Protein: TBP
TATA-box-binding protein (TATA sequence-binding protein) (TBP) (TATA-binding factor) (TATA-box factor) (Transcription factor D) (Transcription initiation factor TFIID TBP subunit)

Gene: TBP, SPT15
Organism: Saccharomyces cerevisiae S288C
Interactions: 190
UniProt ID: P13393

Gene Ontology (top 5):
GO:0000126 - transcription factor TFIIIB complex
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001016 - RNA polymerase III transcription regulatory region sequence-specific DNA binding
GO:0001092 - TFIIA-class transcription factor complex binding
GO:0001179 - RNA polymerase I general transcription initiation factor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

527022

TAF1
Transcription initiation factor TFIID subunit 1

32

8

Small-scale

0.993

High

526976

TOA1
Transcription initiation factor IIA large subunit

17

10

Small-scale

0.985

High

526960

TF3B
Transcription factor IIIB 70 kDa subunit

14

13

Small-scale

0.983

High

526977

T2AG
Transcription initiation factor IIA subunit 2

15

4

Small-scale

0.983

High

526959

TF2B
Transcription initiation factor IIB

12

12

Small-scale

0.977

High

527055

TAF11
Transcription initiation factor TFIID subunit 11

11

2

Small-scale

0.972

High

527028

TAF4
Transcription initiation factor TFIID subunit 4

8

5

Small-scale

0.964

High

420589

SPT3
Protein SPT3

6

4

Small-scale

0.938

High

515098

TAF13
Transcription initiation factor TFIID subunit 13

6

4

Small-scale

0.931

High

527008

NCB1
Negative cofactor 2 complex subunit alpha

5

2

Small-scale

0.909

High

527023

TFC5
Transcription factor TFIIIB component B''

