Protein: COX4
Cytochrome c oxidase subunit 4, mitochondrial (Cytochrome c oxidase polypeptide IV)

Gene: COX4
Organism: Saccharomyces cerevisiae S288C
Interactions: 164
UniProt ID: P04037

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005751 - mitochondrial respiratory chain complex IV
GO:0005758 - mitochondrial intermembrane space
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335712

COX1
Cytochrome c oxidase subunit 1

7

4

Small-scale

0.953

High

336023

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

5

1

Small-scale

0.912

High

335918

COX2
Cytochrome c oxidase subunit 2

7

0

Small-scale

0.902

High

373224

COX13
Cytochrome c oxidase subunit 13, mitochondrial

4

1

Small-scale

0.873

High

336073

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

3

1

Small-scale

0.827

High

373189

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

7

3

Small-scale

0.740

High

336000

COX3
Cytochrome c oxidase subunit 3

2

0

Small-scale

0.728

High

336104

COX6
Cytochrome c oxidase subunit 6, mitochondrial

2

0

High-throughput

0.716

High

373202

COX7
Cytochrome c oxidase subunit 7, mitochondrial

2

0

High-throughput

0.716

High

373207

ADT2
ADP,ATP carrier protein 2

5

3

Small-scale

0.712

High

373191

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

7

0

Small-scale

0.705

High

373200

HSP77
Import motor subunit, mitochondrial

4

1

Small-scale

0.692

High

373226

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

4

1

Small-scale

0.689

High

373188

COX9
Cytochrome c oxidase subunit 9, mitochondrial

5

0

Small-scale

0.673

High

373184

CY1
Cytochrome c1, heme protein, mitochondrial

4

0

Small-scale

0.648

High

373193

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

4

0

Small-scale

0.648

High

373281

RCF2
Respiratory supercomplex factor 2, mitochondrial

4

0

Small-scale

0.648

High

373292

RCF1
Respiratory supercomplex factor 1, mitochondrial

4

0

Small-scale

0.648

High

373243

GRPE
GrpE protein homolog, mitochondrial

3

0

Small-scale

0.619

High

371045

SCE3
Intron-encoded DNA endonuclease aI3

1

4

High-throughput

0.618

High

371050

SCE2
Intron-encoded DNA endonuclease aI4

1

5

High-throughput

0.618

High

373317

SCE4
Intron-encoded DNA endonuclease aI5 alpha

1

5

High-throughput

0.618

High

373178

COX8
Cytochrome c oxidase subunit 8, mitochondrial

3

0

Small-scale

0.613

High

373233

MIC60
MICOS complex subunit MIC60

3

0

High-throughput

0.613

High

373236

QCR10
Cytochrome b-c1 complex subunit 10, mitochondrial

3

0

Small-scale

0.613

High

373280

SHY1
Cytochrome oxidase assembly protein SHY1

2

1

Small-scale

0.611

High

333474

CYB
Cytochrome b

2

3

Small-scale

0.595

High

373177

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.586

High

373249

COX14
Cytochrome c oxidase assembly protein COX14

2

0

Small-scale

0.585

High

373190

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

2

2

High-throughput

0.584

High

373255

HSP7E
Heat shock protein SSC3, mitochondrial

2

1

High-throughput

0.584

High

373286

COX12
Cytochrome c oxidase subunit 12, mitochondrial

2

1

High-throughput

0.584

High

373295

YHM2
Citrate/oxoglutarate carrier protein

2

5

High-throughput

0.584

High

373303

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

2

1

Small-scale

0.584

High

373185

TOM70
Mitochondrial import receptor subunit TOM70

2

0

Small-scale

0.569

High

373287

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

0

Small-scale

0.569

High

373223

CACP
Carnitine O-acetyltransferase, mitochondrial

2

0

High-throughput

0.565

High

333349

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.559

High

333402

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

2

0

High-throughput

0.559

High

373211

QCR9
Cytochrome b-c1 complex subunit 9, mitochondrial

2

0

High-throughput

0.559

High

373216

NFS1
Cysteine desulfurase, mitochondrial

2

0

Small-scale

0.559

High

373217

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

2

0

High-throughput

0.559

High

373267

COX16
Cytochrome c oxidase assembly protein COX16, mitochondrial

2

0

Small-scale

0.559

High

373273

TOM22
Mitochondrial import receptor subunit TOM22

2

0

High-throughput

0.559

High

373310

COX26
Cytochrome c oxidase subunit 26, mitochondrial

2

0

Small-scale

0.559

High

373313

ISD11
Protein ISD11

2

0

Small-scale

0.559

High

373298

STE23
A-factor-processing enzyme

1

1

Small-scale

0.501

High

373271

BXI1
Bax inhibitor 1

1

0

