Protein: SIZ1
E3 SUMO-protein ligase SIZ1 (EC 2.3.2.-) (E3 SUMO-protein transferase SIZ2) (SAP and Miz-finger domain-containing protein 1) (Ubiquitin-like protein ligase 1)

Gene: SIZ1
Organism: Saccharomyces cerevisiae S288C
Interactions: 107
UniProt ID: Q04195

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005935 - cellular bud neck
GO:0005940 - septin ring

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

841429

UBC9
SUMO-conjugating enzyme UBC9

12

14

Small-scale

0.981

High

978700

SMT3
Ubiquitin-like protein SMT3

6

20

Small-scale

0.937

High

550575

PCNA
Proliferating cell nuclear antigen

5

3

Small-scale

0.926

High

690264

CDC3
Cell division control protein 3

3

1

Small-scale

0.653

High

523439

SRS2
ATP-dependent DNA helicase SRS2

2

3

Small-scale

0.614

High

690340

CDC11
Cell division control protein 11

2

3

Small-scale

0.601

High

420163

TOP2
DNA topoisomerase 2

2

4

Small-scale

0.595

High

698570

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

1

Small-scale

0.586

High

765384

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

Small-scale

0.561

High

858856

IMB5
Importin subunit beta-5

1

3

Small-scale

0.552

High

767871

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

1

Small-scale

0.536

High

767915

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.529

High

419571

RAD1
DNA repair protein RAD1

1

2

Small-scale

0.501

High

419635

RAD52
DNA repair and recombination protein RAD52

1

1

Small-scale

0.501

High

730913

CENPA
Histone H3-like centromeric protein CSE4

1

11

Small-scale

0.501

High

764009

SAW1
Single-strand annealing weakened protein 1

1

1

Small-scale

0.501

High

764585

EXO1
Exodeoxyribonuclease 1

1

2

Small-scale

0.501

High

859692

LIF1
Ligase-interacting factor 1

1

1

Small-scale

0.501

High

978698

SGO1
Shugoshin

1

1

High-throughput

0.501

High

861002

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.493

High

978695

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.486

High

977394

NSE5
Non-structural maintenance of chromosome element 5

1

1

Small-scale

0.481

High

978688

EUC1
Transcription factor-like protein EUC1

1

1

Small-scale

0.481

High

141688

YH11B
Transposon Ty1-H Gag-Pol polyprotein

1

1

High-throughput

0.479

High

388125

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.479

High

520643

YPK1
Serine/threonine-protein kinase YPK1

1

4

High-throughput

0.479

High

558240

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

561906

TUP1
General transcriptional corepressor TUP1

1

1

High-throughput

0.479

High

577177

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

4

High-throughput

0.479

High

593784

DBP5
ATP-dependent RNA helicase DBP5

1

4

High-throughput

0.479

High

618859

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

7

High-throughput

0.479

High

627683

NAP1
Nucleosome assembly protein

1

1

High-throughput

0.479

High

629584

CDC10
Cell division control protein 10

1

2

High-throughput

0.479

High

636180

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.479

High

663226

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

687744

BTAF1
TATA-binding protein-associated factor MOT1

1

7

High-throughput

0.479

High

690856

HIR1
Protein HIR1

1

1

High-throughput

0.479

High

692910

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

696171

SWI3
SWI/SNF complex subunit SWI3

1

5

High-throughput

0.479

High

698496

FZF1
Zinc finger protein FZF1

1

3

High-throughput

0.479

High

743405

AP2A
AP-2 complex subunit alpha

1

3

High-throughput

0.479

High

751288

RFC3
Replication factor C subunit 3

1

2

High-throughput

0.479

High

751334

RFC1
Replication factor C subunit 1

1

4

High-throughput

0.479

High

757215

SPP41
Protein SPP41

1

10

High-throughput

0.479

High

772268

RFC4
Replication factor C subunit 4

1

4

High-throughput

0.479

High

797572

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

797942

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.479

High

857423

MSN5
Protein MSN5

1

1

High-throughput

0.479

High

859015

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

859273

INO80
Chromatin-remodeling ATPase INO80

1

7

High-throughput

0.479

High

861535

RT102
Regulator of Ty1 transposition protein 102

