Protein: RPN8
26S proteasome regulatory subunit RPN8

Gene: RPN8
Organism: Saccharomyces cerevisiae S288C
Interactions: 120
UniProt ID: Q08723

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008237 - metallopeptidase activity
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

797613

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

36

20

Small-scale

0.994

High

996267

RPN5
26S proteasome regulatory subunit RPN5

14

20

Small-scale

0.985

High

996269

RPN6
26S proteasome regulatory subunit RPN6

10

20

Small-scale

0.974

High

691507

RPN12
26S proteasome regulatory subunit RPN12

8

3

Small-scale

0.973

High

978506

RPN9
26S proteasome regulatory subunit RPN9

8

20

Small-scale

0.972

High

753971

RPN1
26S proteasome regulatory subunit RPN1

8

14

Small-scale

0.963

High

757036

RPN10
26S proteasome regulatory subunit RPN10

5

2

Small-scale

0.927

High

693372

RPN2
26S proteasome regulatory subunit RPN2

5

14

High-throughput

0.922

High

968091

PRS8
26S proteasome regulatory subunit 8 homolog

5

20

Small-scale

0.916

High

985890

RPN7
26S proteasome regulatory subunit RPN7

4

20

High-throughput

0.900

High

703860

PRS6B
26S proteasome regulatory subunit 6B homolog

4

19

Small-scale

0.892

High

766895

RPN3
26S proteasome regulatory subunit RPN3

4

9

Small-scale

0.887

High

703753

PRS6A
26S proteasome regulatory subunit 6A

4

20

High-throughput

0.881

High

697121

RAD23
UV excision repair protein RAD23

3

13

High-throughput

0.830

High

771745

PRS4
26S proteasome regulatory subunit 4 homolog

2

20

High-throughput

0.776

High

862687

PRS10
26S proteasome subunit RPT4

2

20

High-throughput

0.776

High

703971

PRS7
26S proteasome regulatory subunit 7 homolog

8

15

Small-scale

0.747

High

604840

PSB4
Proteasome subunit beta type-4

9

19

Small-scale

0.747

High

797730

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

6

High-throughput

0.716

High

860042

RPN14
26S proteasome regulatory subunit RPN14

5

3

Small-scale

0.716

High

619393

PSA3
Proteasome subunit alpha type-3

4

16

Small-scale

0.691

High

675492

PSB7
Proteasome subunit beta type-7

4

20

Small-scale

0.691

High

753446

ECM29
Proteasome component ECM29

4

2

High-throughput

0.691

High

771356

PSA6
Proteasome subunit alpha type-6

4

16

Small-scale

0.691

High

837213

PSD10
Probable 26S proteasome regulatory subunit p28

6

2

Small-scale

0.670

High

771389

PSA4
Proteasome subunit alpha type-4

3

18

Small-scale

0.656

High

294165

SEM1
26S proteasome complex subunit SEM1

4

0

Small-scale

0.653

High

619520

PSA2
Proteasome subunit alpha type-2

3

14

Small-scale

0.640

High

625961

PSB2
Proteasome subunit beta type-2

3

16

Small-scale

0.640

High

141878

RPN13
26S proteasome regulatory subunit RPN13

3

0

High-throughput

0.634

High

996265

RPN8
26S proteasome regulatory subunit RPN8

1

16

High-throughput

0.618

High

865888

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

2

Small-scale

0.595

High

597275

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.584

High

675445

PSB5
Proteasome subunit beta type-5

2

20

Small-scale

0.584

High

689214

PSA5
Proteasome subunit alpha type-5

2

16

Small-scale

0.584

High

477476

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

15

High-throughput

0.579

High

628549

SIS1
Protein SIS1

3

2

High-throughput

0.578

High

657280

URA7
CTP synthase 1

2

1

High-throughput

0.567

High

521160

RAD50
DNA repair protein RAD50

2

2

High-throughput

0.558

High

492686

HSP71
Heat shock protein SSA1

2

4

High-throughput

0.552

High

994547

RBX1
RING-box protein HRT1

1

8

High-throughput

0.536

High

544538

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.533

High

439683

SPS1
Sporulation-specific protein 1

1

2

High-throughput

0.489

High

689390

ARP2
Actin-related protein 2

1

5

High-throughput

0.489

High

751094

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.489

High

811672

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

2

High-throughput

0.489

High

864622

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.489

High

984246

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

2

High-throughput

0.489

High

597351

PSA1
Proteasome subunit alpha type-1

1

14

High-throughput

0.479

High

619990

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.479

High

632507

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.479

High

751185

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.479

High

975854

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

715627

SQT1
Ribosome assembly protein SQT1

1

2

High-throughput

0.470

High

728331

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

995500

CUE5
Ubiquitin-binding protein CUE5

1

0

Small-scale

0.458

High

495175

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

695695

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

367025

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.437

High

368469

EF1A
Elongation factor 1-alpha

1

5

Small-scale

0.437

High

471296

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

523317

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

Small-scale

0.437

High

578571

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.437

High

663545

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

663927

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.437

High

743036

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.437

High

751148

RCK2
Serine/threonine-protein kinase RCK2

1

1

High-throughput

0.437

High

752708

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

774010

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

775500

PSMD9
Probable 26S proteasome regulatory subunit p27

1

1

Small-scale

0.437

High

792617

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

859285

INO80
Chromatin-remodeling ATPase INO80

1

4

Small-scale

0.437

High

979062

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

996266

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

513026

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.407

High

705754

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

761335

CAJ1
Protein CAJ1

1

2

High-throughput

0.407

High

769679

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.407

High

988600

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

4

High-throughput

0.407

High

748962

HSM3
DNA mismatch repair protein HSM3

6

0

Small-scale

0.379

High

993162

MLH2
DNA mismatch repair protein MLH2

2

0

High-throughput

0.324

High

977142

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

420522

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.279

Low

615308

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.269

Low

690644

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

0

High-throughput

0.269

Low

763274

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.269

Low

713723

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.261

Low

685463

SYKM
Lysine--tRNA ligase, mitochondrial

1

0

Small-scale

0.251

Low

962640

ACAC
Acetyl-CoA carboxylase

1

0

Small-scale

0.251

Low

358293

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

405867

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

407369

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

408164

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

480357

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

480927

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

558299

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

606774

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

634806

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

636238

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

645692

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

688470

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

692090

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

700662

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

706533

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

716372

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

716518

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

730154

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

730932

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

731559

POC2
Proteasome assembly chaperone 2

1

0

High-throughput

0.249

Low

734144

PXL1
Paxillin-like protein 1

1

0

High-throughput

0.249

Low

745918

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

820215

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

822943

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

960611

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.249

Low

978342

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

986268

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

987062

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

996268

HSP42
Heat shock protein 42

1

0

Small-scale

0.249

Low

873194

TMEDA
Endoplasmic reticulum vesicle protein 25

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024