Protein: ESC1
Silent chromatin protein ESC1 (Establishes silent chromatin protein 1)

Gene: ESC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 120
UniProt ID: Q03661

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0031509 - subtelomeric heterochromatin formation
GO:0034398 - telomere tethering at nuclear periphery
GO:0034399 - nuclear periphery

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

516907

SIR4
Regulatory protein SIR4

6

0

Small-scale

0.703

High

797560

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

2

High-throughput

0.585

High

773985

MLP2
Protein MLP2

2

5

High-throughput

0.584

High

977147

SMT3
Ubiquitin-like protein SMT3

2

2

High-throughput

0.548

High

693356

RPN2
26S proteasome regulatory subunit RPN2

2

3

High-throughput

0.533

High

703728

PRS6A
26S proteasome regulatory subunit 6A

2

3

High-throughput

0.533

High

703845

PRS6B
26S proteasome regulatory subunit 6B homolog

2

5

High-throughput

0.533

High

703954

PRS7
26S proteasome regulatory subunit 7 homolog

2

5

High-throughput

0.533

High

753935

RPN1
26S proteasome regulatory subunit RPN1

2

3

High-throughput

0.533

High

757019

RPN10
26S proteasome regulatory subunit RPN10

2

1

High-throughput

0.533

High

862673

PRS10
26S proteasome subunit RPT4

2

6

High-throughput

0.533

High

968070

PRS8
26S proteasome regulatory subunit 8 homolog

2

5

High-throughput

0.533

High

977140

RPN7
26S proteasome regulatory subunit RPN7

2

1

High-throughput

0.533

High

977146

RPN5
26S proteasome regulatory subunit RPN5

2

1

High-throughput

0.533

High

366811

HSP82
ATP-dependent molecular chaperone HSP82

2

5

High-throughput

0.521

High

492275

HSP71
Heat shock protein SSA1

2

11

High-throughput

0.521

High

494833

HSP72
Heat shock protein SSA2

2

11

High-throughput

0.521

High

512538

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.521

High

628410

SIS1
Protein SIS1

2

6

High-throughput

0.521

High

541918

NSP1
Nucleoporin NSP1

1

1

High-throughput

0.479

High

970953

MLP1
Protein MLP1

1

5

High-throughput

0.479

High

623504

KPC1
Protein kinase C-like 1

1

3

High-throughput

0.470

High

416323

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.458

High

566222

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

745856

NU170
Nucleoporin NUP170

1

0

Small-scale

0.458

High

763523

NUP60
Nucleoporin NUP60

1

0

Small-scale

0.458

High

680967

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

523435

SRS2
ATP-dependent DNA helicase SRS2

1

3

Small-scale

0.439

High

334799

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.437

High

343005

ENO2
Enolase 2

1

2

High-throughput

0.437

High

368358

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.437

High

399615

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.437

High

407287

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

408099

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

411076

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.437

High

416069

DED1
ATP-dependent RNA helicase DED1

1

1

High-throughput

0.437

High

424268

CARA
Carbamoyl phosphate synthase arginine-specific small chain

1

1

High-throughput

0.437

High

472609

YP12B
Transposon Ty1-PR1 Gag-Pol polyprotein

1

1

High-throughput

0.437

High

479812

RS4A
Small ribosomal subunit protein eS4A

1

1

High-throughput

0.437

High

499058

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.437

High

520867

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.437

High

535270

RS17B
Small ribosomal subunit protein eS17B

1

1

High-throughput

0.437

High

544326

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.437

High

613749

RS3A2
Small ribosomal subunit protein eS1B

1

1

High-throughput

0.437

High

663172

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

697114

RAD23
UV excision repair protein RAD23

1

1

High-throughput

0.437

High

700601

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

742971

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.437

High

752648

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

753437

ECM29
Proteasome component ECM29

1

1

High-throughput

0.437

High

771735

PRS4
26S proteasome regulatory subunit 4 homolog

1

6

High-throughput

0.437

High

775347

SCC3
Cohesin subunit SCC3

1

4

High-throughput

0.437

High

797719

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

2

High-throughput

0.437

High

804836

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.437

High

837208

PSD10
Probable 26S proteasome regulatory subunit p28

1

4

High-throughput

0.437

High

858755

ROM1
RHO1 GDP-GTP exchange protein 1

1

2

High-throughput

0.437

High

860038

RPN14
26S proteasome regulatory subunit RPN14

1

5

High-throughput

0.437

High

887663

ACT
Actin

1

3

High-throughput

0.437

High

959999

SEN1
Helicase SEN1

1

2

High-throughput

0.437

High

977138

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.437

High

977141

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

977143

PMG2
Phosphoglycerate mutase 2

1

1

High-throughput

0.437

High

977144

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.437

High

977145

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

Small-scale

0.437

High

767967

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.426

High

450170

HSP73
Heat shock protein SSA3

1

11

High-throughput

0.407

High

766180

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.407

High

775655

DJP1
DnaJ-like protein 1

1

3

High-throughput

0.407

High

977148

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High

691497

RPN12
26S proteasome regulatory subunit RPN12

2

0

High-throughput

0.305

High

766880

RPN3
26S proteasome regulatory subunit RPN3

2

0

High-throughput

0.305

High

977136

RPN9
26S proteasome regulatory subunit RPN9

2

0

High-throughput

0.305

High

977142

RPN8
26S proteasome regulatory subunit RPN8

2

0

High-throughput

0.305

High

977149

RPN6
26S proteasome regulatory subunit RPN6

2

0

High-throughput

0.305

High

613867

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.269

Low

687553

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.261

Low

797224

BUD27
Bud site selection protein 27

1

0

Small-scale

0.251

Low

977135

GIS1
Transcriptional activator/repressor GIS1

1

0

Small-scale

0.251

Low

141870

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.249

Low

294158

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.249

Low

333895

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.249

Low

340262

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.249

Low

393613

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.249

Low

404370

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.249

Low

413688

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

450506

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.249

Low

471931

RL27B
Large ribosomal subunit protein eL27B

1

0

High-throughput

0.249

Low

478973

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

479524

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.249

Low

482435

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

537478

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.249

Low

546535

AMPD
AMP deaminase

1

0

High-throughput

0.249

Low

558675

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

561059

EF3A
Elongation factor 3A

1

0

High-throughput

0.249

Low

576007

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.249

Low

602461

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

606126

RAD53
Serine/threonine-protein kinase RAD53

1

0

Small-scale

0.249

Low

619507

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

619630

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

641049

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.249

Low

645628

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

649297

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

1

0

High-throughput

0.249

Low

687993

IMB3
Importin subunit beta-3

1

0

High-throughput

0.249

Low

688926

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.249

Low

690701

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

692069

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

699368

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.249

Low

713260

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.249

Low

741208

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.249

Low

743117

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.249

Low

753702

RL14B
Large ribosomal subunit protein eL14B

1

0

High-throughput

0.249

Low

774215

TAO3
Cell morphogenesis protein PAG1

1

0

High-throughput

0.249

Low

811044

NU192
Nucleoporin NUP192

1

0

High-throughput

0.249

Low

812107

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

858937

EDC1
Enhancer of mRNA-decapping protein 1

1

0

High-throughput

0.249

Low

865695

YNS1
Uncharacterized oxidoreductase YNL181W

1

0

High-throughput

0.249

Low

970347

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.249

Low

977134

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.249

Low

977137

UBX2
UBX domain-containing protein 2

1

0

High-throughput

0.249

Low

977139

VID22
Vacuolar import and degradation protein 22

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024