Protein: BRX1
Ribosome biogenesis protein BRX1

Gene: BRX1
Organism: Saccharomyces cerevisiae S288C
Interactions: 180
UniProt ID: Q08235

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000465 - exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

731878

EBP2
rRNA-processing protein EBP2

9

8

Small-scale

0.973

High

733957

RPF2
Ribosome biogenesis protein RPF2

6

5

Small-scale

0.943

High

755342

RPF1
Ribosome production factor 1

3

5

High-throughput

0.848

High

732255

RRP14
Ribosomal RNA-processing protein 14

2

3

Small-scale

0.757

High

994463

RRS1
Regulator of ribosome biosynthesis

2

6

Small-scale

0.757

High

754923

SSF1
Ribosome biogenesis protein SSF1

2

9

Small-scale

0.754

High

987646

RRP15
Ribosomal RNA-processing protein 15

2

4

Small-scale

0.754

High

982898

RRP5
rRNA biogenesis protein RRP5

7

6

Small-scale

0.746

High

797406

LOC1
60S ribosomal subunit assembly/export protein LOC1

7

4

Small-scale

0.743

High

860899

PESC
Pescadillo homolog

6

5

Small-scale

0.730

High

597911

PWP1
Periodic tryptophan protein 1

5

6

Small-scale

0.720

High

859520

NSA1
Ribosome biogenesis protein NSA1

5

6

Small-scale

0.709

High

973472

NOG1
Nucleolar GTP-binding protein 1

5

7

Small-scale

0.709

High

764260

NOC2
Nucleolar complex protein 2

5

4

Small-scale

0.707

High

980169

ERB1
Ribosome biogenesis protein ERB1

4

9

High-throughput

0.697

High

994476

IF6
Eukaryotic translation initiation factor 6

4

5

Small-scale

0.696

High

778874

NOP2
25S rRNA

4

12

Small-scale

0.694

High

742076

NOP4
Nucleolar protein 4

4

8

Small-scale

0.691

High

866278

NOP15
Ribosome biogenesis protein 15

4

9

High-throughput

0.691

High

994471

MAK21
Ribosome biogenesis protein MAK21

4

13

High-throughput

0.691

High

638880

SPB4
ATP-dependent rRNA helicase SPB4

4

20

High-throughput

0.686

High

776531

RLP7
Ribosome biogenesis protein RLP7

4

12

Small-scale

0.686

High

976876

HAS1
ATP-dependent RNA helicase HAS1

4

20

High-throughput

0.686

High

979463

PUF6
Pumilio homology domain family member 6

4

6

Small-scale

0.686

High

766605

NOP16
Nucleolar protein 16

3

3

High-throughput

0.658

High

535138

RL3
Large ribosomal subunit protein uL3

3

7

Small-scale

0.656

High

715497

RRP1
Ribosomal RNA-processing protein 1

3

10

Small-scale

0.656

High

754208

CIC1
Proteasome-interacting protein CIC1

3

11

High-throughput

0.656

High

994053

NOP12
Nucleolar protein 12

3

15

High-throughput

0.656

High

994464

NIP7
60S ribosome subunit biogenesis protein NIP7

3

4

Small-scale

0.656

High

994466

YTM1
Ribosome biogenesis protein YTM1

3

8

Small-scale

0.656

High

994474

DBP10
ATP-dependent RNA helicase DBP10

3

7

High-throughput

0.656

High

564384

RL8A
Large ribosomal subunit protein eL8A

3

16

Small-scale

0.640

High

485599

SSBP1
Single-stranded nucleic acid-binding protein

2

3

High-throughput

0.621

High

501260

MAK16
Protein MAK16

1

9

High-throughput

0.618

High

970363

RL6A
Large ribosomal subunit protein eL6A

1

4

High-throughput

0.618

High

994470

SSF2
Ribosome biogenesis protein SSF2

1

9

High-throughput

0.618

High

383382

RL25
Large ribosomal subunit protein uL23

2

6

High-throughput

0.611

High

641083

RL5
Large ribosomal subunit protein uL18

2

6

High-throughput

0.611

High

667290

RL8B
Large ribosomal subunit protein eL8B

2

16

High-throughput

0.611

High

699739

DRS1
ATP-dependent RNA helicase DRS1

2

16

High-throughput

0.611

High

703127

MRT4
Ribosome assembly factor MRT4

2

11

High-throughput

0.611

High

766718

NUG1
Nuclear GTP-binding protein NUG1

2

9

High-throughput

0.611

High

992539

NOC3
Nucleolar complex-associated protein 3

2

9

High-throughput

0.611

High

860758

UTP22
U3 small nucleolar RNA-associated protein 22

2

2

High-throughput

0.588

High

594080

MAK11
Protein MAK11

2

10

Small-scale

0.584

High

748725

ENP1
Essential nuclear protein 1

2

4

High-throughput

0.584

High

978442

RRP17
Ribosomal RNA-processing protein 17

2

3

High-throughput

0.584

High

992622

RLP24
Ribosome biogenesis protein RLP24

2

6

Small-scale

0.584

High

994468

NOP53
Ribosome biogenesis protein NOP53

2

8

High-throughput

0.584

High

757361

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

13

High-throughput

0.576

High

765083

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

4

Small-scale

0.561

High

769652

SSB2
Ribosome-associated molecular chaperone SSB2

2

7

High-throughput

0.549

High

655908

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

1

High-throughput

0.541

High

406417

RL15A
Large ribosomal subunit protein eL15A

1

7

High-throughput

0.536

High

756879

RIX1
Pre-rRNA-processing protein RIX1