4

2

Small-scale

0.896

High

527085

NCB2
Negative cofactor 2 complex subunit beta

4

4

Small-scale

0.882

High

526934

TBP
TATA-box-binding protein

3

4

Small-scale

0.858

High

526962

BTAF1
TATA-binding protein-associated factor MOT1

18

6

Small-scale

0.765

High

526997

TAF5
Transcription initiation factor TFIID subunit 5

18

8

Small-scale

0.763

High

527051

TAF12
Transcription initiation factor TFIID subunit 12

12

2

Small-scale

0.758

High

527031

TAF6
Transcription initiation factor TFIID subunit 6

10

6

Small-scale

0.753

High

527073

TAF10
Transcription initiation factor TFIID subunit 10

9

6

Small-scale

0.748

High

526951

TAF2
Transcription initiation factor TFIID subunit 2

8

2

Small-scale

0.743

High

526990

TAF14
Transcription initiation factor TFIID subunit 14

7

2

Small-scale

0.739

High

381522

GAL4
Regulatory protein GAL4

8

0

Small-scale

0.722

High

527062

TAF9
Transcription initiation factor TFIID subunit 9

6

3

Small-scale

0.719

High

527032

IMB5
Importin subunit beta-5

7

0

Small-scale

0.714

High

527061

TAF7
Transcription initiation factor TFIID subunit 7

5

5

Small-scale

0.706

High

526967

NGG1
Chromatin-remodeling complexes subunit NGG1

4

1

Small-scale

0.696

High

527005

SPT8
Transcription factor SPT8

5

0

Small-scale

0.688

High

527042

ADA2
Transcriptional adapter 2

4

3

Small-scale

0.681

High

526989

SPT7
Transcriptional activator SPT7

4

11

Small-scale

0.676

High

527040

PRS8
26S proteasome regulatory subunit 8 homolog

3

5

Small-scale

0.672

High

526937

HSC82
ATP-dependent molecular chaperone HSC82

3

1

High-throughput

0.650

High

527035

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

3

0

Small-scale

0.646

High

375240

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

4

Small-scale

0.646

High

368711

GCN4
General control transcription factor GCN4

3

0

Small-scale

0.641

High

526938

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

3

Small-scale

0.633

High

526978

RRN6
RNA polymerase I-specific transcription initiation factor RRN6

3

0

Small-scale

0.630

High

145857

MBF1
Multiprotein-bridging factor 1

2

2

Small-scale

0.629

High

527078

TAF3
Transcription initiation factor TFIID subunit 3

3

0

Small-scale

0.622

High

527059

RRN11
RNA polymerase I-specific transcription initiation factor RRN11

3

0

Small-scale

0.619

High

526993

BDF1
Bromodomain-containing factor 1

2

10

Small-scale

0.611

High

527029

SPT20
Transcription factor SPT20

3

0

Small-scale

0.606

High

425280

PHO4
Phosphate system positive regulatory protein PHO4

2

0

Small-scale

0.603

High

526963

IMB3
Importin subunit beta-3

2

1

Small-scale

0.595

High

527063

IMB1
Importin subunit beta-1

2

1

Small-scale

0.595

High

527052

RUVB1
RuvB-like protein 1

1

5

Small-scale

0.589

High

527080

RUVB2
RuvB-like protein 2

1

5

Small-scale

0.589

High

526983

PRS6A
26S proteasome regulatory subunit 6A

2

4

High-throughput

0.588

High

527074

HFI1
Transcriptional coactivator HFI1/ADA1

2

0

Small-scale

0.585

High

526972

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.585

High

527050

TAF8
Transcription initiation factor TFIID subunit 8

2

0

Small-scale

0.585

High

526984

PRS7
26S proteasome regulatory subunit 7 homolog

2

5

Small-scale

0.585

High

526949

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

4

High-throughput

0.584

High

526965

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

High-throughput

0.584

High

527006

CSK2C
Casein kinase II subunit beta'

2

1

Small-scale

0.584

High

516267

RAP1
DNA-binding protein RAP1

2

0

Small-scale

0.577

High

526971

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.577

High

526987

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

Small-scale

0.576

High

527053

HMO1
High mobility group protein 1

1

1

Small-scale

0.573

High

355320

H2B1
Histone H2B.1

2

1

High-throughput

0.571

High

392268

H2A2
Histone H2A.2

2

1

High-throughput

0.571

High

456983

SWI6
Regulatory protein SWI6

2

2

High-throughput

0.571

High

527041

RSC4
Chromatin structure-remodeling complex subunit RSC4

2

13

High-throughput

0.571

High

527049

GCN5
Histone acetyltransferase GCN5

2

5

High-throughput

0.571

High

527084

H2AZ
Histone H2A.Z

2

2

Small-scale

0.571

High

527015

RRN7
RNA polymerase I-specific transcription initiation factor RRN7

2

0

Small-scale

0.569

High

527054

RPN9
26S proteasome regulatory subunit RPN9

2

0

High-throughput

0.563

High

526943

CSK22
Casein kinase II subunit alpha'