1

1

High-throughput

0.479

High

864121

HST1
NAD-dependent protein deacetylase HST1

1

2

High-throughput

0.479

High

946150

ARP4
Actin-related protein 4

1

5

High-throughput

0.479

High

978612

SXM1
Importin beta SMX1

1

2

High-throughput

0.479

High

978689

CYK2
Cytokinesis protein 2

1

4

High-throughput

0.479

High

978690

ARP9
Actin-like protein ARP9

1

3

High-throughput

0.479

High

978692

HRQ1
ATP-dependent helicase HRQ1

1

4

High-throughput

0.479

High

978694

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

9

High-throughput

0.479

High

978696

SHS1
Seventh homolog of septin 1

1

5

High-throughput

0.479

High

978699

MRN1
RNA-binding protein MRN1

1

1

High-throughput

0.479

High

978701

ARP8
Actin-like protein ARP8

1

5

High-throughput

0.479

High

978702

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

811144

BBC1
Myosin tail region-interacting protein MTI1

1

3

High-throughput

0.464

High

141873

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

452126

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.458

High

474138

HAP1
Heme-responsive zinc finger transcription factor HAP1

1

0

High-throughput

0.458

High

519540

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

542154

CYC8
General transcriptional corepressor CYC8

1

0

High-throughput

0.458

High

597593

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.458

High

602376

DPOE
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.458

High

622894

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.458

High

634041

BUD3
Bud site selection protein 3

1

0

High-throughput

0.458

High

690558

CDC12
Cell division control protein 12

1

0

High-throughput

0.458

High

692073

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

755803

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

0

High-throughput

0.458

High

758888

MSS4
Phosphatidylinositol 4-phosphate 5-kinase MSS4

1

0

High-throughput

0.458

High

774175

CSM2
Chromosome segregation in meiosis protein 2

1

0

High-throughput

0.458

High

784966

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.458

High

797274

IES1
Ino eighty subunit 1

1

0

High-throughput

0.458

High

805189

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.458

High

974751

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.458

High

978691

RT103
Regulator of Ty1 transposition protein 103

1

0

High-throughput

0.458

High

978693

FKBP4
FK506-binding protein 4

1

0

High-throughput

0.458

High

494881

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

512612

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

633544

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

754682

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

691666

NUP2
Nucleoporin NUP2

1

4

Small-scale

0.439

High

343148

THDH
Threonine dehydratase, mitochondrial

1

3

High-throughput

0.437

High

425144

LEUC
3-isopropylmalate dehydratase

1

1

High-throughput

0.437

High

625985

PTP1
Tyrosine-protein phosphatase 1

1

1

High-throughput

0.437

High

732024

NNRD
ATP-dependent

1

1

High-throughput

0.437

High

750073

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

1

High-throughput

0.437

High

765157

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

6

High-throughput

0.437

High

772391

VPS27
Vacuolar protein sorting-associated protein 27

1

2

High-throughput

0.437

High

773992

MLP2
Protein MLP2

1

6

High-throughput

0.437

High

798116

COPD
Coatomer subunit delta

1

1

High-throughput

0.437

High

812014

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.437

High

692613

ZUO1
Zuotin

1

2

High-throughput

0.407

High

978697

FRA1
Putative Xaa-Pro aminopeptidase FRA1

2

0

High-throughput

0.313

High

410508

CYSD
Homocysteine/cysteine synthase

1

0

High-throughput

0.269

Low

615374

GYS1
Glycogen [starch] synthase isoform 1

1

0

High-throughput

0.249

Low

689825

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.249

Low

740839

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.249

Low

750967

YGP1
Protein YGP1

1

0

High-throughput

0.249

Low

766885

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.249

Low

972480

PDR12
ATP-dependent permease PDR12

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024