Small-scale

0.493

High

373210

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.486

High

333292

CYC1
Cytochrome c isoform 1

1

1

High-throughput

0.479

High

333327

CYC7
Cytochrome c isoform 2

1

1

High-throughput

0.479

High

342330

CISY1
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

370991

MBI2
Cytochrome b mRNA maturase bI2

1

4

High-throughput

0.479

High

371040

AI2M
Putative COX1/OXI3 intron 2 protein

1

4

High-throughput

0.479

High

371053

MBI4
Intron-encoded RNA maturase bI4

1

4

High-throughput

0.479

High

373179

ADT1
ADP,ATP carrier protein 1

1

3

High-throughput

0.479

High

373194

CISY2
Citrate synthase, peroxisomal

1

2

High-throughput

0.479

High

373206

ADT3
ADP,ATP carrier protein 3

1

3

High-throughput

0.479

High

373212

MPCP
Mitochondrial phosphate carrier protein

1

2

High-throughput

0.479

High

373214

SCO1
Protein SCO1, mitochondrial

1

1

High-throughput

0.479

High

373220

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

2

High-throughput

0.479

High

373227

PREP
Presequence protease, mitochondrial

1

1

High-throughput

0.479

High

373228

SFC1
Succinate/fumarate mitochondrial transporter

1

6

High-throughput

0.479

High

373239

TXTP
Tricarboxylate transport protein

1

5

High-throughput

0.479

High

373247

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

4

High-throughput

0.479

High

373252

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

1

High-throughput

0.479

High

373260

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

2

High-throughput

0.479

High

373261

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

1

High-throughput

0.479

High

373264

PHB1
Prohibitin-1

1

1

High-throughput

0.479

High

373274

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

373290

ODC1
Mitochondrial 2-oxodicarboxylate carrier 1

1

5

High-throughput

0.479

High

373302

NDH2
External NADH-ubiquinone oxidoreductase 2, mitochondrial

1

2

High-throughput

0.479

High

373315

ODC2
Mitochondrial 2-oxodicarboxylate carrier 2

1

3

High-throughput

0.479

High

373316

MBI3
Cytochrome b mRNA maturase bI3

1

3

High-throughput

0.479

High

342187

ATP6
ATP synthase subunit a

1

0

Small-scale

0.458

High

373180

SYWM
Tryptophan--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

373181

VDAC1
Mitochondrial outer membrane protein porin 1

1

0

High-throughput

0.458

High

373182

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

373186

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

373187

CBP6
Cytochrome B pre-mRNA-processing protein 6

1

0

High-throughput

0.458

High

373192

NUC1
Mitochondrial nuclease

1

0

High-throughput

0.458

High

373195

ATPO
ATP synthase subunit 5, mitochondrial

1

0

High-throughput

0.458

High

373203

PET54
Protein PET54

1

0

High-throughput

0.458

High

373204

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

373205

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

373208

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

High-throughput

0.458

High

373209

CBP3
Protein CBP3, mitochondrial

1

0

High-throughput

0.458

High

373213

TOM40
Mitochondrial import receptor subunit TOM40

1

0

High-throughput

0.458

High

373215

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.458

High

373218

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.458

High

373219

MSS51
Protein MSS51, mitochondrial

1

0

Small-scale

0.458

High

373221

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.458

High

373222

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

373225

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.458

High

373229

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.458

High

373230

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.458

High

373231

MCR1
NADH-cytochrome b5 reductase 2

1

0

High-throughput

0.458

High

373232

MGR3L
Protein MRG3-like

1

0

High-throughput

0.458

High

373234

CBP4
Assembly factor CBP4

1

0

High-throughput

0.458

High

373235

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

373238

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

373241

MBA1
Inner membrane mitoribosome receptor MBA1, mitochondrial

1

0

High-throughput

0.458

High

373244

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.458

High

373245

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

373246

PT100
Protein PET100, mitochondrial

1

0

High-throughput

0.458

High

373248

PSD1
Phosphatidylserine decarboxylase proenzyme 1, mitochondrial