1

1

Small-scale

0.561

High

527020

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.561

High

527039

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

Small-scale

0.561

High

526954

RPC4
DNA-directed RNA polymerase III subunit RPC4

2

0

High-throughput

0.559

High

527043

STD1
Protein STD1

1

0

Small-scale

0.549

High

526966

ASF1
Histone chaperone ASF1

2

0

Small-scale

0.547

High

527070

RSC58
Chromatin structure-remodeling complex protein RSC58

2

0

High-throughput

0.547

High

526999

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

Small-scale

0.545

High

526975

RAD23
UV excision repair protein RAD23

1

0

Small-scale

0.537

High

409819

NOT2
General negative regulator of transcription subunit 2

1

1

Small-scale

0.515

High

526952

NAP1
Nucleosome assembly protein

1

1

High-throughput

0.515

High

527083

NOT5
General negative regulator of transcription subunit 5

1

1

Small-scale

0.515

High

356211

H4
Histone H4

1

0

High-throughput

0.513

High

423652

ADR1
Regulatory protein ADR1

1

0

Small-scale

0.512

High

425229

PHO2
Regulatory protein PHO2

1

2

Small-scale

0.501

High

526936

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.501

High

527018

T2FB
Transcription initiation factor IIF subunit beta

1

1

Small-scale

0.500

High

527013

IST3
U2 snRNP component IST3

1

0

High-throughput

0.486

High

355759

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

365688

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

375566

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

4

High-throughput

0.479

High

392037

H2A1
Histone H2A.1

1

1

High-throughput

0.479

High

409940

NOT3
General negative regulator of transcription subunit 3

1

1

High-throughput

0.479

High

429605

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.479

High

526945

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

High-throughput

0.479

High

526947

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

526973

STH1
Nuclear protein STH1/NPS1

1

3

High-throughput

0.479

High

526980

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

526981

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

1

High-throughput

0.479

High

526992

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.479

High

527000

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.479

High

527011

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.479

High

527019

RSC8
Chromatin structure-remodeling complex protein RSC8

1

3

High-throughput

0.479

High

527033

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

15

High-throughput

0.479

High

527057

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.479

High

527066

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

12

High-throughput

0.479

High

526939

EF3A
Elongation factor 3A

1

1

High-throughput

0.470

High

526944

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.460

High

527068

CDC73
Cell division control protein 73

1

0

Small-scale

0.460

High

419442

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

480982

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.458

High

526942

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.458

High

526955

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.458

High

526956

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.458

High

526957

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.458

High

526961

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

526964

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.458

High

526974

RTG1
Retrograde regulation protein 1

1

0

High-throughput

0.458

High

526982

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.458

High

526991

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

526994

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.458

High

526998

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

527003

TRA1
Transcription-associated protein 1

1

0

High-throughput

0.458

High

527004

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

527012

ACA2
ATF/CREB activator 2

1

0

High-throughput

0.458

High

527014

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

527021

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

Small-scale

0.458

High

527026

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

527036

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

527044

ELP4
Elongator complex protein 4

1

0

High-throughput

0.458

High

527046

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.458

High

527048

HOT1
High-osmolarity-induced transcription protein 1

1

0

High-throughput

0.458

High

527056

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

527064

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

0

High-throughput

0.458

High

527065

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

527067

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.458

High

527071

SGO1
Shugoshin

1

0

High-throughput

0.458

High

527075

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

527076

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

527077

MDY2
Ubiquitin-like protein MDY2

1

0

High-throughput

0.458

High

527079

ARP7
Actin-related protein 7

1

0

High-throughput

0.458

High

527082

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

419289

HAP2
Transcriptional activator HAP2

1

1

High-throughput

0.445

High

510091

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

526953

SWI4
Regulatory protein SWI4

1

1

High-throughput

0.445

High

526985

MSN2
Zinc finger protein MSN2

1

1

High-throughput

0.445

High

526986

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.445

High

526995

SET3
SET domain-containing protein 3

1

1

High-throughput

0.445

High

527009

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

527038

H3
Histone H3

1

2

High-throughput

0.445

High

527060

RCO1
Transcriptional regulatory protein RCO1

1

3

High-throughput

0.445

High

360715

TBB
Tubulin beta chain

1

1

High-throughput

0.437

High

404793

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.437

High

485625

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.437

High

526996

MAK5
ATP-dependent RNA helicase MAK5

1

3

High-throughput

0.437

High

527030

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.437

High

527034

SLH1
RQC trigger complex helicase SLH1

1

2

High-throughput

0.437

High

527045

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

1

Small-scale

0.437

High

376607

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

493065

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

526948

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

526969

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.426

High

527001

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.426

High

527010

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

527027

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

527037

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.426

High

527081

RLF2
Chromatin assembly factor 1 subunit p90

1

0

High-throughput

0.426

High

405120

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.407

High

527024

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.407

High

526946

VPS1
Vacuolar protein sorting-associated protein 1

2

0

High-throughput

0.324

High

526940

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

2

0

High-throughput

0.307

High

526941

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.269

Low

527002

BRL1
Nucleus export protein BRL1

1

0

High-throughput

0.269

Low

527025

MTC1
Maintenance of telomere capping protein 1

1

0

High-throughput

0.269

Low

527069

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.269

Low

527007

BFR1
Nuclear segregation protein BFR1

1

0

Small-scale

0.261

Low

402862

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.249

Low

423424

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.249

Low

478828

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

479406

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.249

Low

498416

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.249

Low

526958

POP5
Ribonuclease P/MRP protein subunit POP5

1

0

High-throughput

0.249

Low

526968

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

0

High-throughput

0.249

Low

526970

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

526979

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.249

Low

526988

WHI3
Protein WHI3

1

0

High-throughput

0.249

Low

527016

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.249

Low

527017

BNI1
Protein BNI1

1

0

High-throughput

0.249

Low

527047

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.249

Low

527058

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

424311

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

526935

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.232

Low

526950

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.232

Low

527072

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024