Protein: SEN1
Helicase SEN1 (EC 3.6.4.-) (tRNA-splicing endonuclease positive effector)

Gene: SEN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 204
UniProt ID: Q00416

Gene Ontology (top 5):
GO:0001147 - transcription termination site sequence-specific DNA binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375470

RPB1
DNA-directed RNA polymerase II subunit RPB1

9

5

Small-scale

0.752

High

758921

NAB3
Nuclear polyadenylated RNA-binding protein 3

6

1

Small-scale

0.735

High

696384

PP12
Serine/threonine-protein phosphatase PP1-2

5

4

Small-scale

0.727

High

863163

NRD1
Protein NRD1

11

0

Small-scale

0.726

High

558198

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

2

Small-scale

0.676

High

425551

RAD2
DNA repair protein RAD2

3

3

Small-scale

0.670

High

959992

RNT1
Ribonuclease 3

3

2

Small-scale

0.670

High

339790

CDK1
Cyclin-dependent kinase 1

2

2

Small-scale

0.639

High

650363

SPT5
Transcription elongation factor SPT5

3

3

Small-scale

0.633

High

710196

NCBP1
Nuclear cap-binding protein complex subunit 1

2

2

High-throughput

0.621

High

376894

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

9

Small-scale

0.601

High

748998

PAF1
RNA polymerase II-associated protein 1

2

1

Small-scale

0.588

High

440079

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

3

Small-scale

0.584

High

606719

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

3

Small-scale

0.584

High

688374

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

Small-scale

0.584

High

959988

CTF4
DNA polymerase alpha-binding protein

2

9

Small-scale

0.584

High

960028

NCBP2
Nuclear cap-binding protein subunit 2

2

13

High-throughput

0.584

High

404673

RL7A
Large ribosomal subunit protein uL30A

2

1

High-throughput

0.571

High

604599

RPA2
DNA-directed RNA polymerase I subunit RPA135

2

3

Small-scale

0.571

High

866405

APJ1
J domain-containing protein APJ1

2

5

High-throughput

0.571

High

593082

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

Small-scale

0.559

High

634893

MRC1
Mediator of replication checkpoint protein 1

2

0

Small-scale

0.559

High

492132

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

959987

RPA49
DNA-directed RNA polymerase I subunit RPA49

2

0

Small-scale

0.547

High

697990

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

2

High-throughput

0.541

High

368321

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.536

High

419569

RAD1
DNA repair protein RAD1

1

1

High-throughput

0.536

High

539399

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.536

High

648415

NSR1
Nuclear localization sequence-binding protein

1

17

Small-scale

0.536

High

731709

SDS22
Protein phosphatase 1 regulatory subunit SDS22

1

1

Small-scale

0.536

High

829667

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.536

High

960031

YRA1
RNA annealing protein YRA1

1

8

Small-scale

0.536

High

960005

POB3
FACT complex subunit POB3

2

3

Small-scale

0.533

High

649992

BUD14
Bud site selection protein 14

1

0

High-throughput

0.518

High

795404

SMD3
Small nuclear ribonucleoprotein Sm D3

1

5

High-throughput

0.508

High

811660

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

11

High-throughput

0.508

High

959991

NUP49
Nucleoporin NUP49/NSP49

1

2

Small-scale

0.508

High

624152

DBP2
ATP-dependent RNA helicase DBP2

1

3

Small-scale

0.501

High

687569

PYC2
Pyruvate carboxylase 2

1

0

Small-scale

0.486

High

752080

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

Small-scale

0.486

High

959990

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

Small-scale

0.486

High

960014

YP148
Uncharacterized protein YPR148C

1

0

Small-scale

0.486

High

523432

SRS2
ATP-dependent DNA helicase SRS2

1

2

Small-scale

0.481

High

688917

SMY1
Kinesin-related protein SMY1

1

8

High-throughput

0.481

High

728738

BDF1
Bromodomain-containing factor 1

1

9

High-throughput

0.481

High

959997

STE20
Serine/threonine-protein kinase STE20

1

2

Small-scale

0.481

High

375624

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

Small-scale

0.479

High

405256

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.479

High

429751

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.479

High

481395

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.479

High

501397

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

5

Small-scale

0.479

High

526857

DPOLA
DNA polymerase alpha catalytic subunit A

1

2

Small-scale

0.479

High

535085

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

593175

