Protein: AHA1
Hsp90 co-chaperone AHA1 (Activator of Hsp90 ATPase protein 1)

Gene: AHA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 132
UniProt ID: Q12449

Gene Ontology (top 5):
GO:0001671 - ATPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006457 - protein folding
GO:0051087 - protein-folding chaperone binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

367120

HSP82
ATP-dependent molecular chaperone HSP82

27

11

Small-scale

0.993

High

544634

HSC82
ATP-dependent molecular chaperone HSC82

12

11

Small-scale

0.979

High

865212

HCH1
Hsp90 co-chaperone HCH1

3

1

Small-scale

0.814

High

1015610

AHA1
Hsp90 co-chaperone AHA1

2

1

Small-scale

0.743

High

492910

HSP71
Heat shock protein SSA1

4

5

High-throughput

0.683

High

864188

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

2

1

Small-scale

0.618

High

485867

IF4A
ATP-dependent RNA helicase eIF4A

2

1

High-throughput

0.611

High

753989

RPN1
26S proteasome regulatory subunit RPN1

2

3

High-throughput

0.611

High

513290

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.601

High

681101

HS104
Heat shock protein 104

2

2

High-throughput

0.584

High

797656

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

628611

SIS1
Protein SIS1

2

2

High-throughput

0.571

High

633714

MAS5
Mitochondrial protein import protein MAS5

2

3

High-throughput

0.571

High

785292

MPG1
Mannose-1-phosphate guanyltransferase

2

1

High-throughput

0.571

High

410040

NOT3
General negative regulator of transcription subunit 3

2

0

High-throughput

0.563

High

495362

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

769859

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

597045

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

1

High-throughput

0.541

High

343309

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

1

High-throughput

0.536

High

361091

TBB
Tubulin beta chain

1

1

High-throughput

0.536

High

439687

SPS1
Sporulation-specific protein 1

1

3

High-throughput

0.536

High

454512

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.536

High

540182

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.536

High

562307

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.536

High

579446

GBB
Guanine nucleotide-binding protein subunit beta

1

1

High-throughput

0.536

High

687514

EF2
Elongation factor 2

1

2

High-throughput

0.536

High

703184

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.536

High

707957

GCN1
eIF-2-alpha kinase activator GCN1

1

2

High-throughput

0.536

High

753456

ECM29
Proteasome component ECM29

1

2

High-throughput

0.536

High

760992

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.536

High

767768

IMB4
Importin subunit beta-4

1

1

High-throughput

0.536

High

424938

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

440930

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.513

High

748409

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.513

High

752032

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

772278

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.513

High

961947

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

1015344

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.513

High

659986

MSP1
Outer mitochondrial transmembrane helix translocase

1

2

Small-scale

0.512

High

549771

STI1
Heat shock protein STI1

1

3

Small-scale

0.501

High

604642

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.489

High

697315

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.489

High

759144

DUN1
DNA damage response protein kinase DUN1

1

2

High-throughput

0.489

High

778496

MAD2
Mitotic spindle checkpoint component MAD2

1

0

High-throughput

0.486

High

358323

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

407407

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

408193

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

413779

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

426216

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

471323

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

472460

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

480387

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

482523

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

520659

YPK1
Serine/threonine-protein kinase YPK1

1

3

High-throughput

0.479

High

632157

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

645721

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

700695

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

703764

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.479

High

706564

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

743068

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

752738

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

820245

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

967835

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

991415

SUB2
ATP-dependent RNA helicase SUB2

1

1

High-throughput

0.479

High

996359

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

1015285

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

141591

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383419

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

405894

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

480954

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

549848

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.458

High

578581

SEC18
Vesicular-fusion protein SEC18

1

0

High-throughput

0.458

High

599205

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

High-throughput

0.458

High

657289

URA7
CTP synthase 1

1

0

High-throughput

0.458

High

730183

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

731091

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

757051

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

811262

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

867537

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.458

High

977721

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

983802

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

996047

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

997084

YP225
Protein PBDC1 homolog

1

0

High-throughput

0.458

High

1015020

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

423055

TOM70
Mitochondrial import receptor subunit TOM70

1

4

Small-scale

0.457

High

340329

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.445

High

368524

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

450245

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

556391

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

695857

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

703977

PRS7
26S proteasome regulatory subunit 7 homolog

1

3

High-throughput

0.445

High

761424

XDJ1
DnaJ protein homolog XDJ1

1

3

High-throughput

0.445

High

811506

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.445

High

812348

DPH4
Diphthamide biosynthesis protein 4

1

2

High-throughput

0.445

High

866577

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.445

High

972943

IMA1
Importin subunit alpha

1

1

High-throughput

0.445

High

775297

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.439

High

972035

ULP1
Ubiquitin-like-specific protease 1

1

2

High-throughput

0.439

High

861435

YG5B
Uncharacterized RNA-binding protein YGR250C

1

0

High-throughput

0.438

High

561095

EF3A
Elongation factor 3A

1

3

High-throughput

0.437

High

606787

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.437

High

638904

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

663732

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

774023

MLP2
Protein MLP2

1

1

High-throughput

0.437

High

424774

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

641110

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

733725

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.426

High

762171

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

785607

REF2
RNA end formation protein 2

1

0

High-throughput

0.426

High

817429

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

748567

ARPC1
Actin-related protein 2/3 complex subunit 1

1

3

High-throughput

0.417

High

774684

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

0

High-throughput

0.318

High

732061

MCR1
NADH-cytochrome b5 reductase 2

1

0

Small-scale

0.292

High

632594

RAD51
DNA repair protein RAD51

1

0

Small-scale

0.288

High

429791

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

568920

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.279

Low

640325

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.279

Low

679843

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.279

Low

715567

TOM20
Mitochondrial import receptor subunit TOM20

1

0

Small-scale

0.261

Low

343158

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.249

Low

597609

CCA1
CCA tRNA nucleotidyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

634833

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

716394

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

716527

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

792636

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

978058

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

979088

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

989428

NVJ2
Nucleus-vacuole junction protein 2

1

0

High-throughput

0.249

Low

1015136

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

667544

PAP
Poly(A) polymerase

1

0

High-throughput

0.232

Low

1015611

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024