1

1

High-throughput

0.536

High

767434

UTP7
U3 small nucleolar RNA-associated protein 7

1

7

High-throughput

0.536

High

859445

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

3

High-throughput

0.536

High

992245

RIX7
Ribosome biogenesis ATPase RIX7

1

4

High-throughput

0.536

High

994472

RL7B
Large ribosomal subunit protein uL30B

1

12

High-throughput

0.536

High

994477

RL13A
Large ribosomal subunit protein eL13A

1

8

High-throughput

0.536

High

481076

RL23B
Large ribosomal subunit protein uL14B

2

3

Small-scale

0.533

High

902110

H3
Histone H3

2

5

High-throughput

0.533

High

512984

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.504

High

624185

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.494

High

676430

XPO1
Exportin-1

1

6

High-throughput

0.489

High

715405

SPT7
Transcriptional activator SPT7

1

3

High-throughput

0.489

High

837300

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.489

High

864621

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.489

High

965055

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.489

High

975984

GCN5
Histone acetyltransferase GCN5

1

6

High-throughput

0.489

High

659846

SBA1
Co-chaperone protein SBA1

1

2

Small-scale

0.481

High

141555

RS9A
Small ribosomal subunit protein uS4A

1

8

High-throughput

0.479

High

404720

RL7A
Large ribosomal subunit protein uL30A

1

12

High-throughput

0.479

High

405862

RL26A
Large ribosomal subunit protein uL24A

1

10

High-throughput

0.479

High

407361

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

979113

RRB1
Ribosome assembly protein RRB1

1

7

High-throughput

0.479

High

408158

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

413738

RS14A
Small ribosomal subunit protein uS11A

1

6

High-throughput

0.479

High

426183

RS19A
Small ribosomal subunit protein eS19A

1

6

High-throughput

0.479

High

480351

RS6A
Small ribosomal subunit protein eS6A

1

9

High-throughput

0.479

High

630277

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

632123

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.479

High

634456

SPB1
27S pre-rRNA

1

6

High-throughput

0.479

High

634797

KRR1
KRR1 small subunit processome component

1

8

High-throughput

0.479

High

635660

PWP2
Periodic tryptophan protein 2

1

5

High-throughput

0.479

High

645688

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

730150

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

733166

DBP7
ATP-dependent RNA helicase DBP7

1

18

High-throughput

0.479

High

744251

MAK5
ATP-dependent RNA helicase MAK5

1

20

High-throughput

0.479

High

746275

YBC8
UPF0642 protein YBL028C

1

2

High-throughput

0.479

High

768058

NSA2
Ribosome biogenesis protein NSA2

1

4

High-throughput

0.479

High

792609

UTP10
U3 small nucleolar RNA-associated protein 10

1

4

High-throughput

0.479

High

810934

MTR4
ATP-dependent RNA helicase DOB1

1

6

Small-scale

0.479

High

860264

RL26B
Large ribosomal subunit protein uL24B

1

10

High-throughput

0.479

High

864695

NOG2
Nucleolar GTP-binding protein 2

1

9

High-throughput

0.479

High

865627

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.479

High

865768

NOP13
Nucleolar protein 13

1

5

High-throughput

0.479

High

866864

RCM1
25S rRNA

1

12

High-throughput

0.479

High

967796

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

972646

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.479

High

979054

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.479

High

979733

UTP14
U3 small nucleolar RNA-associated protein 14

1

5

High-throughput

0.479

High

986480

FKBP4
FK506-binding protein 4

1

13

High-throughput

0.479

High

986584

JIP5
WD repeat-containing protein JIP5

1

7

High-throughput

0.479

High

986621

DBP9
ATP-dependent RNA helicase DBP9

1

12

High-throughput

0.479

High

987672

NOC4
Nucleolar complex protein 4

1

13

High-throughput

0.479

High

994459

REXO4
RNA exonuclease 4

1

7

High-throughput

0.479

High

994462

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.479

High

994465

BMS1
Ribosome biogenesis protein BMS1

1

2

High-throughput

0.479

High

994469

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

994475

NOP58
Nucleolar protein 58

1

11

High-throughput

0.479

High

615188

BUR1
Serine/threonine-protein kinase BUR1

1

2

High-throughput

0.470

High

986409

YL455
PWWP domain-containing protein YLR455W

1

1

High-throughput

0.470

High

994461

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.457

High

994473

PKH2
Serine/threonine-protein kinase PKH2

1

3

High-throughput

0.457

High

399650

RLA0
Large ribosomal subunit protein uL10

1

11

High-throughput