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

593256

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.479

High

602371

DPOE
DNA polymerase epsilon catalytic subunit A

1

2

Small-scale

0.479

High

604707

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

619161

SPT6
Transcription elongation factor SPT6

1

1

High-throughput

0.479

High

622187

MCM3
DNA replication licensing factor MCM3

1

2

Small-scale

0.479

High

630241

RRP43
Exosome complex component RRP43

1

1

High-throughput

0.479

High

645102

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

655575

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

2

High-throughput

0.479

High

655642

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

2

High-throughput

0.479

High

667880

MCM5
Minichromosome maintenance protein 5

1

2

Small-scale

0.479

High

675547

MCM4
DNA replication licensing factor MCM4

1

2

Small-scale

0.479

High

701187

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

1

Small-scale

0.479

High

710028

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

3

High-throughput

0.479

High

727980

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

3

Small-scale

0.479

High

733194

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

1

Small-scale

0.479

High

757148

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

2

High-throughput

0.479

High

764582

EXO1
Exodeoxyribonuclease 1

1

5

High-throughput

0.479

High

775227

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.479

High

805014

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.479

High

859005

MCM6
DNA replication licensing factor MCM6

1

1

Small-scale

0.479

High

860247

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.479

High

866602

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

959994

XRN2
5'-3' exoribonuclease 2

1

7

High-throughput

0.479

High

960001

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

960003

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

2

Small-scale

0.479

High

960009

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

960018

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.479

High

960026

SGO1
Shugoshin

1

2

High-throughput

0.479

High

960029

RRP6
Exosome complex exonuclease RRP6

1

6

High-throughput

0.479

High

960030

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

685456

SYKM
Lysine--tRNA ligase, mitochondrial

1

0

Small-scale

0.460

High

935991

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.460

High

960002

ECM11
Protein ECM11

1

0

High-throughput

0.460

High

572018

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

Small-scale

0.458

High

593337

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

622887

DPB2
DNA polymerase epsilon subunit B

1

0

Small-scale

0.458

High

631681

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

Small-scale

0.458

High

698904

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

701342

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.458

High

756059

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

773004

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

775818

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

811311

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

Small-scale

0.458

High

862667

PRS10
26S proteasome subunit RPT4

1

0

High-throughput

0.458

High

959996

SLD5
DNA replication complex GINS protein SLD5

1

0

Small-scale

0.458

High

960006

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.458

High

960013

IWS1
Transcription factor SPN1

1

0

High-throughput

0.458

High

960019

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

960023

CDC45
Cell division control protein 45

1

0

Small-scale

0.458

High

960033

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

797068

RGD2
Rho-GTPase-activating protein RGD2

1

1

High-throughput

0.457

High

355974

H2B2
Histone H2B.2

1

1

Small-scale

0.445

High

356655

H4
Histone H4

1

4

Small-scale

0.445

High

392533

H2A2
Histone H2A.2

1

3

Small-scale

0.445

High

399594

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

416051

DED1
ATP-dependent RNA helicase DED1

1

3

Small-scale

0.445

High

485574

SSBP1
Single-stranded nucleic acid-binding protein

1

14

Small-scale

0.445

High

494709

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

512357

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

514203

NHP6A
Non-histone chromosomal protein 6A

1

7

Small-scale

0.445

High

549466

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.445

High

584781

CSK22
Casein kinase II subunit alpha'

