

811142

BBC1
Myosin tail region-interacting protein MTI1

1

4

High-throughput

0.457

High

842758

AVT4
Vacuolar amino acid transporter 4

1

6

High-throughput

0.457

High

976578

YMD7
Uncharacterized protein YML037C

1

1

High-throughput

0.457

High

976581

UTP5
U3 small nucleolar RNA-associated protein 5

1

2

Small-scale

0.457

High

976589

COG4
Conserved oligomeric Golgi complex subunit 4

1

1

Small-scale

0.457

High

976608

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.457

High

368355

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

424681

PYR1
Multifunctional protein URA2

1

8

High-throughput

0.445

High

478483

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

492260

HSP71
Heat shock protein SSA1

1

19

High-throughput

0.445

High

494824

HSP72
Heat shock protein SSA2

1

19

High-throughput

0.445

High

695403

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

705589

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

760804

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.445

High

701651

SRPR
Signal recognition particle receptor subunit alpha homolog

1

2

Small-scale

0.439

High

784418

COPB2
Coatomer subunit beta'

1

5

Small-scale

0.439

High

383327

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

405808

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

426127

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

480286

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

480856

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

635469

ARE1
Sterol O-acyltransferase 1

1

3

Small-scale

0.437

High

645626

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

706462

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

976599

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

976601

AP3D
AP-3 complex subunit delta

1

5

High-throughput

0.437

High

629491

ERG4
Delta(24(24(1)))-sterol reductase ERG4

2

0

Small-scale

0.320

High

784283

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.288

High

400183

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

Small-scale

0.261

Low

635030

YCZ0
Uncharacterized protein YCR100C

1

0

High-throughput

0.261

Low

735745

RM36
Large ribosomal subunit protein bL31m

1

0

High-throughput

0.261

Low

743962

YBR3
Uncharacterized protein YBR063C

1

0

High-throughput

0.261

Low

746661

CST26
2-acyl-1-lysophosphatidylinositol acyltransferase

1

0

High-throughput

0.261

Low

763790

ERV46
ER-derived vesicles protein ERV46

1

0

High-throughput

0.261

Low

805285

STB2
Protein STB2

1

0

High-throughput

0.261

Low

946209

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.261

Low

976580

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.261

Low

976586

YMI3
Putative uncharacterized protein YML083C

1

0

High-throughput

0.261

Low

976594

NVJ2
Nucleus-vacuole junction protein 2

1

0

High-throughput

0.261

Low

976595

MRX9
MIOREX complex component 9

1

0

High-throughput

0.261

Low

426401

PMM
Phosphomannomutase

1

0

Small-scale

0.251

Low

634327

EMC1
ER membrane protein complex subunit 1

1

0

Small-scale

0.251

Low

745509

KMO
Kynurenine 3-monooxygenase

1

0

Small-scale

0.251

Low

775169

APQ12
Nuclear membrane organization protein APQ12

1

0

Small-scale

0.251

Low

822910

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024