1

0

High-throughput

0.458

High

373250

TIM17
Mitochondrial import inner membrane translocase subunit TIM17

1

0

High-throughput

0.458

High

373251

CEM1
3-oxoacyl-[acyl-carrier-protein] synthase homolog

1

0

High-throughput

0.458

High

373254

OXA1
Mitochondrial inner membrane protein OXA1

1

0

High-throughput

0.458

High

373257

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

373258

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

373262

AIM19
Altered inheritance of mitochondria protein 19, mitochondrial

1

0

High-throughput

0.458

High

373263

PUP1
PUP1 protein homolog

1

0

High-throughput

0.458

High

373265

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.458

High

373269

GCST
Aminomethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

373270

ADRO
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

373275

MIC27
MICOS complex subunit MIC27

1

0

High-throughput

0.458

High

373277

MCY1
Putative mitochondrial cysteine synthase

1

0

High-throughput

0.458

High

373278

TIM21
Mitochondrial import inner membrane translocase subunit TIM21

1

0

Small-scale

0.458

High

373279

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

373283

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

373284

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

373289

MGR2
Protein MGR2

1

0

High-throughput

0.458

High

373293

AIM36
Altered inheritance of mitochondria protein 36, mitochondrial

1

0

High-throughput

0.458

High

373296

HFD1
Fatty aldehyde dehydrogenase HFD1

1

0

High-throughput

0.458

High

373297

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

373299

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.458

High

373300

ATG33
Autophagy-related protein 33

1

0

High-throughput

0.458

High

373301

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.458

High

373304

COQ10
Coenzyme Q-binding protein COQ10, mitochondrial

1

0

High-throughput

0.458

High

373305

MDM38
Mitochondrial distribution and morphology protein 38

1

0

High-throughput

0.458

High

373311

YD381
Uncharacterized mitochondrial outer membrane protein YDR381C-A

1

0

High-throughput

0.458

High

373314

MIC10
MICOS complex subunit MIC10

1

0

High-throughput

0.458

High

355284

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

355716

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

373183

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.437

High

373196

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

373197

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.437

High

373198

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.437

High

373199

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

2

High-throughput

0.437

High

373253

SNF7
Vacuolar-sorting protein SNF7

1

1

High-throughput

0.437

High

373272

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.437

High

373276

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.437

High

373291

VPS60
Vacuolar protein-sorting-associated protein 60

1

1

Small-scale

0.437

High

373240

HSL7
Protein arginine N-methyltransferase HSL7

2

0

High-throughput

0.307

High

373312

YB255
Uncharacterized protein YBR255C-A

2

0

Small-scale

0.305

High

373288

SKI8
Antiviral protein SKI8

1

0

High-throughput

0.282

High

373307

GIN4
Serine/threonine-protein kinase GIN4

1

0

High-throughput

0.261

Low

145655

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.249

Low

357751

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

373201

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

373242

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.249

Low

373256

IRC22
Increased recombination centers protein 22

1

0

High-throughput

0.249

Low

373266

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

373282

YN8B
UPF0674 endoplasmic reticulum membrane protein YNR021W

1

0

High-throughput

0.249

Low

373285

RL34A
Large ribosomal subunit protein eL34A

1

0

High-throughput

0.249

Low

373294

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

373306

YP063
Uncharacterized protein YPR063C

1

0

High-throughput

0.249

Low

373308

OSH2
Oxysterol-binding protein homolog 2

1

0

High-throughput

0.249

Low

373309

YK023
Uncharacterized protein YKL023C-A

1

0

High-throughput

0.249

Low

373237

HMT1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.238

Low

373268

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.238

Low

373259

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024