1

2

Small-scale

0.445

High

593553

DBP3
ATP-dependent RNA helicase DBP3

1

4

Small-scale

0.445

High

593681

DBP4
ATP-dependent RNA helicase HCA4

1

8

Small-scale

0.445

High

597879

PWP1
Periodic tryptophan protein 1

1

11

Small-scale

0.445

High

605121

XRN1
5'-3' exoribonuclease 1

1

7

Small-scale

0.445

High

628361

SIS1
Protein SIS1

1

4

High-throughput

0.445

High

633482

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

633979

GBP2
Serine/arginine

1

18

Small-scale

0.445

High

634730

KRR1
KRR1 small subunit processome component

1

1

Small-scale

0.445

High

643196

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

4

Small-scale

0.445

High

655881

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

1

Small-scale

0.445

High

680930

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

690886

HIR2
Protein HIR2

1

8

Small-scale

0.445

High

691409

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

3

Small-scale

0.445

High

695305

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

703097

MRT4
Ribosome assembly factor MRT4

1

1

Small-scale

0.445

High

704400

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

Small-scale

0.445

High

704906

LHP1
La protein homolog

1

8

Small-scale

0.445

High

733148

DBP7
ATP-dependent RNA helicase DBP7

1

8

Small-scale

0.445

High

742047

NOP4
Nucleolar protein 4

1

13

Small-scale

0.445

High

753042

RRP3
ATP-dependent rRNA helicase RRP3

1

6

Small-scale

0.445

High

754627

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

757320

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

Small-scale

0.445

High

760931

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.445

High

766339

SNU13
13 kDa ribonucleoprotein-associated protein

1

3

Small-scale

0.445

High

766938

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

4

Small-scale

0.445

High

769183

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

778838

NOP2
25S rRNA

1

1

Small-scale

0.445

High

812325

DPH4
Diphthamide biosynthesis protein 4

1

1

High-throughput

0.445

High

859405

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

Small-scale

0.445

High

864582

BRE5
UBP3-associated protein BRE5

1

6

Small-scale

0.445

High

865479

JJJ1
J protein JJJ1

1

2

High-throughput

0.445

High

865737

NOP13
Nucleolar protein 13

1

14

Small-scale

0.445

High

959989

NOP3
Serine/arginine

1

20

Small-scale

0.445

High

959995

IMA1
Importin subunit alpha

1

1

Small-scale

0.445

High

959998

HAS1
ATP-dependent RNA helicase HAS1

1

9

Small-scale

0.445

High

960000

HMO1
High mobility group protein 1

1

6

Small-scale

0.445

High

960004

PUF6
Pumilio homology domain family member 6

1

4

Small-scale

0.445

High

960007

RRP5
rRNA biogenesis protein RRP5

1

2

Small-scale

0.445

High

960010

FKBP4
FK506-binding protein 4

1

3

Small-scale

0.445

High

960012

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

2

Small-scale

0.445

High

960015

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

4

High-throughput

0.445

High

960017

YL419
Putative ATP-dependent RNA helicase YLR419W

1

7

Small-scale

0.445

High

960020

NOP6
Nucleolar protein 6

1

1

Small-scale

0.445

High

960024

NOP12
Nucleolar protein 12

1

18

Small-scale

0.445

High

960025

BRX1
Ribosome biogenesis protein BRX1

1

5

Small-scale

0.445

High

960027

RRS1
Regulator of ribosome biosynthesis

1

1

Small-scale

0.445

High

960032

NOP56
Nucleolar protein 56

1

1

Small-scale

0.445

High

960034

NOP58
Nucleolar protein 58

1

1

Small-scale

0.445

High

960038

MEX67
mRNA export factor MEX67

1

4

Small-scale

0.445

High

701541

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

953509

RL34A
Large ribosomal subunit protein eL34A

1

2

High-throughput

0.437

High

959999

ESC1
Silent chromatin protein ESC1

1

2

High-throughput

0.437

High

145885

MBF1
Multiprotein-bridging factor 1

1

0

Small-scale

0.426

High

366734

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

523300

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

Small-scale

0.426

High

635147

YCQ6
Uncharacterized protein YCR016W

1

0

Small-scale

0.426

High

731851

EBP2
rRNA-processing protein EBP2

1

0

Small-scale

0.426

High

733900

RPF2
Ribosome biogenesis protein RPF2

1

0

Small-scale

0.426

High

750630

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.426

High

752020

SRP68
Signal recognition particle subunit SRP68

1

0

Small-scale

0.426

High

752053

SRP72
Signal recognition particle subunit SRP72

1

0

Small-scale

0.426

High

758086

BFR1
Nuclear segregation protein BFR1

1

0

Small-scale

0.426

High

759426

STM1
Suppressor protein STM1

1

0

Small-scale

0.426

High

760795

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.426

High

764225

NOC2
Nucleolar complex protein 2

1

0

Small-scale

0.426

High

784501

GLC8
Protein GLC8

1

0

Small-scale

0.426

High

791261

KRI1
Protein KRI1

1

0

Small-scale

0.426

High

797383

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

Small-scale

0.426

High

811334

NOP9
Nucleolar protein 9

1

0

Small-scale

0.426

High

811429

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

817392

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

854657

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

859616

LSG1
Large subunit GTPase 1

1

0

Small-scale

0.426

High

865901

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

953675

CTR9
RNA polymerase-associated protein CTR9

1

0

Small-scale

0.426

High

960008

IMB1
Importin subunit beta-1

1

0

Small-scale

0.426

High

960011

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

Small-scale

0.426

High

960016

CDC73
Cell division control protein 73

1

0

Small-scale

0.426

High

960021

NOC3
Nucleolar complex-associated protein 3

1

0

Small-scale

0.426

High

960022

CMS1
Protein CMS1

1

0

Small-scale

0.426

High

960035

RQC2
Ribosome quality control complex subunit 2

1

0

Small-scale

0.426

High

960036

RRP12
Ribosomal RNA-processing protein 12

1

0

Small-scale

0.426

High

960037

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

Small-scale

0.426

High

692872

SPT16
FACT complex subunit SPT16

2

0

Small-scale

0.298

High

959993

SLU7
Pre-mRNA-splicing factor SLU7

1

0

Small-scale

0.251

Low

745820

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

675102

SEC1
Protein transport protein SEC1

1

0

Small-scale

0.232

Low

860020

JAC1
J-type co-chaperone JAC1, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024