0.445

High

499098

RL4A
Large ribosomal subunit protein uL4A

1

11

High-throughput

0.445

High

960025

SEN1
Helicase SEN1

1

5

Small-scale

0.445

High

356764

H4
Histone H4

1

5

High-throughput

0.437

High

358289

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.437

High

376951

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

4

Small-scale

0.437

High

392591

H2A2
Histone H2A.2

1

8

High-throughput

0.437

High

408484

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.437

High

420180

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.437

High

471289

RS22A
Small ribosomal subunit protein uS8A

1

6

High-throughput

0.437

High

471839

RL27A
Large ribosomal subunit protein eL27A

1

4

High-throughput

0.437

High

472425

RL31A
Large ribosomal subunit protein eL31A

1

9

High-throughput

0.437

High

479000

RL20B
Large ribosomal subunit protein eL20B

1

7

High-throughput

0.437

High

479185

RL43B
Large ribosomal subunit protein eL43B

1

8

Small-scale

0.437

High

480918

RS8A
Small ribosomal subunit protein eS8A

1

6

High-throughput

0.437

High

482490

RS18A
Small ribosomal subunit protein uS13A

1

4

High-throughput

0.437

High

524467

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

606159

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.437

High

628537

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

663509

TF2B
Transcription initiation factor IIB

1

7

High-throughput

0.437

High

663925

TF3B
Transcription factor IIIB 70 kDa subunit

1

7

High-throughput

0.437

High

665088

BMH1
Protein BMH1

1

1

High-throughput

0.437

High

688464

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

4

High-throughput

0.437

High

697446

CHD1
Chromo domain-containing protein 1

1

5

High-throughput

0.437

High

700657

RSSA1
Small ribosomal subunit protein uS2A

1

8

High-throughput

0.437

High

701122

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

706525

RS3A1
Small ribosomal subunit protein eS1A

1

6

High-throughput

0.437

High

752703

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

762619

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.437

High

775100

RL34B
Large ribosomal subunit protein eL34B

1

2

High-throughput

0.437

High

775276

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.437

High

860399

EIF2A
Eukaryotic translation initiation factor 2A

1

3

High-throughput

0.437

High

865320

GIS2
Zinc finger protein GIS2

1

6

High-throughput

0.437

High

872816

ORC1
Origin recognition complex subunit 1

1

5

High-throughput

0.437

High

959888

NUM1
Nuclear migration protein NUM1

1

6

High-throughput

0.437

High

977860

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

986264

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

4

High-throughput

0.437

High

987057

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.437

High

991312

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

994460

SGO1
Shugoshin

1

5

High-throughput

0.437

High

994478

H2AZ
Histone H2A.Z

1

7

High-throughput

0.437

High

361054

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

367001

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.407

High

368455

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.407

High

424747

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.407

High

492646

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.407

High

495136

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.407

High

707943

GCN1
eIF-2-alpha kinase activator GCN1

1

5

High-throughput

0.407

High

754762

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.407

High

766248

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

810402

JJJ2
J protein JJJ2

1

2

High-throughput

0.407

High

837369

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.407

High

837473

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

5

High-throughput

0.407

High

984168

RT103
Regulator of Ty1 transposition protein 103

1

0

High-throughput

0.282

High

994479

YB296
Uncharacterized protein YBR296C-A

1

0

High-throughput

0.282

High

961961

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.279

Low

646646

DPB3
DNA polymerase epsilon subunit C

1

0

High-throughput

0.269

Low

604630

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.249

Low

701606

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

977507

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

556338

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

731019

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

982948

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.232

Low

994467

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024